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NASA Spaceline Current Awareness November 21, 2003

Status Report From: NASA Office of Biological and Physical Research (OBPR)
Posted: Sunday, November 30, 2003

Note (#1)

This is an introduction to a special issue consisting of the following eight (#s 2-9) vestibular research papers from the National Space Biomedical Research Institute Neurovestibular Adaptation Research Team.
Oman CM.
Neurovestibular adaptation to spaceflight: research progress.
J Vestib Res. 2002-2003;12(5-6):201-3.
(PI: C.M. Oman/Biomedical Research and Countermeasures)

2
Dornhoffer JL, Mamiya N, Bray P, Skinner RD, Garcia-Rill E.
Effects of rotation on the sleep state-dependent midlatency auditory evoked P50
potential in the human.
J Vestib Res. 2002-2003;12(5-6):205-9.
(PI: J.L. Dornhoffer/Biomedical Research and Countermeasures)

3
Shelhamer M, Clendaniel RA, Roberts DC.
Context-specific adaptation of saccade gain in parabolic flight.
J Vestib Res. 2002-2003;12(5-6):211-21.
(PI: M. Shelhamer/Biomedical Research and Countermeasures)

4
Richards JT, Oman CM, Shebilske WL, Beall AC, Liu A, Natapoff A.
Training, transfer, and retention of three-dimensional spatial memory in
virtual environments.
J Vestib Res. 2002-2003;12(5-6):223-38.
(PI: C.M. Oman/Biomedical Research and Countermeasures)

5
Wall C 3rd, Oddsson LI, Patronik N, Sienko K, Kentala E.
Recovery trajectories of vestibulopathic subjects after perturbations during
locomotion.
J Vestib Res. 2002-2003;12(5-6):239-53.
(PI: C. Wall 3rd/Biomedical Research and Countermeasures)

6
Mulavara AP, Bloomberg JJ.
Identifying head-trunk and lower limb contributions to gaze stabilization
during locomotion.
J Vestib Res. 2002-2003;12(5-6):255-69.
(PI: J.J. Bloomberg/Biomedical Research and Countermeasures)

7
Brown EL, Hecht H, Young LR.
Sensorimotor aspects of high-speed artificial gravity: I. Sensory conflict in
vestibular adaptation.
J Vestib Res. 2002-2003;12(5-6):271-82.
(PI: L.R. Young/Biomedical Research and Countermeasures)

8
Mast FW, Newby NJ, Young LR.
Sensorimotor aspects of high-speed artificial gravity: II. The effect of head
position on illusory self motion.
J Vestib Res. 2002-2003;12(5-6):283-9.
(PI: L.R. Young/Biomedical Research and Countermeasures)

9
DiZio P, Lackner JR.
Sensorimotor aspects of high-speed artificial gravity: III. Sensorimotor
adaptation.
J Vestib Res. 2002-2003;12(5-6):291-9. Review.
(PIs: L.R. Young and J.R. Lackner/Biomedical Research and Countermeasures)

10
Lenarczyk M, Ueno A, Vannais DB, Kraemer S, Kronenberg A, Roberts JC,
Tatsumi K, Hei TK, Waldren CA.

The "pro-drug" RibCys decreases the mutagenicity of high-LET radiation in
cultured mammalian cells.
Radiat Res. 2003 Nov;160(5):579-83.
(PIs: A. Kronenberg and C.A. Waldren; A. Chatterjee, NSCORT in Radiation Health/Biomedical Research and Countermeasures)

11
Ogoh S, Fadel PJ, Hardisty JM, Wasmund WL, Keller DM, Raven PB, Smith ML.
Does pulsatile and sustained neck pressure or neck suction produce differential
cardiovascular and sympathetic responses in humans?
Exp Physiol. 2003 Sep;88(5):595-601.
(PI: M.L. Smith/Biomedical Research and Countermeasures)

12
Lecker SH.
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
Curr Opin Clin Nutr Metab Care. 2003 May;6(3):271-5. Review.
(PI: A.L. Goldberg/Biomedical Research and Countermeasures)

13
Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL.
Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by
intracellular calcium release.
Bone. 2003 Sep;33(3):399-410.
(PI: D.C. Genetos, Graduate Student Researchers Program/Biomedical Research and Countermeasures)

14
Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM.
Host resistance of CD18 knockout mice against systemic infection with Listeria
monocytogenes.
Infect Immun. 2003 Oct;71(10):5986-93.
(PI: C.W. Smith/Biomedical Research and Countermeasures)

15
Boonsirichai K, Sedbrook JC, Chen R, Gilroy S, Masson PH.
ALTERED RESPONSE TO GRAVITY is a peripheral membrane protein that modulates
gravity-induced cytoplasmic alkalinization and lateral auxin transport in plant
statocytes.
Plant Cell. 2003 Nov;15(11):2612-25. Epub 2003 Sep 24.
(PIs: S. Gilroy and P.H. Masson/Fundamental Space Biology)

16
Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo
H.

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring
intracellular calcium increase.
Free Radic Biol Med. 2003 Oct 1;35(7):729-41.
(PI: H. Jo/Fundamental Space Biology)

17
Xu XH, Shi Y, Liu SH, Wang HP, Chang SG, Fisher JW, Pisharody S, Moran
M, Wignarajah K.
Method for the control of NOx emissions in long-range space travel.
Energy Fuels. 2003 Sep-Oct;17(5):1303-10.
(PI: J.W. Fisher/Advanced Human Support Technology)

18
Kounaves SP, Lukow SR, Comeau BP, Hecht MH, Grannan-Feldman SM,
Manatt K, West SJ, Wen X, Frant M, Gillette T.
Mars Surveyor Program '01 Mars Environmental Compatibility Assessment wet
chemistry lab: a sensor array for chemical analysis of the Martian soil.
J Geophys Res Planets. 2003 24 Jul;108(E7):1-12.
(PI: S.P. Kounaves/Advanced Human Support Technology)

19

Note (#19)

STS-78 results
Narici M, Kayser B, Barattini P, Cerretelli P.
Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps surae.
Eur J Appl Physiol. 2003 Oct;90(3-4):275-82. Epub 2003 Sep 17.

20
Gandia P, Bareille MP, Saivin S, Le-Traon AP, Lavit M, Guell A, Houin G.
Influence of simulated weightlessness on the oral pharmacokinetics of
acetaminophen as a gastric emptying probe in man: a plasma and a saliva study.
J Clin Pharmacol. 2003 Nov;43(11):1235-43.

21
Kamiya H, Sasaki S, Ikeuchi T, Umemoto Y, Tatsura H, Hayashi Y, Kaneko S,
Kohri K.

Effect of simulated microgravity on testosterone and sperm motility in mice.
J Androl. 2003 Nov-Dec;24(6):885-90.

22
Yoshimura K, Matsuo Y, Kamiya R.
Gravitaxis in Chlamydomonas reinhardtii studied with novel mutants.
Plant Cell Physiol. 2003 Oct;44(10):1112-8.

Note (#23)

Interactions between phototropic and gravitropic responses (including clinostat rotation to eliminate gravitropic response) were studied.
23
Fuchs I, Philippar K, Ljung K, Sandberg G, Hedrich R.
Blue light regulates an auxin-induced K+-channel gene in the maize coleoptile.
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11795-800. Epub 2003 Sep 19.

24
Zhou H, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK.

Note (#24)

PIs Eric Hall and William Morgan were quoted in an article about radiation adaptation/bystander effects: "Hormesis: A Healthful Dose of Radiation?", Science, October 17, 2003, p. 378. This was part of a longer article about hormesis, the concept that beneficial effects may result from exposure to toxins or radiation at low doses.
Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells.
Radiat Res. 2003 Nov;160(5):512-6.

26
Hahn PJ, Lai ZW, Nevaldine B, Schiff N, Fiore NC, Silverstone AE.
Bcl2-independent chromatin cleavage is a very early event during induction of apoptosis in mouse thymocytes after treatment with either dexamethasone or ionizing radiation.
Radiat Res. 2003 Nov;160(5):559-67.

27
Epperly MW, Gretton JE, Sikora CA, Jefferson M, Bernarding M, Nie S,
Greenberger JS.

Mitochondrial localization of superoxide dismutase is required for decreasing
radiation-induced cellular damage.
Radiat Res. 2003 Nov;160(5):568-78.

28
Ferrari A, Pelliccioni M.
On the conversion coefficients for cosmic ray dosimetry.
Radiat Prot Dosimetry. 2003;104(3):211-20.

29
Qin YX, Kaplan T, Saldanha A, Rubin C.
Fluid pressure gradients, arising from oscillations in intramedullary pressure, is
correlated with the formation of bone and inhibition of intracortical porosity.
J Biomech. 2003 Oct;36(10):1427-37.

30
Ventre-Dominey J, Nighoghossian N, Denise P.
Evidence for interacting cortical control of vestibular function and spatial
representation in man.
Neuropsychologia. 2003;41(14):1884-98.

31
Roberts TJ, Marsh RL.
Probing the limits to muscle-powered accelerations: lessons from jumping
bullfrogs.
J Exp Biol. 2003 Aug;206(Pt 15):2567-80.

32
Pandy MG.
Simple and complex models for studying muscle function in walking.
Philos Trans R Soc Lond B Biol Sci. 2003 Sep 29;358(1437):1501-9.

33
Dupont Salter AC, Richmond FJ, Loeb GE.
Effects of muscle immobilization at different lengths on tetrodotoxin-induced
disuse atrophy.
IEEE Trans Neural Syst Rehabil Eng. 2003 Sep;11(3):209-17.

34
Dupont Salter AC, Richmond FJ, Loeb GE.
Prevention of muscle disuse atrophy by low-frequency electrical stimulation in rats.
IEEE Trans Neural Syst Rehabil Eng. 2003 Sep;11(3):218-26.

35
Priplata AA, Niemi JB, Harry JD, Lipsitz LA, Collins JJ.
Vibrating insoles and balance control in elderly people.
Lancet. 2003 Oct 4;362(9390):1123-4.

36

Note (#36)

Article summarizing circadian rhythm and sleep disruption research and treatments being devised, in anticipation of annual Society of Neuroscience conference; this subject highlighted also in editorial in same issue of Nature.
Abbott A.
Restless nights, listless days.
Nature. 2003 Oct 30;425(6961):896-8.

37
Tang B, Fan XL, Wu SD.
Effects of simulated weightlessness on myosin heavy chain expression of soleus intrafusal muscle fibers in rats.
Space Med Med Eng (Beijing). 2003 Aug;16(4):235-8.

38
Zhan H, Zhang Z, Xin YM, Li T, Wei SH.
Changes of cardiac catecholamines in rats after repeated +Gz exposures and
protective effects of low-G preconditioning and tea polyphenols.
Space Med Med Eng (Beijing). 2003 Aug;16(4):239-42.

39
Yuan LT, Wen LY, Luo YN, Hu PZ, Jiang WZ, Wu XY.
[Changes of dentin, dental pulp and periodontium tissue in tail-suspended rats]
Space Med Med Eng (Beijing). 2003 Aug;16(4):248-52. Chinese.

40
Fu ZJ, Cheng HW, Zhang LF, Ma J, Zhang LN, Ma XW.
[Changes of potassium channel activity of hindlimb arterial smooth muscle cells
in tail-suspended rats]
Space Med Med Eng (Beijing). 2003 Aug;16(4):253-6. Chinese.

41
Ma YJ, Yuan YH, Xie LQ, Li YH, Wan YM, Shi ZZ.
[Effects of simulated weightlessness and mechanical loading on bone interstitial
fluid flow in rats]
Space Med Med Eng (Beijing). 2003 Aug;16(4):257-9. Chinese.

42
Fu CJ, Yu BB, Yang LJ, Zhang LF.
[Changes of osteocalcin in bone and bone marrow in tail suspended rats]
Space Med Med Eng (Beijing). 2003 Aug;16(4):260-3. Chinese.

43
Liu YS, Huang WF, Liu XH, Wang J, Zhao DM, Wu X.
[Effects of exercise training during 21 d -6 degrees head down bed rest on
dynamic posture equilibrium and motor coordination]
Space Med Med Eng (Beijing). 2003 Aug;16(4):264-8. Chinese.

44
Cao XS, Yang LJ, Wu XY, Wu YH, Zhang LN, Zhang LF.
[Changes of bone morphogenesis proteins and transforming growth factor-beta in
hind-limb bones of 21 d tail-suspended rats]
Space Med Med Eng (Beijing). 2003 Aug;16(4):269-71. Chinese.

45
Li YZ, Shi HZ, Fan QC, Tao Y, Bai GE, Duan YR, Xie JS.
[Effects of Qiang Gu Kang Wei prescription on morphology of bone in rats under
simulated weightlessness]
Space Med Med Eng (Beijing). 2003 Aug;16(4):272-6. Chinese.

46
Yang CB, Sun XQ, Wang YC, Yao YJ, Wu BM.
[Development of self-generating lower body negative pressure device]
Space Med Med Eng (Beijing). 2003 Aug;16(4):281-3. Chinese.

47
Liang LX, Liu ZX, Wan YM, Yang TB.
[Changes of endocrine hormones during -6 degrees head down bed rest in
human]
Space Med Med Eng (Beijing). 2003 Aug;16(4):284-6. Chinese.

// end //

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