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NASA Spaceline 25 February 2005 Current Awareness

Status Report From: Spaceline
Posted: Friday, February 18, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Smith SM, Wastney ME, O'brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir Space Station. J Bone Miner Res. 2005 Feb;20(2):208-18. Epub 2004 Nov 08. (PI: L.C. Shackelford) Note (#1) Shuttle-Mir Program results.
  2. Doty SB. Space flight and bone formation. Mater.wiss Werkst.tech. 2004;35(12):951-61. Review. (PI: S.B. Doty) Note (#2) Review article with results of STS and Cosmos flights; includes specific data from STS-95 experiment.
  3. Tesch PA, Berg HE, Bring D, Evans HJ, Leblanc AD. Effects of 17-day spaceflight on knee extensor muscle function and size. Eur J Appl Physiol. 2005 Jan;93(4):463-8. Epub 2004 Oct 23. (PI: A.D. LeBlanc) Note (#3) STS-78 results.
  4. Tou JC, Arnaud SB, Grindeland R, Wade C. The effect of purified compared with nonpurified diet on bone changes induced by hindlimb suspension of female rats. Exp Biol Med (Maywood). 2005 Jan;230(1):31-9. (PI: C. Wade)
  5. Haddad F, Baldwin KM, Tesch PA. Pretranslational markers of contractile protein expression in human skeletal muscle: effect of limb unloading plus resistance exercise. J Appl Physiol. 2005 Jan;98(1):46-52. Epub 2004 Aug 06. (PIs: K.M. Baldwin, P.A. Tesch)
  6. Hunter RB, Kandarian SC. Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest. 2004 Nov;114(10):1504-11. (PI: S.C. Kandarian)
  7. Grenon SM, Hurwitz S, Sheynberg N, Xiao X, Judson B, Ramsdell CD, Kim C, Cohen RJ, Williams GH. Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment. J Appl Physiol. 2004 Nov;97(5):1660-6. Epub 2004 Jul 02. (PIs: R.J. Cohen, G.H. Williams)
  8. Zhao Y, Shao G, Piao CQ, Berenguer J, Hei TK. Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in human bronchial epithelial cells induced by heavy-ion radiation. Radiat Res. 2004 Dec;162(6):655-9. (PI: Y. Zhao)
  9. Borak TB, Doke T, Fuse T, Guetersloh S, Heilbronn L, Hara K, Moyers M, Suzuki S, Taddei P, Terasawa K, Zeitlin CJ. Comparisons of LET distributions for protons with energies between 50 and 200 MeV determined using a spherical tissue-equivalent proportional counter (TEPC) and a position-sensitive silicon spectrometer (RRMD-III). Radiat Res. 2004 Dec;162(6):687-92. (PI: T.B. Borak)
  10. Guan J, Wan XS, Zhou Z, Ware J, Donahue JJ, Biaglow JE, Kennedy AR. Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res. 2004 Nov;162(5):572-9. (PI: A.R. Kennedy)
  11. Powers J, Bernstein D. The mouse as a model of cardiovascular adaptations to microgravity. J Appl Physiol. 2004 Nov;97(5):1686-92. Epub 2004 Jul 16. (PI: D. Bernstein)
  12. Paule MG, Chelonis JJ, Blake DJ, Dornhoffer JL. Effects of drug countermeasures for space motion sickness on working memory in humans. Neurotoxicol Teratol. 2004 Nov-Dec;26(6):825-37. (PI: J.L. Dornhoffer)
  13. Taube JS, Stackman RW, Calton JL, Oman CM. Rat head direction cell responses in zero-gravity parabolic flight. J Neurophysiol. 2004 Nov;92(5):2887-997. Epub 2004 Jun 22. (PI: C.M. Oman) Note (#13) Parabolic flight results.
  14. Clark GB, Lee D, Dauwalder M, Roux SJ. Immunolocalization and histochemical evidence for the association of two different Arabidopsis annexins with secretion during early seedling growth and development. Planta. 2005 Feb;220(4):621-31. Epub 2004 Sep 11. (PI: S.J. Roux)

Other papers of interest:

  1. Giger JM, Haddad F, Qin AX, Zeng M, Baldwin KM. The effect of unloading on type I myosin heavy chain gene regulation in rat soleus muscle. J Appl Physiol. 2004 Dec 10; [Epub ahead of print]
  2. Bickel CS, Slade J, Mahoney E, Haddad F, Dudley GA, Adams GR. Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise. J Appl Physiol. 2005 Feb;98(2):482-8. Epub 2004 Oct 01.
  3. Kujawa M, Baran W, Jankowska-Steifer E. Quantitative ultrastructural changes in satellite cells of rats immobilized after soleus muscle denervation. Exp Mol Pathol. 2005 Feb;78(1):78-85.
  4. Fluckey JD, Dupont-Versteegden EE, Knox M, Gaddy D, Tesch PA, Peterson CA. Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathway. Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1070-5. Epub 2004 Aug 10.
  5. Spaak J, Montmerle S, Sundblad P, Linnarsson D. Long-term bed rest-induced reductions in stroke volume during rest and exercise: cardiac dysfunction vs. volume depletion. J Appl Physiol. 2005 Feb;98(2):648-54. Epub 2004 Oct 22.
  6. Dupont E, Canu MH, Stevens L, Falempin M. Effects of a 14-day period of hindpaw sensory restriction on mRNA and protein levels of NGF and BDNF in the hindpaw primary somatosensory cortex. Brain Res Mol Brain Res. 2005 Jan 5;133(1):78-86. Note F Hindlimb suspension used.
  7. Payne SJ. Analysis of the effects of gravity and wall thickness in a model of blood flow through axisymmetric vessels. Med Biol Eng Comput. 2004 Nov;42(6):799-806.
  8. Darquenne C, Prisk GK. Effect of small flow reversals on aerosol mixing in the alveolar region of the human lung. J Appl Physiol. 2004 Dec;97(6):2083-9. Epub 2004 Aug 06. Note H Parabolic flight results.
  9. Wilson TE, Cui J, Crandall CG. Mean body temperature does not modulate eccrine sweat rate during upright tilt. J Appl Physiol. 2004 Dec 3; [Epub ahead of print]
  10. Hochleitner B, Hengster P, Duo L, Bucher H, Klima G, Margreiter R. A novel bioartificial liver with culture of porcine hepatocyte aggregates under simulated microgravity. Artif Organs. 2005 Jan;29(1):58-66. Note J Microgravity simulated by rotating culture vessel.
  11. Han Y, Cang HX, Zhou JX, Wang YP, Bi RC, Colelesage J, Delbaere LT, Nahoum V, Shi R, Zhou M, Zhu DW, Lin SX. Protein crystal growth on board Shenzhou 3: a concerted effort improves crystal diffraction quality and facilitates structure determination. Biochem Biophys Res Commun. 2004 Nov 19;324(3):1081-6. Note K Shenzhou 3 Chinese spacecraft results.
  12. Poole KE, Warburton EA, Reeve J. Rapid long-term bone loss following stroke in a man with osteoporosis and atherosclerosis. Osteoporos Int. 2005 Mar;16(3):302-305. Epub 2004 Jun 10. Note K Demonstrated that osteoporotic patients who experienced unloading due to loss of motor function caused by a stroke are susceptible to further bone loss.

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