NASA Spaceline 1 July 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, July 1, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Zhong N, Garman RA, Squire ME, Donahue LR, Rubin CT, Hadjiargyrou M, Judex S. Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of mice. Aviat Space Environ Med. 2005 Jun;76(6):530-5. (HSR&T PIs: C.T. Rubin and M. Hadjiargyrou)
  2. Lee EH, Ding W, Kulkarni AD, Granstein RD. Tumor growth and immune function in mice during hind-limb unloading. Aviat Space Environ Med. 2005 Jun;76(6):536-40. (HSR&T PI: A.D. Kulkarni)
  3. Webb JT, Pilmanis AA, Balldin UI, Fischer JR. Altitude decompression sickness susceptibility: influence of anthropometric and physiologic variables. Aviat Space Environ Med. 2005 Jun;76(6):547-51. (HSR&T PI: A.A. Pilmanis)
  4. Campbell MR, Williams DR, Buckey JC Jr, Kirkpatrick AW. Animal surgery during spaceflight on the Neurolab Shuttle mission. Aviat Space Environ Med. 2005 Jun;76(6):589-93. Note (#4) STS-90 (Neurolab) results.
  5. Foale CM, Kaleri AY, Sargsyan AE, Hamilton DR, Melton S, Martin D, Dulchavsky SA. Diagnostic instrumentation aboard ISS: just-in-time training for non-physician crewmembers. Aviat Space Environ Med. 2005 Jun;76(6):594-8. (HSR&T PI: S.A. Dulchavsky) Note (#5) Describes computer-based ultrasound training onboard ISS.
  6. Michailova A, Saucerman J, Belik ME, McCulloch AD. Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Biophys J. 2005 Mar;88(3):2234-49. (HSR&T PI: A.D. McCulloch)
  7. Hart CE, Sharenbroich L, Bornstein BJ, Trout D, King B, Mjolsness E, Wold BJ. A mathematical and computational framework for quantitative comparison and integration of large-scale gene expression data. Nucleic Acids Res. 2005 May 10;33(8):2580-94. Print 2005. (HSR&T PI: B.J. Wold) Note (#7) This paper can be obtained online at no charge.
  8. Li L, Roden J, Shapiro BE, Wold BJ, Bhatia S, Forman SJ, Bhatia R. Reproducibility, fidelity, and discriminant validity of mRNA amplification for microarray analysis from primary hematopoietic cells. J Mol Diagn. 2005 Feb;7(1):48-56. (HSR&T PI: B.J. Wold)
  9. Angelaki DE. The physiology of the peripheral vestibular system: the birth of a field. J Neurophysiol. 2005 Jun;93(6):3032-3. Note (#9) This essay comments on the historical significance of three American Physiological Society classic papers by Cesar Fernandez and Jay Goldberg, published in 1976. The three papers, which were supported by NASA and NIH, are here:
    Physiology of Peripheral Neurons Innervating Otolith Organs of the Squirrel Monkey.
    I. Response to Static Tilts and to Long-Duration Centrifugal Force
    II. Directional Selectivity and Force-Response Relations
    III. Response Dynamics
  10. Hancock CR, Brault JJ, Wiseman RW, Terjung RL, Meyer RA. 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1298-304. Epub 2005 Feb 2. (HSR&T PI: R.W. Wiseman)
  11. Wheeler SR, Skeath JB. The identification and expression of achaete-scute genes in the branchiopod crustacean Triops longicaudatus. Gene Expr Patterns. 2005 Jun;5(5):695-700. Epub 2005 Apr 9. (HSR&T PI: J.B. Skeath)
  12. Wheeler SR, Carrico ML, Wilson BA, Skeath JB. The Tribolium columnar genes reveal conservation and plasticity in neural precursor patterning along the embryonic dorsal-ventral axis. Dev Biol. 2005 Mar 15;279(2):491-500. (HSR&T PI: J.B. Skeath)
  13. Shimada N, Sokunbi G, Moorman SJ. Changes in gravitational force affect gene expression in developing organ systems at different developmental times. BMC Dev Biol. 2005 May 31;5(1):10 [Epub ahead of print] (HSR&T PI: S.J. Moorman) Note (#13) This paper can be obtained online at no charge.

Other papers of interest:

  1. Bleeker MW, De Groot PC, Rongen GA, Rittweger J, Felsenberg D, Smits P, Hopman MT. Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study. J Appl Physiol. 2005 Jun 2; [Epub ahead of print]
  2. Bleeker MW, De Groot PC, Poelkens F, Rongen GA, Smits P, Hopman MT. Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1747-55. Epub 2004 Dec 2.
  3. Kramerova I, Kudryashova E, Venkatraman G, Spencer MJ. Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway. Hum Mol Genet. 2005 Jun 16; [Epub ahead of print] Note C Hindlimb unloading used.
  4. Siu PM, Pistilli EE, Alway SE. Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats. Am J Physiol Regul Integr Comp Physiol. 2005 May 26; [Epub ahead of print]
  5. Bleeker MW, Kooijman M, Rongen GA, Hopman MT, Smits P. Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle. J Physiol. 2005 Jun 1;565(Pt 2):685-94. Epub 2005 Mar 31.
  6. Eiken O, Tipton MJ, Kolegard R, Lindborg B, Mekjavic IB. Motion sickness decreases arterial pressure and therefore acceleration tolerance. Aviat Space Environ Med. 2005 Jun;76(6):541-6.
  7. Paul MA, MacLellan M, Gray G. Motion-sickness medications for aircrew: impact on psychomotor performance. Aviat Space Environ Med. 2005 Jun;76(6):560-5.
  8. Wan YM, Ma YJ, Zhang XY, Zeng B, Wang HH, Li YH. [Effects of rotation on osteonectin and osteopontin mRNA level of cultured osteoblasts in rats.] Sheng Li Xue Bao. 2005 Jun 25;57(3):384-8. Chinese.
  9. Facer SR, Zaharias RS, Andracki ME, Lafoon J, Hunter SK, Schneider GB. Rotary culture enhances pre-osteoblast aggregation and mineralization. J Dent Res. 2005 Jun;84(6):542-7.
  10. Hsu SH, Kuo CC, Yen HJ, Whu SW, Tsai CL. The effect of two different bioreactors on the neocartilage formation in type II collagen modified polyester scaffolds seeded with chondrocytes. Artif Organs. 2005 Jun;29(6):467-74.
  11. Lin R, Wang H. Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport. Plant Physiol. 2005 Jun;138(2):949-64. Epub 2005 May 20.
  12. Jones N. Space physiology: lie back and think of science. Nature. 2005 Jun 9;435(7043):730-1. Note L This News Feature describes the bed rest study being conducted in Toulouse. Author Nicola Jones, editor of, visited and participated in aspects of the study for a few days.

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