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NASA Spaceline 29 July 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, July 29, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Grenon SM, Xiao X, Hurwitz S, Ramsdell CD, Sheynberg N, Kim C, Williams GH, Cohen RJ. Simulated microgravity induces microvolt T wave alternans. Ann Noninvasive Electrocardiol. 2005 Jul;10(3):363-70. (HSR&T PIs: G.H. Williams and R.J. Cohen) Note (#1) From abstract: "HDTB (head-down tilt bed rest) leads to an increase in MTWA (microvolt T wave alternans), providing the first evidence that simulated microgravity has a measurable effect on electrical repolarization processes. Possible contributing factors include loss in potassium and changes in sympathetic function."
  2. Zhong Q, Sridhar S, Ruan L, Ding KH, Xie D, Insogna K, Kang B, Xu J, Bollag RJ, Isales CM. Multiple melanocortin receptors are expressed in bone cells. Bone. 2005 May;36(5):820-31. Epub 2005 Mar 31. (HSR&T PI: C.M. Isales)
  3. Rice L, Alfrey CP. The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem. 2005;15(6):245-50. (HSR&T PI: C.P. Alfrey) Note (#3) A review of the latest information about neocytolysis, the selective hemolysis of young circulating red blood cells under certain conditions. The phenomenon of neocytolysis was discovered by Clarence Alfrey's group while investigating the mechanism of space flight anemia, in three papers: (1), (2), and (3).
  4. Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. Early immune response and regulation of IL-2 receptor subunits. Cell Signal. 2005 Sep;17(9):1111-1124. Epub 2005 Feb 25. (HSR&T PI: M. Hughes-Fulford)
  5. Elmore E, Lao XY, Ko M, Rightnar S, Nelson G, Redpath J. Neoplastic transformation in vitro induced by low doses of 232 MeV protons. Int J Radiat Biol. 2005 Apr;81(4):291-7. (HSR&T PIs: G. Nelson and J. Redpath)
  6. Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ. Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res. 2005 Jul;164(1):17-26. (HSR&T PI: D.J. Chen)
  7. Wise KC, Manna SK, Yamauchi K, Ramesh V, Wilson BL, Thomas RL, Sarkar S, Kulkarni AD, Pellis NR, Ramesh GT. Activation of nuclear transcription factor-kappaB in mouse brain induced by a simulated microgravity environment. In Vitro Cell Dev Biol Anim. 2005 Mar;41(3):118-23. (HSR&T PI: G.T. Ramesh) Note (#7) Hindlimb unloading used.
  8. Heisterkamp A, Maxwell IZ, Mazur E, Underwood JM, Nickerson JA, Kumar S, Ingber DE. Pulse energy dependence of subcellular dissection by femtosecond laser pulses. Opt Express. 2005 May 16;13(10):3690-6. (HSR&T PI: D.E. Ingber) Note (#8) This paper can be obtained online at no charge.
  9. Yang Y, Soyemi OO, Landry MR, Soller BR. Influence of a fat layer on the near infrared spectra of human muscle: quantitative analysis based on two-layered Monte Carlo simulations and phantom experiments. Opt Express. 2005 Mar 7;13(5):1570-9. (HSR&T PI: B.R. Soller) Note (#9) This paper can be obtained online at no charge.
  10. Soyemi OO, Landry MR, Yang Y, Idwasi PO, Soller BR. Skin color correction for tissue spectroscopy: demonstration of a novel approach with tissue-mimicking phantoms. Appl Spectrosc. 2005 Feb;59(2):237-44. (HSR&T PI: B.R. Soller)
  11. Blumberg S, Gajraj A, Pennington MW, Meiners JC. 3-D characterization of tethered microspheres by total internal reflection fluorescence microscopy. Biophys J. 2005 May 27; [Epub ahead of print] (HSR&T PI: J.C. Meiners)
  12. Berger BW, Gendron CM, Robinson CR, Kaler EW, Lenhoff AM. The role of protein and surfactant interactions in membrane-protein crystallization. Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):724-30. Epub 2005 May 26. (HSR&T PI: E.W. Kaler)
  13. Vivares D, Kaler EW, Lenhoff AM. Quantitative imaging by confocal scanning fluorescence microscopy of protein crystallization via liquid-liquid phase separation. Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):819-25. Epub 2005 May 26. (HSR&T PI: E.W. Kaler)

Other papers of interest:

  1. Mognato M, Celotti L. Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation. Mutat Res. 2005 Jul 15; [Epub ahead of print] Note (A) Used rotating wall vessel bioreactor.
  2. Ho ML, Tsai TN, Chang JK, Shao TS, Jeng YR, Hsu C. Down-regulation of N-methyl D-aspartate receptor in rat-modeled disuse osteopenia. Osteoporos Int. 2005 Jul 5; [Epub ahead of print]
  3. Gutjahr C, Riemann M, Muller A, Duchting P, Weiler EW, Nick P. Cholodny-Went revisited: a role for jasmonate in gravitropism of rice coleoptiles. Planta. 2005 Jul 27;:1-11 [Epub ahead of print]
  4. Pinto M, Prise KM, Michael BD. Evidence for complexity at the nanometer scale of radiation-induced DNA DSBs as a determinant of rejoining kinetics. Radiat Res. 2005 Jul;164(1):73-85.
  5. Meijer AE, Jernberg AR, Heiden T, Stenerlow B, Persson LM, Tilly N, Lind BK, Edgren MR. Dose and time dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET. Int J Radiat Biol. 2005 Apr;81(4):261-72.
  6. Murray D, Allalunis-Turner M, Weinfeld M. VIIIth International Workshop on Radiation Damage to DNA. Int J Radiat Biol. 2005 Apr;81(4):327-37.
  7. Chang PW, Zhang QM, Takatori K, Tachibana A, Yonei S. Increased sensitivity to sparsely ionizing radiation due to excessive base excision in clustered DNA damage sites in Escherichia coli. Int J Radiat Biol. 2005 Feb;81(2):115-23.
  8. Manti L, Durante M, Cirrone GA, Grossi G, Lattuada M, Pugliese M, Sabini MG, Scampoli P, Valastro L, Gialanella G. Modelled microgravity does not modify the yield of chromosome aberrations induced by high-energy protons in human lymphocytes. Int J Radiat Biol. 2005 Feb;81(2):147-55. Note (H) Used rotating wall vessel bioreactor.
  9. Mairs RJ, Boyd M. National symposium on low-dose radiation and bystander effects -12 October 2004, Cancer Research UK Beatson Laboratories, Glasgow. Sponsored by Glasgow University School for Cancer Studies, the Department of Health and the National Cancer Research Institute. Int J Radiat Biol. 2005 Mar;81(3):259-62.
  10. Mukhamedieva LN. [The concept of hygienic evaluation of multicomponent chemical contamination of air on piloted orbital stations] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):14-9. Russian.
  11. Noskov VB, Nichiporuk IA, Morukov BV, Malenchenko IuI. [Investigations of human body liquids in long-duration space flight] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):27-31. Russian. Note (K) ISS results.
  12. Krasnov IB, Gulevskaia TS, Morgunov VA. [Morphology of vessels and vascular plexus in the rat's brain following 93-day simulation of the effects of microgravity] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):32-6. Russian.
  13. Erokhin AN, Berkovich IuA. [Analysis of characteristics of a salad space greenhouse with a diode lighting unit] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):36-43. Russian.
  14. Rakova NM, Svistunova IuV, Novikova ND. [Studies on the growth and reproduction of bacterial communities on structural materials of the International Space Station] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):44-6. Russian. Note (N) ISS results.
  15. Klimarev SI. [UHF desorption of carbon dioxide from zeolite in physical/chemical human life support systems] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):47-51. Russian.
  16. Buravkova LB, Rykova MP, Antropova EN, Grigor'eva OV. [Modification of a method for determining the cytotoxic activity of lymphocytes--natural killers in space experiments] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):55-9. Russian.
  17. Akulov VA. [The biomechanic criterium of adequacy of the modelled and natural force of gravity] Aviakosm Ekolog Med. 2005 Jan-Feb;39(1):59-61. Russian. Note (Q) Analyzes short radius centrifugation.

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