SpaceRef

SpaceRef


NASA Spaceline 26 August 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, August 26, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Sonnenfeld G. Experimentation with animal models in space. Introduction. Adv Space Biol Med. 2005;10:1-5. (HSR&T PI: G. Sonnenfeld) Note: Introduction to the volume containing 10 reviews of various animal models for space flight, including types of models and different species used, their benefits and limitations, and space flight results. Nine articles are in the NASA section; 1 article is in the Of Interest section.
  2. Morey-Holton E, Globus RK, Kaplansky A, Durnova G. The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data. Adv Space Biol Med. 2005;10:7-40. Review. (HSR&T PI: E. Morey-Holton) Note: Compares hindlimb unloading data with Cosmos 2044 flight results.
  3. Grindeland RE, Ilyin EA, Holley DC, Skidmore MG. International collaboration on Russian spacecraft and the case for free flyer biosatellites. Adv Space Biol Med. 2005;10:41-80. Review. (HSR&T PI: R.E. Grindeland) Note: Brief history of various ballistic and orbital mammalian space flights, with a more extensive description of Cosmos (Bion) flight results.
  4. Chapes SK, Ganta RR. Mouse infection models for space flight immunology. Adv Space Biol Med. 2005;10:81-104. Review. (HSR&T PI: S.K. Chapes)
  5. Cohen B, Yakushin SB, Holstein GR, Dai M, Tomko DL, Badakva AM, Kozlovskaya IB. Vestibular experiments in space. Adv Space Biol Med. 2005;10:105-64. Review. (HSR&T PIs: B. Cohen and G.R. Holstein; D.L. Tomko) Note: Includes summary of Shuttle and Cosmos/Bion results with rodents and other animals, emphasizing non-human primates from Cosmos 2044 and 2229.
  6. Tosini G, Aguzzi J. Effect of space flight on circadian rhythms. Adv Space Biol Med. 2005;10:165-74. Review. (HSR&T PI: G. Tosini)
  7. Alberts JR, Ronca AE. Development as adaptation: a paradigm for gravitational and space biology. Adv Space Biol Med. 2005;10:175-207. Review. (HSR&T PIs: J.R. Alberts and A.E. Ronca) Note: STS-66 (NIH.R1 experiment), STS-70 (NIH.R2 experiment), and Cosmos 1514 results.
  8. Doty SB, Vico L, Wronski T, Morey-Holton E. Use of animal models to study skeletal effects of space flight. Adv Space Biol Med. 2005;10:209-24. Review. (HSR&T PIs: S.B. Doty and E. Morey-Holton) Note: General results from various Cosmos/Bion and Shuttle flights.
  9. Wade CE. Responses across the gravity continuum: hypergravity to microgravity. Adv Space Biol Med. 2005;10:225-45. Review. (HSR&T PI: C.E. Wade)
  10. Hoban-Higgins TM, Robinson EL, Fuller CA. Primates in space flight. Adv Space Biol Med. 2005;10:303-25. Review. (HSR&T PI: C.A. Fuller) Note: Brief history of various ballistic and orbital non-human primate space flights, with concentration on results obtained from Mercury, Biosatellite 3, Shuttle, and Cosmos (Bion).

    All articles (5 NASA articles and 6 articles of interest) in the following issue of Current Pharmaceutical Biotechnology pertain to the physiological changes associated with human space exploration and ground-based simulation models, and include Earth-based medical applications:
  11. Clement G, Reschke M, Wood S. Neurovestibular and sensorimotor studies in space and Earth benefits. Curr Pharm Biotechnol. 2005 Aug;6(4):267-83. Review. (HSR&T PI: M. Reschke) Note: Review of human neurovestibular system studies during Shuttle flights, with a specific example from Neurolab (STS-90).
  12. Cooke WH, Convertino VA. Cardiovascular consequences of weightlessness promote advances in clinical and trauma care. Curr Pharm Biotechnol. 2005 Aug;6(4):285-97. Review. (HSR&T PI: V.A. Convertino)
  13. Macias BR, Groppo ER, Eastlack RK, Watenpaugh DE, Lee SM, Schneider SM, Boda WL, Smith SM, Cutuk A, Pedowitz RA, Meyer RS, Hargens AR. Space exercise and Earth benefits. Curr Pharm Biotechnol. 2005 Aug;6(4):305-17. Review. (HSR&T PI: A.R. Hargens)
  14. Pantalos GM, Bennett TE, Sharp MK, Woodruff SJ, O'Leary SD, Gillars KJ, Schurfranz T, Everett SD, Lemon M, Schwartz J. The effect of gravitational acceleration on cardiac diastolic function: a biofluid mechanical perspective with initial results. Curr Pharm Biotechnol. 2005 Aug;6(4):331-41. (HSR&T PI: M.K. Sharp) Note: Authors use a mock circulatory system to isolate the effect of gravity on cardiac diastolic function, comparing ground to flight results on STS-85 and STS-95.
  15. Sonnenfeld G. The immune system in space, including Earth-based benefits of space-based research. Curr Pharm Biotechnol. 2005 Aug;6(4):343-9. Review. (HSR&T PI: G. Sonnenfeld) Note: Reviews immunological parameters influenced by space flight and ground-based simulation conditions.
  16. Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL. Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res. 2005 May;23(3):562-8. Epub 2005 Jan 19. (HSR&T PI: R.L. Sah)
  17. McGowan KB, Sah RL. Treatment of cartilage with beta-aminopropionitrile accelerates subsequent collagen maturation and modulates integrative repair. J Orthop Res. 2005 May;23(3):594-601. Epub 2005 Jan 19. (HSR&T PI: R.L. Sah)
  18. Englert C, McGowan KB, Klein TJ, Giurea A, Schumacher BL, Sah RL. Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum. 2005 Apr;52(4):1091-9. (HSR&T PI: R.L. Sah)

Other papers of interest:

  1. Horn ER. Gravity effects on life processes in aquatic animals. Adv Space Biol Med. 2005;10:247-301. Review. Note: Thorough review of neurophysiology and developmental biology studies in space using aquatic animals; includes some contrasting hypergravity studies.
  2. Hinghofer-Szalkay H. Traveling space: biological considerations, and the benefits for terrestrial medicine. Curr Pharm Biotechnol. 2005 Aug;6(4):251. Editorial.
  3. Hinghofer-Szalkay H, Rossler A. Benefit of repeated receptor stimulation as a spaceflight medical tool to promote cardiovascular fitness: different orthostatic paradigms compared. Curr Pharm Biotechnol. 2005 Aug;6(4):253-66.
  4. Gerzer R, Heer M. Regulation of body fluid and salt homeostasis--from observations in space to new concepts on Earth. Curr Pharm Biotechnol. 2005 Aug;6(4):299-304. Review. Note: Authors review their own research on salt and fluid homeostasis, including studies on Shuttle and Soyuz.
  5. Mano T. Autonomic neural functions in space. Curr Pharm Biotechnol. 2005 Aug;6(4):319-24. Review. Note: Review includes description of autonomic neural function studies using microneurography on humans during Neurolab (STS-90).
  6. Norsk P. Cardiovascular and fluid volume control in humans in space. Curr Pharm Biotechnol. 2005 Aug;6(4):325-30. Review. Note: Includes discussion of the validity of ground-based simulation models, comparing ground and flight results (from EuroMir95 and Shuttle).
  7. Lipshits M, Bengoetxea A, Cheron G, McIntyre J. Two reference frames for visual perception in two gravity conditions. Perception. 2005;34(5):545-55. Note: ISS results.
  8. Day BL, Fitzpatrick RC. Virtual head rotation reveals a process of route reconstruction from vestibular signals. J Physiol. 2005 Jul 7; [Epub ahead of print]
  9. Basta D, Todt I, Scherer H, Clarke A, Ernst A. Postural control in otolith disorders. Hum Mov Sci. 2005 Jun 10; [Epub ahead of print]
  10. Vibert N, Hoang T, Gilchrist DP, Macdougall HG, Burgess AM, Roberts RD, Vidal PP, Curthoys IS. Psychophysiological correlates of the inter-individual variability of head movement control in seated humans. Gait Posture. 2005 May 31; [Epub ahead of print]
  11. Gronkvist MJ, Bergsten E, Eiken O, Gustafsson PM. Contributions of lower limb and abdominal compression to ventilation inhomogeneity in hypergravity. Respir Physiol Neurobiol. 2005 Aug 25;148(1-2):113-23.
  12. Simeoni M, Francia N, Santucci D, Chiarotti F, Alleva E. Effects of acute hypergravity exposure and parity on maternal behavior in CD-1 mice. Acta Neurobiol Exp (Wars). 2005;65(2):151-60.
  13. Xie MJ, Zhang LF, Ma J, Cheng HW. [Enhanced BK(Ca) single-channel activities in cerebrovascular smooth muscle cells of simulated microgravity rats.] Sheng Li Xue Bao. 2005 Aug 25;57(4):439-45. Chinese. Note: Hindlimb unloading used.
  14. Zhong H, Roy RR, Siengthai B, Edgerton VR. Effects of inactivity on fiber size and myonuclear number in rat soleus muscle. J Appl Physiol. 2005 Jun 30; [Epub ahead of print]
  15. Frimel TN, Walter GA, Gibbs JD, Gaidosh GS, Vandenborne K. Noninvasive monitoring of muscle damage during reloading following limb disuse. Muscle Nerve. 2005 Jul 7; [Epub ahead of print]
  16. Roy RR, Zhong H, Siengthai B, Edgerton VR. Activity-dependent influences are greater for fibers in rat medial gastrocnemius than tibialis anterior muscle. Muscle Nerve. 2005 Jun 16; [Epub ahead of print]
  17. Shinder ME, Perachio AA, Kaufman GD. Fos responses to short-term adaptation of the horizontal vestibuloocular reflex before and after vestibular compensation in the Mongolian gerbil. Brain Res. 2005 Jul 19;1050(1-2):79-93.
  18. Timoszyk WK, Nessler JA, Acosta C, Roy RR, Edgerton VR, Reinkensmeyer DJ, de Leon R. Hindlimb loading determines stepping quantity and quality following spinal cord transection. Brain Res. 2005 Jul 19;1050(1-2):180-9.
  19. Gasiorowska A, Nazar K, Mikulski T, Cybulski G, Niewiadomski W, Smorawinski J, Krzeminski K, Porta S, Kaciuba-Uscilko H. Hemodynamic and neuroendocrine predictors of lower body negative pressure (LBNP) intolerance in healthy young men. J Physiol Pharmacol. 2005 Jun;56(2):179-93. Note: This paper can currently be obtained online at no charge.
  20. Jee WS. The past, present, and future of bone morphometry: its contribution to an improved understanding of bone biology. J Bone Miner Metab. 2005;23 Suppl:1-10.
  21. Liu FX, Cao MJ, Rong TZ, Pan GT. [Locating maize male sterility gene induced by space flight using microsatellite markers] Yi Chuan Xue Bao. 2005 Jul;32(7):753-7. Chinese.
  22. Debi BR, Chhun T, Taketa S, Tsurumi S, Xia K, Miyao A, Hirochika H, Ichii M. Defects in root development and gravity response in the aem1 mutant of rice are associated with reduced auxin efflux. J Plant Physiol. 2005 Jun;162(6):678-85.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

NanoRacks