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NASA Spaceline 7 October 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, October 7, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Radiat Res. 2005 Oct;164(4):453-590. Note: A special section of this issue of Radiation Research ?includes important contributions relating basic DNA damage and repair processes to the understanding of the health risks of concern for space flight, studies of biological countermeasures to radiation effects, and applications of charged-particle beams such as protons and carbon ions for cancer therapy? (from Introduction by F.A. Cucinotta). The special section contains 16 PI/NASA papers and 9 ?Other papers," all of which are listed below.
  2. George K, Willingham V, Cucinotta FA. Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting. Radiat Res. 2005 Oct;164(4):474-80. (HSR&T PI: F.A. Cucinotta)
  3. Chang PY, Bakke J, Orduna J, Lin S, Doppalaudi R. Proton-induced genetic damage in lacZ transgenic mice. Radiat Res. 2005 Oct;164(4):481-6. (HSR&T PI: P.Y. Chang)
  4. Ford JR, Maslowski AJ, Redd RA, Braby LA. Radiation responses of perfused tracheal tissue. Radiat Res. 2005 Oct;164(4):487-92. (HSR&T PI: L.A. Braby)
  5. Sutherland BM, Cuomo NC, Bennett PV. Induction of anchorage-independent growth in primary human cells exposed to protons or HZE ions separately or in dual exposures. Radiat Res. 2005 Oct;164(4):493-6. (HSR&T PIs: B.M. Sutherland and A.M. Gewirtz)
  6. Zhang Q, Williams ES, Askin KF, Peng Y, Bedford JS, Liber HL, Bailey SM. Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles. Radiat Res. 2005 Oct;164(4):497-504. (HSR&T PI: S.M. Bailey)
  7. Kawata T, Ito H, Saito M, Uno T, Okayasu R, Liu C, Kan'o M, George K, Cucinotta FA. Caffeine sensitizes nondividing human fibroblasts to X rays by inducing a high frequency of misrepair. Radiat Res. 2005 Oct;164(4):509-13. (HSR&T PI: F.A. Cucinotta)
  8. Desai N, Davis E, O'neill P, Durante M, Cucinotta FA, Wu H. Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation. Radiat Res. 2005 Oct;164(4):518-22. (HSR&T PIs: F.A. Cucinotta and H. Wu)
  9. Ding LH, Shingyoji M, Chen F, Chatterjee A, Kasai KE, Chen DJ. Gene expression changes in normal human skin fibroblasts induced by HZE-particle radiation. Radiat Res. 2005 Oct;164(4):523-6. (HSR&T PIs: A. Chatterjee and D.J. Chen)
  10. Chang PY, Bjornstad KA, Rosen CJ, McNamara MP, Mancini R, Goldstein LE, Chylack LT, Blakely EA. Effects of iron ions, protons and X rays on human lens cell differentiation. Radiat Res. 2005 Oct;164(4):531-9. (HSR&T PI: E.A. Blakely)
  11. Giedzinski E, Rola R, Fike JR, Limoli CL. Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons. Radiat Res. 2005 Oct;164(4):540-4. (HSR&T PI: C.L. Limoli)
  12. Guida P, Vazquez ME, Otto S. Cytotoxic effects of low- and high-LET radiation on human neuronal progenitor cells: induction of apoptosis and TP53 gene expression. Radiat Res. 2005 Oct;164(4):545-51. (HSR&T PI: M.E. Vazquez)
  13. Rabin BM, Joseph JA, Shukitt-Hale B. A longitudinal study of operant responding in rats irradiated when 2 months old. Radiat Res. 2005 Oct;164(4):552-5. (HSR&T PI: B.M. Rabin)
  14. Rola R, Sarkissian V, Obenaus A, Nelson GA, Otsuka S, Limoli CL, Fike JR. High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat Res. 2005 Oct;164(4):556-60. (HSR&T PI: G.A. Nelson)
  15. Ballarini F, Ottolenghi A. A model of chromosome aberration induction: applications to space research. Radiat Res. 2005 Oct;164(4):567-70.
  16. Durante M, George K, Gialanella G, Grossi G, La Tessa C, Manti L, Miller J, Pugliese M, Scampoli P, Cucinotta FA. Cytogenetic effects of high-energy iron ions: dependence on shielding thickness and material. Radiat Res. 2005 Oct;164(4):571-6. (HSR&T PIs: J. Miller and F.A. Cucinotta)
  17. Dini V, Antonelli F, Belli M, Campa A, Esposito G, Simone G, Sorrentino E, Tabocchini MA. Influence of PMMA shielding on DNA fragmentation induced in human fibroblasts by iron and titanium ions. Radiat Res. 2005 Oct;164(4):577-81.
  18. Davidson AJ, Tataroglu O, Menaker M. Circadian effects of timed meals (and other rewards). Methods Enzymol. 2005;393:509-23. (HSR&T PI: M. Menaker)
  19. Peirson SN, Thompson S, Hankins MW, Foster RG. Mammalian photoentrainment: results, methods, and approaches. Methods Enzymol. 2005;393:697-726. (HSR&T PI: R.G. Foster)
  20. Liu LY, Wang N, Lupton JR, Turner ND, Chapkin RS, Davidson LA. A two-stage normalization method for partially degraded mRNA microarray data. Bioinformatics. 2005 Sep 8; [Epub ahead of print] (HSR&T PI: J.R. Lupton)
  21. Davin LB, Lewis NG. Dirigent phenoxy radical coupling: advances and challenges. Curr Opin Biotechnol. 2005 Aug;16(4):398-406. (HSR&T PI: N.G. Lewis)
  22. Davin LB, Lewis NG. Lignin primary structures and dirigent sites. Curr Opin Biotechnol. 2005 Aug;16(4):407-15. (HSR&T PI: N.G. Lewis)
  23. Klisch SM, Sah RL, Hoger A. A cartilage growth mixture model for infinitesimal strains: solutions of boundary-value problems related to in vitro growth experiments. Biomech Model Mechanobiol. 2005 Jun;3(4):209-23. Epub 2005 (HSR&T PI: R.L. Sah)

Other papers of interest:

  1. Reddy MC, Vasquez KM. Repair of genome destabilizing lesions. Radiat Res. 2005 Oct;164(4):345-56.
  2. Moore SR, Ritter LE, Gibbons CF, Grosovsky AJ. Spontaneous and radiation-induced genomic instability in human cell lines differing in cellular TP53 status. Radiat Res. 2005 Oct;164(4):357-68.
  3. Coleman MA, Yin E, Peterson LE, Nelson D, Sorensen K, Tucker JD, Wyrobek AJ. Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response. Radiat Res. 2005 Oct;164(4):369-82.
  4. Cramers P, Atanasova P, Vrolijk H, Darroudi F, van Zeeland AA, Huiskamp R, Mullenders LH, Kleinjans JC. Pre-exposure to low doses: modulation of X-ray-induced DNA damage and repair? Radiat Res. 2005 Oct;164(4):383-90.
  5. Brooks AL. Paradigm shifts in radiation biology: their impact on intervention for radiation-induced disease. Radiat Res. 2005 Oct;164(4):454-61.
  6. Demant P. The genetic factors in cancer development and their implications for cancer prevention and detection. Radiat Res. 2005 Oct;164(4):462-6.
  7. Durante M. Biomarkers of space radiation risk. Radiat Res. 2005 Oct;164(4):467-73.
  8. Suzuki M, Tsuruoka C, Uchihori Y, Ebisawa S, Yasuda H, Fujitaka K. Reduction in life span of normal human fibroblasts exposed to very low-dose-rate charged particles. Radiat Res. 2005 Oct;164(4):505-8.
  9. Antonelli F, Belli M, Cuttone G, Dini V, Esposito G, Simone G, Sorrentino E, Tabocchini MA. Induction and repair of DNA double-strand breaks in human cells: dephosphorylation of histone H2AX and its inhibition by calyculin A. Radiat Res. 2005 Oct;164(4):514-7.
  10. Baumstark-Khan C, Hellweg CE, Arenz A, Meier MM. Cellular monitoring of the nuclear factor kappaB pathway for assessment of space environmental radiation. Radiat Res. 2005 Oct;164(4):527-30.
  11. Wang B, Murakami M, Eguchi-Kasai K, Nojima K, Shang Y, Tanaka K, Fujita K, Coffigny H, Hayata I. Effects of prenatal irradiation with an accelerated heavy-ion beam on postnatal development in rats: I. Neurophysiological alterations. Radiat Res. 2005 Oct;164(4):561-6.
  12. Miller JH, Aceves-Gaona A, Ernst MB, Haranczyk M, Gutowski M, Vorpagel ER, Dupuis M. Structure and energetics of clustered damage sites. Radiat Res. 2005 Oct;164(4):582-5.
  13. Gerardi S, Galeazzi G, Cherubini R. A microcollimated ion beam facility for investigations of the effects of low-dose radiation. Radiat Res. 2005 Oct;164(4):586-90.
  14. van Lieshout JJ, Harms MP, Pott F, Jenstrup M, Secher NH. Stroke volume of the heart and thoracic fluid content during head-up and head-down tilt in humans. Acta Anaesthesiol Scand. 2005 Oct;49(9):1287-92.
  15. Harada Y, Tomita N, Nakajima M, Ikeuchi K, Wakitani S. Effect of low loading and joint immobilization for spontaneous repair of osteochondral defect in the knees of weightless (tail suspension) rats. J Orthop Sci. 2005 Sep;10(5):508-14. Note: From abstract: "These results, combined with our previous report, suggest that dynamic compressive strain stimulates regeneration of the joint surface structures."
  16. Seebeck P, Thompson MS, Parwani A, Taylor WR, Schell H, Duda GN. Gait evaluation: a tool to monitor bone healing? Clin Biomech (Bristol, Avon). 2005 Nov;20(9):883-91. Epub 2005 Jul 8.
  17. Yakushin SB, Raphan T, Cohen B. Spatial properties of central vestibular neurons. J Neurophysiol. 2005 Sep 28; [Epub ahead of print]
  18. Crane BT, Tian J, Demer JL. Kinematics of vertical saccades during the yaw vestibulo-ocular reflex in humans. Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2800-9.
  19. Dijk DJ, von Schantz M. Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators. J Biol Rhythms. 2005 Aug;20(4):279-90.
  20. Yang C, Li GC. [Effect of space flight on the in vitro cells] Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Aug;30(4):467-70. Chinese.

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