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NASA Spaceline 14 October 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, October 14, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T-cell activation. FASEB J. 2005 Oct 6; [Epub ahead of print] (HSR&T PI: M. Hughes-Fulford) Note: "Researchers at the San Francisco VA Medical Center have identified a set of key immune-response genes that do not turn on in a weightless environment. The discovery is another clue in the effort to solve an almost 40-year-old mystery: why the human immune system does not function well in the weightlessness of space," from UCSF press release dated 10/12/2005 (Also on SpaceRef).
  2. Finni T, Hodgson JA, Lai AM, Edgerton VR, Sinha S. Muscle synergism during isometric plantarflexion in Achilles tendon rupture patients and in normal subjects revealed by velocity-encoded cine phase-contrast MRI. Clin Biomech (Bristol, Avon). 2005 Sep 26; [Epub ahead of print] (HSR&T PI: S. Sinha)
  3. Bailey MR, Pishchalnikov YA, Sapozhnikov OA, Cleveland RO, McAteer JA, Miller NA, Pishchalnikova IV, Connors BA, Crum LA, Evan AP. Cavitation detection during shock-wave lithotripsy. Ultrasound Med Biol. 2005 Sep;31(9):1245-56. (HSR&T PI: L.A. Crum)
  4. Koscheyev VS, Leon GR, Coca A. Finger heat flux/temperature as an indicator of thermal imbalance with application for extravehicular activity. Acta Astronaut. 2005 Nov;57(9):713-21. (HSR&T PI: V.S. Koscheyev)
  5. Bennett PV, Cuomo NL, Paul S, Tafrov ST, Sutherland BM. Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells. Free Radic Biol Med. 2005 Sep 15;39(6):832-9. (HSR&T PIs: B.M. Sutherland and A.M. Gewirtz)
  6. Mundt CW, Montgomery KN, Udoh UE, Barker VN, Thonier GC, Tellier AM, Ricks RD, Darling RB, Cagle YD, Cabrol NA, Ruoss SJ, Swain JL, Hines JW, Kovacs GT. A multiparameter wearable physiologic monitoring system for space and terrestrial applications. IEEE Trans Inf Technol Biomed. 2005 Sep;9(3):382-91.
  7. Andrews RJ. Neuroprotection trek--the next generation: the measurement is the message. Ann N Y Acad Sci. 2005 Aug;1053:1-11. Note: This paper describes the role of the NASA Smart Probe Project and the NASA Nanoelectrode Array Project in improving measurement of the effectiveness of pharmacological neuroprotective agents.
  8. Indic P, Forger DB, Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005;22(4):613-29. (HSR&T PI: E.B. Klerman)
  9. Li J, Yang H, Ann Peer W, Richter G, Blakeslee J, Bandyopadhyay A, Titapiwantakun B, Undurraga S, Khodakovskaya M, Richards EL, Krizek B, Murphy AS, Gilroy S, Gaxiola R. Arabidopsis H+-PPase AVP1 regulates auxin-mediated organ development. Science. 2005 Oct 7;310(5745):121-5. (HSR&T PI: S. Gilroy; G. Richter, Graduate Student Researcher Program) Note: This paper, which is described in a Perspective in this issue of Science, describes how an intracellular plant proton pump controls auxin transport and therefore auxin-dependent plant development.
  10. Atilgan E, Wirtz D, Sun S. Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells. Biophys J. 2005 Aug 5; [Epub ahead of print] (HSR&T PI: D. Wirtz) Note: This paper can currently be obtained online without charge.
  11. Esue O, Tseng Y, Wirtz D. The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ. Biochem Biophys Res Commun. 2005 Jul 29;333(2):508-16. (HSR&T PI: D. Wirtz)

Other papers of interest:

  1. Kimmerly DS, O'leary DD, Menon RS, Gati JS, Shoemaker JK. Cortical regions associated with autonomic cardiovascular regulation during lower body negative pressure in humans. J Physiol. 2005 Sep 8; [Epub ahead of print]
  2. Furlan R, Colombo S, Perego F, Atzeni F, Diana A, Barbic F, Porta A, Pace F, Malliani A, Sarzi-Puttini P. Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia. J Rheumatol. 2005 Sep;32(9):1787-93. Note: (from abstract): "We tested the hypothesis that FM is characterized by sympathetic overactivity and alterations in cardiovascular autonomic response to gravitational stimulus."
  3. Hyatt JP, Roy RR, Baldwin KM, Wernig A, Edgerton VR. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle Nerve. 2005 Sep 23; [Epub ahead of print]
  4. Lees SJ, Rathbone CR, Booth FW. Age-associated decrease in muscle precursor cell differentiation. Am J Physiol Cell Physiol. 2005 Sep 28; [Epub ahead of print]
  5. Debold EP, Patlak JB, Warshaw DM. Slip sliding away: load-dependence of velocity generated by skeletal muscle myosin molecules in the laser trap. Biophys J. 2005 Sep 16; [Epub ahead of print] Note: This paper can currently be obtained online without charge.
  6. Dantas RO, Oliveira RB, Aprile LR, Hara SH, Sifrim DA. Saliva transport to the distal esophagus. Scand J Gastroenterol. 2005 Sep;40(9):1010-6. Note: (from abstract): Authors examined the role of peristalsis and gravity in saliva transport to the distal esophagus and determined that the process "does not require complete normal peristalsis or gravity and mainly depends on an efficient pharyngeal pump."
  7. Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, Kingsbury L, Arora S, Schwartz JR, Niebler GE, Dinges DF; U.S. Modafinil in Shift Work Sleep Disorder Study Group. Modafinil for excessive sleepiness associated with shift-work sleep disorder. N Engl J Med. 2005 Aug 4;353(5):476-86. Erratum in: N Engl J Med. 2005 Sep 8;353(10):1078.
  8. Yamazoe A, Hayashi K, Kepinski S, Leyser O, Nozaki H. Characterization of terfestatin a, a new specific inhibitor for auxin signaling. Plant Physiol. 2005 Oct;139(2):779-89. Epub 2005 Sep 23. Note: (excerpted from abstract): "TrfA treatment antagonized auxin responses in roots, including ? and root gravitropism, but had only limited effects on shoot auxin responses." Results "indicate that TrfA acts as a modulator of Aux/IAA stability and thus provides a new tool for dissecting auxin signaling.?

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