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NASA Spaceline 2 December 2005 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, December 2, 2005

PubMed's abstract is linked when available and each will open in a new window.

  1. Trappe T, Trappe S, Lee G, Widrick J, Fitts R, Costill D. Cardiorespiratory responses to physical work during and following 17 days of bedrest and spaceflight. J Appl Physiol. 2005 Nov 23; [Epub ahead of print] (HSR&T PI: R. Fitts) Note: STS-78 results.
  2. Miles MP, Heil DP, Larson KR, Conant SB, Schneider SM. Prior resistance training and sex influence muscle responses to arm suspension. Med Sci Sports Exerc. 2005 Nov;37(11):1983-9.
  3. Zupan LH, Merfeld DM. Human ocular torsion and perceived roll responses to linear acceleration. J Vestib Res. 2005;15(4):173-83. (HSR&T PI: D.M. Merfeld)
  4. Wright WG, Dizio P, Lackner JR. Vertical linear self-motion perception during visual and inertial motion: More than weighted summation of sensory inputs. J Vestib Res. 2005;15(4):185-95. (HSR&T PI: J.R. Lackner)
  5. Mark S. Sex- and gender-based medicine: Venus, Mars, and beyond. Gend Med. 2005 Sep;2(3):131-6.
  6. Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, Delrosario R, Peterson L, Balmain A, Cai WW. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene. 2005 Nov 24;24(53):7924-34. (HSR&T PI: A. Balmain)
  7. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene. 2005 Aug 18;24(35):5521-4. (HSR&T PI: A. Balmain)
  8. Perez-Losada J, Mao JH, Balmain A. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res. 2005 Aug 1;65(15):6488-92. Review. (HSR&T PI: A. Balmain)
  9. Wang D, Gao L. Proteomic analysis of neural differentiation of mouse embryonic stem cells. Proteomics. 2005 Nov;5(17):4414-26. (HSR&T PI: D. Wang)
  10. Wang R, Xu J, Juliette L, Castilleja A, Love J, Sung SY, Zhau HE, Goodwin TJ, Chung LW. Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone. Semin Cancer Biol. 2005 Oct;15(5):353-64. (HSR&T PI: L.W. Chung) Note: Reports STS-107 results (including photographs). Experiment used rotary wall vessel culture in space.
  11. Rockman MV, Hahn MW, Soranzo N, Zimprich F, Goldstein DB, Wray GA. Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biol. 2005 Nov 15;3(12):e387 [Epub ahead of print] (HSR&T PI: G.A. Wray) Note: This paper was highlighted in the November 25 issue of Science (PubMed 16311304), where it was pointed out that this research provides some of the first evidence that changes in how genes are regulated, rather than in the proteins they code for, was important in human evolution. This paper can be obtained online without charge.

Other papers of interest:

  1. Norsk P, Damgaard M, Petersen L, Gybel M, Pump B, Gabrielsen A, Christensen NJ. Vasorelaxation in space. Hypertension. 2005 Nov 21; [Epub ahead of print] Note: Reports STS-107 and parabolic flight results. This paper suggests that gravity is a constant stressor of the cardiovascular system and that this concept may provide a way to investigate how to alleviate gravitational stress in heart failure. The paper also suggests that it may be healthy for the cardiovascular system to fly in space.
  2. Maruyama M, Takamura M, Takata S, Murai H, Usui S, Furusho H, Sakagami S, Yuasa T, Shimakura A, Kaneko S. Effect of pimobendan on cardiopulmonary baroreflex control of sympathetic nerve activity in healthy young men. Auton Neurosci. 2005 Oct 30;122(1-2):100-6. Epub 2005 Sep 30.
  3. Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A, Raven PB. The effect of changes in cardiac output on the regulated middle cerebral artery mean blood velocity at rest and during exercise. J Physiol. 2005 Oct 6; [Epub ahead of print]
  4. Wang X, Kawano F, Matsuoka Y, Fukunaga K, Terada M, Sudoh M, Ishihara A, Ohira Y. Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle. Am J Physiol Cell Physiol. 2005 Nov 16; [Epub ahead of print] Note: Hindlimb unloading was used.
  5. Hayashi N, Koba S, Yoshida T. Disuse atrophy increases the muscle mechanoreflex in rats. J Appl Physiol. 2005 Oct;99(4):1442-5. Epub 2005 Jun 23.
  6. Zhang J, Peng Z, Yang M, Zhang X, Wei J, Xu M, Zheng QY. Observation of the morphology and calcium content of vestibular otoconia in rats after simulated weightlessness. Acta Otolaryngol. 2005 Oct;125(10):1039-42.
  7. Peru A, Moro V, Sattibaldi L, Morgant JS, Aglioti SM. Gravitational influences on reference frames for mapping somatic stimuli in brain-damaged patients. Exp Brain Res. 2005 Nov 16;:1-8 [Epub ahead of print]
  8. Rajguru SM, Ifediba MA, Rabbitt RD. Biomechanics of horizontal canal benign paroxysmal positional vertigo. J Vestib Res. 2005;15(4):203-14.
  9. Suzuki M, Tsuruoka C, Kanai T, Kato T, Yatagai F, Watanabe M. Cellular and molecular effects for mutation induction in normal human cells irradiated with accelerated neon ions. Mutat Res. 2005 Nov 14; [Epub ahead of print]
  10. Maclachlan T, Narayanan B, Gerlach VL, Smithson G, Gerwien RW, Folkerts O, Fey EG, Watkins B, Seed T, Alvarez E. Human fibroblast growth factor 20 (FGF-20; CG53135-05): A novel cytoprotectant with radioprotective potential. Int J Radiat Biol. 2005 Aug;81(8):567-79.
  11. Takahashi A, Matsumoto H, Furusawa Y, Ohnishi K, Ishioka N, Ohnishi T. Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status. Int J Radiat Biol. 2005 Aug;81(8):581-6.
  12. Belloni P, Meschini R, Czene S, Harms-Ringdahl M, Palitti F. Studies on radiation-induced apoptosis in G(0) human lymphocytes. Int J Radiat Biol. 2005 Aug;81(8):587-99.
  13. Pogoda De La Vega U, Rettberg P, Douki T, Cadet J, Horneck G. Sensitivity to polychromatic UV-radiation of strains of Deinococcus radiodurans differing in their DNA repair capacity. Int J Radiat Biol. 2005 Aug;81(8):601-11.
  14. Lantos P. Radiation doses potentially received on-board aeroplanes during recent solar particle events. Radiat Prot Dosimetry. 2005 Oct 13; [Epub ahead of print] Note: From abstract: ?Because the doses received on-board aeroplanes are now monitored to fulfil legal requirements in some countries, including the European Community, the models to calculate doses received during solar events have left their purely academic status to become a part of operational systems as well.?
  15. Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science. 2005 Nov 18;310(5751):1139-43. Review. Note: This paper, co-authored by PI Yu-Li Wang, was part of a special section on ?Materials and Biology? in this issue of Science.
  16. Kim JB. Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol. 2005 Oct;15(5):365-77. Note: This paper describes the rotary cell culture system as one of the 3-D cell culture methods useful in cancer biology. From p. 372: ?The NASA developed rotary cell culture system (RCCS) introduces a revolutionary new concept in tissue engineering.?
  17. Kennedy D. NASA: back to eating seed corn. Science. 2005 Nov 25;310(5752):1245. Editorial.

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