NASA Spaceline 15 December 2006 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Thursday, January 4, 2007

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Allen MR, Hogan HA, Bloomfield SA. Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats. J Musculoskelet Neuronal Interact. 2006 Jul-Sep;6(3):217-25. (HSR&T PI: S.A. Bloomfield) Note: From abstract: ?This relatively rapid return of muscle strength, coupled with continued depression of bone density at the proximal tibia metaphysis, may increase the risk for skeletal injury during recovery from prolonged periods of reduced mechanical loading.? This paper can be obtained online without charge via the publisher?s site.
  2. Kataoka A, Hemmer C, Chase PB. Computational simulation of hypertrophic cardiomyopathy mutations in troponin I: Influence of increased myofilament calcium sensitivity on isometric force, ATPase and [Ca(2+)](i). J Biomech. 2006 Nov 29; [Epub ahead of print] (HSR&T PI: P.B. Chase)
  3. Yan B, Wang H, Li F, Li CY. Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. Br J Cancer. 2006 Dec 18;95(12):1696-700. Epub 2006 Dec 5. (HSR&T PI: C-Y. Li)
  4. Cucinotta FA, Benton EV, eds. Space radiation transport, shielding, and risk assessment models. Radiat Meas. 2006 Oct-Nov;41(9-10):1051-249. Note: This special issue of the journal, devoted to the topic listed in the title above, contains 22 papers. 18 of the papers are listed below and 4 are listed in the ?Other papers of interest? section. The issue is summarized in a preface on page 1051 (text is not free).
  5. Nikjoo H, Uehara S, Emfietzoglou D, Cucinotta FA. Track-structure codes in radiation research. Radiat Meas. 2006 Oct-Nov;41(9-10):1052-74. (HSR&T PI: F.A. Cucinotta)
  6. Ponomarev AL, Cucinotta FA. Novel image processing interface to relate DSB spatial distribution from experiments with phosphorylation foci to the state-of-the-art models of DNA breakage. Radiat Meas. 2006 Oct-Nov;41(9-10):1075-9. (HSR&T PI: F.A. Cucinotta)
  7. De Angelis G, Wilson JW, Clowdsley MS, Qualls GD, Singleterry RC. Modeling of the Martian environment for radiation analysis. Radiat Meas. 2006 Oct-Nov;41(9-10):1097-102. (HSR&T PI: J.W. Wilson)
  8. Heinbockel JH, Wilson JW, Blattnig SR, Qualls GD, Badavi FF, Cucinotta FA. HZE ion fragmentation cross-section sensitivity and propagated errors in HZE exposure estimates. Radiat Meas. 2006 Oct-Nov;41(9-10):1103-14. (HSR&T PIs: J.W. Wilson, F.A. Cucinotta)
  9. Kim M-HY, Cucinotta FA, Wilson JW. Mean occurrence frequency and temporal risk analysis of solar particle events. Radiat Meas. 2006 Oct-Nov;41(9-10):1115-22. (HSR&T PIs: F.A. Cucinotta, J.W. Wilson)
  10. Lee K, Pinsky L, Andersen V, Zeitlin C, Cleghorn T, Cucinotta F, Saganti P, Atwell W, Turner R. Helium cosmic ray flux measurements at Mars. Radiat Meas. 2006 Oct-Nov;41(9-10):1123-5. (HSR&T PI: R. Turner) Note: Mars Odyssey results.
  11. Yukihara EG, Sawakuchi GO, Guduru S, McKeever SWS, Gaza R, Benton ER, Yasuda N, Uchihori Y, Kitamura H. Application of the optically stimulated luminescence (OSL) technique in space dosimetry. Radiat Meas. 2006 Oct-Nov;41(9-10):1126-35. (HSR&T PI: E.R. Benton) Note: Includes some ISS results.
  12. Townsend LW, Neal JS. A simple method for solar energetic particle event dose forecasting. Radiat Meas. 2006 Oct-Nov;41(9-10):1136-41.
  13. Braby LA, Ford JR. Energy deposition in different diameter sites can help characterize the incident radiation. Radiat Meas. 2006 Oct-Nov;41(9-10):1147-51. (HSR&T PI: J.R. Ford)
  14. Saganti PB, Cucinotta FA, Wilson JW, Cleghorn TF, Zeitlin CJ. Model calculations of the particle spectrum of the galactic cosmic ray (GCR) environment: Assessment with ACE/CRIS and MARIE measurements. Radiat Meas. 2006 Oct-Nov;41(9-10):1152-7. (HSR&T PIs: P.B. Saganti/F.A. Cucinotta) Note: ACE, Mars Odyssey results.
  15. Zeitlin C, Guetersloh SB, Heilbronn LH, Miller J, Shavers M. Radiation tests of the Extravehicular Mobility Unit space suit for the International Space Station using energetic protons. Radiat Meas. 2006 Oct-Nov;41(9-10):1158-72. (HSR&T PIs: C. Zeitlin, J. Miller)
  16. Cucinotta FA, Kim M-HY, Ren L. Evaluating shielding effectiveness for reducing space radiation cancer risks. Radiat Meas. 2006 Oct-Nov;41(9-10):1173-85. (HSR&T PI: F.A. Cucinotta)
  17. Benton ER, Benton EV, Frank AL, Moyers MF. Characterization of the radiation shielding properties of US and Russian EVA suits using passive detectors. Radiat Meas. 2006 Oct-Nov;41(9-10):1191-201. (HSR&T PI: E.R. Benton)
  18. Huo WM, Dateo CE, Fletcher GD. Molecular data for a biochemical model of DNA damage: Electron impact ionization and dissociative ionization cross sections of DNA bases and sugar-phosphate backbone. Radiat Meas. 2006 Oct-Nov;41(9-10):1202-8.
  19. Desai N, Sodolak J, Gersey B, Durante M, Lin ZW, Rusek A, Cucinotta FA, Wu H. In vitro H2AX phosphorylation and micronuclei induction in human fibroblasts across the Bragg curve of a 577 MeV/nucleon Fe incident beam. Radiat Meas. 2006 Oct-Nov;41(9-10):1209-15. (HSR&T PIs: F.A. Cucinotta, H. Wu)
  20. Moyers MF, Saganti PB, Nelson GA. EVA space suit proton and electron threshold energy measurements by XCT and range shifting. Radiat Meas. 2006 Oct-Nov;41(9-10):1216-26. (HSR&T PI: G.A. Nelson)
  21. Taddei PJ, Borak TB, Guetersloh SB, Gersey BB, Zeitlin C, Heilbronn L, Miller J, Murakami T, Iwata Y. The response of a spherical tissue-equivalent proportional counter to different heavy ions having similar velocities. Radiat Meas. 2006 Oct-Nov;41(9-10):1227-34. (HSR&T PI: T.B. Borak/NSCORT in Radiation Health)
  22. Cucinotta FA, Wilson JW, Saganti P, Hu X, Kim M-HY, Cleghorn T, Zeitlin C, Tripathi RK. Isotopic dependence of GCR fluence behind shielding. Radiat Meas. 2006 Oct-Nov;41(9-10):1235-49. (HSR&T PIs: F.A. Cucinotta, J.W. Wilson, C. Zeitlin)
  23. Nauman EA, Ott CM, Sander E, Tucker DL, Pierson D, Wilson JW, Nickerson CA. A novel quantitative biosystem to model physiological fluid shear stress on cells. Appl Environ Microbiol. 2006 Dec 1; [Epub ahead of print] (HSR&T PI: C.A. Nickerson) Note: From abstract: ?we...demonstrated a progressive relationship between the applied fluid shear and the bacterial genetic and phenotypic responses. By applying this model to different cell types, including other bacterial pathogens, entire classes of genes and proteins involved in cellular interactions may be discovered that have not previously been identified during growth under conventional culture conditions, leading to new targets for vaccine and therapeutic development.?
  24. Fritzsch B, Beisel KW, Hansen LA. The molecular basis of neurosensory cell formation in ear development: A blueprint for hair cell and sensory neuron regeneration? Bioessays. 2006 Dec;28(12):1181-93. (HSR&T PI: B. Fritzsch)

Other papers of interest:

  1. Baar K, Nader G, Bodine S. Resistance exercise, muscle loading/unloading and the control of muscle mass. Essays Biochem. 2006;42:61-74.
  2. Hamrick MW, Skedros JG, Pennington C, McNeil PL. Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone. J Musculoskelet Neuronal Interact. 2006 Jul-Sep;6(3):258-63. Note: This paper can be obtained online without charge via the publisher?s site.
  3. Rittweger J, Gerrits K, Altenburg T, Reeves N, Maganaris CN, de Haan A. Bone adaptation to altered loading after spinal cord injury: A study of bone and muscle strength. J Musculoskelet Neuronal Interact. 2006 Jul-Sep;6(3):269-76. Note: This paper can be obtained online without charge via the publisher?s site.
  4. Hudelmaier M, Glaser C, Hausschild A, Burgkart R, Eckstein F. Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report. J Musculoskelet Neuronal Interact. 2006 Jul-Sep;6(3):284-90. Note: This paper can be obtained online without charge via the publisher?s site.
  5. Vainionpaa A, Korpelainen R, Sievanen H, Vihriala E, Leppaluoto J, Jamsa T. Effect of impact exercise and its intensity on bone geometry at weight-bearing tibia and femur. Bone. 2006 Nov 29; [Epub ahead of print]
  6. Laurens J, Droulez J. Bayesian processing of vestibular information. Biol Cybern. 2006 Dec 5; [Epub ahead of print]
  7. Niita K, Sato T, Iwase H, Nose H, Nakashima H, Sihver L. PHITS?a particle and heavy ion transport code system. Radiat Meas. 2006 Oct-Nov;41(9-10):1080-90.
  8. Gudowska I, Sobolevsky N. Calculations of particle and heavy ion interactions with space shielding materials using the SHIELD-HIT transport code. Radiat Meas. 2006 Oct-Nov;41(9-10):1091-6.
  9. Sato T, Niita K, Iwase H, Nakashima H, Yamaguchi Y, Sihver L. Applicability of particle and heavy ion transport code PHITS to the shielding design of spacecrafts. Radiat Meas. 2006 Oct-Nov;41(9-10):1142-6. Note: Used STS-89 and STS?91 data.
  10. Fukumoto M, Kuwahara Y, Ohkubo Y, Wang L. Analysis of carcinogenic mechanisms of liver cancers induced by chronic exposure to alpha-particles from internally deposited Thorotrast. Radiat Meas. 2006 Oct-Nov;41(9-10):1186-90.
  11. van Oort BE, Tyler NJ, Gerkema MP, Folkow L, Stokkan KA. Where clocks are redundant: Weak circadian mechanisms in reindeer living under polar photic conditions. Naturwissenschaften. 2006 Nov 28; [Epub ahead of print]
  12. Ambesi Impiombato FS, Curcio F, Meli A, Zambito AM. Fresh new air in space? 'MoMa' on the A.S.I. launch pad. Orig Life Evol Biosph. 2006 Nov 28; [Epub ahead of print] Note: Describes an Italian Space Agency feasibility study.
  13. Roberto MA, Bohmer RM, Edmondson AC. Facing ambiguous threats. Harv Bus Rev. 2006 Nov;84(11):106-13, 157. Note: From abstract: ?Some have argued that NASA's failure to respond with appropriate intensity to the so-called foam strike [on Columbia] that led to the accident was evidence of irresponsible or incompetent management. The authors' research, however, suggests that NASA was exhibiting a natural, albeit unfortunate, pattern of behavior common in many organizations. The foam strike is a prime example of what the authors call an ambiguous threat ? a signal that may or may not portend future harm.?

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