NASA Spaceline 17 August 2007 Current Space Life Science Awareness


The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Scheer FA, Wright KP Jr, Kronauer RE, Czeisler CA. Plasticity of the intrinsic period of the human circadian timing system. PLoS ONE. 2007 Aug 8;2(8):e721. (PI: C.A. Czeisler) Note: From Discussion in paper: "In this study, we developed a model-based lighting regimen that was effective for entraining individuals at a normal phase angle to the 24.65-h Martian sol and to a 23.5-h rest-activity cycle. Second, we showed for the first time plasticity of the human circadian timing system that regulates period, with prior entrainment to non-24-h rest-activity and light-dark cycles resulting in long-term changes in the intrinsic human circadian period (after-effects of entrainment)." This paper can be obtained online without charge.
  2. Rickards CA, Cohen KD, Bergeron LL, Burton BL, Khatri PJ, Lee CT, Ryan KL, Cooke WH, Doerr DF, Convertino VA. Cerebral blood flow response and its association with symptoms during orthostatic hypotension. Aviat Space Environ Med. 2007 Jul;78(7):653-8. (PI: V.A. Convertino)
  3. Costes SV, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH. Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol. 2007 Aug 3;3(8):e155 [Epub ahead of print] (PI: M.H. Barcellos-Hoff) Note: From Author Summary in paper: "These results contradict the current dogma that the molecular response to randomly generated DNA damages is independent of their nuclear locations. Instead, this suggests the existence of repair centers in the nucleus. Overall, our approach shows that nuclear architecture plays a role in the DNA damage response, reminding us that the nucleus is not simply a soup of DNA and proteins." This paper can be obtained online without charge.
  4. Seidman SH. Translational motion perception and vestiboocular responses in the absence of non-inertial cues. Exp Brain Res. 2007 Aug 7; [Epub ahead of print] (PI: D. Tomko/S.H. Seidman)
  5. Popovic ZB, Grimm RA, Ahmad A, Agler D, Favia M, Dan G, Lim P, Casas F, Greenberg NL, Thomas JD. Longitudinal rotation: An unrecognized motion pattern in patients with dilated cardiomyopathy. Heart. 2007 Jul 30; [Epub ahead of print] (PI: J.D. Thomas)
  6. Wilson JW, Coleman C, Nickerson CA. Cloning and transfer of the Salmonella SPI-2 type III secretion system for studies in a range of Gram negative genera. Appl Environ Microbiol. 2007 Aug 3; [Epub ahead of print] (PI: C.A. Nickerson)
  7. Guo Y, Liu Y, Tang JX, Valles JM Jr. Polymerization force driven buckling of microtubule bundles determines the wavelength of patterns formed in tubulin solutions. Phys Rev Lett. 2007 May 11;98(19):198103. Epub 2007 May 11. (PIs: J.X. Tang, J.M. Valles Jr.)
  8. Miyake K, Tanaka T, McNeil PL. Lectin-based food poisoning: A new mechanism of protein toxicity. PLoS ONE. 2007 Aug 1;2(8):e687. (PI: P.L. McNeil) Note: Paul McNeil is extending his NASA-funded research on repair of plasma membrane disruptions to other areas, such as a possible explanation of lectin toxicity (inhibitory effect of lectins on exocytosis involved in plasma membrane repair of gut epithelial cells), and, in a paper cited in the 8/10/07 list, about disruption of cell plasma membranes in the oral cavity due to toothbrush brushing. The paper cited above in PLoS ONE can be obtained online without charge.

Other papers of interest:

  1. Biolo G, Ciocchi B, Stulle M, Bosutti A, Barazzoni R, Zanetti M, Antonione R, Lebenstedt M, Platen P, Heer M, Guarnieri G. Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest. Am J Clin Nutr. 2007 Aug;86(2):366-72.
  2. Cui J, Durand S, Crandall CG. Baroreflex control of muscle sympathetic nerve activity during skin surface cooling. J Appl Physiol. 2007 Aug 2; [Epub ahead of print]
  3. Islamov RR, Tyapkina OV, Bukharaeva EA, Yagodina LO, Ibragimova NN, Valiullina VV, Kozlovskaya IB, Nikolsky EE. Expression of choline acetyltransferase in rat spinal motoneurons after antiorthostatic suspension. Dokl Biol Sci. 2007 Jun;414(1):205-7. Note: This ia an English translation of the Russian original published in Doklady Akademii Nauk 2007;414(6):842-4.
  4. Scheele C, Nielsen AR, Walden TB, Sewell DA, Fischer CP, Brogan RJ, Petrovic N, Larsson O, Tesch PA, Wennmalm K, Hutchinson DS, Cannon B, Wahlestedt C, Pedersen BK, Timmons JA. Altered regulation of the PINK1 locus: A link between type 2 diabetes and neurodegeneration? FASEB J. 2007 Jun 12; [Epub ahead of print] Note: From abstract: "…regulation of the PINK1 locus, previously linked to neurodegenerative disease, is altered in obesity, type 2 diabetes and inactivity…"
  5. Campbell JJ, Blain EJ, Chowdhury TT, Knight MM. Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochem Biophys Res Commun. 2007 Sep 21;361(2):329-34. Epub 2007 Jul 17.
  6. Tabareau N, Bennequin D, Berthoz A, Slotine JJ, Girard B. Geometry of the superior colliculus mapping and efficient oculomotor computation. Biol Cybern. 2007 Aug 10; [Epub ahead of print]
  7. Gong L, Jin X, Li Q, Liu J, An L. Heavy ion beams induce survivin expression in human hepatoma SMMC-7721 cells more effectively than X-rays. Acta Biochim Biophys Sin (Shanghai). 2007 Aug;39(8):575-82.
  8. Paul MA, Miller JC, Gray G, Buick F, Blazeski S, Arendt J. Circadian phase delay induced by phototherapeutic devices. Aviat Space Environ Med. 2007 Jul;78(7):645-52.
  9. Diels C, Ukai K, Howarth PA. Visually induced motion sickness with radial displays: Effects of gaze angle and fixation. Aviat Space Environ Med. 2007 Jul;78(7):659-65.
  10. Campbell MR, Mohler SR, Harsch VA, Baisden D. Hubertus Strughold: The "Father of Space Medicine." Aviat Space Environ Med. 2007 Jul;78(7):716-9; discussion 719.
  11. Chen XD, Lan J, Wang XG. [Primary effects on Isatis indigotica after spaceflight] Zhong Yao Cai. 2007 Apr;30(4):381-3. Chinese. Note: Chinese satellite results.
  12. Menon C, Lira C. Active articulation for future space applications inspired by the hydraulic system of spiders. Bioinspir Biomim. 2006 Jun;1(2):52-61. Epub 2006 Aug 17.

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