NASA Spaceline 17 August 2007 Current Space Life Science Awareness
Posted: Saturday, September 1, 2007
The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.
Scheer FA, Wright KP Jr, Kronauer RE, Czeisler CA.Plasticity of the intrinsic period of the human circadian timing system.PLoS ONE. 2007 Aug 8;2(8):e721.(PI: C.A. Czeisler)Note:
From Discussion in paper: "In this study, we developed a model-based lighting regimen that was effective for entraining individuals at a normal phase angle to the 24.65-h Martian sol and to a 23.5-h rest-activity cycle. Second, we showed for the first time plasticity of the human circadian timing system that regulates period, with prior entrainment to non-24-h rest-activity and light-dark cycles resulting in long-term changes in the intrinsic human circadian period (after-effects of entrainment)." This paper can be obtained online without charge.
Costes SV, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH.Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains.PLoS Comput Biol. 2007 Aug 3;3(8):e155 [Epub ahead of print](PI: M.H. Barcellos-Hoff)Note:
From Author Summary in paper: "These results contradict the current dogma that the molecular response to randomly generated DNA damages is independent of their nuclear locations. Instead, this suggests the existence of repair centers in the nucleus. Overall, our approach shows that nuclear architecture plays a role in the DNA damage response, reminding us that the nucleus is not simply a soup of DNA and proteins." This paper can be obtained online without charge.
Seidman SH.Translational motion perception and vestiboocular responses in the absence of non-inertial cues.Exp Brain Res. 2007 Aug 7; [Epub ahead of print](PI: D. Tomko/S.H. Seidman)
Wilson JW, Coleman C, Nickerson CA.Cloning and transfer of the Salmonella SPI-2 type III secretion system for studies in a range of Gram negative genera.Appl Environ Microbiol. 2007 Aug 3; [Epub ahead of print](PI: C.A. Nickerson)
Guo Y, Liu Y, Tang JX, Valles JM Jr.Polymerization force driven buckling of microtubule bundles determines the wavelength of patterns formed in tubulin solutions.Phys Rev Lett. 2007 May 11;98(19):198103. Epub 2007 May 11.(PIs: J.X. Tang, J.M. Valles Jr.)
Miyake K, Tanaka T, McNeil PL.Lectin-based food poisoning: A new mechanism of protein toxicity.PLoS ONE. 2007 Aug 1;2(8):e687.(PI: P.L. McNeil)Note:
Paul McNeil is extending his NASA-funded research on repair of plasma membrane disruptions to other areas, such as a possible explanation of lectin toxicity (inhibitory effect of lectins on exocytosis involved in plasma membrane repair of gut epithelial cells), and, in a paper cited in the 8/10/07 list, about disruption of cell plasma membranes in the oral cavity due to toothbrush brushing. The paper cited above in PLoS ONE can be obtained online without charge.