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NASA Spaceline 1 February 2008 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Sunday, February 17, 2008

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Zhi J, Xu G, Rubin CT, Hadjiargyrou M. The lipogenic gene Spot 14 is activated in bone by disuse yet remains unaffected by a mechanical signal anabolic to the skeleton. Calcif Tissue Int. 2008 Jan 25; [Epub ahead of print] (PI: C.T. Rubin)
  2. Behnke BJ, Zawieja DC, Gashev AA, Ray CA, Delp MD. Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity. J Appl Physiol. 2008 Jan 24; [Epub ahead of print] (PIs: C.A. Ray, M.D. Delp)
  3. Kuipers NT, Sauder CL, Carter JR, Ray CA. Neurovascular responses to mental stress in the supine and upright postures. J Appl Physiol. 2008 Jan 24; [Epub ahead of print] (PI: C.A. Ray)
  4. Saxena R, Pan G, McDonald JM. Osteoblast and osteoclast differentiation in modeled microgravity. Ann N Y Acad Sci. 2007 Nov;1116:494-8. Epub 2007 Jul 26. (PI: J.M. McDonald) Note: This paper is in the volume "Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling," Annals of the New York Academy of Sciences, Volume 1116. A preprint of the paper may be available.
  5. Billard MJ, McIntyre BW. CD45RA T-cell activation without proliferation by a partial agonist monoclonal antibody to beta1 integrin. Immunol Cell Biol. 2008 Jan 15; [Epub ahead of print] (PI: B.W. McIntyre)
  6. Chen SS, Fitzgerald W, Zimmerberg J, Kleinman HK, Margolis L. Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation. Stem Cells. 2007 Mar;25(3):553-61. (PI: J. Zimmerberg) Note: Used rotating bioreactor.
  7. Gilroy S, Masson P (Eds.). Plant Tropisms. Ames, Iowa: Blackwell Publishing, 240 pp., October 2007. (PIs: S. Gilroy, P. Masson) Note: Most chapters in this book are authored by current or former PIs. The chapters are: (1) Valster AH, Blancaflor EB. Mechanisms of gravity perception in higher plants; (2) Harrison BR, Morita MT, Masson PH, Tasaka M. Signal transduction in gravitropism; (3) Muday GK, Rahman A. Auxin transport and the integration of gravitropic growth; (4) Mullen JL, Kiss JZ. Phototropism and its relationship to gravitropism; (5) Monshausen GB, Swanson SJ, Gilroy S. Touch sensing and thigmotropism; (6) Cassab GI. Other tropisms and their relationship to gravitropism; (7) Braun M, Hemmersbach R. Single-cell gravitropism and gravitaxis; (8) Correll MJ, Kiss JZ. Space-based research on plant tropisms; (9) Brown CS, Sederoff HW, Davies E, Ferl RJ, Stankovic B. Plan(t)s for space exploration.

Other papers of interest:

  1. Sazontova TG, Anchishkina NA, Arkhipenko YV. Induction of HSPs and antioxidant defense enzymes during activation of free radical oxidation at the early stage of hypokinesia. Bull Exp Biol Med. 2007 Apr;143(4):403-7. Note: This is an English translation of the Russian original published in Byulleten’ Eksperimental’noi Biologii i Meditsiny 2007 Apr;143(4):378–82.
  2. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1209-14. Epub 2008 Jan 22. Note: This paper, which is listed on the cover and is described in "THIS WEEK IN PNAS/In This Issue," can be obtained online without charge.
  3. Thi MM, Iacobas DA, Iacobas S, Spray DC. Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts. Ann N Y Acad Sci. 2007 Nov;1117:73-81. Epub 2007 Jul 23. Note: This paper and the following two papers are in the volume "Skeletal Biology and Medicine, Part B: Disease Mechanisms and Therapeutic Challenges," Annals of the New York Academy of Sciences, Volume 1117. Preprints of the papers may be able to be obtained by clicking to the publisher's site from PubMed, clicking to the Abstract, clicking on the link below "All Versions of this Article" on the right side, and then clicking on "Full Text (Rapid PDF)."
  4. Celil Aydemir AB, Lee S, Won Kim D, Gardner TR, Prince D, Mok Ahn J, Young-In Lee F. Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. Ann N Y Acad Sci. 2007 Nov;1117:138-42. Epub 2007 Jun 21.
  5. Isales CM, McDonald JM. Future developments in therapy. Ann N Y Acad Sci. 2007 Nov;1117:258-63. Epub 2007 Jun 21.
  6. Sewright KA, Hubal MJ, Kearns A, Holbrook MT, Clarkson PM. Sex differences in response to maximal eccentric exercise. Med Sci Sports Exerc. 2008 Feb;40(2):242-51.
  7. Iliakis G, Wu W, Wang M. DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ. Int J Hyperthermia. 2008 Feb;24(1):17-29.
  8. Lee HJ, Kim JS, Moon C, Kim JC, Jo SK, Kim SH. Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse. Environ Toxicol. 2008 Jan 23; [Epub ahead of print]
  9. Inaniwa T, Kohno T, Tomitani T, Sato S. Monitoring the irradiation field of (12)C and (16)O SOBP beams using positron emitters produced through projectile fragmentation reactions. Phys Med Biol. 2008 Feb 7;53(3):529-42. Epub 2008 Jan 7.
  10. Piérard GE, Piérard-Franchimont C, Hermanns-Lê T, Quatresooz P. [Polishing up functional dermatopathology, dermometrology and mechanobiology] Rev Med Liege. 2007;62 Spec No:73-8. French.

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