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NASA Spaceline 22 February 2008 Current Space Life Science Awareness

Status Report From: Stafford-Covey Return to Flight Task Group (SCTG)
Posted: Friday, March 7, 2008

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Baek K, Barlow AA, Allen MR, Bloomfield SA. Food restriction and simulated microgravity: Effects on bone and serum leptin. J Appl Physiol. 2008 Feb 14; [Epub ahead of print] (PI: S.A. Bloomfield) Note: From discussion of paper: "This experiment is the first to demonstrate the independent and combined effects of food restriction and hindlimb unloading on skeletal integrity. Our data confirm our hypothesis that food restriction and hindlimb unloading independently impair skeletal integrity via decreased bone formation but probably not, as we hypothesized, by increased bone resorption." "These data provide evidence for an additional negative effect of under-nutrition in the context of disuse bone loss. We conclude that bone loss during spaceflight could be aggravated by consistent reductions in food intake as is frequently observed during short-term shuttle missions. These results may also have serious implications for bed-rest patients who restrict food intake or for those individuals who utilize food restriction in attempts to lose weight."
  2. Shibata S, Hastings JL, Prasad A, Fu Q, Okazaki K, Palmer MD, Zhang R, Levine BD. The "dynamic" Starling mechanism: Effects of ageing and physical fitness on ventricular-arterial coupling. J Physiol. 2008 Feb 7; [Epub ahead of print] (PI: S. Shibata, NSBRI Postdoctoral Fellowship Program)
  3. Rostek C, Turner EL, Robbins M, Rightnar S, Xiao W, Obenaus A, Harkness TA. Involvement of homologous recombination repair after proton-induced DNA damage. Mutagenesis. 2008 Feb 10; [Epub ahead of print] (PI: G. Nelson/A. Obenaus)
  4. Rentschler ME, Platt SR, Berg K, Dumpert J, Oleynikov D, Farritor SM. Miniature in vivo robots for remote and harsh environments. IEEE Trans Inf Technol Biomed. 2008 Jan;12(1):66-75. Note: This paper reports results of tests with robots (that support surgical procedures) during the undersea NEEMO 9 mission (NEEMO = NASA Extreme Environment Mission Operations).
  5. Mehta SK, Tyring SK, Gilden DH, Cohrs RJ, Leal MJ, Castro VA, Feiveson AH, Ott CM, Pierson DL. Varicella-zoster virus in the saliva of patients with herpes zoster. J Infect Dis. 2008 Feb 8; [Epub ahead of print] (PI: D.L. Pierson) Note: This paper can be obtained online without charge. J. Breuer commented on this paper and another paper.
  6. Marquette ML, Byerly D, Sognier M. A novel in vitro three-dimensional skeletal muscle model. In Vitro Cell Dev Biol Anim. 2007 Jul-Aug;43(7):255-63. Epub 2007 Sep 5. (PI: M.L. Marquette, NASA Graduate Student Researcher Program)
  7. Jackson GW, McNichols RJ, Fox GE, Willson RC. Toward universal Flavivirus identification by mass cataloging. J Mol Diagn. 2008 Feb 8; [Epub ahead of print]

Other papers of interest:

  1. Lydakis C, Momen A, Blaha C, Gugoff S, Gray K, Herr M, Leuenberger UA, Sinoway LI. Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise. J Hum Hypertens. 2008 Feb 14; [Epub ahead of print]
  2. Schrage WG. Not a search in vein: Novel stimulus for vascular dysfunction after simulated microgravity. J Appl Physiol. 2008 Feb 14; [Epub ahead of print] Note: This article comments on Michael Delp's paper that appeared in CA list 2/1/08. These articles will appear together in a future print issue of this journal.
  3. Yee A, Bosworth KA, Conway DE, Eskin SG, McIntire LV. Gene expression of endothelial cells under pulsatile non-reversing vs. steady shear stress; comparison of nitric oxide production. Ann Biomed Eng. 2008 Feb 7; [Epub ahead of print]
  4. Seynnes OR, Maganaris CN, de Boer MD, di Prampero PE, Narici MV. Early structural adaptations to unloading in the human calf muscles. Acta Physiol (Oxf). 2008 Feb 7; [Epub ahead of print]
  5. Mizoguchi F, Mizuno A, Hayata T, Nakashima K, Heller S, Ushida T, Sokabe M, Miyasaka N, Suzuki M, Ezura Y, Noda M. Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol. 2008 Feb 8; [Epub ahead of print]
  6. Afonin BV, Goncharova NP, Sedova EA. Skin electrical activity of the stomach and intestine during long-term antiorthostatic hypokinesia. Hum Physiol. 2007 Nov;33(6):747-51. Note: This paper is a translation in English of the Russian original published in Fiziologiya Cheloveka 2007 Nov-Dec;33(6):100-4.
  7. Vines AM, Lyng FM, McClean B, Seymour C, Mothersill CE. Bystander signal production and response are independent processes which are cell line dependent. Int J Radiat Biol. 2008 Feb;84(2):83-90.
  8. Joubert A, Zimmerman KM, Bencokova Z, Gastaldo J, Chavaudra N, Favaudon V, Arlett CF, Foray N. DNA double-strand break repair defects in syndromes associated with acute radiation response: At least two different assays to predict intrinsic radiosensitivity? Int J Radiat Biol. 2008 Feb;84(2):107-25.
  9. Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Koch CJ, Little JB. Genotype-dependent radiosensitivity: Clonogenic survival, apoptosis and cell-cycle redistribution. Int J Radiat Biol. 2008 Feb;84(2):151-64.
  10. Schubert MC, Migliaccio AA, Minor LB, Clendaniel RA. Retention of VOR gain following short-term VOR adaptation. Exp Brain Res. 2008 Jan 30; [Epub ahead of print]
  11. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17. Note: This paper (pdf) can be obtained online without charge.
  12. Liu Y, Cockell CS, Wang G, Hu C, Chen L, De Philippis R. Control of lunar and Martian dust-Experimental insights from artificial and natural cyanobacterial and algal crusts in the desert of Inner Mongolia, China. Astrobiology. 2008 Feb;8(1):75-86.
  13. De Micco V, Aronne G, Joseleau JP, Ruel K. Xylem development and cell wall changes of soybean seedlings grown in space. Ann Bot (Lond). 2008 Feb 5; [Epub ahead of print] Note: Foton-M2 results.
  14. Tanimoto M, Tremblay R, Colasanti J. Altered gravitropic response, amyloplast sedimentation and circumnutation in the Arabidopsis shoot gravitropism 5 mutant are associated with reduced starch levels. Plant Mol Biol. 2008 Feb 8; [Epub ahead of print] Note: This paper may be able to be obtained online without charge.

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