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NASA Spaceline 28 March 2008 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Sunday, April 20, 2008

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Colleran PN, Behnke BJ, Wilkerson MK, Donato AJ, Delp MD. Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca2+ release mechanism. Am J Physiol Regul Integr Comp Physiol. 2008 Mar 19; [Epub ahead of print] (PI: M.D. Delp) Note: C.A. Ray commented on this paper in an Editorial Focus entitled "New insights into orthostatic hypotension." He states: "Hence, this study is the first to fully describe the effects of hindlimb unloading on the adrenergic vasoconstrictor dynamics of mesenteric arteries [a change in rate of constriction was found], and the first to describe the impairment of the Ca2+-release mechanism in the dysfunction of the vasoconstrictor response."
  2. Delp MD. Unraveling the complex web of impaired wound healing with mechanical unloading and physical deconditioning. J Appl Physiol. 2008 Mar 20; [Epub ahead of print] (PI: M.D. Delp) Note: This is a comment on the significance of a paper by Radek et al. that appeared in CA list 2/29/08. The Radek et al. paper indicated impaired keratinocyte and endothelial cell function during wound healing in hindlimb-unloaded rats, with implications for bed rest or inactive geriatric patients.
  3. De Witt JK, Hagan RD, Cromwell RL. The effect of increasing inertia upon vertical ground reaction forces and temporal kinematics during locomotion. J Exp Biol. 2008 Apr;211(Pt 7):1087-92. Note: This Wyle/NASA study, supported by the Exercise Countermeasures Project at NASA JSC, is described in a commentary by K. Phillips, which can be obtained without cost at. A photograph of the experimental setup is included.
  4. McKay TL, Gedeon DJ, Vickerman MB, Hylton AG, Ribita D, Olar HH, Kaiser PK, Parsons-Wingerter P. Selective inhibition of angiogenesis in small blood vessels and decrease in vessel diameter throughout the vascular tree by triamcinolone acetonide. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1184-90. Note: This NASA Glenn Research Center study is featured on the cover of the journal.
  5. Paap B, Wilson DM 3rd, Sutherland BM. Human abasic endonuclease action on multilesion abasic clusters: Implications for radiation-induced biological damage. Nucleic Acids Res. 2008 Mar 19; [Epub ahead of print] (PIs: B.M. Sutherland, A. Gewirtz) Note: This paper can be obtained online without charge.
  6. Bortolami SB, Pigeon P, Dizio P, Lackner JR. Dynamics model for analyzing reaching movements during active and passive torso rotation. Exp Brain Res. 2008 Mar 11; [Epub ahead of print] (PI: J.R. Lackner)
  7. Bortolami SB, Pigeon P, Dizio P, Lackner JR. Kinetic analysis of arm reaching movements during voluntary and passive rotation of the torso. Exp Brain Res. 2008 Mar 11; [Epub ahead of print] (PI: J.R. Lackner)
  8. Glazier JA, Zhang Y, Swat M, Zaitlen B, Schnell S. Coordinated action of N-CAM, N-cadherin, EphA4, and ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick. Curr Top Dev Biol. 2008;81:205-47. (PI: J.A. Glazier)

Other papers of interest:

  1. Kiiski J, Heinonen A, Järvinen T, Kannus P, Sievänen H. Transmission of vertical whole body vibration to the human body. J Bone Miner Res. 2008 Mar 18; [Epub ahead of print]
  2. Roy RR, Pierotti DJ, Garfinkel A, Zhong H, Baldwin KM, Edgerton VR. Persistence of motor unit and muscle fiber types in the presence of inactivity. J Exp Biol. 2008 Apr;211(Pt 7):1041-9.
  3. Liu CH, Goldberg AL, Qiu XB. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Med J. 2007 Nov-Dec;30(6):469-79. Note: This paper can be obtained online without charge (pdf file).
  4. Santarcangelo EL, Balocchi R, Scattina E, Manzoni D, Bruschini L, Ghelarducci B, Varanini M. Hypnotizability-dependent modulation of the changes in heart rate control induced by upright stance. Brain Res Bull. 2008 Mar 28;75(5):692-7. Epub 2007 Dec 18.
  5. Scott JM, Esch BT, Lusina SJ, McKenzie DC, Koehle MS, Sheel AW, Warburton DE. Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males. Appl Physiol Nutr Metab. 2008 Apr;33(2):246-53.
  6. Suzuki F, Fukami T, Tsuji A, Takagi K, Matsuda M. Discrepancies of MRI findings between recumbent and upright positions in atlantoaxial lesion. Report of two cases. Eur Spine J. 2008 Mar 12; [Epub ahead of print]
  7. Dayal D, Martin SM, Limoli CL, Spitz DR. Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. Biochem J. 2008 Mar 19; [Epub ahead of print] Note: This paper can be obtained online without charge.
  8. Grabherr L, Nicoucar K, Mast FW, Merfeld DM. Vestibular thresholds for yaw rotation about an earth-vertical axis as a function of frequency. Exp Brain Res. 2008 Mar 19; [Epub ahead of print]
  9. Zhao X, Jones SM, Yamoah EN, Wang Lundberg Y. Otoconin-90 deletion leads to imbalance but normal hearing: A comparison with other otoconia mutants. Neuroscience. 2008 Feb 10; [Epub ahead of print]
  10. Fomina GA, Kotovskaya AR, Temnova EV. [Effect of prophylactic device "Braslet" on hemodynamic changes during long-term missions to orbital station Mir] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):8-13. Russian. Note: Mir results.
  11. Matiushev TV, Vartbaronov RA, Ryzhenkov SP. [The baroreflex model of regulation of systemic circulation vessels in humans influenced by postural effects] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):17-23. Russian.
  12. Afonin BV, Noskov VB, Nichiporuk IA, Sedova EA, Goncharova NP. [State of the abdominal organs and vessels on the background of simulated venous plethora in the splanchnic vascular system] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):24-7. Russian.
  13. Sidorenko LA, Krasnov IB, Gulevskaya TS, Morgunov VA. [Electron microscopy and histology of the third ventricle ependyma of rat's brain after repeated simulation of the effects of microgravity] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):28-31. Russian.
  14. Loginov VI. [Readaptation processes in the calcitonin-producing system of the rat's thyroid following 30-day suspension] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):31-5. Russian.
  15. Tyurin-Kyz'min AYu. [Role of the gravity vector in blood cell interaction with solid surface] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):36-41. Russian.
  16. Nefedova EL, Levinskikh MA. [Gas-exchange profiles of different algae communities as applied to biological system of human life support] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):46-9. Russian.
  17. Kurakov AV, Novikova ND, Ozerskaya SM, Deshevaya EA, Gevorkian SA, Goginian VB. [Opportunistic pathogenic and toxic micro-fungi among synthetic polymer destructors] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):49-55. Russian.
  18. Nazarov NM, Malykh EYu. [Iodine-containing urine preservative] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):60-3. Russian.
  19. Medenkov AA. [Human factor in aviation and cosmonautics] Aviakosm Ekolog Med. 2007 Sep-Oct;41(5):63-7. Russian.

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