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NASA Spaceline 4 April 2008 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Monday, April 21, 2008

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Sayson JV, Hargens AR. Pathophysiology of low back pain during exposure to microgravity. Aviat Space Environ Med. 2008 Apr;79(4):365-73. (PI: A.R. Hargens) Note: A review of this subject.
  2. Sutton JP. National Space Biomedical Research Institute and space medicine. Aviat Space Environ Med. 2008 Apr;79(4):452. Note: This article outlines the objectives and operation of NSBRI.
  3. Wambi C, Sanzari J, Wan XS, Nuth M, Davis J, Ko YH, Sayers CM, Baran M, Ware JH, Kennedy AR. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat Res. 2008 Apr;169(4):384-96. (PI: A.R. Kennedy)
  4. Asaithamby A, Uematsu N, Chatterjee A, Story MD, Burma S, Chen DJ. Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res. 2008 Apr;169(4):437-46. (PIs: M.D. Story/J.D. Minna, S. Burma, D.J. Chen)
  5. Moorman SJ, Shorr AZ. The primary cilium as a gravitational force transducer and a regulator of transcriptional noise. Dev Dyn. 2008 Mar 25; [Epub ahead of print] (PI: S.J. Moorman) Note: Stephen Moorman suggests in this paper that the primary cilium may be a gravitational force transducer and that it may use this ability, in combination with the regularly occurring small changes in Earth's gravity (due to the Sun and Moon), to provide a stable benchmark that can filter enviromental noise in order to better regulate the variability of gene expression levels, especially during development. This would be for "those cell types that do not use other stimuli such as shear forces associated with fluid flow to stimulate the primary cilia."
  6. Li L, He H, Zhang J, Wang X, Bai S, Stolc V, Tongprasit W, Young ND, Yu O, Deng XW. Transcriptional analysis of highly syntenic regions between Medicago truncatula and Glycine max using tiling microarrays. Genome Biol. 2008 Mar 19;9(3):R57 [Epub ahead of print] Note: This paper can be obtained online without charge.

Other papers of interest:

  1. Burns JW, Kruyer WB, Celio PV, Deering J, Loecker TH, Richardson LA, Fanton JW, Davis H, Dick EJ Jr. Cardiac ischemia model for +Gz using miniature swine and baboons. Aviat Space Environ Med. 2008 Apr;79(4):374-83.
  2. Klosterhalfen S, Muth ER, Kellermann S, Meissner K, Enck P. Nausea induced by vection drum: Contributions of body position, visual pattern, and gender. Aviat Space Environ Med. 2008 Apr;79(4):384-9.
  3. Joseph JA, Griffin MJ. Motion sickness: Effect of the magnitude of roll and pitch oscillation. Aviat Space Environ Med. 2008 Apr;79(4):390-6.
  4. Mallows RJ, Newman DG. Cardiovascular data acquisition in a dynamic motion environment. Aviat Space Environ Med. 2008 Apr;79(4):416-9.
  5. Ceyte H, Trousselard M, Barraud PA, Roux A, Cian C. Perceived head-trunk angle during microgravity produced by parabolic flight. Aviat Space Environ Med. 2008 Apr;79(4):420-3. Note: Parabolic flight results.
  6. Executive Committee of the Space Medicine Association. International Space Station life science research funding. Aviat Space Environ Med. 2008 Apr;79(4):440-1. Note: This Policy Statement, adopted by the Aerospace Medical Association as prepared by the Executive Committee of the Space Medicine Association of AsMA, articulates why funds should be restored to U.S. life sciences research for ISS. Up to 50% of the U.S. part of the ISS laboratory could be left empty, according to the article. From the article: "We believe that only a narrow window is available to perform this research before access to the ISS is lost, and this time deadline elevates this issue to a crisis situation."
  7. No author. Annual Meeting Program and Abstract Issue. Aviat Space Environ Med. 2008 Mar;79(3):163-364. Note: This issue, which contains the program and abstracts for the annual meeting of the Aerospace Medical Association to be held in Boston in May, can be obtained online without charge. There are numerous sessions and abstracts related to space medicine at this year's meeting.
  8. Alexandrova NP, Donina ZA, Danilova GA. Effect of central hypervolemia on respiratory function. J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 1):9-15. Note: This paper can be obtained online without charge.
  9. Sakuma K, Akiho M, Nakashima H, Nakao R, Hirata M, Inashima S, Yamaguchi A, Yasuhara M. Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice. Acta Neuropathol. 2008 Mar 28; [Epub ahead of print] Note: This paper can currently be obtained online without charge.
  10. Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, Zhu J, Sachdeva R, Sonnad S, Kaiser LR, Rubinstein NA, Powers SK, Shrager JB. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008 Mar 27;358(13):1327-35.
  11. Szalay EA, Harriman D, Eastlund B, Mercer D. Quantifying postoperative bone loss in children. J Pediatr Orthop. 2008 April/May;28(3):320-3. Note: From abstract: "That children can lose up to 34% of BMD in 4 to 6 weeks is sobering."
  12. Carlson DJ, Stewart RD, Semenenko VA, Sandison GA. Combined use of Monte Carlo DNA damage simulations and deterministic repair models to examine putative mechanisms of cell killing. Radiat Res. 2008 Apr;169(4):447-59.
  13. Reed-Jones RJ, Vallis LA, Reed-Jones JG, Trick LM. The relationship between postural stability and virtual environment adaptation. Neurosci Lett. 2008 Mar 4; [Epub ahead of print]
  14. Miller DM, Cotter LA, Gandhi NJ, Schor RH, Cass SP, Huff NO, Raj SG, Shulman JA, Yates BJ. Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy. Exp Brain Res. 2008 Mar 27; [Epub ahead of print]
  15. Senot P, Baillet S, Renault B, Berthoz A. Cortical dynamics of anticipatory mechanisms in interception: A neuromagnetic study. J Cogn Neurosci. 2008 Mar 27; [Epub ahead of print]
  16. Marcelli V, Esposito F, Aragri A, Furia T, Riccardi P, Tosetti M, Biagi L, Marciano E, Di Salle F. Spatio-temporal pattern of vestibular information processing after brief caloric stimulation. Eur J Radiol. 2008 Mar 12; [Epub ahead of print]
  17. Young G, Zavelina L, Hooper V. Assessment of workload using NASA Task Load Index in perianesthesia nursing. J Perianesth Nurs. 2008 Apr;23(2):102-10.

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