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NASA Spaceline 8 September 2008 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Wednesday, October 1, 2008

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Globus RK. Extracellular matrix and integrin interactions in the skeletal responses to mechanical loading and unloading. Clin Rev Bone Miner Metab. 2007 Dec;5(4):210-21. (PI: R.K. Globus) Note: This issue, which just recently became available, contains six papers (the three papers listed here and three papers in the Other section) reviewing the response of the skeleton to mechanical load. There is an introduction by PI D.D. Bikle. The first page of each paper is available without cost at these links. This journal is not covered in PubMed.
  2. Long RK, Halloran BP, Bikle DD. Integrin regulation of the IGF-I receptor in bone, and the response to load. Clin Rev Bone Miner Metab. 2007 Dec;5(4):222-33. (PIs: R.K. Long, NSBRI Postdoctoral Fellowship Program; D.D. Bikle)
  3. Sibonga JD, Cavanagh PR, Lang TF, LeBlanc AD, Schneider VS, Shackelford LC, Smith SM, Vico L. Adaptation of the skeletal system during long-duration spaceflight. Clin Rev Bone Miner Metab. 2007 Dec;5(4):249-61. (PIs: P.R. Cavanagh, T.F. Lang, L.C. Shackelford, S.M. Smith) Note: Skylab, Mir, ISS results.
  4. Widrick JJ, Maddalozzo GF, Hu H, Herron JC, Iwaniec UT, Turner RT. Detrimental effects of re-loading recovery on force, shortening velocity, and power of soleus muscles from hindlimb unloaded rats. Am J Physiol Regul Integr Comp Physiol. 2008 Aug 27. [Epub ahead of print] (PI: R.T. Turner)
  5. Macias BR, Minocha R, Cutuk AA, Hill J, Shiau J, Hargens AR. Intramuscular pressures in antigravity muscles using gravity-independent, pneumatic hardware. Aviat Space Environ Med. 2008 Aug;79(8):749-53. (PI: A.R. Hargens)
  6. Layne CS, Forth KE. Plantar stimulation as a possible countermeasure to microgravity-induced neuromotor degradation. Aviat Space Environ Med. 2008 Aug;79(8):787-94.
  7. Mukherjee B, Camacho CV, Tomimatsu N, Miller J, Burma S. Modulation of the DNA-damage response to HZE particles by shielding. DNA Repair (Amst). 2008 Aug 11. [Epub ahead of print] (PIs: S. Burma; J.D. Minna/S.Burma/NSCOR)
  8. Zhang Y, Rohde LH, Emami K, Hammond D, Casey R, Mehta SK, Jeevarajan AS, Pierson DL, Wu H. Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest. DNA Repair (Amst). 2008 Aug 11. [Epub ahead of print] (NASA Space Radiation Health Program support)
  9. Mao JH, Wu D, Delrosario R, Castellanos A, Balmain A, Perez-Losada J. Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background. Oncogene. 2008 Aug 4. [Epub ahead of print] (PI: A. Balmain)
  10. Lim P, Buakhamsri A, Popovic ZB, Greenberg NL, Patel D, Thomas JD, Grimm RA. Longitudinal strain delay index by speckle tracking imaging. A new marker of response to cardiac resynchronization therapy. Circulation. 2008 Aug 25. [Epub ahead of print] (PI: J.D. Thomas)

Other papers of interest:

  1. Di Rienzo M, Castiglioni P, Iellamo F, Volterrani M, Pagani M, Mancia G, Karemaker JM, Parati G. Dynamic adaptation of cardiac baroreflex sensitivity to prolonged exposure to microgravity: Data from a 16-day spaceflight. J Appl Physiol. 2008 Aug 28. [Epub ahead of print] Note: STS-107 results.
  2. Fomina GA, Kotovskaya AR, Pochuev VI, Zhernavkov AF. Mechanisms of changes in human hemodynamics under the conditions of microgravity and prognosis of postflight orthostatic stability. Hum Physiol. 2008 May;34(3):343-7. Note: Space flight results, from short and long term flights. This paper is a translation in English of the Russian original published in Fiziologiya Cheloveka 2008 May-Jun;34(3):92-7.
  3. Newman DG, Callister R. Cardiovascular training effects in fighter pilots induced by occupational high G exposure. Aviat Space Environ Med. 2008 Aug;79(8):774-8.
  4. Leon GR, Koscheyev VS, Stone EA. Visual analog scales for assessment of thermal perception in different environments. Aviat Space Environ Med. 2008 Aug;79(8):784-6.
  5. Turner CH. Skeletal adaptation to mechanical loading. Clin Rev Bone Miner Metab. 2007 Dec;5(4):181-94.
  6. Klein-Nulend J, Bakker AD. Osteocytes: Mechanosensors of bone and orchestrators of mechanical adaptation. Clin Rev Bone Miner Metab. 2007 Dec;5(4):195-209.
  7. Lanyon LE, Armstrong VJ, Saxon LK, Sunters A, Sugiyama T, Zaman G, Price JS. Estrogen receptors critically regulate bones’ adaptive responses to loading. Clin Rev Bone Miner Metab. 2007 Dec;5(4):234-48.
  8. Shin D, Finni T, Ahn S, Hodgson JA, Lee HD, Edgerton VR, Sinha S. The effect of chronic unloading and rehabilitation on human Achilles tendon properties – A velocity encoded phase contrast MRI study. J Appl Physiol. 2008 Aug 7. [Epub ahead of print]
  9. Siller-Jackson AJ, Burra S, Gu S, Xia X, Bonewald LF, Sprague E, Jiang JX. Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem. 2008 Jul 31. [Epub ahead of print] Note: This article may currently be obtained online without charge.
  10. Dupont-Versteegden EE, Nagarajan R, Beggs ML, Bearden ED, Simpson PM, Peterson CA. Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling. Am J Physiol Regul Integr Comp Physiol. 2008 Aug 27. [Epub ahead of print]
  11. Schubert MC, Della Santina CC, Shelhamer M. Incremental angular vestibulo-ocular reflex adaptation to active head rotation. Exp Brain Res. 2008 Aug 20. [Epub ahead of print]
  12. Gubbels SP, Woessner DW, Mitchell JC, Ricci AJ, Brigande JV. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature. 2008 Aug 27. [Epub ahead of print]
  13. Na S, Collin O, Chowdhury F, Tay B, Ouyang M, Wang Y, Wang N. Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6626-31. Epub 2008 May 2.
  14. Sun Y, Yuan Y, Yi Z, Zhuang F, Fan Y. [Advances in the research of cell electrofusion under microgravity] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Jun;25(3):720-3. Chinese.
  15. Soga K, Kotake T, Wakabayashi K, Kamisaka S, Hoson T. Transient increase in the transcript levels of gamma-tubulin complex genes during reorientation of cortical microtubules by gravity in azuki bean (Vigna angularis) epicotyls. J Plant Res. 2008 Jul 26. [Epub ahead of print]

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