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NASA Spaceline 5 December 2008 Current Space Life Science Awareness

Status Report From: Spaceline
Posted: Friday, January 9, 2009

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

  1. Smith SR, Lovejoy JC, Bray GA, Rood J, Most MM, Ryan DH. Triiodothyronine increases calcium loss in a bed rest antigravity model for space flight. Metabolism. 2008 Dec;57(12):1696-703.
  2. Ponomarev AL, Costes SV, Cucinotta FA. Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci. Int J Radiat Biol. 2008 Nov;84(11):916-29. (PI: F.A. Cucinotta)
  3. Acevedo SE, McGinnis G, Raber J. Effects of 137Cs gamma irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice. Radiat Res. 2008 Oct;170(4):422-8. (PI: J. Raber)
  4. Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB. Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):909-17.
  5. Chang J, Adams JH, Ahn HS, Bashindzhagyan GL, Christl M, Ganel O, Guzik TG, Isbert J, Kim KC, Kuznetsov EN, Panasyuk MI, Panov AD, Schmidt WK, Seo ES, Sokolskaya NV, Watts JW, Wefel JP, Wu J, Zatsepin VI. An excess of cosmic ray electrons at energies of 300-800 GeV. Nature. 2008 Nov 20;456(7220):362-5. Note: This paper is highlighted in an Editor's Summary and a News and Views article.
  6. Harm DL, Taylor LC, Reschke MF, Somers JT, Bloomberg JJ. Sensorimotor coordination aftereffects of exposure to a virtual environment. Visual Comput. 2008 Nov;24(11):995-9. (PI: D.L. Harm) Note: The first page and color photographs of the authors (scroll down) are available at the publisher's abstract page.
  7. Chapes SK, Ganta RR. Defining the immune response to Ehrlichia species using murine models. Vet Parasitol. 2008 Dec 20;158(4):344-59. Epub 2008 Oct 17. (PI: S.K. Chapes)
  8. Kuntz SG, Schwarz EM, Demodena JA, De Buysscher T, Trout D, Shizuya H, Sternberg PW, Wold BJ. Multigenome DNA sequence conservation identifies Hox cis-regulatory elements. Genome Res. 2008 Nov 3. [Epub ahead of print] (PI: B.J. Wold)

Other papers of interest:

  1. Joseph JA, Griffin MJ. Motion sickness: Effect of changes in magnitude of combined lateral and roll oscillation. Aviat Space Environ Med. 2008 Nov;79(11):1019-27.
  2. Kirkpatrick AW, Doarn CR, Campbell MR, Barnes SL, Broderick TJ. Manual suturing quality at acceleration levels equivalent to spaceflight and a lunar base. Aviat Space Environ Med. 2008 Nov;79(11):1065-6. Note: Parabolic flight results.
  3. Low R, Teoh T, Loh A, Ooi A. Vertebral fracture in a pilot during centrifuge training: Finding of osteopenia. Aviat Space Environ Med. 2008 Nov;79(11):1067-70.
  4. Grigor'ev AI, Ivanova SM, Morukov BV, Maksimov GV. Development of cell hypoxia induced by factors of long-term spaceflight. Dokl Biochem Biophys. 2008 Oct;422(1):308-11. Note: ISS results. From paper: "The goal of this work was to study the erythrocyte metabolism, shape, and morphometric properties; the viscosity and lipid and phospholipid composition of the plasma membrane; the activity of transport enzymes; and the efficiency of oxygen retention by hemoglobin immediately after LSF." This paper is a translation in English of the Russian original published in Doklady Akademii Nauk 2008;422(6):823-6. The first page of the paper is available at the publisher's site abstract (as is the case with many Springer journals).
  5. Javorka M, Turianikova Z, Tonhajzerova I, Javorka K, Baumert M. The effect of orthostasis on recurrence quantification analysis of heart rate and blood pressure dynamics. Physiol Meas. 2008 Nov 27;30(1):29-41. [Epub ahead of print]
  6. Lott ME, Hogeman C, Herr M, Bhagat M, Sinoway LI. Gender differences in limb vasoconstriction responses to increases in transmural pressures. Am J Physiol Heart Circ Physiol. 2008 Nov 21. [Epub ahead of print]
  7. Griffith JF, Genant HK. Bone mass and architecture determination: State of the art. Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):737-64. Note: This issue, whose topic is osteoporosis, includes papers on skeletal growth and peak bone strength, bone remodelling, nutrition and bone, and bisphosphonates. To view the table of contents, click on the volume/issue in the publisher's site abstract for the paper above.
  8. Chen X, Gong X. [Bone adaptive digital analysis for femur bone being in disuse and overload condition] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Oct;25(5):1074-8. Chinese.
  9. Aleyaasin M, Harrigan JJ. Vibration exercise for treatment of osteoporosis: A theoretical model. Proc Inst Mech Eng [H]. 2008 Oct;222(7):1161-6.
  10. Rittweger J, Felsenberg D. Recovery of muscle atrophy and bone loss from 90 days bed rest: Results from a one-year follow-up. Bone. 2008 Oct 31. [Epub ahead of print] Note: This is a follow-up to the Long Term Bed Rest Study perfomed at MEDES, Toulouse, France in 2001 and 2002.
  11. Caulkins C, Ebramzadeh E, Winet H. Skeletal muscle contractions uncoupled from gravitational loading directly increase cortical bone blood flow rates in vivo. J Orthop Res. 2008 Nov 18. [Epub ahead of print] Note: Uncoupling from gravitational loading was done by suspending animals in a sling.
  12. Yokogawa M, Yamazaki T, Inoue K, Inaoka PT, Tsuji K, Tachino K. Age-associated changes in atrophy of the extensor digitorum longus muscle in hindlimb-suspended rats. J Phys Ther Sci. 2008;20(2):129-33. Note: This article may be obtained online without charge.
  13. Inaoka PT, Tachino K, Amano R, Yamazaki T, Yokogawa M, Tanaka S. Uptake behavior of thallium-201 in hindlimb muscles of rats. J Phys Ther Sci. 2008;20(2):117-22. Note: This article may be obtained online without charge.
  14. Kawahara Y, Nikawa T, Hirasaka K, Miyashita T, Kataoka K, Yuge L. Preventive effect of isometric contraction exercise on disuse muscle atrophy using tail suspension mice. J Phys Ther Sci. 2008;20(1):39-44. Note: This article may be obtained online without charge.
  15. Pignalosa D, Bertucci A, Gialanella G, Grossi G, Manti L, Pugliese M, Scampolia P, Durante M. Chromosome inter- and intrachanges detected by arm-specific DNA probes in the progeny of human lymphocytes exposed to energetic heavy ions. Radiat Res. 2008 Oct;170(4):458-66. Note: Heavy ion exposure was performed at the NASA Space Radiation Laboratory at Brookhaven.
  16. Anzenberg V, Chandiramani S, Coderre JA. LET-dependent bystander effects caused by irradiation of human prostate carcinoma cells with X rays or alpha particles. Radiat Res. 2008 Oct;170(4):467-76.
  17. Wu W, Wang M, Mussfeldt T, Iliakis G. Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ. Radiat Res. 2008 Oct;170(4):512-20.
  18. Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: Two randomised controlled multicentre trials. Lancet. 2008 Dec 1. [Epub ahead of print] Note: There were a number of news items about this research, describing its potential in alleviating jet lag.
  19. Petkova VI, Ehrsson HH. If I were you: Perceptual illusion of body swapping. PLoS ONE. 2008;3(12):e3832. Epub 2008 Dec 3. Note: This research, which also generated a number of news items, demonstrates the power of manipulating the visual perspective and correlated visual and sensory signals. This article may be obtained online without charge.
  20. Lopez JI, Mouw JK, Weaver VM. Biomechanical regulation of cell orientation and fate. Oncogene. 2008 Nov 24;27(55):6981-93.
  21. Alméras T, Fournier M. Biomechanical design and long-term stability of trees: Morphological and wood traits involved in the balance between weight increase and the gravitropic reaction. J Theor Biol. 2008 Nov 1. [Epub ahead of print]

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