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NASA Spaceline Current Awareness April 2, 2010

Status Report From: Spaceline
Posted: Friday, April 2, 2010

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

Talbot NC, Caperna TJ, Blomberg L, Graninger PG, Stodieck LS. The effects of space flight and microgravity on the growth and differentiation of PICM-19 pig liver stem cells. In Vitro Cell Dev Biol Anim. 2010 Mar 24. [Epub ahead of print] Note: STS-126 results.

Li Y, Solomon TP, Haus JM, Saidel GM, Cabrera ME, Kirwan JP. Computational model of cellular metabolic dynamics: Effect of insulin on glucose disposal in human skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Mar 23. [Epub ahead of print] (PI: M.E. Cabrera/G.M. Saidel)

Gleghorn JP, Doty SB, Warren RF, Wright TM, Maher SA, Bonassar LJ. Analysis of frictional behavior and changes in morphology resulting from cartilage articulation with porous polyurethane foams. J Orthop Res. 2010 Mar 22. [Epub ahead of print] (PI: J.P. Gleghorn, NASA Graduate Student Researcher Program)

Makinde AY, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. Radiat Res. 2010 Apr;173(4):441-52.

Mao XW, Favre CJ, Fike JR, Kubinova L, Anderson E, Campbell-Beachler M, Jones T, Smith A, Rightnar S, Nelson GA. High-LET radiation-induced response of microvessels in the hippocampus. Radiat Res. 2010 Apr;173(4):486-93. (PI: G.A. Nelson/NSCOR) Note: An illustration from this paper is shown on the cover of the journal; see the publisher's abstract. The illustration shows hippocampal microvessels, 12 months after irradiation, with morphological changes, e.g., "tortuous with nonuniform contours," compared with normal controls.

Yumoto K, Globus RK, Mojarrab R, Arakaki J, Wang A, Searby ND, Almeida EA, Limoli CL. Short-term effects of whole-body exposure to (56)Fe ions in combination with musculoskeletal disuse on bone cells. Radiat Res. 2010 Apr;173(4):494-504. (PIs: R.K. Globus, C.L. Limoli) Note: Among the results, from the abstract: "Together, radiation and hindlimb unloading had a greater effect on suppressing osteoblastogenesis ex vivo than either treatment alone."

Hada M, Gersey B, Saganti PB, Wilkins R, Cucinotta FA, Wu H. mBAND analysis of chromosome aberrations in human epithelial cells induced by (gamma)-rays and secondary neutrons of low dose rate. Mutat Res. 2010 Mar 23. [Epub ahead of print] (PIs: F.A. Cucinotta, H. Wu)

Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D. Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res. 2010 Apr 1;70(7):2829-39. Epub 2010 Mar 23. (PI: S. Burma)

Other papers of interest:

Martin-Vazquez M, Reyes del Paso GA. Physical training and the dynamics of the cardiac baroreflex: A comparison when blood pressure rises and falls. Int J Psychophysiol. 2010 Mar 17. [Epub ahead of print]

Vaddadi G, Esler MD, Dawood T, Lambert E. Persistence of muscle sympathetic nerve activity during vasovagal syncope. Eur Heart J. 2010 Mar 19. [Epub ahead of print]

Reybrouck T, Heidbuechel H, Willems R, Ector H. Tilt training and pacing: A report on 9 patients with neurally mediated syncope. Acta Cardiol. 2010 Feb;65(1):3-7. Note: This article may be obtained online without charge.

Baldwin KM, Haddad F. Research in the exercise sciences: Where we are and where do we go from here--Part II. Exerc Sport Sci Rev. 2010 Apr;38(2):42-50.

Nakajima S, Ohsawa I, Ohta S, Ohno M, Mikami T. Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res. 2010 Mar 20. [Epub ahead of print]

Dumont N, Frenette J. Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro. A mechanism partly dependent on the insulin-like growth factor-1 signaling molecule. Am J Pathol. 2010 Mar 19. [Epub ahead of print]

Mittal A, Bhatnagar S, Kumar A, Lach-Trifilieff E, Wauters S, Li H, Makonchuk DY, Glass DJ, Kumar A. The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol. 2010 Mar 22;188(6):833-49.

Cotton CJ, Harlow HJ. Avoidance of skeletal muscle atrophy in spontaneous and facultative hibernators. Physiol Biochem Zool. 2010 Mar 25. [Epub ahead of print]

Zhao S, Shao C, Goropashnaya AV, Stewart NC, Xu Y, Toien O, Barnes BM, Fedorov VB, Yan J. Genomic analysis of expressed sequence tags in American black bear Ursus americanus. BMC Genomics. 2010 Mar 26;11:201. [Epub ahead of print] Note: This article may be obtained online without charge.

McAteer ME, Niziolek PJ, Ellis SN, Alge DL, Robling AG. Mechanical stimulation and intermittent parathyroid hormone treatment induce disproportional osteogenic, geometric, and biomechanical effects in growing mouse bone. Calcif Tissue Int. 2010 Mar 20. [Epub ahead of print]

Gaudio A, Pennisi P, Bratengeier C, Torrisi V, Lindner B, Mangiafico RA, Pulvirenti I, Hawa G, Tringali G, Fiore CE. Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab. 2010 Mar 19. [Epub ahead of print]

von Stengel S, Kemmler W, Engelke K, Kalender WA. Effects of whole body vibration on bone mineral density and falls: Results of the randomized controlled ELVIS study with postmenopausal women. Osteoporos Int. 2010 Mar 20. [Epub ahead of print]

Galli C, Passeri G, Macaluso GM. Osteocytes and WNT: The mechanical control of bone formation. J Dent Res. 2010 Apr;89(4):331-43. Epub 2010 Mar 3.

Ulbrich C, Westphal K, Pietsch J, Winkler HD, Leder A, Bauer J, Kossmehl P, Grosse J, Schoenberger J, Infanger M, Egli M, Grimm D. Characterization of human chondrocytes exposed to simulated microgravity. Cell Physiol Biochem. 2010;25(4-5):551-60. Epub 2010 Mar 23. Note: This article may be obtained online without charge.

Cui Y, Zhou J, Li C, Wang P, Zhang M, Liu Z, Yi Y, Zhang J. Effects of simulated weightlessness on liver Hsp70 and Hsp70mRNA expression in rats. Int J Clin Exp Med. 2010;3(1):48-54. Note: This article may be obtained online without charge.

Nakajima I, Tachibana M, Ohashi N, Imai H, Asari Y, Matsuyama S. Emergency medical support system for extravehicular activity training held at weightless environment test building (WETS) of the Japan Aerospace Exploration Agency (JAXA): Future prospects and a look back over the past decade. J Med Syst. 2009 Dec 9. [Epub ahead of print]

Brown SL, Kolozsvary A, Liu J, Jenrow KA, Ryu S, Kim JH. Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality. Radiat Res. 2010 Apr;173(4):462-8.

Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, MacVittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. Animal models for medical countermeasures to radiation exposure. Radiat Res. 2010 Apr;173(4):557-78. Note: This article may be obtained online without charge.

Altmeyer A, Jung AC, Ignat M, Benzina S, Denis JM, Gueulette J, Noel G, Mutter D, Bischoff P. Pharmacological enhancement of autophagy induced in a hepatocellular carcinoma cell line by high-LET radiation. Anticancer Res. 2010 Feb;30(2):303-10.

Coy SL, Krylov EV, Schneider BB, Covey TR, Brenner DJ, Tyburski JB, Patterson AD, Krausz KW, Fornace AJ, Nazarov EG. Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS-MS). Int J Mass Spectrom. 2010 Apr 15;291(3):108-17.

Pavy-Le Traon A, Taillard J. [Sleep and space flights] Medecine du Sommeil. 2010 Jan-Mar;7(1):8-14. French. Note: This article may be obtained online without charge when accessed via the Table of Contents. Click on the volume and issue at the upper left of the publisher's abstract to access the Table of Contents.

Muench M, Silva EJ, Ronda JM, Czeisler CA, Duffy JF. EEG sleep spectra in older adults across all circadian phases during NREM sleep. Sleep. 2010 Mar 1;33(3):389-401.

Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: The end game. Nat Rev Mol Cell Biol. 2010 Apr;11(4):288-300.

Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010 Mar 22;188(6):877-90.

Belyy V, Anishkin A, Kamaraju K, Liu N, Sukharev S. The tension-transmitting 'clutch' in the mechanosensitive channel MscS. Nat Struct Mol Biol. 2010 Mar 7. [Epub ahead of print]

Probst A, Vaishampayan P, Osman S, Moissl-Eichinger C, Andersen G, Venkateswaran K. Microbial diversity of anaerobes from spacecraft assembly clean rooms. Appl Environ Microbiol. 2010 Mar 12. [Epub ahead of print]



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