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NASA Spaceline Current Awareness September 10, 2010

Status Report From: Spaceline
Posted: Friday, September 10, 2010

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

Reich KA, Chen YW, Thompson PD, Hoffman EP, Clarkson PM. 48 hours of unloading and 24 hours of reloading leads to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans. J Appl Physiol. 2010 Aug 26. [Epub ahead of print] (PI: K.A. Reich, American College of Sports Medicine/NASA Space Physiology Research Grant)

Hyldahl RD, O'Fallon KS, Schwartz LM, Clarkson PM. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. J Appl Physiol. 2010 Aug 26. [Epub ahead of print] (PI: R.D. Hyldahl, American College of Sports Medicine/NASA Space Physiology Research Grant)

Hagelstrom RT, Blagoev KB, Niedernhofer LJ, Goodwin EH, Bailey SM. Hyper telomere recombination accelerates replicative senescence and may promote premature aging. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15768-73. Epub 2010 Aug 23. (PI: S.M. Bailey)

Ware JH, Sanzari J, Avery S, Sayers C, Krigsfeld G, Nuth M, Wan XS, Rusek A, Kennedy AR. Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice. Radiat Res. 2010 Sep;174(3):325-30. (PI: A.R. Kennedy)

Shuryak I, Ullrich RL, Sachs RK, Brenner DJ. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat Res. 2010 Sep;174(3):357-66. (PIs: R.L. Ullrich/NSCOR; L. Hlatky/R.K. Sachs/NSCOR)

Visscher AM, Paul AL, Kirst M, Guy CL, Schuerger AC, Ferl RJ. Growth performance and root transcriptome remodeling of Arabidopsis in response to Mars-like levels of magnesium sulfate. PLoS One. 2010 Aug 23;5(8). pii: e12348. (PI: R.J. Ferl) Note: This article may be obtained online without charge.

Other papers of interest:

Kuzichkin DS, Morukov BV, Markin AA, Juravlyova OA, Zabolotskaya IV, Vostrikova LV. Hemostasis system indices after short-term space flights and during 7-day "dry" immersion experiment. Hum Physiol. 2010 Jul;36(4):478-82. Note: Space flight results; flight(s) unspecified. This paper is a translation in English of the Russian original published in Fiziologiya Cheloveka 2010 Jul-Aug;36(4):125-9.

Berthet K, Lukaszewicz AC, Bousser MG, Payen D. Lower body positive pressure application with an antigravity suit in acute carotid occlusion. Stroke Res Treat. 2010 Apr 1;2010. pii: 950524. Note: This article may be obtained online without charge via PubMed Central.

Alibegovic AC, Sonne MP, Hojbjerre L, Bork-Jensen J, Jacobsen S, Nilsson E, Faerch K, Hiscock NJ, Mortensen B, Friedrichsen M, Stallknecht B, Dela F, Vaag A. Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am J Physiol Endocrinol Metab. 2010 Aug 24. [Epub ahead of print] Note: Nine-day bed rest experiment.

Rauch F. What is new in neuro-musculoskeletal interactions: From medical myths to YouTube. J Musculoskelet Neuronal Interact. 2010 Sep;10(3):191-2. Note: This article summarizes recent research in this field. "YouTube" in the title refers to a study of ankle fractures culled from YouTube videos and followed up with radiographs. Last sentence of the article: "The authors conclude that YouTube has a promising future...in the study of fracture mechanisms." The article may be obtained online without charge.

Rauch F, Sievanen H, Boonen S, Cardinale M, Degens H, Felsenberg D, Roth J, Schoenau E, Verschueren S, Rittweger J. Reporting whole-body vibration intervention studies: Recommendations of the International Society of Musculoskeletal and Neuronal Interactions. J Musculoskelet Neuronal Interact. 2010 Sep;10(3):193-8. Note: This article may be obtained online without charge.

Belavy DL, Bock O, Boerst H, Armbrecht G, Gast U, Degner C, Beller G, Soll H, Salanova M, Habazettl H, Heer M, de Haan A, Stegeman DF, Cerretelli P, Blottner D, Rittweger J, Gelfi C, Kornak U, Felsenberg D. The 2(nd) Berlin BedRest Study: Protocol and implementation. J Musculoskelet Neuronal Interact. 2010 Sep;10(3):207-19. Note: This article outlines the procedures followed in this bed rest study, including photographs, and provides recommendations for future studies. The article may be obtained online without charge.

Klika V, Marik F. A thermodynamic model of bone remodelling: The influence of dynamic loading together with biochemical control. J Musculoskelet Neuronal Interact. 2010 Sep;10(3):220-30. Note: This article may be obtained online without charge.

Belav DL, Beller G, Armbrecht G, Perschel FH, Fitzner R, Bock O, Boerst H, Degner C, Gast U, Felsenberg D. Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest. Osteoporos Int. 2010 Sep 3. [Epub ahead of print] Note: Second Berlin Bed Rest Study.

Prostyakov IV, Novikov VE, Morukov BV. Bone mineral density and microarchitecture in participants of a 105-day experiment in isolated environment. Hum Physiol. 2010 Jul;36(4):473-7. Note: MARS-105 experiment. This paper is a translation in English of the Russian original published in Fiziologiya Cheloveka 2010 Jul-Aug;36(4):119-24.

Gong H, Zhang M. A computational model for cortical endosteal surface remodeling induced by mechanical disuse. Mol Cell Biomech. 2010 Mar;7(1):1-11.

Nelson CJ, Otis JP, Carey HV. Global analysis of circulating metabolites in hibernating ground squirrels. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Jul 30. [Epub ahead of print]

Crawford IA. Astrobiological benefits of human space exploration. Astrobiology. 2010 Jul-Aug;10(6):577-87. Note: From Introduction: "The question for future exploration is whether a continued reliance of robotic space probes will be sufficient to meet the core objectives of astrobiology or whether the search for life in the Universe would benefit from a renewed, and greatly expanded, program of human exploration beyond low Earth orbit (LEO)." Potential benefits supporting the latter approach are given in the article.

Durante M, Reitz G, Angerer O. Space radiation research in Europe: Flight experiments and ground-based studies. Radiat Environ Biophys. 2010 Aug;49(3):295-302. Epub 2010 Jun 8. Note: Many of the papers in this issue (table of contents) derive from a "Heavy Ions in Therapy and Space Symposium 2009" held in Germany in July 2009. Most of the relevant papers have appeared in previous Current Awareness lists as epubs. This article may be obtained online without charge.

Friedrich T, Weyrather W, Elsaesser T, Durante M, Scholz M. Accuracy of RBE: Experimental and theoretical considerations. Radiat Environ Biophys. 2010 Aug;49(3):345-9. Epub 2010 Jun 17.

Mariotti L, Facoetti A, Alloni D, Bertolotti A, Ranza E, Ottolenghi A. Effects of ionizing radiation on cell-to-cell communication. Radiat Res. 2010 Sep;174(3):280-9.

Abe C, Shibata A, Iwata C, Morita H. Restriction of rear-up-behavior-induced attenuation of vestibulo-cardiovascular reflex in rats. Neurosci Lett. 2010 Aug 18. [Epub ahead of print]

Usoskin D, Zilberter M, Linnarsson S, Hjerling-Leffler J, Uhlen P, Harkany T, Ernfors P. En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons. Proc Natl Acad Sci U S A. 2010 Aug 24. [Epub ahead of print] Note: This article may be obtained online without charge.

Wang N. Structural basis of stress concentration in the cytoskeleton. Mol Cell Biomech. 2010 Mar;7(1):33-44.

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: A bioinformatics study. Tissue Eng Part A. 2010 Aug 31. [Epub ahead of print]

Gurkan UA, Krueger A, Akkus O. Ossifying bone marrow explant culture as a three-dimensional mechanoresponsive in vitro model of osteogenesis. Tissue Eng Part A. 2010 Aug 31. [Epub ahead of print]

Zhang ZY, Teoh SH, Teo EY, Khoon Chong MS, Shin CW, Tien FT, Choolani MA, Chan JK. A comparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering. Biomaterials. 2010 Aug 24. [Epub ahead of print]

Andreeva Z, Barton D, Armour WJ, Li MY, Liao LF, McKellar HL, Pethybridge KA, Marc J. Inhibition of phospholipase C disrupts cytoskeletal organization and gravitropic growth in Arabidopsis roots. Planta. 2010 Aug 29. [Epub ahead of print]


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