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NASA Spaceline Current Awareness November 12, 2010

Status Report From: Spaceline
Posted: Friday, November 12, 2010

The abstract in PubMed or at the publisher's site is linked when available and will open in a new window.

Dregalla RC, Zhou J, Idate RR, Battaglia CL, Liber HL, Bailey SM. Regulatory roles of tankyrase 1 at telomeres and in DNA repair: Suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY). 2010 Oct;2(10):691-708. (PI: S.M. Bailey) Note: This article may be obtained online without charge. The article is described in an editorial by S. Chang.

Aypar U, Morgan WF, Baulch JE. Radiation-induced genomic instability: Are epigenetic mechanisms the missing link? Int J Radiat Biol. 2010 Nov 2. [Epub ahead of print] (PIs: W.F. Morgan, J.E. Baulch)

Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res. 2010 Nov 2. [Epub ahead of print] (PI: J.D. Minna/J.W. Shay/NSCOR)

Kong Z, Raghavan P, Xie D, Boike T, Burma S, Chen D, Chakraborty A, Hsieh JT, Saha D. Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells. Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1210-8. (PI: S. Burma)

Damron FH, Yu HD. Pseudomonas aeruginosa MucD regulates alginate pathway through activation of MucA degradation via MucP proteolytic activity. J Bacteriol. 2010 Oct 29. [Epub ahead of print] (PIs: H.D. Yu; F.H. Damron, NASA Graduate Student Researcher Program)

Shagimardanova EI, Gusev OA, Sychev VN, Levinskikh MA, Sharipova MR, Il'inskaya ON, Bingham G, Sugimoto M. Expression of stress response genes in barley Hordeum vulgare in a spaceflight environment. Mol Biol. 2010 Oct;44(5):734-40. (PI: G. Bingham) Note: ISS results. This paper is a translation in English of the Russian original published in Molekulyarnaya Biologiya 2010;44(5):831-8. The results of this paper contrast with the results of a similar experiment (which had different analytical techniques) reported in the 7/23/10 Current Awareness list.

Other papers of interest:

Reisner AT, Xu D, Ryan KL, Convertino VA, Rickards CA, Mukkamala R. Monitoring non-invasive cardiac output and stroke volume during experimental human hypovolaemia and resuscitation. Br J Anaesth. 2010 Nov 4. [Epub ahead of print]

Li J, Li MG, Ma GX, Liu Y, Meng G, Han L, Liu X. [Effect of tea polyphenols and esmolol on vascular endothelial cell secreting endothelin stimulated by simulated high level of Ang II caused by simulated microgravity] Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):383-4. Chinese. Note: Translated journal title is Chinese Journal of Applied Physiology.

Moore-Harrison T, Lightfoot JT. Driven to be inactive?-The genetics of physical activity. Prog Mol Biol Transl Sci. 2010;94:271-90. Note: This is Chapter 10 in the volume "Genes and Obesity." Find volume 94.

Cox LG, van Rietbergen B, van Donkelaar CC, Ito K. Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties. Biomech Model Mechanobiol. 2010 Nov 5. [Epub ahead of print] Note: This article may be obtained online without charge.

Tezval M, Biblis M, Sehmisch S, Schmelz U, Kolios L, Rack T, Stuermer KM, Stuermer EK. Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model. Calcif Tissue Int. 2010 Oct 31. [Epub ahead of print] Note: This article may be obtained online without charge.

Karsenty G, Oury F. The central regulation of bone mass, the first link between bone remodeling and energy metabolism. J Clin Endocrinol Metab. 2010 Nov;95(11):4795-801.

Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y. Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport. 2010 Oct 28. [Epub ahead of print]

Kravtsova VV, Shenkman BS, Mikhailov VM, Nikol'skii EE, Krivoi II. [Effect of functional unloading and dystrophin deficit on the local hyperpolarization of the postsynaptic membrane of a skeletal muscle fiber] Biofizika. 2010 Sep-Oct;55(5):834-41. Russian.

Ogneva IV, Altaeva EG. [Effects of nifedipine on the mechanical properties of sarcolemma and modulation of calcium accumulation dynamics in fibers of the rat soleus muscle under short-term hypogravity conditions] Biofizika. 2010 Sep-Oct;55(5):918-24. Russian.

Zhou Y, Wang B, Wang YC, Wu YH, Zhang S, Geng J, Sun XQ. [Apoptosis in myocyte after repeated + Gz exposures in rats] Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):275-7. Chinese. Note: Translated journal title is Chinese Journal of Applied Physiology.

Vinciguerra M, Musaro A, Rosenthal N. Regulation of muscle atrophy in aging and disease. Adv Exp Med Biol. 2010;694:211-33.

Maguire A, Morrissey B, Walsh JE, Lyng FM. Medium-mediated effects increase cell killing in a human keratinocyte cell line exposed to solar-simulated radiation. Int J Radiat Biol. 2010 Oct 25. [Epub ahead of print] Note: The researchers used a Q-sun solar simulator (Q-panel, Cleveland, Ohio) to simulate solar radiation.

Mock B, Jones TA, Jones SM. Gravity receptor aging in the CBA/CaJ strain: A comparison to auditory aging. J Assoc Res Otolaryngol. 2010 Nov 5. [Epub ahead of print]

Yeom J, Park S. A gravitational impulse model predicts collision impulse and mechanical work during a step-to-step transition. J Biomech. 2010 Oct 23. [Epub ahead of print] Note: The authors propose a new model to better understand steps during walking.

Pagani L, Semenova EA, Moriggi E, Revell VL, Hack LM, Lockley SW, Arendt J, Skene DJ, Meier F, Izakovic J, Wirz-Justice A, Cajochen C, Sergeeva OJ, Cheresiz SV, Danilenko KV, Eckert A, Brown SA. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One. 2010 Oct 15;5(10):e13376. Note: This article may be obtained online without charge.

Yulug B, Erkol G, Kilic E. An interesting link between microgravity and psychiatric diseases. J Neuropsychiatry Clin Neurosci. 2010 Fall;22(4):451-g.e12-451.e12. Note: The authors cite several flight and ground results to speculate on a possible link between stress, microgravity, and psychiatric problems. This Letter may be obtained online without charge.

Soga K, Yamaguchi A, Kotake T, Wakabayashi K, Hoson T. Transient increase in the levels of gamma-tubulin complex and katanin are responsible for reorientation by ethylene and hypergravity of cortical microtubules. Plant Signal Behav. 2010 Nov 8;5(11). [Epub ahead of print]

Jesudason R, Sato S, Parameswaran H, Araujo AD, Majumdar A, Allen PG, Bartolak-Suki E, Suki B. Mechanical forces regulate elastase activity and binding site availability in lung elastin. Biophys J. 2010 Nov 3;99(9):3076-83.



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