NASA Spaceline Current Awareness 8 June 2012 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Saturday, June 9, 2012

image Next list: June 22, 2012

Papers deriving from NASA support:

Shibata S, Fu Q, Bivens TB, Hastings JL, Wang W, Levine BD.
Short-term exercise training improves the cardiovascular response to exercise in the Postural Orthostatic Tachycardia Syndrome.
J Physiol. 2012 May 28. [Epub ahead of print]
(PI: S. Shibata, NSBRI Postdoctoral Fellowship Program)

Pendergast DR, Olszowka A, Farhi LE.
Cardiovascular and pulmonary responses to increased acceleration forces during rest and exercise.
Aviat Space Environ Med. 2012 May;83(5):488-95.
(PI: L.E. Farhi)

Morgan JL, Skulan JL, Gordon GW, Romaniello SJ, Smith SM, Anbar AD.
Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes.
Proc Natl Acad Sci U S A. 2012 May 31. [Epub ahead of print]
(PIs: A.D. Anbar, S.M. Smith)
NOTE: Bed rest study. Press release:
This article may be obtained online without charge.

Shahnazari M, Wronski T, Chu V, Williams A, Leeper A, Stolina M, Ke HZ, Halloran B.
Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody.
Calcif Tissue Int. 2012 May 27. [Epub ahead of print]
(PI: B. Halloran)

Khaled S, Gupta KB, Kucik DF.
Ionizing radiation increases adhesiveness of human aortic endothelial cells via a chemokine-dependent mechanism.
Radiat Res. 2012 May;177(5):594-601. Epub 2011 Nov 15.
(PI: D.F. Kucik)

Haerich P, Eggers C, Pecaut MJ.
Investigation of the effects of head irradiation with gamma rays and protons on startle and pre-pulse inhibition behavior in mice.
Radiat Res. 2012 May;177(5):685-92. Epub 2012 Apr 2.

Shankaran H, Weber TJ, von Neubeck C, Sowa MB.
Using imaging methods to interrogate radiation-induced cell signaling.
Radiat Res. 2012 Apr;177(4):496-507. Epub 2012 Mar 1.
(PI: M.B. Sowa)

Brogan J, Li F, Li W, He Z, Huang Q, Li CY.
Imaging molecular pathways: Reporter genes.
Radiat Res. 2012 Apr;177(4):508-13. Epub 2012 Feb 21.
(PI: C.Y. Li)

Badavi FF.
A dynamic model for the validation of cosmic rays anisotropy at low Earth orbit.
IEEE Trans Nucl Sci. 2012 Apr;59(2):447-55.
(PI: C. Sandridge)
NOTE: Article includes modeling and exposure estimates for ISS.

Wood SJ, Reschke MF, Owen Black F.
Continuous equilibrium scores: Factoring in the time before a fall.
Gait Posture. 2012 May 26. [Epub ahead of print]

Other papers of interest:

Zuj KA, Edgell H, Shoemaker JK, Custaud MA, Arbeille P, Hughson RL.
Responses of women to sublingual nitroglycerin before and after 56 days of 6* head down bed rest.
J Appl Physiol. 2012 May 31. [Epub ahead of print]
NOTE: WISE-2005 bed rest study.

Shoemaker JK, Usselman CW, Rothwell A, Wong SW.
Altered cortical activation patterns associated with baroreflex unloading following 24 hours of physical deconditioning.
Exp Physiol. 2012 May 21. [Epub ahead of print]
NOTE: Bed rest study.

Mekjavic IB, Kounalakis SN, Keramidas ME, Biolo G, Narici M, Eiken O.
Heat production and heat loss responses to cold water immersion after 35 days horizontal bed rest.
Aviat Space Environ Med. 2012 May;83(5):472-6.
NOTE: Bed rest study (conducted in Slovenia).

Cancedda R, Liu Y, Ruggiu A, Tavella S, Biticchi R, Santucci D, Schwartz S, Ciparelli P, Falcetti G, Tenconi C, Cotronei V, Pignataro S.
The Mice Drawer System (MDS) experiment and the space endurance record-breaking mice.
PLoS One. 2012;7(5):e32243. Epub 2012 May 29.
NOTE: ISS results. This experiment is described in detail, including a description of the Tissue Sharing Program resulting from the experiment. The article may be obtained online without charge.

Kimoto M, Zeredo JL, Toda K.
Hypergravity conditioning on ileal movements in rats.
Aviat Space Environ Med. 2012 May;83(5):483-7.

Kollet O, Canaani J, Kalinkovich A, Lapidot T.
Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis.
Inflamm Allergy Drug Targets. 2012 Jun 1;11(3):170-80.
NOTE: This article has a section on microgravity.

Schiavone G, Izzo D, Simoes LF, de Croon GC.
Autonomous spacecraft landing through human pre-attentive vision.
Bioinspir Biomim. 2012 Jun;7(2):025007. Epub 2012 May 22.
NOTE: This article may be obtained online without charge.

Jani A, Orlicky DJ, Karimpour-Fard A, Epperson LE, Russell RL, Hunter LE, Martin SL.
The changing kidney proteome provides evidence for dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation.
Physiol Genomics. 2012 May 29. [Epub ahead of print]

Lin DC, Hershey JD, Mattoon JS, Robbins CT.
Skeletal muscles of hibernating brown bears are unusually resistant to effects of denervation.
J Exp Biol. 2012 Jun 15;215(Pt 12):2081-7.

Mirzoev TM, Biriukov NS, Veselova OM, Larina IM, Shenkman BS, Ogneva IV.
[Desmin content and cell breathing in rats' m. soleus fibers after 3- and 7-day recovery from 14-day suspension]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):41-6. Russian.

Bogdanis GC.
Effects of physical activity and inactivity on muscle fatigue.
Front Physiol. 2012;3:142. Epub 2012 May 18.
NOTE: This article may be obtained online without charge.

Goodman CA, Kotecki JA, Jacobs BL, Hornberger TA.
Muscle fiber type-dependent differences in the regulation of protein synthesis.
PLoS One. 2012;7(5):e37890. Epub 2012 May 22.
NOTE: This article may be obtained online without charge.

Monsour M, Ivanova TD, Wilson TD, Garland SJ.
Influence of vestibular afferent input on common modulation of human soleus motor units during standing.
Motor Control. 2012 May 15. [Epub ahead of print]

Meynial-Denis D, Guerin O, Schneider SM, Volkert D, Sieber CC.
New strategies to fight against sarcopenia at old age.
J Aging Res. 2012;2012:676042. Epub 2012 Apr 26.
NOTE: This editorial, which may be obtained online without charge, introduces a special issue on this topic:

Sun Y, Shuang F, Chen DM, Zhou RB.
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
Osteoporos Int. 2012 May 31. [Epub ahead of print]

Siu WS, Wong HL, Lau CP, Shum WT, Wong CW, Gao S, Fung KP, Lau CB, Hung LK, Ko CH, Leung PC.
The effects of an antiosteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action.
Phytother Res. 2012 May 24. [Epub ahead of print]

Shi Y, Fu Y, Tong W, Geng Y, Lui PP, Tang T, Zhang X, Dai K.
Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway.
J Cell Biochem. 2012 May 21. [Epub ahead of print]

Liu L, Zong C, Li B, Shen D, Tang Z, Chen J, Zheng Q, Tong X, Gao C, Wang J.
The interaction between 1 integrins and ERK1/2 in osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modelled by a perfusion system.
J Tissue Eng Regen Med. 2012 May 18. [Epub ahead of print]

Hu ZP, Kim YM, Sowa MB, Robinson RJ, Gao X, Metz TO, Morgan WF, Zhang Q.
Metabolomic response of human skin tissue to low dose ionizing radiation.
Mol Biosyst. 2012 Jul 6;8(7):1979-86. Epub 2012 May 18.

Shi L, Fujioka K, Sun J, Kinomura A, Inaba T, Ikura T, Ohtaki M, Yoshida M, Kodama Y, Livingston GK, Kamiya K, Tashiro S.
A modified system for analyzing ionizing radiation-induced chromosome abnormalities.
Radiat Res. 2012 May;177(5):533-8. Epub 2012 Apr 17.

Al-Mayah AH, Irons SL, Pink RC, Carter DR, Kadhim MA.
Possible role of exosomes containing RNA in mediating nontargeted effect of ionizing radiation.
Radiat Res. 2012 May;177(5):539-45.

Ushigome T, Shikazono N, Fujii K, Watanabe R, Suzuki M, Tsuruoka C, Tauchi H, Yokoya A.
Yield of single- and double-strand breaks and nucleobase lesions in fully hydrated plasmid DNA films irradiated with high-LET charged particles.
Radiat Res. 2012 May;177(5):614-27. Epub 2011 Dec 29.

Jakob B, Durante M.
Radiation dose detection by imaging response in biological targets.
Radiat Res. 2012 Apr;177(4):524-32. Epub 2012 Feb 14.

Mothersill C, Smith RW, Fazzari J, McNeill F, Prestwich W, Seymour CB.
Evidence for a physical component to the radiation-induced bystander effect?
Int J Radiat Biol. 2012 May 29. [Epub ahead of print]

Kundrat P, Friedland W.
Non-linear response of cells to signals leads to revised characteristics of bystander effects inferred from their modelling.
Int J Radiat Biol. 2012 May 28. [Epub ahead of print]

Abdelkawi S.
Lens crystallin response to whole body irradiation with single and fractionated doses of gamma radiation.
Int J Radiat Biol. 2012 May 22. [Epub ahead of print]

Suzuki K, Yamashita S.
Low-dose radiation exposure and carcinogenesis.
Jpn J Clin Oncol. 2012 May 28. [Epub ahead of print]

Shafirkin AV, Mukhamedieva LN, Tatarkin SV, Barantseva MY.
[Evaluation of the risk of delayed adverse effects of chronic combined exposure to radiation and chemical factors with the purpose to ensure safety in orbital and exploration space missions]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):23-9. Russian.

Barteneva SS, Petrov VM.
[Rates of aberrant lymphocytes elimination in various bio-objects]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):30-5. Russian.

Ushakov IB, Shtemberg AS.
[The problems of studying the effects of far long-duration space mission factors on the higher nervous activity in model experiments with animals]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):5-16. Russian.

Zamoschina TA, Krivova NA, Khodanovich MY, Trukhanov KA, Tukhvatulin RT, Zaeva OB, Zelenskaya AE, Gul EV.
[Influence of simulated hypomagnetic environment in a far space flight on the rhythmic structure of rat's behavior]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):17-23. Russian.

Soyka F, Giordano PR, Barnett-Cowan M, Buelthoff HH.
Modeling direction discrimination thresholds for yaw rotations around an earth-vertical axis for arbitrary motion profiles.
Exp Brain Res. 2012 May 24. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Grewal T, Dawood T, Hammam E, Kwok K, Macefield VG.
Low-frequency physiological activation of the vestibular utricle causes biphasic modulation of skin sympathetic nerve activity in humans.
Exp Brain Res. 2012 May 24. [Epub ahead of print]

Wang JQ, Li HX, Chen XM, Mo FF, Qi RR, Guo JS, Cai YL.
Temporal change in NMDA receptor signaling and GABA(A) receptor exypression in rat caudal vestibular nucleus during motion sickness habituation.
Brain Res. 2012 Jun 21;1461:30-40. Epub 2012 Apr 28.

Tal D, Gonen A, Wiener G, Bar R, Gil A, Nachum Z, Shupak A.
Artificial horizon effects on motion sickness and performance.
Otol Neurotol. 2012 May 25. [Epub ahead of print]

Golding JF, Doolan K, Acharya A, Tribak M, Gresty MA.
Cognitive cues and visually induced motion sickness.
Aviat Space Environ Med. 2012 May;83(5):477-82.

Tribukait A, Eiken O.
Flight experience and the perception of pitch angular displacements in a gondola centrifuge.
Aviat Space Environ Med. 2012 May;83(5):496-503.

Wada T, Konno H, Fujisawa S, Doi S.
Can passengers' active head tilt decrease the severity of carsickness? Effect of head tilt on severity of motion sickness in a lateral acceleration environment.
Hum Factors. 2012 Apr;54(2):226-34.

Salas E, King HB, Rosen MA.
Improving teamwork and safety: Toward a practical systems approach, a commentary on Deneckere et al.
Soc Sci Med. 2012 May 8. [Epub ahead of print]

Beck M, Tabury K, Moreels M, Jacquet P, Van Oostveldt P, De Vos WH, Baatout S.
Simulated microgravity decreases apoptosis in fetal fibroblasts.
Int J Mol Med. 2012 Aug;30(2):309-13. Epub 2012 May 14.

Di S, Tian Z, Qian A, Li J, Wu J, Wang Z, Zhang D, Yin D, Brandi ML, Shang P.
Large gradient high magnetic field affects FLG29.1 cells differentiation to form osteoclast-like cells.
Int J Radiat Biol. 2012 May 29. [Epub ahead of print]

Miri A, Hashmani K, Al-Aqaba M, Faraj LA, Fares U, Otri AM, Said DG, Dua HS.
The effect of gravitational force on limbal stem cell growth.
Br J Ophthalmol. 2012 May 19. [Epub ahead of print]

Jagielska A, Norman AL, Whyte G, Van Vliet KJ, Guck J, Franklin RJ.
Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.
Stem Cells Dev. 2012 May 30. [Epub ahead of print]

Nassoy P, Lamaze C.
Stressing caveolae new role in cell mechanics.
Trends Cell Biol. 2012 May 19. [Epub ahead of print]

Sun Y, Villa-Diaz LG, Lam RH, Chen W, Krebsbach PH, Fu J.
Mechanics regulates fate decisions of human embryonic stem cells.
PLoS One. 2012;7(5):e37178. Epub 2012 May 16.
NOTE: This article may be obtained online without charge.

Rikien A.
Space plant biology research in Lithuania.
Endeavour. 2012 May 19. [Epub ahead of print]

Glinkova E, Zhuchkina NI, Koltovoi NA, Koltovaya NA.
[Gamma-radiation action on cells of algae Euglena gracilis]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):35-41. Russian.

Tikhomirov AA, Ushakova SA, Golovko TK, Velichko VV, Tabalenkova GN, Zakhozhiy IG, Garmash EV, Matusevich VV.
[Optimization of the mineral nutrition of plants constituting the phototrophic component of closed biological life support systems]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):46-50. Russian.

Krivobok AS, Berkovich YA, Ilyin VK, Chuvilskaya NA, Scherbakova VA.
[Methods of extending the resource of fiber ionite artificial soils in space greenhouses]
Aviakosm Ekolog Med. 2012 Jan-Feb;46(1):51-6. Russian.

Trappe HJ.
Role of music in intensive care medicine.
Int J Crit Illn Inj Sci. 2012 Jan-Apr;2(1):27-31.
NOTE: From abstract: "The most benefit on health in intensive care medicine patients is visible in classical (Bach, Mozart or Italian composers) music and meditation music, whereas heavy metal music or techno are not only ineffective but possibly dangerous and can lead to stress and/or life-threatening arrhythmias, particularly in intensive care medicine patients." This article may be obtained online without charge, in html format, via PubMed Central or at the publisher's site:;year=2012;volume=2;issue=1;spage=27;epage=31;aulast=Trappe

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