SpaceRef

SpaceRef


NASA Spaceline Current Awareness 11 July 2012 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Tuesday, July 24, 2012

image Papers deriving from NASA support:

1 Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M.
The Rel/NF-B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity.
J Leukoc Biol. 2012 Jul 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22750545
(PI: M. Hughes-Fulford)
NOTE: ISS results.

2 Scott JM, Martin DS, Ploutz-Snyder R, Caine T, Matz T, Arzeno NM, Buxton R, Ploutz-Snyder L.
Reliability and validity of panoramic ultrasound for muscle quantification.
Ultrasound Med Biol. 2012 Jul 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22749820
(PI: L. Ploutz-Snyder)

3 Yarrow JF, McCoy SC, Ferreira JA, Pingel JE, Conrad BP, Wronski TJ, Williams AA, Borst SE, Brown M.
A rehabilitation exercise program induces severe bone mineral deficits in estrogen-deficient rats after extended disuse.
Menopause. 2012 Jun 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22713863

4 Bederman I, Chandramouli V, Sandlers Y, Henderson L, Cabrera ME.
Time-course of hepatic gluconeogenesis during hindlimb suspension unloading.
Exp Physiol. 2012 Jun 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22707505
(PI: M.E. Cabrera)

5 Ramanathan R, James JT, McCoy T.
Acceptable levels for ingestion of dimethylsilanediol in water on the International Space Station.
Aviat Space Environ Med. 2012 Jun;83(6):598-603.
http://www.ncbi.nlm.nih.gov/pubmed/22764615
NOTE: ISS results.

6 Little MP, Azizova TV, Bazyka D, Bouffler SD, Cardis E, Chekin S, Chumak VV, Cucinotta FA, de Vathaire F, Hall P, Harrison JD, Hildebrandt G, Ivanov V, Kashcheev VV, Klymenko SV, Kreuzer M, Laurent O, Ozasa K, Schneider T, Tapio S, Taylor AM, Tzoulaki I, Vandoolaeghe WL, Wakeford R, Zablotska LB, Zhang W, Lipshultz SE.
Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.
Environ Health Perspect. 2012 Jun 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22728254
(PI: F.A. Cucinotta)
NOTE: This article may be obtained online without charge.

7 Sridharan DM, Whalen MK, Almendrala D, Cucinotta FA, Kawahara M, Yannone SM, Pluth JM.
Increased Artemis levels confer radioresistance to both high and low LET radiation exposures.
Radiat Oncol. 2012 Jun 19;7:96. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22713703
(PIs: J.M. Pluth, F.A. Cucinotta)
NOTE: This article may be obtained online without charge.

8 Ponomarev AL, George K, Cucinotta FA.
Computational model of chromosome aberration yield induced by high- and low-LET radiation exposures.
Radiat Res. 2012 Jun;177(6):727-37. Epub 2012 Apr 10.
http://www.ncbi.nlm.nih.gov/pubmed/22490019
(PI: F.A. Cucinotta)
NOTE: Editor's note accompanying paper: "Congratulations to Dr. Francis A. Cucinotta, this is his 50th publication in Radiation Research."

9 Adamczyk AM, Norman RB, Sriprisan SI, Townsend LW, Norbury JW, Blattnig SR, Slaba TC.
NUCFRG3: Light ion improvements to the nuclear fragmentation model.
Nucl Instrum Methods Phys Res A. 2012 Jun 21;678:21-32.
http://dx.doi.org//10.1016/j.nima.2012.02.021
(PIs: J.W. Norbury, L.W. Townsend)

10 Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X.
Cancer therapy targeting the HER2-PI3K pathway: Potential impact on the heart.
Front Pharmacol. 2012;3:113. Epub 2012 Jun 27.
http://www.ncbi.nlm.nih.gov/pubmed/22754526
(PI: D. Goukassian)
NOTE: This article may be obtained online without charge.

11 Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE.
Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep.
Neurobiol Aging. 2012 Jun 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22727943
(PI: E.B. Klerman)

12 Goel N, Dinges DF.
Predicting risk in space: Genetic markers for differential vulnerability to sleep restriction.
Acta Astronaut. 2012 Aug-Sep;77:207-13.
(PI: D.F. Dinges)
http://dx.doi.org/10.1016/j.actaastro.2012.04.002

13 La Duc MT, Vaishampayan P, Nilsson HR, Torok T, Venkateswaran K.
Pyrosequencing-derived bacterial, archaeal, and fungal diversity of spacecraft hardware destined for Mars.
Appl Environ Microbiol. 2012 Jun 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22729532

14 Stroble ST, Kounaves SP.
An electrochemically-based total organic carbon analyzer for planetary and terrestrial on-site applications.
Anal Chem. 2012 Jun 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22725848

Other papers of interest:

1 Fraser KS, Greaves DK, Shoemaker JK, Blaber AP, Hughson RL.
Heart rate and daily physical activity with long-duration habitation of the International Space Station.
Aviat Space Environ Med. 2012 Jun;83(6):577-84.
http://www.ncbi.nlm.nih.gov/pubmed/22764612
NOTE: ISS results.

2 Rai B, Kaur J, Foing BH.
Stress, workload and physiology demand during extravehicular activity: A pilot study.
N Am J Med Sci. 2012 Jun;4(6):266-9.
http://www.ncbi.nlm.nih.gov/pubmed/22754877
NOTE: Mars Desert Research Station study. This article may be obtained online without charge via PubMed Central or at the publisher's site: http://www.najms.org/temp/NorthAmJMedSci46266-4446047_122100.pdf

3 Drudi L, Ball CG, Kirkpatrick AW, Saary J, Grenon SM.
Surgery in space: Where are we at now?
Acta Astronaut. 2012 Oct-Nov;79:61-6.
http://dx.doi.org/10.1016/j.actaastro.2012.04.014

4 Ma B, Darquenne C.
Aerosol bolus dispersion in acinar airways - Influence of gravity and airway asymmetry.
J Appl Physiol. 2012 Jun 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22678957

5 Wang J, Liu C, Li T, Wang Y, Wang D.
Proteomic analysis of pulmonary tissue in tail-suspended rats under simulated weightlessness.
J Proteomics. 2012 Jun 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22721986

6 Ratovoson D, Jourdan F, Huon V.
Influence of gravity on the skin thermal behavior: Experimental study using dynamic infrared thermography.
Skin Res Technol. 2012 Jun 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22724900

7 Jimenez C, Fortrat JO, Delapierre B, Melin B.
Moderate exercise effects on orthostatic intolerance while wearing protective clothing.
Aviat Space Environ Med. 2012 Jun;83(6):570-6.
http://www.ncbi.nlm.nih.gov/pubmed/22764611

8 Convertino VA.
Blood pressure measurement for accurate assessment of patient status in emergency medical settings.
Aviat Space Environ Med. 2012 Jun;83(6):614-9.
http://www.ncbi.nlm.nih.gov/pubmed/22764618

9 Morgagni F, Autore A, Landolfi A, Ciniglio Appiani M, Ciniglio Appiani G.
Predictors of ear barotrauma in aircrews exposed to simulated high altitude.
Aviat Space Environ Med. 2012 Jun;83(6):594-7.
http://www.ncbi.nlm.nih.gov/pubmed/22764614

10 Williams CT, Barnes BM, Richter M, Buck CL.
Hibernation and circadian rhythms of body temperature in free-living arctic ground squirrels.
Physiol Biochem Zool. 2012 Jul-Aug;85(4):397-404. Epub 2012 Jun 8.
http://www.ncbi.nlm.nih.gov/pubmed/22705489

11 Pietsch J, Sickmann A, Weber G, Bauer J, Egli M, Wildgruber R, Infanger M, Grimm D.
Metabolic enzyme diversity in different human thyroid cell lines and their sensitivity to gravitational forces.
Proteomics. 2012 Jun 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22707460
NOTE: Used Random Positioning Machine.

12 Lang SM, Kazi AA, Hong-Brown L, Lang CH.
Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice.
PLoS One. 2012;7(6):e38910. Epub 2012 Jun 22.
http://www.ncbi.nlm.nih.gov/pubmed/22745686
NOTE: This article may be obtained online without charge.

13 Lomonosova YN, Shenkman BS, Nemirovskaya TL.
Attenuation of unloading-induced rat soleus atrophy with the heat-shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin.
FASEB J. 2012 Jul 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22751006

14 Li L, Liu HJ, Yang MH, Li JL, Wang L, Chen XP, Fan M.
[The relationship between contractile characteristics and fiber type conversion in hind-limb unloading mice soleus]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):97-101. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/22737903
NOTE: Translated journal title is Chinese Journal of Applied Physiology.

15 Deschenes MR, Sherman EG, Glass EK.
The effects of pre-habilitative conditioning on unloading-induced adaptations in young and aged neuromuscular systems.
Exp Gerontol. 2012 Jun 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22750484

16 Yamada E, Bastie CC, Koga H, Wang Y, Cuervo AM, Pessin JE.
Mouse skeletal muscle fiber-type specific macroautophagy and muscle wasting is regulated by a Fyn/STAT3/Vps34 signaling pathway.
Cell Rep. 2012 May 31;1(5):557-69. Epub 2012 May 3.
http://www.ncbi.nlm.nih.gov/pubmed/22745922
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher's site: http://dx.doi.org/10.1016/j.celrep.2012.03.014

17 Kaeaeriaeinen M, Kauhanen S.
Skeletal muscle injury and repair: The effect of disuse and denervation on muscle and clinical relevance in pedicled and free muscle flaps.
J Reconstr Microsurg. 2012 Jun 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22711205

18 Jash S, Adhya S.
Induction of muscle regeneration by RNA-mediated mitochondrial restoration.
FASEB J. 2012 Jul 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22751011

19 Osawa Y, Oguma Y.
Effects of combining whole-body vibration with exercise on the consequences of detraining on muscle performance in untrained adults.
J Strength Cond Res. 2012 Jun 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22739330

20 Ceccarelli G, Benedetti L, Galli D, Pre D, Silvani G, Crosetto N, Magenes G, Cusella De Angelis MG.
Low-amplitude high frequency vibration down-regulates myostatin and atrogin-1 expression, two components of the atrophy pathway in muscle cells.
J Tissue Eng Regen Med. 2012 Jun 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22711460

21 Langlet C, Bastide B, Canu MH.
Hindlimb unloading affects cortical motor maps and decreases corticospinal excitability.
Exp Neurol. 2012 Jun 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22750326

22 Zobel BB, Del Vescovo R, Oliva G, Russo V, Setola R.
Assessing bone loss in micro-gravity: A fuzzy approach.
Comput Methods Programs Biomed. 2012 Jun 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22727257

23 Lloyd SA, Lewis GS, Zhang Y, Paul EM, Donahue HJ.
Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.
J Bone Miner Res. 2012 Jun 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22714552

24 Ma Y, Wang H.
PI3K/Akt/FoxO: A novel participant in signal transduction in bone cells under mechanical stimulation.
Cell Biol Int. 2012 Jun 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22716317
NOTE: This article may be obtained online without charge.

25 Hoey DA, Chen JC, Jacobs CR.
The primary cilium as a novel extracellular sensor in bone.
Front Endocrinol (Lausanne). 2012;3:75. Epub 2012 Jun 13.
http://www.ncbi.nlm.nih.gov/pubmed/22707948
NOTE: This article may be obtained online without charge.

26 Klammer H, Iliakis G.
The impact of serotonin on the development of bystander damage assessed by -H2AX foci analysis.
Int J Radiat Biol. 2012 Jul 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22747498

27 Lyng FM, Desplanques M, Kumar Jella K, Garcia A, McClean B.
The importance of serum serotonin levels in the measurement of radiation-induced bystander cell death in HaCaT cells.
Int J Radiat Biol. 2012 Jun 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22724434

28 Mamlouk O, Balagurumoorthy P, Wang K, Adelstein SJ, Kassis AI.
Bystander effect in tumor cells produced by iodine-125 labeled human lymphocytes.
Int J Radiat Biol. 2012 Jul 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22712702

29 Mariotti L, Bertolotti A, Ranza E, Babini G, Ottolenghi A.
Investigation of the mechanisms underpinning IL-6 cytokine release in bystander responses: The roles of radiation dose, radiation quality and specific ROS/RNS scavengers.
Int J Radiat Biol. 2012 Jun 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22709338

30 Young EF, Smilenov LB, Lieberman HB, Hall EJ.
Combined haploinsufficiency and genetic control of the G(2)/M checkpoint in irradiated cells.
Radiat Res. 2012 Jun;177(6):743-50. Epub 2012 May 18.
http://www.ncbi.nlm.nih.gov/pubmed/22607586

31 Park Y, Noh HA, Cho H.
Effect of low-energy electron irradiation on DNA damage by Fe(3+) ion.
Radiat Res. 2012 Jun;177(6):775-80. Epub 2012 Apr 4.
http://www.ncbi.nlm.nih.gov/pubmed/22475012

32 Singh VK, Christensen J, Fatanmi OO, Gille D, Ducey EJ, Wise SY, Karsunky H, Sedello AK.
Myeloid progenitors: A radiation countermeasure that is effective when initiated days after irradiation.
Radiat Res. 2012 Jun;177(6):781-91. Epub 2012 May 4.
http://www.ncbi.nlm.nih.gov/pubmed/22559205

33 Pearce LL, Zheng X, Martinez-Bosch S, Kerr PP, Khlangwiset P, Epperly MW, Fink MP, Greenberger JS, Peterson J.
l-Arginine is a radioprotector for hematopoietic progenitor cells.
Radiat Res. 2012 Jun;177(6):792-803. Epub 2011 Dec 16.
http://www.ncbi.nlm.nih.gov/pubmed/22175298

34 Cevette MJ, Stepanek J, Cocco D, Galea AM, Pradhan GN, Wagner LS, Oakley SR, Smith BE, Zapala DA, Brookler KH.
Oculo-vestibular recoupling using galvanic vestibular stimulation to mitigate simulator sickness.
Aviat Space Environ Med. 2012 Jun;83(6):549-55.
http://www.ncbi.nlm.nih.gov/pubmed/22764608

35 Bianco IH, Ma LH, Schoppik D, Robson DN, Orger MB, Beck JC, Li JM, Schier AF, Engert F, Baker R.
The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex.
Curr Biol. 2012 Jun 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22704987

36 Li C, Han L, Ma CW, Lai SK, Lai CH, Shum DK, Chan YS.
Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors in rats: Role in coding linear accelerations.
Brain Struct Funct. 2012 Jun 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22706760
NOTE: This article may be obtained online without charge.

37 Fortenberry B, Gorchetchnikov A, Grossberg S.
Learned integration of visual, vestibular, and motor cues in multiple brain regions computes head direction during visually guided navigation.
Hippocampus. 2012 Jun 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22707350

38 Bertolini G, Ramat S, Bockisch CJ, Marti S, Straumann D, Palla A.
Is vestibular self-motion perception controlled by the velocity storage? Insights from patients with chronic degeneration of the vestibulo-cerebellum.
PLoS One. 2012;7(6):e36763. Epub 2012 Jun 15.
http://www.ncbi.nlm.nih.gov/pubmed/22719833
NOTE: This article may be obtained online without charge.

39 Falconer CJ, Mast FW.
Balancing the mind.
Exp Psychol. 2012 Jun 28:1-8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22750744

40 Stochl J, Croudace T.
Predictors of human rotation.
Laterality. 2012 Jun 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22708777

41 Machado ML, Kroichvili N, Freret T, Philoxene B, Lelong-Boulouard V, Denise P, Besnard S.
Spatial and non-spatial performance in mutant mice devoid of otoliths.
Neurosci Lett. 2012 Jul 26;522(1):57-61.
http://www.ncbi.nlm.nih.gov/pubmed/22705908

42 Suedfeld P, Brcic J, Johnson PJ, Gushin V.
Personal growth following long-duration spaceflight.
Acta Astronaut. 2012 Oct-Nov;79:118-23.
http://dx.doi.org/10.1016/j.actaastro.2012.04.039
NOTE: Mir, ISS results.

43 Nakano H, Hosokawa A, Tagawa R, Inaka K, Ohta K, Nakatsu T, Kato H, Watanabe K.
Crystallization and preliminary X-ray crystallographic analysis of Pz peptidase B from Geobacillus collagenovorans MO-1.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):757-9. Epub 2012 Jun 27.
http://www.ncbi.nlm.nih.gov/pubmed/22750857
NOTE: ISS results.

44 Samuelson L, Gerber DA.
Improved function and growth of pancreatic cells in a three dimensional bioreactor environment.
Tissue Eng Part C Methods. 2012 Jun 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22712746

45 Wang Y, Zhang Y, Zhang S, Peng G, Liu T, Li Y, Xiang D, Wassler MJ, Shelat HS, Geng Y.
Rotating microgravity-bioreactor cultivation enhances the hepatic differentiation of mouse embryonic stem cells on biodegradable polymer scaffolds.
Tissue Eng Part A. 2012 Jun 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22712633

46 Mathieu PS, Loboa E.
Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways.
Tissue Eng Part B Rev. 2012 Jun 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22741572

47 Kuipers AJ, Middelbeek J, van Leeuwen FN.
Mechanoregulation of cytoskeletal dynamics by TRP channels.
Eur J Cell Biol. 2012 Jun 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22727433

48 Tabdili H, Langer M, Shi Q, Poh YC, Wang N, Leckband D.
Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.
J Cell Sci. 2012 Jun 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22718345

49 Murtazin R, Petrov N.
Short profile for the human spacecraft Soyuz-TMA rendezvous mission to the ISS.
Acta Astronaut. 2012 Aug-Sep;77:77-82.
http://dx.doi.org/10.1016/j.actaastro.2012.03.019
NOTE: This paper discusses a way to shorten rendezvous missions of Soyuz to ISS.

50 Winter FH, Neufeld MJ, Dougherty K.
Was the rocket invented or accidentally discovered? Some new observations on its origins.
Acta Astronaut. 2012 Aug-Sep;77:131-7.
http://dx.doi.org/10.1016/j.actaastro.2012.03.014

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

SpaceRef Newsletter