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NASA Spaceline Current Awareness 18 March 2011 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 18, 2011

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Papers deriving from NASA support:

1
Arai T, Lee K, Stenger MB, Platts SH, Meck JV, Cohen RJ.
Preliminary application of a novel algorithm to monitor changes in pre-flight total peripheral resistance for prediction of post-flight orthostatic intolerance in astronauts.
Acta Astronaut. 2011 Apr-May;68(7-8):770-7.
http://dx.doi.org/10.1016/j.actaastro.2010.10.008
NOTE: Space flight results.

2
Gast MA, Moore SK.
A glimpse from the inside of a space suit: What is it really like to train for an EVA?
Acta Astronaut. 2011 Jan-Feb;68(1-2):316-25.
http://dx.doi.org/10.1016/j.actaastro.2010.08.015
NOTE: The html version of this article may be obtained online without charge if the publisher's abstract is accessed via the Table of Contents (go to the Table of Contents from the publisher's abstract by clicking on the volume and issue, find the article and click on the title link to return to the publisher's abstract, and scroll down to the text).

3
Kim MH, De Angelis G, Cucinotta FA.
Probabilistic assessment of radiation risk for astronauts in space missions.
Acta Astronaut. 2011 Apr-May;68(7-8):747-59.
http://dx.doi.org/10.1016/j.actaastro.2010.08.035
(PI: F.A. Cucinotta)

4
Singleterry RC Jr., Blattnig SR, Clowdsley MS, Qualls GD, Sandridge CA, Simonsen LC, Slaba TC, Walker SA, Badavi FF, Spangler JL, Aumann AR, Zapp EN, Rutledge RD, Lee KT, Norman RB, Norbury JW.
OLTARIS: On-line tool for the assessment of radiation in space.
Acta Astronaut. 2011 Apr-May;68(7-8):1086-97.
http://dx.doi.org/10.1016/j.actaastro.2010.09.022

5
Autsavapromporn N, de Toledo SM, Little JB, Jay-Gerin JP, Harris AL, Azzam EI.
The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose alpha-particle-irradiated human cells.
Radiat Res. 2011 Mar;175(3):347-57. Epub 2011 Jan 10.
http://www.ncbi.nlm.nih.gov/pubmed/21388278
(PI: E.I. Azzam)

6
Allen C, Borak TB, Tsujii H, Nickoloff JA.
Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.
Mutat Res. 2011 Mar 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21376738
(PI: T.B. Borak)

7
Kanas N.
From Earth's orbit to the outer planets and beyond: Psychological issues in space.
Acta Astronaut. 2011 Mar-Apr;68(5-6):576-81.
http://dx.doi.org/10.1016/j.actaastro.2010.04.012
(PI: N. Kanas)

Other papers of interest:

1
Morukov B, Rykova M, Antropova E, Berendeeva T, Ponomaryov S, Larina I.
T-cell immunity and cytokine production in cosmonauts after long-duration space flights.
Acta Astronaut. 2011 Apr-May;68(7-8):739-46.
http://dx.doi.org/10.1016/j.actaastro.2010.08.036
NOTE: ISS results.

2
Ivanova K, Eiermann P, Tsiockas W, Hauslage J, Hemmersbach R, Gerzer R.
Natriuretic peptide-sensitive guanylyl cyclase expression is down-regulated in human melanoma cells at simulated weightlessness.
Acta Astronaut. 2011 Apr-May;68(7-8):652-5.
http://dx.doi.org/10.1016/j.actaastro.2010.08.002
NOTE: Fast rotating clinostat was used to simulate weightlessness.

3
Waldie JM, Newman DJ.
A gravity loading countermeasure skinsuit.
Acta Astronaut. 2011 Apr-May;68(7-8):722-30.
http://dx.doi.org/10.1016/j.actaastro.2010.07.022
NOTE: Parabolic flight results.

4
Groemer GE, Storrie-Lombardi M, Sattler B, Hauser O, Bickert K, Hauth E, Hauth S, Luger U, Schildhammer D, Foeger D, Klauck J.
Reducing biological contamination by a space suited astronaut: Laboratory and field test results from Aouda.X.
Acta Astronaut. 2011 Jan-Feb;68(1-2):218-25.
http://dx.doi.org/10.1016/j.actaastro.2010.08.018
NOTE: The html version of this article may be obtained online without charge if the publisher's abstract is accessed via the Table of Contents.

5
Tsuchida A, Imagawa K, Yokoyama T, Sakai J, Matsuura M, Toukaku Y, Nakai M, Ito T, Nishikawa T, Hirai M, Kaneko Y, Yamaguchi J.
KIBO (Japanese Experiment Module in ISS) operations--2008/3-2009/10.
Acta Astronaut. 2011 Apr-May;68(7-8):1318-24.
http://dx.doi.org/10.1016/j.actaastro.2010.09.026

6
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schondorff R, Stewart JM, van Dijk JG.
Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome.
Auton Neurosci. 2011 Mar 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21393070

7
Raj SR.
Highlights in clinical autonomic neurosciences: Orthostatic hypotension is bad for you.
Auton Neurosci. 2011 Mar 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21388894
NOTE: This article is a summary of four recent papers. From the author's commentary: "These reports, from two large long-term population-based studies, when taken together, emphasize the point that orthostatic hypotension (OH) is associated with significant morbidity and mortality."

8
Kaasik P, Riso EM, Seene T.
Extracellular matrix and myofibrils during unloading and reloading of skeletal muscle.
Int J Sports Med. 2011 Mar 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21380971
NOTE: Hindlimb suspension of rats was used.

9
Senf SM, Sandesara PB, Reed SA, Judge AR.
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle.
Am J Physiol Cell Physiol. 2011 Mar 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21389279
NOTE: The disuse technique that was used was cast immobilization.

10
Neerup TS, Stahlhut M, Petersen JS, Daugaard JR, Jensen JE, Peng Z, Morko J, Thorkildsen C.
ZP2307, a novel, cyclic PTH(1-17) analog that augments bone mass in ovariectomized rats.
Bone. 2011 Mar 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21376152

11
Matsukawa N, Matsumoto M, Bukawa W, Chiji H, Nakayama K, Hara H, Tsukahara T.
Improvement of bone strength and dermal thickness due to dietary edible bird's nest extract in ovariectomized rats.
Biosci Biotechnol Biochem. 2011 Mar 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21389609
NOTE: This article may be obtained online without charge.

12
Liu J, Dyer RM, Neerchal NK, Tasch U, Rajkondawar PG.
Diversity in the magnitude of hind limb unloading occurs with similar forms of lameness in dairy cows.
J Dairy Res. 2011 Mar 9:1-10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21385514
NOTE: A weighty approach to hindlimb unloading?

13
Turner HC, Brenner DJ, Chen Y, Bertucci A, Zhang J, Wang H, Lyulko OV, Xu Y, Shuryak I, Schaefer J, Simaan N, Randers-Pehrson G, Yao YL, Amundson SA, Garty G.
Adapting the gamma-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects.
Radiat Res. 2011 Mar;175(3):282-90. Epub 2010 Dec 28.
http://www.ncbi.nlm.nih.gov/pubmed/21388271

14
Sugihara T, Murano H, Nakamura M, Ichinohe K, Tanaka K.
p53-Mediated gene activation in mice at high doses of chronic low-dose-rate gamma radiation.
Radiat Res. 2011 Mar;175(3):328-35. Epub 2010 Dec 28.
http://www.ncbi.nlm.nih.gov/pubmed/21388276

15
Kim KS, Minor LB, Santina CC, Lasker DM.
Variation in response dynamics of regular and irregular vestibular-nerve afferents during sinusoidal head rotations and currents in the chinchilla.
Exp Brain Res. 2011 Mar 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21369854

16
Tanimoto M, Ota Y, Inoue M, Oda Y.
Origin of inner ear hair cells: Morphological and functional differentiation from ciliary cells into hair cells in zebrafish inner ear.
J Neurosci. 2011 Mar 9;31(10):3784-94.
http://www.ncbi.nlm.nih.gov/pubmed/21389233

17
Kage A, Asato E, Chiba Y, Wada Y, Katsu-Kimura Y, Kubota A, Sawai S, Niihori M, Baba SA, Mogami Y.
Gravity-dependent changes in bioconvection of Tetrahymena and Chlamydomonas during parabolic flight: Increases in wave number induced by pre- and post-parabola hypergravity.
Zoolog Sci. 2011 Mar;28(3):206-14.
http://www.ncbi.nlm.nih.gov/pubmed/21385062
NOTE: Parabolic flight results.

18
Lindsey BW, Dumbarton TC, Moorman SJ, Smith FM, Croll RP.
Effects of simulated microgravity on the development of the swimbladder and buoyancy control in larval zebrafish (Danio rerio).
J Exp Zool A Ecol Genet Physiol. 2011 Mar 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21394929

19
Redden RA, Doolin EJ.
Microgravity assay of neuroblastoma: In vitro aggregation kinetics and organoid morphology correlate with MYCN expression.
In Vitro Cell Dev Biol Anim. 2011 Mar 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21384249

20
Ma X, Yang C, Zhuang F.
[Mircocarriers' motion in rotating wall vessels]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Dec;27(6):1433-8. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/21375011
NOTE: Translated journal title is Journal of Biomedical Engineering.

21
Gardel M, Schwarz U.
Cell-substrate interactions.
J Phys Condens Matter. 2010 May 19;22(19):190301. Epub 2010 Apr 23.
http://www.ncbi.nlm.nih.gov/pubmed/21386358
NOTE: This article is the preface to a special section on the topic of cell-substrate interactions. The preface may be obtained online without charge. Aspects of mechanosensing are discussed in some of the papers. Table of contents of the issue: http://iopscience.iop.org/0953-8984/22/19

22
Shivashankar GV.
Mechanosignaling to cell nucleus and gene regulation.
Annu Rev Biophys. 2011 Mar 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21391812

23
Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP.
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition.
Circ Res. 2011 Mar 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21393577

24
Zhang Z, Friedman H, Meir S, Belausov E, Philosoph-Hadas S.
Actomyosin mediates gravisensing and early transduction events in reoriented cut snapdragon spikes.
J Plant Physiol. 2011 Mar 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21388706

25
Haeuplik-Meusburger S, Peldszus R, Holzgethan V.
Greenhouse design integration benefits for extended spaceflight.
Acta Astronaut. 2011 Jan-Feb;68(1-2):85-90.
http://dx.doi.org/10.1016/j.actaastro.2010.07.008
NOTE: The html version of this article may be obtained online without charge if the publisher's abstract is accessed via the Table of Contents.

26
Buckley ND, Champagne CP, Masotti AI, Wagar LE, Tompkins TA, Green-Johnson JM.
Harnessing functional food strategies for the health challenges of space travel--Fermented soy for astronaut nutrition.
Acta Astronaut. 2011 Apr-May;68(7-8):731-8.
http://dx.doi.org/10.1016/j.actaastro.2010.08.023


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