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NASA Spaceline Current Awareness 16 March 2012 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 16, 2012

image

Papers deriving from NASA support:

1
Kramer LA, Sargsyan AE, Hasan KM, Polk JD, Hamilton DR.
Orbital and intracranial effects of microgravity: Findings at 3-T MR imaging.
Radiology. 2012 Mar 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22416248
NOTE: Shuttle and ISS results. Press release: http://www2.rsna.org/timssnet/media/pressreleases/pr_target.cfm?ID=596

2
Souza RB, Baum T, Wu S, Feeley BT, Kadel N, Li X, Link TM, Majumdar S.
Effects of unloading on knee articular cartilage T1rho and T2 MRI relaxation times.
J Orthop Sports Phys Ther. 2012 Mar 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22402583
(PI: R.B. Souza, NSBRI Postdoctoral Fellowship Program)
NOTE: This article may be obtained online without charge.

3
Haley GE, Villasana L, Dayger C, Davis MJ, Raber J.
Apolipoprotein E genotype-dependent paradoxical short-term effects of (56)Fe irradiation on the brain.
Int J Radiat Oncol Biol Phys. 2012 Mar 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22401921
(PIs: G.E. Haley, NSBRI Postdoctoral Fellowship Program; J. Raber; G. Nelson/J. Raber/NSCOR)

4
Suman S, Johnson MD, Fornace AJ Jr, Datta K.
Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland.
Int J Radiat Oncol Biol Phys. 2012 Feb 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22381906
(PI: A.J. Fornace Jr)

5
Chaudhry MA, Omaruddin RA, Kreger B, de Toledo SM, Azzam EI.
Micro RNA responses to chronic or acute exposures to low dose ionizing radiation.
Mol Biol Rep. 2012 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22367372
(PI: E.I. Azzam)

6
Luo-Owen X, Pecaut MJ, Rizvi A, Gridley DS.
Low-dose total-body irradiation modulates immune response to acute proton radiation.
Radiat Res. 2012 Mar;177(3):251-64. Epub 2011 Dec 7.
http://www.ncbi.nlm.nih.gov/pubmed/22149957

7
Hu S, Smirnova OA, Cucinotta FA.
A biomathematical model of lymphopoiesis following severe radiation accidents-potential use for dose assessment.
Health Phys. 2012 Apr;102(4):425-36.
http://www.ncbi.nlm.nih.gov/pubmed/22378204
(PI: F.A. Cucinotta)

8
Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA.
Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans.
PLoS One. 2012;7(2):e30037. Epub 2012 Feb 17.
http://www.ncbi.nlm.nih.gov/pubmed/22363414
(PI: C.A. Czeisler)
NOTE: This article may be obtained online without charge.

9
Mayfield JD, Paul AL, Ferl RJ.
The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system.
J Exp Bot. 2012 Feb 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22378945
(PI: R.J. Ferl)
NOTE: This article may be obtained online without charge.

10
Hopkins JA, Kiss JZ.
Phototropism and gravitropism in transgenic lines of Arabidopsis altered in the phytochrome pathway.
Physiol Plant. 2012 Mar 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22380624
(PI: J.Z. Kiss)

Other papers of interest:

1
Tavella S, Ruggiu A, Giuliani A, Brun F, Canciani B, Manescu A, Marozzi K, Cilli M, Costa D, Yi Liu Y, Piccardi F, Tasso R, Tromba G, Rustichelli F, Cancedda R.
Bone turnover in wild type and pleiotrophin-transgenic mice housed for three months in the International Space Station (ISS).
PLoS One 2012;7(3):e33179. Epub 2012 Mar 15.
http://dx.doi.org/10.1371/journal.pone.0033179
NOTE: ISS results. This article may be obtained online without charge.

2
Rizzo AM, Corsetto PA, Montorfano G, Milani S, Zava S, Tavella S, Cancedda R, Berra B.
Effects of long-term space flight on erythrocytes and oxidative stress of rodents.
PLoS One. 2012;7(3):e32361. Epub 2012 Mar 7.
http://www.ncbi.nlm.nih.gov/pubmed/22412864
NOTE: ISS results. This article may be obtained online without charge.

3
Goswami N, Roessler A, Hinghofer-Szalkay H, Montani JP, Steptoe A.
Delaying orthostatic syncope with mental challenge: A pilot study.
Physiol Behav. 2012 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22387271

4
Yang H, Cooke WH, Reed KS, Carter JR.
Sex differences in hemodynamic and sympathetic neural firing patterns during orthostatic challenge in humans.
J Appl Physiol. 2012 Mar 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22403351

5
Uhm JS, Youn HJ, Chung WB, Choi YS, Park CS, Oh YS, Chung WS, Park KI, Kim TS.
Positive result in the early passive phase of the tilt-table test: A predictor of neurocardiogenic syncope in young men.
Korean J Intern Med. 2012 Mar;27(1):60-5. Epub 2012 Feb 28.
http://www.ncbi.nlm.nih.gov/pubmed/22403501
NOTE: This article may be obtained online without charge.

6
Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK.
Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Nature. 2012 Mar 1;483(7387):96-9.
http://www.ncbi.nlm.nih.gov/pubmed/22367544

7
Edgell H, Robertson AD, Hughson RL.
Hemodynamics and brain blood flow during posture change in younger women and post-menopausal women compared to age-matched men.
J Appl Physiol. 2012 Feb 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22362404

8
Pleil JD, Hansel A.
Submarines, spacecraft and exhaled breath.
J Breath Res. 2012 Mar;6(1):019001. Epub 2012 Feb 27.
http://www.ncbi.nlm.nih.gov/pubmed/22366644
NOTE: This is a report of a meeting of the submarine air monitoring and air purification community. This article may be obtained online without charge. This issue of the journal also contains articles deriving from the 9th International Conference on Breath Odor Research.

9
Law J, Macbeth PB.
Ultrasound: From Earth to space.
Mcgill J Med. 2011 Jun;13(2):59-65.
http://www.ncbi.nlm.nih.gov/pubmed/22399873
NOTE: This is one of a series of articles in a focus section on Aerospace Medicine in this issue. The articles are:
Clement J. The Canadian Space Agency Space Learning Grants.
Stewart GE, Drudi L. Medical education for Exploration Class Missions: NASA Aerospace Medicine Elective at the Kennedy Space Centre.
Law J, Macbeth PB. Ultrasound: From Earth to space.
Saint-Jacques D. Medical care in the Arctic and on orbit.
Thirsk R. Physicians as astronauts.
Williams D, Turnock M. Human space exploration - The next fifty years.
Woodson J, Dalitsch WM III, Persson JL, McGhee J, Ciccone C, Parsa B. Exploring the possibility for a common system for joint aeromedical standards.
The entire issue may be obtained online without charge: http://www.med.mcgill.ca/mjm/mjm1302.pdf

10
Meigal AY.
Ontogenetic model of gravitation and weightlessness: Theoretical and applied aspects.
Hum Physiol. 2011 Nov;37(6):755-62.
http://dx.doi.org/10.1134/S0362119711060119
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2011 Nov-Dec;37(6):130-8: http://www.ncbi.nlm.nih.gov/pubmed/22332438

11
Kumar A, Bhatnagar S, Paul PK.
TWEAK and TRAF6 regulate skeletal muscle atrophy.
Curr Opin Clin Nutr Metab Care. 2012 Feb 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22366923

12
Kohno S, Yamashita Y, Abe T, Hirasaka K, Oarada M, Ohno A, Teshima-Kondo S, Higashibata A, Choi I, Mills EM, Okumura Y, Terao J, Nikawa T.
Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages.
J Appl Physiol. 2012 Mar 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22383511

13
Lomonosova YN, Kalamkarov GR, Bugrova AE, Shevchenko TF, Kartashkina NL, Lysenko EA, Shenkman BS, Nemirovskaya TL.
Role of NO-synthase in regulation of protein metabolism of stretched rat m. soleus muscle during functional unloading.
Biochemistry (Mosc). 2012 Feb;77(2):208-16.
http://www.ncbi.nlm.nih.gov/pubmed/22348482
NOTE: This is a translation in English of the Russian original published in Biokhimiya 2012;77(2):256-66.

14
Powers SK, Wiggs MP, Duarte J, Zergeroglu AM, Demirel HA.
Mitochondrial signaling contributes to disuse muscle atrophy.
Am J Physiol Endocrinol Metab. 2012 Mar 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22395111

15
Miyabara EH, Nascimento TL, Rodrigues DC, Moriscot AS, Davila WF, AitMou Y, DeTombe PP, Mestril R.
Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy.
Pflugers Arch. 2012 Mar 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22391802

16
Li Z, Tan C, Wu Y, Ding Y, Wang H, Chen W, Zhu Y, Ma H, Yang H, Liang W, Jiang S, Wang D, Wang L, Tang G, Wang J.
Whole-body vibration and resistance exercise prevent long-term hindlimb unloading-induced bone loss: Independent and interactive effects.
Eur J Appl Physiol. 2012 Feb 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22371114

17
Bu G, Shuang F, Wu Y, Ren D, Hou S.
AQP9: A novel target for bone loss induced by microgravity.
Biochem Biophys Res Commun. 2012 Feb 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22390930
NOTE: Simulated microgravity.

18
Novotny SA, Warren GL, Lin AS, Guldberg RE, Baltgalvis KA, Lowe DA.
Prednisolone treatment and restricted physical activity further compromise bone of mdx mice.
J Musculoskelet Neuronal Interact. 2012 Mar;12(1):16-23.
http://www.ncbi.nlm.nih.gov/pubmed/22373947
NOTE: This article may be obtained online without charge.

19
Macione J, Nesbitt S, Pandit V, Kotha S.
Design and analysis of a novel mechanical loading machine for dynamic in vivo axial loading.
Rev Sci Instrum. 2012 Feb;83(2):025113.
http://www.ncbi.nlm.nih.gov/pubmed/22380131

20
Knapp KM, Welsman JR, Hopkins SJ, Fogelman I, Blake GM.
Obesity increases precision errors in dual-energy X-ray absorptiometry measurements.
J Clin Densitom. 2012 Mar 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22402120

21
Gomez-Cabello A, Ara I, Gonzalez-Agueero A, Casajus JA, Vicente-Rodriguez G.
Effects of training on bone mass in older adults: A systematic review.
Sports Med. 2012 Apr 1;42(4):301-25.
http://www.ncbi.nlm.nih.gov/pubmed/22376192

22
Sinha S, Shin DD, Hodgson JA, Kinugasa R, Edgerton VR.
Computer-controlled, MR-compatible foot-pedal device to study dynamics of the muscle tendon complex under isometric, concentric, and eccentric contractions.
J Magn Reson Imaging. 2012 Mar 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22392816

23
Rastogi S, Coates PJ, Lorimore SA, Wright EG.
Bystander-type effects mediated by long-lived inflammatory signaling in irradiated bone marrow.
Radiat Res. 2012 Mar;177(3):244-50. Epub 2011 Dec 9.
http://www.ncbi.nlm.nih.gov/pubmed/22149991

24
Zeeb H, Hammer GP, Blettner M.
Epidemiological investigations of aircrew: An occupational group with low-level cosmic radiation exposure.
J Radiol Prot. 2012 Mar;32(1):N15-9. Epub 2012 Mar 6.
http://www.ncbi.nlm.nih.gov/pubmed/22395103
NOTE: This article may be obtained online without charge.

25
Ackermann M, van den Bogert AJ.
Predictive simulation of gait at low gravity reveals skipping as the preferred locomotion strategy.
J Biomech. 2012 Feb 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22365845

26
Yakushin SB.
Tuning of gravity-dependent and gravity-independent vertical angular VOR gain changes by frequency of adaptation.
J Neurophysiol. 2012 Mar 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22402654

27
Ustinova K, Perkins J.
Gaze and viewing angle influence visual stabilization of upright posture.
Brain Behav. 2011 Sep;1(1):19-25.
http://www.ncbi.nlm.nih.gov/pubmed/22398978
NOTE: This article may be obtained online without charge.

28
Jackson DN, Bedell HE.
Vertical heterophoria and susceptibility to visually induced motion sickness.
Strabismus. 2012 Mar;20(1):17-23.
http://www.ncbi.nlm.nih.gov/pubmed/22390327

29
Roditi RE, Crane BT.
Directional asymmetries and age effects in human self-motion perception.
J Assoc Res Otolaryngol. 2012 Mar 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22402987

30
Duncan JS, Fritzsch B.
Transforming the vestibular system one molecule at a time: The molecular and developmental basis of vertebrate auditory evolution.
Adv Exp Med Biol. 2012;739:173-86.
http://www.ncbi.nlm.nih.gov/pubmed/22399402
NOTE: This is a chapter in a volume entitled "Sensing in Nature."

31
Xu H, Wu J, Weng Y, Zhang J, Shang P.
Two-dimensional clinorotation influences cellular morphology, cytoskeleton and secretion of MLO-Y4 osteocyte-like cells.
Biologia. 2012 Feb;67(1): 255-62.
http://dx.doi.org/10.2478/s11756-011-0161-8

32
Zhang BY, Wei XL, Yang FY, Zhang YW.
Effects of space flight factors on genetic diversity of Buchloe dactyloides seeds.
Afr J Biotechnol. 2011 Oct 5;10(60):12812-20.
http://www.academicjournals.org/AJB/abstracts/abs2011/5Oct/Bao-Yi%20et%2...
NOTE: Results from seeds flown on a Chinese satellite. This article may be obtained online without charge.

33
Le Bourg E.
Combined effects of two mild stresses (cold and hypergravity) on longevity, behavioral aging, and resistance to severe stresses in Drosophila melanogaster.
Biogerontology. 2012 Mar 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22391643

34
Hao T, Wang YM, Li JJ, DU ZY, Duan CM, Wang CY, Song JP, Wang LJ, Li YH, Wang Y.
[Effect of lentinan against immunosuppression of lymphocytes cultured in simulated microgravity environment]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jan;20(1):182-6. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/22391193
NOTE: Translated title of journal is Journal of Experimental Hematology.

35
Luo MZ, Li SS, Gao X, Lu Y, Yang ZQ, Zhang W, Shang P.
[Effects of high magneto-gravitational environment on calcium/calmodulin signal of MG63 osteoblast-like cells]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Mar;28(3):225-7. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/22394626
NOTE: Translated title of journal is Chinese Journal of Cellular and Molecular Immunology.

36
Marshall KL, Lumpkin EA.
The molecular basis of mechanosensory transduction.
Adv Exp Med Biol. 2012;739:142-55.
http://www.ncbi.nlm.nih.gov/pubmed/22399400
NOTE: This is a chapter in a volume entitled "Sensing in Nature."

37
Kee YS, Ren Y, Dorfman D, Iijima M, Firtel R, Iglesias PA, Robinson DN.
A mechanosensory system governs myosin II accumulation in dividing cells.
Mol Biol Cell. 2012 Feb 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22379107
NOTE: This article may be obtained online without charge.

38
Band LR, Wells DM, Larrieu A, Sun J, Middleton AM, French AP, Brunoud G, Sato EM, Wilson MH, Peret B, Oliva M, Swarup R, Sairanen I, Parry G, Ljung K, Beeckman T, Garibaldi JM, Estelle M, Owen MR, Vissenberg K, Hodgman TC, Pridmore TP, King JR, Vernoux T, Bennett MJ.
Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism.
Proc Natl Acad Sci U S A. 2012 Mar 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22393022

39
Wan Y, Jasik J, Wang L, Hao H, Volkmann D, Menzel D, Mancuso S, Baluka F, Lin J.
The signal transducer NPH3 integrates the phototropin1 photosensor with PIN2-based polar auxin transport in Arabidopsis root phototropism.
Plant Cell. 2012 Feb 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22374399

40
Goldstein RE, Warren PB, Ball RC.
Shape of a ponytail and the statistical physics of hair fiber bundles.
Phys Rev Lett. 2012 Feb 17;108(7):078101. Epub 2012 Feb 13.
http://www.ncbi.nlm.nih.gov/pubmed/22401258


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