Papers deriving from NASA support:
Khan M, Steppan J, Schuleri K, Ryoo S, Tuday E, Bugaj L, Santhanam L, Berkowitz T, Nyhan D, Shoukas AA, Berkowitz DE.
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.
Eur J Appl Physiol. 2011 Dec 8. [Epub ahead of print]
(PIs: A.A. Shoukas, D.E. Berkowitz)
Macias BR, Swift JM, Nilsson MI, Hogan HA, Bouse SD, Bloomfield SA.
Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse.
J Appl Physiol. 2011 Dec 15. [Epub ahead of print]
(PIs: S.A. Bloomfield; B.R. Macias and J.M. Swift, NSBRI Graduate Training Fellowships)
Yang H, Magpayo N, Rusek A, Chiang IH, Sivertz M, Held KD.
Effects of very low fluences of high-energy protons or iron ions on irradiated and bystander cells.
Radiat Res. 2011 Dec;176(6):695-705. Epub 2011 Oct 12.
(PI: K.D. Held)
Poulose SM, Bielinski DF, Carrihill-Knoll K, Rabin BM, Shukitt-Hale B.
Exposure to (16)O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy.
Radiat Res. 2011 Dec;176(6):761-9. Epub 2011 Sep 30.
(PI: B.M. Rabin)
Slaba TC, Blattnig SR, Clowdsley MS.
Variation in lunar neutron dose estimates.
Radiat Res. 2011 Dec;176(6):827-41. Epub 2011 Aug 22.
(PIs: J. Norbury, C. Sandridge)
Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA.
Breaking the 'harmony' of TNF- signaling for cancer treatment.
Oncogene. 2011 Dec 12. [Epub ahead of print]
(PI: D.A. Goukassian)
NOTE: From abstract: "In summary, p75 is essential for tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts. Blocking p75 expression may lead to tumor regression. This may represent new and effective therapy against lung neoplasms and potentially tumors of other origin." This article may be obtained online without charge.
Rithidech KN, Lai X, Honikel L, Reungpatthanaphong P, Witzmann FA.
Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments.
Health Phys. 2012 Jan;102(1):39-53.
(PI: K.N. Rithidech)
NOTE: From conclusion: "The data reported here demonstrated that when using a proteomic approach with the LC-MS/MS system, the global expression profiles of secreted proteins strongly supported the induction of AR [adaptive response] by low dose radiation given to human lymphocytes (obtained from freshly drawn blood) before subsequent exposure to high dose radiation. The data also suggested that a specific subset of proteins (with defense mechanisms) was secreted by 0.03-Gy irradiated lymphocytes within 4 h and that such proteins altered cell response to injury induced by succeeding high dose irradiation. These data indicated that the majority of secreted proteins found in the medium from cultures without an adaptive response are those frequently associated with stress and inflammatory response."
Carra C, Saha J, Cucinotta FA.
Theoretical prediction of the binding free energy for mutants of replication protein A.
J Mol Model. 2011 Dec 10. [Epub ahead of print]
(PI: F.A. Cucinotta)
Chen BP, Li M, Asaithamby A.
New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.
Cancer Lett. 2011 Dec 9. [Epub ahead of print]
(PI: B.P. Chen)
Pisacane VL, Dolecek QE, Rosenfeld AB, Malak H.
Proton and iron ion observations from a solid-state microdosimeter.
Radiat Prot Dosimetry. 2011 Dec 7. [Epub ahead of print]
(PI: V.L. Pisacane)
A low earth orbit dynamic model for the proton anisotropy validation.
Nucl Instrum Methods Phys Res B. 2011 Nov 1;269(21):2614-22.
(PI: C. Sandridge)
NOTE: Used measurements from tri-service experiment-5 (TSX-5) satellite.
Perchonok MH, Cooper MR, Catauro PM.
Mission to Mars: Food production and processing for the Final Frontier.
Annu Rev Food Sci Technol. 2011 Mar 2. [Epub ahead of print]
(PIs: M.H. Perchonok, M.R. Cooper, P.M. Catauro)
Smartt AE, Xu T, Jegier P, Carswell JJ, Blount SA, Sayler GS, Ripp S.
Pathogen detection using engineered bacteriophages.
Anal Bioanal Chem. 2011 Nov 20. [Epub ahead of print]
(PI: G.S. Sayler)
Other papers of interest:
Arinell K, Christensen K, Blanc S, Larsson A, Frobert O.
Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk.
BMC Physiol. 2011 Dec 9;11:17. [Epub ahead of print]
NOTE: WISE-2005 bed rest study. This article may be obtained online without charge.
Lack of evidence for prescription of antepartum bed rest.
Expert Rev Obstet Gynecol. 2011 Jul 1;6(4):385-93.
NOTE: As the abstract mentions, this Perspective draws upon aerospace research using bed rest as a model for the argument against the routine prescription of bed rest before birth. The author suggests a number of reasons why such bed rest is still prescribed, including: "Research documents that most obstetric healthcare providers are unaware of the adverse effects of bed rest or they believe that effects are of minor consequence [refs]. Therefore, continued use appears to be due to a lack of knowledge or attention to research regarding effectiveness and the adverse side effects, or a discounting of the evidence [refs]. One possible reason could be because obstetric providers primarily read medical research while the majority of evidence regarding the side effects of bed rest in nonpregnant and pregnant individuals is produced by other related disciplines."
Goswami N, Batzel JJ, Loeppky JA, Hinghofer-Szalkay H.
Teaching fluid shifts during orthostasis using a classic paper by Foux et al.
Adv Physiol Educ. 2011 Dec;35(4):330-5.
NOTE: This article may be obtained online without charge.
Haerkens MH, Simons R, Kuipers A.
[Doctor, may I travel in space? Aeromedical considerations regarding commercial suborbital space flights]
Ned Tijdschr Geneeskd. 2011;155(48):A3904. Dutch.
NOTE: This article may be obtained online without charge: http://www.ntvg.nl/publicatie/Dokter-mag-ik-de-ruimte/volledig The article is in Dutch but this url can be pasted in Google and translated.
Ju YI, Sone T, Ohnaru K, Choi HJ, Fukunaga M.
Differential effects of jump versus running exercise on trabecular architecture during remobilization after suspension-induced osteopenia in growing rats.
J Appl Physiol. 2011 Dec 8. [Epub ahead of print]
Wang H, Wan Y, Tam KF, Ling S, Bai Y, Deng Y, Liu Y, Zhang H, Cheung WH, Qin L, Cheng JC, Leung KS, Li Y.
Resistive vibration exercise retards bone loss in weight-bearing skeletons during 60 days bed rest.
Osteoporos Int. 2011 Dec 9. [Epub ahead of print]
NOTE: This bed rest study was performed in China.
Qi W, Yan YB, Lei W, Wu ZX, Zhang Y, Liu D, Shi L, Cao PC, Liu N.
Prevention of disuse osteoporosis in rats by Cordyceps sinensis extract.
Osteoporos Int. 2011 Dec 13. [Epub ahead of print]
Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D'Agostino J, Lang T, Kiel DP, Bouxsein ML.
QCT measures of bone strength at the thoracic and lumbar spine: The Framingham Study.
J Bone Miner Res. 2011 Dec 5. [Epub ahead of print]
Rhee SH, Baek GH.
A correlation exists between subchondral bone mineral density of the distal radius and systemic bone mineral density.
Clin Orthop Relat Res. 2011 Dec 3. [Epub ahead of print]
NOTE: This article may temporarily (until December 31) be obtained online without charge.
Marin PJ, Herrero AJ, Garcia-Lopez D, Rhea MR, Lopez-Chicharro J, Gonzalez-Gallego J, Garatachea N.
Acute effects of whole-body vibration on neuromuscular responses in older individuals: Implications for prescription of vibratory stimulation.
J Strength Cond Res. 2011 Dec 8. [Epub ahead of print]
Abellan Van Kan G, Cderbaum JM, Cesari M, Dahinden P, Fariello RG, Fielding RA, Goodpaster BH, Hettwer S, Isaac M, Laurent D, Morley JE, Pahor M, Rooks D, Roubenoff R, Rutkove SB, Shaheen A, Vamvakas S, Vrijbloed JW, Vellas B.
Sarcopenia: Biomarkers and imaging (International Conference on Sarcopenia Research).
J Nutr Health Aging. 2011;15(10):834-46.
Du G, Drexler GA, Friedland W, Greubel C, Hable V, Kruecken R, Kugler A, Tonelli L, Friedl AA, Dollinger G.
Spatial dynamics of DNA damage response protein foci along the ion trajectory of high-LET particles.
Radiat Res. 2011 Dec;176(6):706-15. Epub 2011 Jul 28.
Kantemiris I, Karaiskos P, Papagiannis P, Angelopoulos A.
Dose and dose averaged LET comparison of (1)H, (4)He, (6)Li, (8)Be, (10)B, (12)C, (14)N, and (16)O ion beams forming a spread-out Bragg peak.
Med Phys. 2011 Dec;38(12):6585.
Francis Z, Incerti S, Ivanchenko V, Champion C, Karamitros M, Bernal MA, Bitar ZE.
Monte Carlo simulation of energy-deposit clustering for ions of the same LET in liquid water.
Phys Med Biol. 2011 Jan 7;57(1):209-24.
Casellato C, Tagliabue M, Pedrocchi A, Papaxanthis C, Ferrigno G, Pozzo T.
Reaching while standing in microgravity: A new postural solution to oversimplify movement control.
Exp Brain Res. 2011 Dec 8. [Epub ahead of print]
NOTE: Parabolic flight results. This article may temporarily (until December 31) be obtained online without charge.
Benson PW, Hooker JB, Koch KL, Weinberg RB.
Bitter taster status predicts susceptibility to vection-induced motion sickness and nausea.
Neurogastroenterol Motil. 2011 Dec 5. [Epub ahead of print]
Murdin L, Golding J, Bronstein A.
Managing motion sickness.
BMJ. 2011 Dec 2;343:d7430.
NOTE: A clinical approach to motion sickness.
Gao H, Liu Z, Zhang L.
Secondary metabolism in simulated microgravity and space flight.
Protein Cell. 2011 Nov;2(11):858-61.
NOTE: Brief review of this topic.
Jia Y, Tian X, Wu Z, Tian X, Zhou J, Fang Y, Zhu C.
Novel mechano luminescent sensors based on piezoelectric/electroluminescent composites.
Sensors (Basel). 2011;11(4):3962-9. Epub 2011 Apr 1.
NOTE: This article may be obtained online without charge via PubMed Central and at the publisher's site.
Suslak TJ, Armstrong JD, Jarman AP.
A general mathematical model of transduction events in mechano-sensory stretch receptors.
Lillywhite HB, Albert JS, Sheehy CM 3rd, Seymour RS.
Gravity and the evolution of cardiopulmonary morphology in snakes.
Comp Biochem Physiol A Mol Integr Physiol. 2012 Feb;161(2):230-42. Epub 2011 Nov 4.
Hayatsu M, Ono M, Hamamoto C, Suzuki S.
Cytochemical and electron probe X-ray microanalysis studies on the distribution change of intracellular calcium in columella cells of soybean roots under simulated microgravity.
J Electron Microsc (Tokyo). 2011 Dec 8. [Epub ahead of print]
Hotta H, Masunaga K, Miyazaki S, Watanabe N, Kasuya Y.
A gentle mechanical skin stimulation technique for inhibition of micturition contractions of the urinary bladder.
Auton Neurosci. 2011 Dec 10. [Epub ahead of print]
NOTE: Practical advice?