SpaceRef

SpaceRef


NASA Spaceline Current Awareness 13 September 2011 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Tuesday, September 13, 2011

image

Papers deriving from NASA support:

1
Hamilton DR, Sargsyan AE, Garcia K, Ebert DJ, Whitson PA, Feiveson AH, Alferova IV, Dulchavsky SA, Matveev VP, Bogomolov VV, Duncan JM.
Cardiac and vascular responses to thigh cuffs and respiratory maneuvers on crewmembers of the International Space Station.
J Appl Physiol. 2011 Sep 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21903875
(PIs: J.M. Duncan, S.A. Dulchavsky)
NOTE: ISS results.

2
Hurst VW 4th, Whittam SW, Austin PN, Branson RD, Beck G.
Cardiopulmonary resuscitation during spaceflight: Examining the role of timing devices.
Aviat Space Environ Med. 2011 Aug;82(8):810-3.
http://www.ncbi.nlm.nih.gov/pubmed/21853860

3
Popovic ZB, Desai MY, Buakhamsri A, Puntawagkoon C, Borowski A, Levine BD, Tang WW, Thomas JD.
Predictors of mitral annulus early diastolic velocity: Impact of long-axis function, ventricular filling pattern, and relaxation.
Eur J Echocardiogr. 2011 Aug 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21865226
(PI: J.D. Thomas)

4
Hackney KJ, Cook SB, Ploutz-Snyder LL.
Nutrition and resistance exercise during reconditioning from unloading.
Aviat Space Environ Med. 2011 Aug;82(8):805-9.
http://www.ncbi.nlm.nih.gov/pubmed/21853859
(PIs: K.J. Hackney, S.B. Cook, NASA Graduate Student Researcher Program)

5
Nagel MA, Choe A, Cohrs RJ, Traktinskiy I, Sorensen K, Mehta SK, Pierson DL, Tyring SK, Haitz K, DiGiorgio C, LaPolla W, Gilden D.
Persistence of varicella zoster virus DNA in saliva after herpes zoster.
J Infect Dis. 2011 Sep 15;204(6):820-4.
http://www.ncbi.nlm.nih.gov/pubmed/21849278
(PI: D.L. Pierson)
NOTE: This article may be obtained online without charge. There is a comment on this article which may also be obtained online without charge: http://jid.oxfordjournals.org/content/204/6/815.full

6
Hada M, Huff JL, Patel ZS, Kawata T, Pluth JM, George KA, Cucinotta FA.
AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Mutat Res. 2011 Aug 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21889946
(PIs: J.M. Pluth, F.A. Cucinotta)

7
Hu S, Cucinotta FA.
Computational studies on full-length Ku70 with DNA duplexes: Base interactions and a helical path.
J Mol Model. 2011 Aug 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21870196
(PI: F.A. Cucinotta)

8
Elmore E, Lao XY, Kapadia R, Swete M, Redpath JL.
Neoplastic transformation in vitro by mixed beams of high-energy iron ions and protons.
Radiat Res. 2011 Sep;176(3):291-302. Epub 2011 Jul 6.
http://www.ncbi.nlm.nih.gov/pubmed/21732791
(PI: J. Redpath)

9
Wang J, Su F, Smilenov LB, Zhou L, Hu W, Ding N, Zhou G.
Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity.
Radiat Oncol. 2011 Aug 17;6:96.
http://www.ncbi.nlm.nih.gov/pubmed/21849032
(PI: E.J. Hall)
NOTE: This article may be obtained online without charge.

10
Badavi FF, Nealy JE, Wilson JW.
The Low Earth Orbit validation of a dynamic and anisotropic trapped radiation model through ISS measurements.
Adv Space Res. 2011 Oct 15;48(8):1441-58.
http://dx.doi.org/10.1016/j.asr.2011.06.009
(PI: C. Sandridge)
NOTE: ISS, Shuttle results.

11
Dilda V, MacDougall HG, Moore ST.
Tolerance to extended galvanic vestibular stimulation: Optimal exposure for astronaut training.
Aviat Space Environ Med. 2011 Aug;82(8):770-4.
http://www.ncbi.nlm.nih.gov/pubmed/21853854
(PI: S.T. Moore)

12
Sheehan SE, Oman CM, Duda KR.
Motion sickness: A cholinomimetic agent hypothesis.
J Vestib Res. 2011 Jan 1;21(4):209-17.
http://www.ncbi.nlm.nih.gov/pubmed/21846953
(PI: C.M. Oman)

13
Shine JM, Moore ST, Bolitho SJ, Morris TR, Dilda V, Naismith SL, Lewis SJ.
Assessing the utility of Freezing of Gait Questionnaires in Parkinson's Disease.
Parkinsonism Relat Disord. 2011 Aug 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21872523
(PI: S.T. Moore)

14
John SP, Hasenstein KH.
Effects of mechanostimulation on gravitropism and signal persistence in flax roots.
Plant Signal Behav. 2011 Sep;6(9):1365-70.
http://www.ncbi.nlm.nih.gov/pubmed/21847020
(PI: K.H. Hasenstein)

Other papers of interest:

1
Hughes-Fulford M.
To infinity ... and beyond! Human spaceflight and life science.
FASEB J. 2011 Sep;25(9):2858-64.
http://www.ncbi.nlm.nih.gov/pubmed/21880668
NOTE: This FASEB Journal Silver Anniversary Review is a brief overview of the history of the life sciences in space flight, with sections on fluid shift and space anemia, space osteoporosis, and immunosuppression in space, and questions on future support. The article may be obtained online without charge. The cover image is related to this topic: http://www.fasebj.org/content/25/9.cover-expansion
University of California, San Francisco press release: http://www.ucsf.edu/news/2011/09/10589/advances-space-medicine-threatene...

2
Hunter AJ, Snodgrass SJ, Quain D, Parsons MW, Levi CR.
HOBOE (Head-of-Bed Optimization of Elevation) study: Association of higher angle with reduced cerebral blood flow velocity in acute ischemic stroke.
Phys Ther. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21868612
NOTE: Interesting acronym.

3
Brun CR, Shoemaker JK, Bocking A, Hammond JA, Poole M, Mottola MF.
Bed-rest exercise, activity restriction, and high-risk pregnancies: A feasibility study.
Appl Physiol Nutr Metab. 2011 Aug;36(4):577-82. Epub 2011 Aug 19.
http://www.ncbi.nlm.nih.gov/pubmed/21854162

4
Tschakovsky ME, Matusiak K, Vipond C, McVicar L.
Lower limb localized vascular phenomena explain initial orthostatic hypotension upon standing from squat.
Am J Physiol Heart Circ Physiol. 2011 Aug 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21856921

5
Ulbrich C, Pietsch J, Grosse J, Wehland M, Schulz H, Saar K, Huebner N, Hauslage J, Hemmersbach R, Braun M, van Loon J, Vagt N, Egli M, Richter P, Einspanier R, Sharbati S, Baltz T, Infanger M, Ma X, Grimm D.
Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: Relationship between the extracellular matrix and the cytoskeleton.
Cell Physiol Biochem. 2011;28(2):185-98. Epub 2011 Aug 16.
http://www.ncbi.nlm.nih.gov/pubmed/21865726
NOTE: Parabolic flight results. This article may be obtained online without charge.

6
Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M.
MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss.
J Cell Biochem. 2011 Aug 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21866567

7
Lau RY, Guo X.
A review on current osteoporosis research: With special focus on disuse bone loss.
J Osteoporos. 2011;2011:293808. Epub 2011 Aug 16.
http://www.ncbi.nlm.nih.gov/pubmed/21876833
NOTE: This article may be obtained online without charge via PubMed Central or the publisher's site.

8
Villalon KL, Gozansky WS, Van Pelt RE, Wolfe P, Jankowski CM, Schwartz RS, Kohrt WM.
A losing battle: Weight regain does not restore weight loss-induced bone loss in postmenopausal women.
Obesity (Silver Spring). 2011 Aug 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21852813
NOTE: Analogy with space flight?

9
Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM, Wan Y.
Biphasic and dosage-dependent regulation of osteoclastogenesis by -catenin.
Mol Cell Biol. 2011 Aug 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21876000

10
Rogers RS, Dawson AW, Wang Z, Thyfault JP, Hinton PS.
Acute response of serum markers of bone turnover to a single-bout of resistance-training or plyometrics.
J Appl Physiol. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21868687

11
Bogado CE, Boailchuk JA, Zanchetta MB, Massari FE, Zanchetta JR.
Denosumab: An update.
Drugs Today (Barc). 2011 Aug;47(8):605-13.
http://www.ncbi.nlm.nih.gov/pubmed/21850283

12
Yokota H, Leong DJ, Sun HB.
Mechanical loading: Bone remodeling and cartilage maintenance.
Curr Osteoporos Rep. 2011 Aug 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21858507

13
Lips P, van Schoor NM.
The effect of vitamin D on bone and osteoporosis.
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91.
http://www.ncbi.nlm.nih.gov/pubmed/21872800

14
Lau RW, Liao LR, Yu F, Teo T, Chung RC, Pang MY.
The effects of whole body vibration therapy on bone mineral density and leg muscle strength in older adults: A systematic review and meta-analysis.
Clin Rehabil. 2011 Aug 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21849376

15
Stein TP, Blanc S.
Does protein supplementation prevent muscle disuse atrophy and loss of strength?
Crit Rev Food Sci Nutr. 2011 Oct-Nov;51(9):828-34.
http://www.ncbi.nlm.nih.gov/pubmed/21888533
NOTE: The article includes a table summarizing protein and energy intake results from flights ranging from Apollo to ISS.

16
Korthuis RJ.
Skeletal Muscle Circulation.
San Rafael (CA): Morgan & Claypool Life Sciences; 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21850766
NOTE: This monograph may be obtained online without charge.

17
Aversa Z, Alamdari N, Hasselgren PO.
Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness.
Crit Rev Clin Lab Sci. 2011 Mar-Apr;48(2):71-86.
http://www.ncbi.nlm.nih.gov/pubmed/21871000

18
Smith HK, Merry TL.
Voluntary resistance wheel exercise during postnatal growth in rats enhances skeletal muscle satellite cell and myonuclear content at adulthood.
Acta Physiol (Oxf). 2011 Aug 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21854550
NOTE: This study has a reduced muscle activity component, achieved with botulinum toxin.

19
Item F, Denkinger J, Fontana P, Weber M, Boutellier U, Toigo M.
Combined effects of whole-body vibration, resistance exercise, and vascular occlusion on skeletal muscle and performance.
Int J Sports Med. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21870317

20
Doria C, Toniolo L, Verratti V, Cancellara P, Pietrangelo T, Marconi V, Paoli A, Pogliaghi S, Fano G, Reggiani C, Capelli C.
Improved V'O2 uptake kinetics and shift in muscle fiber type in high altitude trekkers.
J Appl Physiol. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21868681

21
Hindle AG, Karimpour-Fard A, Epperson LE, Hunter LE, Martin SL.
Skeletal muscle proteomics: Carbohydrate metabolism oscillates with seasonal and torpor-arousal physiology of hibernation.
Am J Physiol Regul Integr Comp Physiol. 2011 Aug 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21865542

22
Laske TG, Garshelis DL, Iaizzo PA.
Monitoring the wild black bear's reaction to human and environmental stressors.
BMC Physiol. 2011 Aug 17;11:13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21849079
NOTE: This article may be obtained online without charge.

23
Di Fino L, Casolino M, De Santis C, Larosa M, La Tessa C, Narici L, Picozza P, Zaconte V.
Heavy-ion anisotropy measured by ALTEA in the International Space Station.
Radiat Res. 2011 Sep;176(3):397-406. Epub 2011 May 11.
http://www.ncbi.nlm.nih.gov/pubmed/21561339
NOTE: ISS results. Graphics from the article are shown on the cover of the journal.

24
Ponnaiya B, Suzuki M, Tsuruoka C, Uchihori Y, Wei Y, Hei TK.
Detection of chromosomal instability in bystander cells after Si490-ion irradiation.
Radiat Res. 2011 Sep;176(3):280-90. Epub 2011 Jun 30.
http://www.ncbi.nlm.nih.gov/pubmed/21718104

25
Yang M, Kim JS, Son Y, Kim J, Kim JY, Kim SH, Kim JC, Shin T, Moon C.
Detrimental effect of fast neutrons on cultured immature rat hippocampal cells: Relative biological effectiveness of in vitro cell death indices.
Radiat Res. 2011 Sep;176(3):303-10. Epub 2011 Jun 21.
http://www.ncbi.nlm.nih.gov/pubmed/21692651

26
Abdelrazzak AB, Stevens DL, Bauer G, O'Neill P, Hill MA.
The role of radiation quality in the stimulation of intercellular induction of apoptosis in transformed cells at very low doses.
Radiat Res. 2011 Sep;176(3):346-55. Epub 2011 Jun 10.
http://www.ncbi.nlm.nih.gov/pubmed/21663396.

27
Sieber F, Muir SA, Cohen EP, Fish BL, Maeder M, Schock AM, Althouse BJ, Moulder JE.
Dietary selenium for the mitigation of radiation injury: Effects of selenium dose escalation and timing of supplementation.
Radiat Res. 2011 Sep;176(3):366-74. Epub 2011 Jul 8.
http://www.ncbi.nlm.nih.gov/pubmed/21867430

28
Nakayama M, Kaida A, Deguchi S, Sakaguchi K, Miura M.
Radiosensitivity of early and late M-phase HeLa cells isolated by a combination of fluorescent ubiquitination-based cell cycle indicator (Fucci) and mitotic shake-off.
Radiat Res. 2011 Sep;176(3):407-11. Epub 2011 Jun 21.
http://www.ncbi.nlm.nih.gov/pubmed/21692656

29
Bernal MA, deAlmeida CE, Sampaio C, Incerti S, Champion C, Nieminen P.
The invariance of the total direct DNA strand break yield.
Med Phys. 2011 Jul;38(7):4147-53.
http://www.ncbi.nlm.nih.gov/pubmed/21859016

30
Chen A, DeAngelis GC, Angelaki DE.
Representation of vestibular and visual cues to self-motion in ventral intraparietal cortex.
J Neurosci. 2011 Aug 17;31(33):12036-52.
http://www.ncbi.nlm.nih.gov/pubmed/21849564

31
Blouin JS, Dakin CJ, van den Doel K, Chua R, McFayden B, Inglis JT.
Extracting phase - dependent human vestibular reflexes during locomotion using both time and frequency correlation approaches.
J Appl Physiol. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21868684

32
Van Impe A, Coxon JP, Goble DJ, Doumas M, Swinnen SP.
White matter fractional anisotropy predicts balance performance in older adults.
Neurobiol Aging. 2011 Aug 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21872363

33
Albert J.
Sensory transduction: The 'swarm intelligence' of auditory hair bundles.
Curr Biol. 2011 Aug 23;21(16):R632-4.
http://www.ncbi.nlm.nih.gov/pubmed/21855005

34
Holly JE, Davis SM, Sullivan KE.
Differences between perception and eye movements during complex motions.
J Vestib Res. 2011 Jan 1;21(4):193-208.
http://www.ncbi.nlm.nih.gov/pubmed/21846952

35
Ash A, Palmisano S, Govan DG, Kim J.
Display lag and gain effects on vection experienced by active observers.
Aviat Space Environ Med. 2011 Aug;82(8):763-9.
http://www.ncbi.nlm.nih.gov/pubmed/21853853

36
Palmisano S, Allison RS, Kim J, Bonato F.
Simulated viewpoint jitter shakes sensory conflict accounts of vection.
Seeing Perceiving. 2011;24(2):173-200.
http://www.ncbi.nlm.nih.gov/pubmed/21864457

37
Chan DD, Van Dyke WS, Bahls M, Connell SD, Critser P, Kelleher JE, Kramer MA, Pearce SM, Sharma S, Neu CP.
Mechanostasis in apoptosis and medicine.
Prog Biophys Mol Biol. 2011 Aug 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21846479
NOTE: Microgravity is characterized in this paper as an example of a subphysiologic mechanical stress, as compared to a supraphysiologic stress such as injury.

38
Milstein JN, Meiners JC.
On the role of DNA biomechanics in the regulation of gene expression.
J R Soc Interface. 2011 Aug 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21865249
NOTE: This article may be obtained online without charge.

39
Horn ER, Gabriel M.
Gravity-related critical periods in vestibular and tail development of Xenopus laevis.
J Exp Zool A Ecol Genet Physiol. 2011 Aug 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21866581
NOTE: Results of experiment carried on Soyuz flight to ISS; results were also compared with other experiments on Shuttle, Salyut, and Bion.

40
Schaffhauser DF, Andrini O, Ghezzi C, Forster IC, Franco-Obregon A, Egli M, Dittrich PS.
Microfluidic platform for electrophysiological studies on Xenopus laevis oocytes under varying gravity levels.
Lab Chip. 2011 Aug 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21870012
NOTE: Includes parabolic flight results.

41
Brungs S, Hauslage J, Hilbig R, Hemmersbach R, Anken R.
Effects of simulated weightlessness on fish otolith growth: Clinostat versus Rotating-Wall Vessel.
Adv Space Res. 2011 Sep 1;48(5):792-8.
http://dx.doi.org/10.1016/j.asr.2011.04.014

42
Sugimoto M, Ishii M, Mori IC, Elena S, Gusev OA, Kihara M, Hoki T, Sychev VN, Levinskikh MA, Novikova ND, Grigoriev AI.
Viability of barley seeds after long-term exposure to outer side of International Space Station.
Adv Space Res. 2011 Sep 15;48(6):1155-60.
http://dx.doi.org/10.1016/j.asr.2011.05.017
NOTE: ISS results.

43
Di SM, Qian AR, Qu LN, Zhang W, Wang Z, Ding C, Li YH, Ren HG, Shang P.
Graviresponses of osteocytes under altered gravity.
Adv Space Res. 2011 Sep 15;48(6):1161-6.
http://dx.doi.org/10.1016/j.asr.2011.05.030
NOTE: Parabolic flight results.

44
Doarn CR, Merrell RC.
Reflections of space exploration and its impact on telemedicine.
Telemed J E Health. 2011 Sep;17(7):507-8.
http://www.ncbi.nlm.nih.gov/pubmed/21851159
NOTE: The first page, which constitutes nearly all of this editorial, can be obtained online without charge at the publisher's site citation.

45
Nicogossian AE, Doarn CR.
Armenia 1988 earthquake and telemedicine: Lessons learned and forgotten.
Telemed J E Health. 2011 Aug 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21861701

46
Sanderson K.
Commercial space flight: Scientists in space.
Nature. 2011 Aug 25;476(7361):477-8.
http://www.ncbi.nlm.nih.gov/pubmed/21870357
NOTE: This article, about astronauts who may fly on commercial space flights, may be obtained online without charge: http://www.nature.com/naturejobs/2011/110825/full/nj7361-477a.html

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

SpaceRef Newsletter