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NASA Spaceline Current Awareness 10 June 2011 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, June 10, 2011

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Papers deriving from NASA support:

1
Stenger MB, Evans JM, Knapp CF, Lee SM, Phillips TR, Perez SA, Moore AD Jr, Paloski WH, Platts SH.
Artificial gravity training reduces bed rest-induced cardiovascular deconditioning.
Eur J Appl Physiol. 2011 May 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21626041
NOTE: NASA Artificial Gravity Pilot study.

2
Porter J, Gibson CR, Strauss S.
Determining spherical lens correction for astronaut training underwater.
Optom Vis Sci. 2011 May 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21623249

3
Rodionova NV.
The dynamics of proliferation and differentiation of osteogenic cells under supportive unloading.
Cytol Genet. 2011 Apr;45(2):80-4.
http://dx.doi.org/10.3103/S0095452711020137
NOTE: NASA financial support was acknowledged. This paper was also published in Tsitologiya i Genetika 2011 Mar-Apr;45(2):22-7: http://www.ncbi.nlm.nih.gov/pubmed/21568220

4
Mezentsev A, Amundson SA.
Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model.
Radiat Res. 2011 Jun;175(6):677-88. Epub 2011 Apr 12.
http://www.ncbi.nlm.nih.gov/pubmed/21486161
(PI: S.A. Amundson)
NOTE: A graphic from this article is featured on the cover of the journal.

5
Meador JA, Ghandhi SA, Amundson SA.
p53-Independent downregulation of histone gene expression in human cell lines by high- and low-LET radiation.
Radiat Res. 2011 Jun;175(6):689-99. Epub 2011 Apr 26.
http://www.ncbi.nlm.nih.gov/pubmed/21520998
(PI: S.A. Amundson)

6
Epperly MW, Wang H, Jones JA, Dixon T, Montesinos CA, Greenberger JS.
Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration.
Radiat Res. 2011 Jun;175(6):759-65. Epub 2011 Apr 5.
http://www.ncbi.nlm.nih.gov/pubmed/21466381
NOTE: This article may be obtained online without charge.

7
Yu T, Parks BW, Yu S, Srivastava R, Gupta K, Wu X, Khaled S, Chang PY, Kabarowski JH, Kucik DF.
Iron-ion radiation accelerates atherosclerosis in apolipoprotein E-deficient mice.
Radiat Res. 2011 Jun;175(6):766-73. Epub 2011 Apr 5.
http://www.ncbi.nlm.nih.gov/pubmed/21466380
(PI: D.F. Kucik)
NOTE: This article was highlighted in an April 6 press release: http://www.uab.edu/news/latest/item/1039-deep-space-travel-could-create-...

8
Li Y, Cucinotta FA.
Modeling non-homologous end joining.
J Theor Biol. 2011 May 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21635903
(PI: F.A. Cucinotta)

9
Lu Y, Meyyappan M, Li J.
Trace detection of hydrogen peroxide vapor using a carbon-nanotube-based chemical sensor.
Small. 2011 May 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21567945

10
Damron FH, Davis MR Jr, Withers TR, Ernst RK, Goldberg JB, Yu G, Yu HD.
Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1.
Mol Microbiol. 2011 Jun 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21631603
(PI: F.H. Damron, NASA Graduate Student Researcher Program)

Other papers of interest:

1
Petersen LG, Damgaard M, Petersen JC, Norsk P.
Mechanisms of increase in cardiac output during acute weightlessness in humans.
J Appl Physiol. 2011 Jun 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21636570
NOTE: Parabolic flight results.

2
Porta A, Bassani T, Bari V, Tobaldini E, Takahashi AC, Catai AM, Montano N.
Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt.
Comput Biol Med. 2011 May 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21621756
NOTE: This article may be obtained online without charge.

3
Padilla J, Simmons GH, Davis JW, Whyte JJ, Zderic TW, Hamilton MT, Bowles DK, Laughlin MH.
Impact of exercise training on endothelial transcriptional profiles in healthy swine: A genome-wide microarray analysis.
Am J Physiol Heart Circ Physiol. 2011 May 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21622830

4
Thyfault JP, Krogh-Madsen R.
Metabolic disruptions induced by reduced ambulatory activity in free living humans.
J Appl Physiol. 2011 Jun 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21636564
NOTE: From paper: "Unfortunately, the larger scientific and medical community does not seem to appreciate the links between inactivity and insulin resistance. There are logical reasons for this disconnect. First, it is our opinion that most of the medical community believes that exercise or increased physical activity is something that can 'improve' health rather than a physiological stimuli that is absolutely 'necessary' for normal function and health."

5
Joyner MJ.
Giant sucking sound: Can physiology fill the intellectual void left by the reductionists?
J Appl Physiol. 2011 Jun 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21636568

6
Seene T, Kaasik P, Riso EM.
Review on aging, unloading and reloading: Changes in skeletal muscle quantity and quality.
Arch Gerontol Geriatr. 2011 May 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21632125

7
Fujita N, Murakami S, Arakawa T, Miki A, Fujino H.
The combined effect of electrical stimulation and resistance isometric contraction on muscle atrophy in rat tibialis anterior muscle.
Bosn J Basic Med Sci. 2011 May;11(2):74-9.
http://www.ncbi.nlm.nih.gov/pubmed/21619551
NOTE: This article may be obtained online without charge: http://www.bjbms.org/archives/2011-2/1-Naoto_Fujita.pdf

8
Duddy WJ, Cohen T, Duguez S, Partridge TA.
The isolated muscle fibre as a model of disuse atrophy: Characterization using PhAct, a method to quantify f-actin.
Exp Cell Res. 2011 May 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21635888

9
Hornberger TA.
Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle.
Int J Biochem Cell Biol. 2011 May 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21621634

10
Walker DK, Dickinson JM, Timmerman KL, Drummond MJ, Reidy PT, Fry CS, Gundermann DM, Rasmussen BB.
Exercise, amino acids and aging in the control of human muscle protein synthesis.
Med Sci Sports Exerc. 2011 May 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21606874

11
Kapinas K, Delany AM.
MicroRNA biogenesis and regulation of bone remodeling.
Arthritis Res Ther. 2011 May 27;13(3):220. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21635717

12
Maimoun L, Fattal C, Sultan C.
Bone remodeling and calcium homeostasis in patients with spinal cord injury: A review.
Metabolism. 2011 May 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21632079

13
Ng KW.
Regulation of glucose metabolism and the skeleton.
Clin Endocrinol (Oxf). 2011 May 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21623861
NOTE: This article may be obtained online without charge.

14
Inose H, Zhou B, Yadav VK, Guo XE, Karsenty G, Ducy P.
Efficacy of serotonin inhibition in mouse models of bone loss.
J Bone Miner Res. 2011 May 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21608033
NOTE: This article may be obtained online without charge.

15
Oury F, Karsenty G.
Towards a serotonin-dependent leptin roadmap in the brain.
Trends Endocrinol Metab. 2011 May 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21602053

16
Ding Y, Zou J, Li Z, Tian J, Abdelalim S, Du F, She R, Wang D, Tan C, Wang H, Chen W, Lv D, Chang L.
Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect.
PLoS One. 2011;6(5):e20008. Epub 2011 May 23.
http://www.ncbi.nlm.nih.gov/pubmed/21625440
NOTE: This article may be obtained online without charge.

17
Hurtado A, Cregg JM, Wang HB, Wendell DF, Oudega M, Gilbert RJ, McDonald JW.
Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic acid microfibers.
Biomaterials. 2011 June 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21636129
NOTE: Interesting research, though not space life sciences. The article may be obtained online without charge.

18
Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Stroem CE, Helleday T, Hu MC, Chen DJ, Shiloh Y.
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
EMBO Rep. 2011 Jun 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21637298

19
ezaova M, Rudolfova G, Tich A, Baikova A, Mutna D, Havelek R, Vavrova J, Odraka K, Lukaova E, Kozubek S.
Accumulation of DNA damage and cell death after fractionated irradiation.
Radiat Res. 2011 Jun;175(6):708-18. Epub 2011 Mar 25.
http://www.ncbi.nlm.nih.gov/pubmed/21438660

20
Benvenuti SM, Bianchin M, Angrilli A.
Effects of simulated microgravity on brain plasticity: A startle reflex habituation study.
Physiol Behav. 2011 May 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21627974
NOTE: Short-term bed rest study.

21
Lambrey S, Doeller C, Berthoz A, Burgess N.
Imagining being somewhere else: Neural basis of changing perspective in space.
Cereb Cortex. 2011 May 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21625010

22
Laurens J, Strauman D, Hess BJ.
Spinning versus wobbling: How the brain solves a geometry problem.
J Neurosci. 2011 Jun 1;31(22):8093-101.
http://www.ncbi.nlm.nih.gov/pubmed/21632931

23
Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P.
Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.
J Biol Rhythms. 2011 Jun;26(3):249-59.
http://www.ncbi.nlm.nih.gov/pubmed/21628552

24
Qazi H, Shi ZD, Tarbell JM.
Fluid shear stress regulates the invasive potential of glioma cells via modulation of migratory activity and matrix metalloproteinase expression.
PLoS One. 2011;6(5):e20348. Epub 2011 May 26.
http://www.ncbi.nlm.nih.gov/pubmed/21637818
NOTE: This article may be obtained online without charge.

// end //

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