NASA Spaceline Current Awareness 28 September 2012 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 28, 2012


Next list: October 12, 2012

Papers that are just out and that will be covered in the next list: (and entire issue)

Papers deriving from NASA support:

Morgan JL, Zwart SR, Heer M, Ploutz-Snyder R, Ericson K, Smith SM.
Bone metabolism and nutritional status during 30-day head-down tilt bed rest.
J Appl Physiol. 2012 Sep 20. [Epub ahead of print]
(PI: S.M. Smith, Flight Analogs Project)
NOTE: Bed rest study.

Lin W, Serra-Hsu F, Cheng J, Qin YX.
Frequency specific ultrasound attenuation is sensitive to trabecular bone structure.
Ultrasound Med Biol. 2012 Sep 10. [Epub ahead of print]
(PI: Y.X. Qin)
NOTE: This article may temporarily be obtained online without charge.

Harber MP, Konopka AR, Undem MK, Hinkley JM, Minchev K, Kaminsky LA, Trappe TA, Trappe SW.
Aerobic exercise training induces skeletal muscle hypertrophy and age-dependent adaptations in myofiber function in young and older men.
J Appl Physiol. 2012 Sep 13. [Epub ahead of print]
(PI: S.W. Trappe/T.A. Trappe)

Broxterman RM, Ade CJ, Poole DC, Harms CA, Barstow TJ.
A single test for the determination of parameters of the speed-time relationship for running.
Respir Physiol Neurobiol. 2012 Sep 4. [Epub ahead of print]
(PI: T.J. Barstow)

Brinley AA, Theriot CA, Nelman-Gonzalez M, Crucian B, Stowe RP, Barrett AD, Pierson DL.
Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system.
J Cell Biochem. 2012 Sep 18. [Epub ahead of print]
(PIs: A.A. Brinley, NASA Graduate Student Researcher Program; R.P. Stowe; D.L. Pierson)
NOTE: Used rotating wall vessel bioreactor as modeled spaceflight system.

Steffen LS, Bacher JW, Peng Y, Le PN, Ding LH, Genik PC, Ray FA, Bedford JS, Fallgren CM, Bailey SM, Ullrich RL, Weil MM, Story MD.
Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation.
Mutagenesis. 2012 Sep 17. [Epub ahead of print]
(PIs: R.L. Ullrich/J.W. Bacher/J.S. Bedford/M.M. Weil/M.D. Story/NSCOR; J.S. Bedford)

Mao XW, Crapo JD, Gridley DS.
Mitochondrial oxidative stress-induced apoptosis and radioprotection in proton-irradiated rat retina.
Radiat Res. 2012 Sep;178(3):118-25. Epub 2012 Jul 10.

Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, Dubois K, Wiegant WW, Thierry A, Burma S, van Attikum H, Llorente B.
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.
Nature. 2012 Sep 27;489(7417):581-4. Epub 2012 Sep 9.
(PI: S. Burma)

Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M.
Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.
Oncogene. 2012 Sep 10. [Epub ahead of print]
(PI: J.D. Minna/L. Girard/A.F. Gazdar/NSCOR)

Petrik D, Lagace DC, Eisch AJ.
The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
Neuropharmacology. 2012 Jan;62(1):21-34. Epub 2011 Sep 19.
(PI: B.P. Chen/A.J. Eisch)

St Hilaire MA, Sullivan JP, Anderson C, Cohen DA, Barger LK, Lockley SW, Klerman EB.
Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing.
Accid Anal Prev. 2012 Sep 4. [Epub ahead of print]
(PIs: L.K. Barger, E.B. Klerman)
NOTE: Part of this study included scientists or engineers working on a Mars sol schedule in support of the Phoenix Mars Lander.

Morris HC, Damon M, Maule J, Monaco LA, Wainwright N.
Rapid culture-independent microbial analysis aboard the International Space Station (ISS) Stage Two: Quantifying three microbial biomarkers.
Astrobiology. 2012 Sep;12(9):830-40.
NOTE: ISS results.

Swan JW, Vasquez PA, Whitson PA, Fincke EM, Wakata K, Magnus SH, De Winne F, Barratt MR, Agui JH, Green RD, Hall NR, Bohman DY, Bunnell CT, Gast AP, Furst EM.
Multi-scale kinetics of a field-directed colloidal phase transition.
Proc Natl Acad Sci U S A. 2012 Sep 17. [Epub ahead of print]
NOTE: ISS experiment. Co-authors and ISS astronauts Whitson, Fincke, Wakata, Magnus, De Winne, and Barratt performed the research. This article may be obtained online without charge.

Paul AL, Denison FC, Schultz ER, Zupanska AK, Ferl RJ.
14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?
Front Plant Sci. 2012;3:190. Epub 2012 Aug 20.
(PIs: A.L. Paul, R.J. Ferl)
NOTE: This article may be obtained online without charge.

Other papers of interest:

Edgell H, Grinberg A, Gagne N, Beavers KR, Hughson RL.
Cardiovascular responses to lower body negative pressure before and after 4-hours of head-down bed-rest and seated control in men and women.
J Appl Physiol. 2012 Sep 13. [Epub ahead of print]
NOTE: Bed rest study.

Parsaik A, Allison TG, Singer W, Sletten DM, Joyner MJ, Benarroch EE, Low PA, Sandroni P.
Deconditioning in patients with orthostatic intolerance.
Neurology. 2012 Sep 19. [Epub ahead of print]

Tan CO.
Defining the characteristic relationship between arterial pressure and cerebral flow.
J Appl Physiol. 2012 Sep 6. [Epub ahead of print]

Phillips AA, Bredin SS, Cote AT, Drury CT, Warburton DE.
Aortic distensibility is reduced during intense lower body negative pressure and is related to low frequency power of systolic blood pressure.
Eur J Appl Physiol. 2012 Sep 14. [Epub ahead of print]

Goldstein DS, Sewell L, Holmes C, Pechnik S, Diedrich A, Robertson D.
Temporary elimination of orthostatic hypotension by norepinephrine infusion.
Clin Auton Res. 2012 Sep 16. [Epub ahead of print]

Morrison SA, Ainslie PN, Lucas RA, Cheung SS, Cotter JD.
Compression garments do not alter cerebrovascular responses to orthostatic stress after mild passive heating.
Scand J Med Sci Sports. 2012 Sep 12. [Epub ahead of print]

Ogata H, Fujimaru I, Yamada K, Kondo T.
Suppression of cardiocirculatory responses to orthostatic stress by passive walking-like leg movement in healthy young men.
J Physiol Anthropol. 2012 Sep 12;31:24. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Berdahl JP, Yu DY, Morgan WH.
The translaminar pressure gradient in sustained zero gravity, idiopathic intracranial hypertension, and glaucoma.
Med Hypotheses. 2012 Sep 14. [Epub ahead of print]
NOTE: This article presents a hypothesis related to the intraocular pressure/intracranial pressure in space issue. This article may temporarily be obtained online without charge.

Lawley JS, Oliver SJ, Mullins P, Morris D, Junglee NA, Jelleyman C, Macdonald JH.
Optic nerve sheath diameter is not related to high altitude headache: A randomized controlled trial.
High Alt Med Biol. 2012 Sep;13(3):193-9.

Huin-Schohn C, Gueguinou N, Schenten V, Bascove M, Koch GG, Baatout S, Tschirhart E, Frippiat JP.
Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis.
FASEB J. 2012 Sep 25. [Epub ahead of print]
NOTE: ISS results.

Young KM, Cramp RL, Franklin CE.
Hot and steady: Elevated temperatures do not enhance muscle disuse atrophy during prolonged aestivation in the ectotherm Cyclorana alboguttata.
J Morphol. 2012 Sep 20. [Epub ahead of print]

Wu TJ, Wei TS, Chou YH, Yang CP, Wu CL, Chen YC, Liu SY.
Whole-body vibration for functional constipation: A single-center, single-blinded, randomized, controlled trial.
Colorectal Dis. 2012 Sep 11. [Epub ahead of print]
NOTE: Shake, rattle, and go.

Miokovic T, Armbrecht G, Felsenberg D, Belavy DL.
Heterogeneous atrophy occurs within individual lower limb muscles during 60d bed-rest.
J Appl Physiol. 2012 Sep 13. [Epub ahead of print]
NOTE: Second Berlin Bed Rest Study.

Ye F, Baligand C, Keener JE, Vohra RS, Lim W, Ruhella A, Bose P, Daniels M, Walter GA, Thompson FJ, Vandenborne K.
Hindlimb muscle morphology and function in a new atrophy model combining spinal cord injury and cast immobilization.
J Neurotrauma. 2012 Sep 17. [Epub ahead of print]

Nedergaard A, Karsdal MA, Sun S, Henriksen K.
Serological muscle loss biomarkers: An overview of current concepts and future possibilities.
J Cachexia Sarcopenia Muscle. 2012 Sep 21. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Cabello-Verrugio C, Cordova G, Salas JD.
Angiotensin II: Role in skeletal muscle atrophy.
Curr Protein Pept Sci. 2012 Sep 10. [Epub ahead of print]

Friedrichsen M, Ribel-Madsen R, Mortensen B, Hansen CN, Alibegovic AC, Hojbjerre L, Sonne MP, Wojtaszewski JF, Stallknecht B, Dela F, Vaag A.
Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared to normal birth weight.
Eur J Endocrinol. 2012 Sep 11. [Epub ahead of print]

Casey DP, Joyner MJ.
Influence of -adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging.
J Appl Physiol. 2012 Sep 6. [Epub ahead of print]

Schulte FA, Zwahlen A, Lambers FM, Kuhn G, Ruffoni D, Betts D, Webster DJ, Mueller R.
Strain-adaptive in silico modeling of bone adaptation - A computer simulation validated by in vivo micro-computed tomography data.
Bone. 2012 Sep 13. [Epub ahead of print]

Grimston SK, Watkins MP, Brodt MD, Silva MJ, Civitelli R.
Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice.
PLoS One. 2012;7(9):e44222. Epub 2012 Sep 10.
NOTE: This article may be obtained online without charge.

Cohen A, Lang TF, McMahon DJ, Liu XS, Guo XE, Zhang C, Stein EM, Dempster DW, Young P, Saeed I, Lappe JM, Recker RR, Shane E.
Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history.
J Clin Endocrinol Metab. 2012 Sep 7. [Epub ahead of print]

Fournier C, Zahnreich S, Kraft D, Friedrich T, Voss KO, Durante M, Ritter S.
The fate of a normal human cell traversed by a single charged particle.
Sci Rep. 2012;2:643. Epub 2012 Sep 10.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher's site:

Park SH, Kang JO.
Basics of particle therapy I: Physics.
Radiation Oncol J. 2011 Sep;29(3):135-46. Epub 2011 Sep 30.
NOTE: This article may be obtained online without charge:

Mazzeo E, Hehlgans S, Valentini V, Baumann M, Cordes N.
The impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity of A431 cancer cells.
Radiat Res. 2012 Sep;178(3):224-33. Epub 2012 Jul 16.

Riecke A, Rufa CG, Cordes M, Hartmann J, Meineke V, Abend M.
Gene expression comparisons performed for biodosimetry purposes on in vitro peripheral blood cellular subsets and irradiated individuals.
Radiat Res. 2012 Sep;178(3):234-43. Epub 2012 Jul 7.

White O, Lefevre P, Wing AM, Bracewell RM, Thonnard JL.
Active collisions in altered gravity reveal eye-hand coordination strategies.
PLoS One. 2012;7(9):e44291. Epub 2012 Sep 12.
NOTE: Parabolic flight results. This article may be obtained online without charge.

Zaal PM, Nieuwenhuizen FM, van Paassen MM, Mulder M.
Modeling human control of self-motion direction with optic flow and vestibular motion.
IEEE Trans Syst Man Cybern B Cybern. 2012 Sep 11. [Epub ahead of print]

Osler CJ, Reynolds RF.
Dynamic transformation of vestibular signals for orientation.
Exp Brain Res. 2012 Sep 19. [Epub ahead of print]

Bernardin D, Kadone H, Bennequin D, Sugar T, Zaoui M, Berthoz A.
Gaze anticipation during human locomotion.
Exp Brain Res. 2012 Sep 12. [Epub ahead of print]

Klingner CM, Volk GF, Flatz C, Brodoehl S, Dieterich M, Witte OW, Guntinas-Lichius O.
Components of vestibular cortical function.
Behav Brain Res. 2012 Sep 6;236C:194-9. [Epub ahead of print]

Klier EM, Meng H, Angelaki DE.
Reaching the limit of the oculomotor plant: 3D kinematics after abducens nerve stimulation during the torsional vestibulo-ocular reflex.
J Neurosci. 2012 Sep 19;32(38):13237-43.

Robertson MD, Russell-Jones D, Umpleby AM, Dijk DJ.
Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men.
Metabolism. 2012 Sep 14. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Tosini G, Baba K, Hwang CK, Iuvone PM.
Melatonin: An underappreciated player in retinal physiology and pathophysiology.
Exp Eye Res. 2012 Aug 31;103C:82-9. [Epub ahead of print]

Grosse J, Wehland M, Pietsch J, Schulz H, Saar K, Huebner N, Eilles C, Bauer J, Abou-El-Ardat K, Baatout S, Ma X, Infanger M, Hemmersbach R, Grimm D.
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids.
FASEB J. 2012 Sep 10. [Epub ahead of print]

Meigal A.
Interplanetary space flight compared with fetal/neonatal motor strategy: Theoretical and practical implications.
Pathophysiology. 2012 Sep 7. [Epub ahead of print]

Chadha A, Cook B.
Dissection of gain control mechanisms in Drosophila mechanotransduction.
J Neurosci. 2012 Sep 19;32(38):13052-61.

Song MJ, Brady-Kalnay SM, McBride SH, Phillips-Mason P, Dean D, Knothe Tate ML.
Mapping the mechanome of live stem cells using a novel method to measure local strain fields in situ at the fluid-cell interface.
PLoS One. 2012;7(9):e43601. Epub 2012 Sep 10.
NOTE: This article may be obtained online without charge.

Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR.
Primary cilia mediated mechanotransduction in human mesenchymal stem cells.
Stem Cells. 2012 Sep 11. [Epub ahead of print]

Costa P, Almeida FV, Connelly JT.
Biophysical signals controlling cell fate decisions: How do stem cells really feel?
Int J Biochem Cell Biol. 2012 Sep 11. [Epub ahead of print]

Higuera GA, van Boxtel A, van Blitterswijk CA, Moroni L.
The physics of tissue formation with mesenchymal stem cells.
Trends Biotechnol. 2012 Sep 6. [Epub ahead of print]

Hunter J.
Post-publication peer review: Opening up scientific conversation.
Front Comput Neurosci. 2012;6:63. Epub 2012 Aug 30.
NOTE: This article may be obtained online without charge.

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