NASA Spaceline Current Awareness 30 November 2012 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, November 30, 2012


Next list: December 14, 2012

Papers deriving from NASA support:

Simon JC, Sapozhnikov OA, Khokhlova VA, Wang YN, Crum LA, Bailey MR.
Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound.
Phys Med Biol. 2012 Dec 7;57(23):8061-78. Epub 2012 Nov 16.
(PI: L.A. Crum)

McClintic AM, Dickey TC, Gofeld M, Kliot M, Loeser JD, Richebe P, Mourad PD.
Intense focused ultrasound preferentially stimulates subcutaneous and focal neuropathic tissue: Preliminary results.
Pain Med. 2012 Nov 8. [Epub ahead of print]

Sun Y, Butler JP, Ferrigno M, Albert MS, Loring SH.
"Ventilatory alternans": A left-right alternation of inspiratory airflow in humans.
Respir Physiol Neurobiol. 2012 Nov 8. [Epub ahead of print]
(PI: M.S. Albert)

Ellman R, Spatz J, Cloutier A, Palme R, Christiansen B, Bouxsein ML.
Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass.
J Bone Miner Res. 2012 Nov 19. [Epub ahead of print]
(PIs: M.L. Bouxsein; NSBRI?; R. Ellman, NASA Harriet G. Jenkins Predoctoral Fellowship)

Nagaraja MP, Risin D.
A review: The current state of bone loss research: Data from spaceflight and microgravity simulators.
J Cell Biochem. 2012 Nov 13. [Epub ahead of print]

Baer LA, Wu X, Tou JC, Johnson E, Wolf SE, Wade CE.
Contributions of severe burn and disuse to bone structure and strength in rats.
Bone. 2012 Nov 6. [Epub ahead of print]
(PI: C.E. Wade)

Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, Chen DJ, Komatsu K.
Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.
PLoS One. 2012;7(11):e49245. Epub 2012 Nov 7.
(PI: S. Burma)
NOTE: This article may be obtained online without charge.

Autsavapromporn N, De Toledo SM, Jay-Gerin JP, Harris AL, Azzam EI.
Human cell responses to ionizing radiation are differentially affected by the expressed connexins.
J Radiat Res. 2012 Nov 8. [Epub ahead of print]
(PI: E.I. Azzam)
NOTE: This article may be obtained online without charge.

Meng X, Laidler LL, Kosmacek EA, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey MA, Leslie KK.
Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53.
Gynecol Oncol. 2012 Nov 9. [Epub ahead of print]
(PI: F. Ianzini)

Ly P, Eskiocak U, Parker CR, Harris KJ, Wright WE, Shay JW.
RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion.
Cell Res. 2012 Nov;22(11):1605-8. Epub 2012 Oct 9.
(PIs: J.W. Shay; A. Fornace/W.E. Wright/J.W. Shay/NSCOR; J. Minna/J.W. Shay/NSCOR)

Wang X, Chen M, Khodursky AB, Xiao G.
Bayesian joint analysis of gene expression data and gene functional annotations.
Stat Biosci. 2012 Nov;4(2):300-18.
(PI: J. Minna/NSCOR)

Lowe XR, Wyrobek AJ.
Characterization of the early CNS stress biomarkers and profiles associated with neuropsychiatric diseases.
Curr Genomics. 2012 Sep;13(6):489-97.
(PI: A.J. Wyrobek)

Cohen HS, Kimball KT, Mulavara AP, Bloomberg JJ, Paloski WH.
Posturography and locomotor tests of dynamic balance after long-duration spaceflight.
J Vestib Res. 2012 Jan 1;22(4):191-6.
(PI: J.J. Bloomberg)
NOTE: ISS results.

Moeller R, Reitz G, Li Z, Klein S, Nicholson WL.
Multifactorial resistance of Bacillus subtilis spores to high-energy proton radiation: Role of spore structural components and the homologous recombination and non-homologous end joining DNA repair pathways.
Astrobiology. 2012 Nov;12(11):1069-77. Epub 2012 Oct 22.

Hasenstein KH, John S, Scherp P, Povinelli D, Mopper S.
Analysis of magnetic gradients to study gravitropism.
Am J Bot. 2012 Nov 21. [Epub ahead of print]
(PI: K.H. Hasenstein)
NOTE: Parabolic flight results. This article may temporarily be obtained online without charge.

Other papers of interest:

Blaber AP, Zuj KA, Goswami N.
Cerebrovascular autoregulation: Lessons learned from spaceflight research.
Eur J Appl Physiol. 2012 Nov 7. [Epub ahead of print]
NOTE: This article is the fourth of six articles in the series on Space Physiology, described in Current Awareness List #572.

Robertson D, Diedrich A, Chapleau MW.
Editorial on Arterial Baroreflex Issue.
Auton Neurosci. 2012 Dec 24;172(1-2):1-3.
NOTE: This editorial introduces an issue on the arterial baroreflex (the citation for one paper in the issue is below):

Fisher JP, Kim A, Hartwich D, Fadel PJ.
New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.
Auton Neurosci. 2012 Dec 24;172(1-2):13-22.

Lewis NC, Ainslie PN, Atkinson G, Jones H, Grant EJ, Lucas SJ.
Initial orthostatic hypotension and cerebral blood flow regulation: Effect of 1-adrenoreceptor activity.
Am J Physiol Regul Integr Comp Physiol. 2012 Nov 21. [Epub ahead of print]

Reihmane D, Hansen AV, Gram M, Kuhlman AB, Norregaard J, Pedersen HP, Lund MT, Helge JW, Dela F.
Immobilisation increases interleukin-6, but not tumor necrosis factor-, release from the leg during exercise in humans.
Exp Physiol. 2012 Nov 9. [Epub ahead of print]

Muller MD, Mast JL, Patel H, Sinoway LI.
Cardiac mechanics are impaired during fatiguing exercise and cold pressor test in healthy older adults.
J Appl Physiol. 2012 Nov 15. [Epub ahead of print]

Afonin BV, Ermolenko AE, Inozemtsev SL.
Functional state of the liver during simulation of the hemodynamic effects of microgravity on the human body.
Hum Physiol. 2012 Jul;38(4):433-7.
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2012 Jul-Aug;38(4):108-13:

Zhuravleva OA, Morukov BV, Markin AA, Vostrikova LV, Zabolotskaya IV, Kuzichkin DS.
Lipid peroxidation rate and the antioxidant protection system during a three-day dry immersion experiment.
Hum Physiol. 2012 Sep;38(5):555-7.
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2012 Sep-Oct;38(5):120-3:

Dalecki M, Bock O, Schulze B.
Cognitive impairment during 5 m water immersion.
J Appl Physiol. 2012 Oct;113(7):1075-81. Epub 2012 Aug 9.

Holmgren H, Gerth E, Ljungstroem E, Larsson P, Almstrand AC, Bake B, Olin AC.
Effects of breath holding at low and high lung volumes on amount of exhaled particles.
Respir Physiol Neurobiol. 2012 Oct 31. [Epub ahead of print]

Jorgensen A, Foster PP, Eftedal I, Wisloff U, Paulsen G, Havnes MB, Brubakk AO.
Exercise-induced myofibrillar disruption with sarcolemmal integrity prior to simulated diving has no effect on vascular bubble formation in rats.
Eur J Appl Physiol. 2012 Nov 6. [Epub ahead of print]

Mader TH, Lee AG, Gibson CR, Kramer LA, Pass AF, Sargsyan A.
Author reply.
Ophthalmology. 2012 Nov;119(11):2421-2.
NOTE: This is the reply of T.H. Mader et al. to the letter by D.H. Kim and C.F. Parsa that was listed in the previous Current Awareness list. These letters continue the discussion of the posssible effects and causes of space flight on intraocular pressure.

Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE.
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.
Sci Transl Med. 2012 Nov 7;4(159):159ra147.
NOTE: Disease-on-a-chip.

Stein TP.
Weight, muscle and bone loss during space flight: Another perspective.
Eur J Appl Physiol. 2012 Nov 29. [Epub ahead of print]

Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourde C, Leinwand LA, Kuhl D, Foeller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD.
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
EMBO Mol Med. 2012 Nov 19. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Andres-Mateos E, Mejias R, Soleimani A, Lin BM, Burks TN, Marx R, Lin B, Zellars RC, Zhang Y, Huso DL, Marr TG, Leinwand LA, Merriman DK, Cohn RD.
Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.
PLoS One. 2012;7(11):e48884. Epub 2012 Nov 14.
NOTE: This article may be obtained online without charge.

Polge C, Heng AE, Combaret L, Bechet D, Taillandier D, Attaix D.
Recent progress in elucidating signalling proteolytic pathways in muscle wasting: Potential clinical implications.
Nutr Metab Cardiovasc Dis. 2012 Nov 10. [Epub ahead of print]

Calvani R, Joseph AM, Adhihetty PJ, Miccheli A, Bossola M, Leeuwenburgh C, Bernabei R, Marzetti E.
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.
Biol Chem. 2012 Nov 21. [Epub ahead of print]

Broos S, Malisoux L, Theisen D, Francaux M, Deldicque L, Thomis MA.
Role of alpha-actinin-3 in contractile properties of human single muscle fibers: A case series study in paraplegics.
PLoS One. 2012;7(11):e49281. Epub 2012 Nov 8.
NOTE: This article may be obtained online without charge.

Thomas KE, Bent LR.
Subthreshold vestibular reflex effects in seated humans can contribute to soleus activation when combined with cutaneous inputs.
Motor Control. 2012 Nov 15. [Epub ahead of print]

Mula J, Lee JD, Liu F, Yang L, Peterson CA.
Automated image analysis of skeletal muscle fiber cross-sectional area.
J Appl Physiol. 2012 Nov 8. [Epub ahead of print]

Mateus J, Hargens AR.
Bone hemodynamic responses to changes in external pressure.
Bone. 2012 Nov 17. [Epub ahead of print]

Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F.
Silent information regulator (Sir)T1 inhibits NFB signaling to maintain normal skeletal remodeling.
J Bone Miner Res. 2012 Nov 21. [Epub ahead of print]

Cardoso L, Fritton SP, Gailani G, Benalla M, Cowin SC.
Advances in assessment of bone porosity, permeability and interstitial fluid flow.
J Biomech. 2012 Nov 19. [Epub ahead of print]

Tanaka Y, Nakano J, Hamaue Y, Sekino Y, Sakamoto J, Kataoka H, Okita M.
Hindlimb suspension does not influence mechanical sensitivity, epidermal thickness, and peripheral nerve density in the glabrous skin of the rat hind paw.
Physiol Res. 2012 Nov 22. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Wirth F, Schempf G, Stein G, Wellmann K, Manthou M, Scholl C, Sidorenko M, Semler J, Eisel L, Harrach R, Angelova S, Jaminet P, Ankerne J, Ashrafi M, Ozsoy O, Ozsoy U, Schubert H, Abdulla D, Dunlop S, Angelov DN, Irintchev A, Schoenau E.
Whole-body vibration improves functional recovery in spinal cord-injured rats.
J Neurotrauma. 2012 Nov 16. [Epub ahead of print]

Desmoulin GT, Enns-Bray WS, Hewitt CR, Hunter CJ.
Multi-unit sustained vibration loading platform for biological tissues: Design, validation and experimentation.
J Biomech. 2012 Nov 13. [Epub ahead of print]

Jeffrey BA, Hannan MT, Quinn EK, Zimmerman S, Barton BA, Rubin CT, Kiel DP.
Self-reported adherence with the use of a device in a clinical trial as validated by electronic monitors: The VIBES study.
BMC Med Res Methodol. 2012 Nov 14;12:171. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Zhang L, Zou Y, Wang L, Pei X.
Hybrid force control based on ICMAC for an Astronaut Rehabilitative Training Robot.
Int J Adv Robotic Sys. 2012 Aug 10;9:55.
NOTE: This article may be obtained online without charge.

Sun W, Jia X, Xie T, Xu F, Liu Q.
Construction of boundary-surface-based Chinese female astronaut computational phantom and proton dose estimation.
J Radiat Res. 2012 Nov 7. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Friedrich T, Durante M, Scholz M.
Modeling cell survival after photon irradiation based on double-strand break clustering in megabase pair chromatin loops.
Radiat Res. 2012 Nov;178(5):385-94. Epub 2012 Sep 21.

Curwen GB, Tawn EJ, Cadwell KK, Guyatt L, Thompson J, Hill MA.
mFISH analysis of chromosome aberrations induced in vitro by -particle radiation: Examination of dose-response relationships.
Radiat Res. 2012 Nov;178(5):414-24. Epub 2012 Oct 19.

Bladen CL, Kozlowski DJ, Dynan WS.
Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, alone and in combination in a vertebrate embryo model.
Radiat Res. 2012 Nov;178(5):499-503. Epub 2012 Oct 23.

Budworth H, Snijders AM, Marchetti F, Mannion B, Bhatnagar S, Kwoh E, Tan Y, Wang SX, Blakely WF, Coleman M, Peterson L, Wyrobek AJ.
DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood.
PLoS One. 2012;7(11):e48619. Epub 2012 Nov 7.
NOTE: This article may be obtained online without charge.

Willey JS, Long DL, Vanderman KS, Loeser RF.
Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage.
Int J Radiat Biol. 2012 Nov 7. [Epub ahead of print]

Danielsson A, Claesson K, Parris TZ, Helou K, Nemes S, Elmroth K, Elgqvist J, Jensen H, Hultborn R.
Differential gene expression in human fibroblasts after alpha-particle emitter (211)At compared with (60)Co irradiation.
Int J Radiat Biol. 2012 Nov 7. [Epub ahead of print]

Staaf E, Brehwens K, Haghdoost S, Czub J, Wojcik A.
Gamma-H2AX foci in cells exposed to a mixed beam of X-rays and alpha particles.
Genome Integr. 2012 Nov 2;3:8. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Haro KJ, Sheth A, Scheinberg DA.
Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.
PLoS One. 2012;7(11):e48841. Epub 2012 Nov 14.
NOTE: This article may be obtained online without charge.

Dalecki M, Dern S, Steinberg F.
Mental rotation of a letter, hand and complex scene in microgravity.
Neurosci Lett. 2012 Nov 9. [Epub ahead of print]
NOTE: Parabolic flight results.

Correia Gracio BJ, de Winkel KN, Groen EL, Wentink M, Bos JE.
The time constant of the somatogravic illusion.
Exp Brain Res. 2012 Nov 4. [Epub ahead of print]

Bosco G, Delle Monache S, Lacquaniti F.
Catching what we can't see: Manual interception of occluded fly-ball trajectories.
PLoS One. 2012;7(11):e49381. Epub 2012 Nov 14.

Clemens IA, Selen LP, Koppen M, Medendorp WP.
Visual stability across combined eye and body motion.
J Vis. 2012 Nov 14;12(12):8.
NOTE: This article may be obtained online without charge.

Bjasch D, Bockisch CJ, Straumann D, Tarnutzer AA.
Differential effects of visual feedback on subjective visual vertical accuracy and precision.
PLoS One. 2012;7(11):e49311. Epub 2012 Nov 12.
NOTE: This article may be obtained online without charge.

Israel I, Giannopulu I.
Subjective posture in tridimensional space.
J Vestib Res. 2012 Jan 1;22(4):173-80.

Mersmann F, Bohm S, Bierbaum S, Dietrich R, Arampatzis A.
Young and old adults prioritize dynamic stability control following gait perturbations when performing a concurrent cognitive task.
Gait Posture. 2012 Oct 31. [Epub ahead of print]

Lin CL, Jung TP, Chuang SW, Duann JR, Lin CT, Chiu TW.
Self-adjustments may account for the contradictory correlations between HRV and motion-sickness severity.
Int J Psychophysiol. 2012 Nov 15. [Epub ahead of print]

Scherer MR, Claro PJ, Heaton KJ.
Sleep deprivation has no effect on dynamic visual acuity in military service members who are healthy.
Phys Ther. 2012 Nov 15. [Epub ahead of print]

Sellix MT, Evans JA, Leise TL, Castanon-Cervantes O, Hill DD, DeLisser P, Block GD, Menaker M, Davidson AJ.
Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators.
J Neurosci. 2012 Nov 14;32(46):16193-202.

Radugina EA, Grigoryan EN.
Morphogenetic changes during newt tail regeneration under changed gravity conditions.
Biol Bull. 2012 Sep;39(5):402-8.
NOTE: This is an English translation of the Russian original published in Izvestiya Akademii Nauk, Seriya Biologicheskaya 2012 Sep-Oct;(5):478-85:

Safonova TN, Mordkovich NN, Polyakov KM, Manuvera VA, Veiko VP, Popov VO.
Crystallization of uridine phosphorylase from Shewanella oneidensis MR-1 in the laboratory and under microgravity and preliminary X-ray diffraction analysis.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1387-9. Epub 2012 Oct 30.
NOTE: Protein was crystallized on ISS.

Timofeev V, Smirnova E, Chupova L, Esipov R, Kuranova I.
X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.
Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1660-70. Epub 2012 Nov 9.
NOTE: Used crystals grown on ISS.

Quirk S.
Crystallization and preliminary X-ray characterization of the Vitis vinifera fucokinase:GDP-fucose pyrophosphorylase.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1109-12. Epub 2012 Aug 31.
NOTE: Used rotary cell-culture system.

Berto A, Van der Poel WH, Hakze-van der Honing R, Martelli F, La Ragione RM, Inglese N, Collins J, Grierson S, Johne R, Reetz J, Dastjerdi A, Banks M.
Replication of hepatitis E virus in three-dimensional cell culture.
J Virol Methods. 2012 Nov 14. [Epub ahead of print]
NOTE: Used rotary cell-culture system.

Moissl-Eichinger C, Rettberg P, Pukall R.
The first collection of spacecraft-associated microorganisms: A public source for extremotolerant microorganisms from spacecraft assembly clean rooms.
Astrobiology. 2012 Nov;12(11):1024-34.

Sawada Y, Murase M, Sokabe M.
The gating mechanism of the bacterial mechanosensitive channel MscL revealed by molecular dynamics simulations: From tension sensing to channel opening.
Channels (Austin). 2012 Jul-Aug;6(4):317-31.
NOTE: The authors suggest that an individual amino acid is the primary tension sensor of this mechanosensitive channel.

Tyler WJ.
The mechanobiology of brain function.
Nat Rev Neurosci. 2012 Dec;13(12):867-78.

Borau C, Kim T, Bidone T, Garcia-Aznar JM, Kamm RD.
Dynamic mechanisms of cell rigidity sensing: Insights from a computational model of actomyosin networks.
PLoS One. 2012;7(11):e49174. Epub 2012 Nov 5.
NOTE: This article may be obtained online without charge.

Uzbekov RE, Maurel DB, Aveline PC, Pallu S, Benhamou CL, Rochefort GY.
Centrosome fine ultrastructure of the osteocyte mechanosensitive primary cilium.
Microsc Microanal. 2012 Nov 21:1-12. [Epub ahead of print]

Higuchi S, Lin Q, Wang J, Lim TK, Joshi SB, Anand GS, Chung MC, Sheetz MP, Fujita H.
Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells.
J Biosci Bioeng. 2012 Nov 17. [Epub ahead of print]

Chamindu DT, Moldrup P, Jensen MP, Jones SB, de Jonge LW, Schjonning P, Scow K, Hopmans JW, Rolston DE, Kawamoto K, Komatsu T.
Diffusion aspects of designing porous growth media for Earth and space.
Soil Sci Soc Am J. 2012 Sep;76(5):1564-78.

Vandenbussche F, Callebert P, Zadnikova P, Benkova E, Van Der Straeten D.
Brassinosteroid control of shoot gravitropism interacts with ethylene and depends on auxin signaling components.
Am J Bot. 2012 Nov 14. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Bai H, Murali B, Barber K, Wolverton C.
Low phosphate alters lateral root setpoint angle and gravitropism.
Am J Bot. 2012 Nov 1. [Epub ahead of print]

Wassim A, Ichrak BR, Saida A.
Putative role of proteins involved in detoxification of reactive oxygen species in the early response to gravitropic stimulation of poplar stems.
Plant Signal Behav. 2013 Jan;8(1).
NOTE: This article may be obtained online without charge.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.