NASA Spaceline Current Awareness 8 March 2013 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, March 8, 2013

image Next list: March 22, 2013

Papers deriving from NASA support:

Taylor CR, Hanna M, Behnke BJ, Stabley JN, McCullough DJ, Davis RT 3rd, Ghosh P, Papadopoulos A, Muller-Delp JM, Delp MD.
Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure.
FASEB J. 2013 Mar 1. [Epub ahead of print]
(PI: M.D. Delp)
NOTE: STS-135 results. From abstract: "Collectively, spaceflight-induced reductions in myogenic vasoconstriction and stiffness and increases in maximal diameter of cerebral arteries signify that elevations in brain blood flow may occur during spaceflight. Such changes in cerebral vascular control of perfusion could contribute to increases in intracranial pressure and an associated impairment of visual acuity in astronauts during spaceflight."

Taibbi G, Kaplowitz K, Cromwell RL, Godley BF, Zanello SB, Vizzeri G.
Effects of 30-day head-down bed rest on ocular structures and visual function in a healthy subject.
Aviat Space Environ Med. 2013 Feb;84(2):148-54.
(PIs: R.L. Cromwell, S.B. Zanello)

Murray DH, Pilmanis AA, Blue RS, Pattarini JM, Law J, Bayne CG, Turney MW, Clark JB.
Pathophysiology, prevention, and treatment of ebullism.
Aviat Space Environ Med. 2013 Feb;84(2):89-96.

Linnarsson D, Carpenter J, Fubini B, Gerde P, Karlsson LL, Loftus DJ, Prisk GK, Staufer U, Tranfield EM, van Westrenen W.
Toxicity of lunar dust.
Planet Space Sci. 2012 Dec;74(1):57-71.
(PIs: D.J. Loftus, G.K. Prisk)
NOTE: This article is in a special issue dedicated to the topic "Scientific Preparations for Lunar Exploration." The issue derives from a workshop of the same name hosted at ESA ESTEC in 2012. This article and the article below and 11 articles in the Other section are included in this list. The full Table of Contents can be viewed at:

Goswami N, Roma PG, De Boever P, Clement G, Hargens AR, Loeppky JA, Evans JM, Stein TP, Blaber AP, Van Loon JJ, Mano T, Iwase S, Reitz G, Hinghofer-Szalkay HG.
Using the Moon as a high-fidelity analogue environment to study biological and behavioral effects of long-duration space exploration.
Planet Space Sci. 2012 Dec;74(1):111-20.
(PIs: P.G. Roma, A.R. Hargens)

Beheshti A, Sachs RK, Peluso M, Rietman E, Hahnfeldt P, Hlatky L.
Age and space irradiation modulate tumor progression: Implications for carcinogenesis risk.
Radiat Res. 2013 Feb;179(2):208-20. Epub 2013 Jan 4.
(PIs: L. Hlatky/R.K. Sachs/P. Hahnfeldt/NSCOR)

Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, DiMaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD.
Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.
Mol Cancer Res. 2013 Feb 28. [Epub ahead of print]
(PIs: J.D. Minna/A.F. Gazdar/J.W. Shay/NSCOR)

Dingfelder M.
Updated model for dielectric response function of liquid water.
Appl Radiat Isot. 2013 Jan 18. [Epub ahead of print]
(PI: M. Dingfelder)

Songer JE, Eatock RA.
Tuning and timing in mammalian type I hair cells and calyceal synapses.
J Neurosci. 2013 Feb 20;33(8):3706-24.
(PI: J.E. Songer, NSBRI Postdoctoral Fellowship Program)
NOTE: This research is featured on the cover of the journal:

Yang LM, Zhong D, Blount P.
Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity.
Cell Rep. 2013 Feb 21;3(2):520-7. Epub 2013 Feb 14.
(PI: P. Blount)
NOTE: This article may be obtained online without charge.

Foster JS, Khodadad CL, Ahrendt SR, Parrish ML.
Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis.
Sci Rep. 2013 Feb 26;3:1340.
NOTE: This article may be obtained online without charge.

Other papers of interest:

Kapitonova MY, Muid S, Froemming GR, Yusoff WN, Othman S, Ali AM, Nawawi HM.
Real space flight travel is associated with ultrastructural changes, cytoskeletal disruption and premature senescence of HUVEC.
Malays J Pathol. 2012 Dec;34(2):103-13.
NOTE: ISS results. This article may be obtained online without charge:

Rafanelli C, Gostoli S, Roncuzzi R, Sassone B.
Psychological correlates of vasovagal versus medically unexplained syncope.
Gen Hosp Psychiatry. 2013 Feb 13. [Epub ahead of print]

Takahashi K, Kakimoto Y, Toda K, Naruse K.
Mechanobiology in cardiac physiology and diseases.
J Cell Mol Med. 2013 Feb;17(2):225-32.
NOTE: This article may be obtained online without charge.

Zhang Y, Wang H, Lai C, Wang L, Deng Y.
Comparative proteomic analysis of human SH-SY5Y neuroblastoma cells under simulated microgravity.
Astrobiology. 2013 Feb;13(2):143-50.
NOTE: Used clinostat to simulate microgravity.

Weiss P, Gardette B, Chirie B, Collina-Girard J, Delauze HG.
Simulation and preparation of surface EVA in reduced gravity at the Marseilles Bay subsea analogue sites.
Planet Space Sci. 2012 Dec;74(1):121-34.

Doarn CR, Mohler SR.
Physician training in aerospace medicine-an historical review in the United States.
Aviat Space Environ Med. 2013 Feb;84(2):158-62.

Howard BJ, Fraser SF, Sethi P, Cerin E, Hamilton MT, Owen N, Dunstan DW, Kingwell BA.
Impact on hemostatic parameters of interrupting sitting with intermittent activity.
Med Sci Sports Exerc. 2013 Feb 22. [Epub ahead of print]
NOTE: This article and the following two articles are representative of the growing body of research on the negative effects of sitting and inactivity.

Leon-Munoz LM, Martinez-Gomez D, Balboa-Castillo T, Lopez-Garcia E, Guallar-Castillon P, Rodriguez-Artalejo F.
Continued sedentariness, change in sitting time, and mortality in older adults.
Med Sci Sports Exerc. 2013 Feb 22. [Epub ahead of print]

Duvivier BM, Schaper NC, Bremers MA, van Crombrugge G, Menheere PP, Kars M, Savelberg HH.
Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous exercise (cycling) in sedentary subjects when energy expenditure is comparable.
PLoS One. 2013;8(2):e55542. Epub 2013 Feb 13.
NOTE: This article may be obtained online without charge.

Qi Z, Zhang Y, Guo W, Ji L, Ding S.
Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading.
Int J Mol Sci. 2012 Dec 11;13(12):16971-85.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher's site:

Li J, Spieker AJ, Rosen GD, Rutkove SB.
Electrical impedance alterations in the rat hind limb with unloading.
J Musculoskelet Neuronal Interact. 2013 Mar;13(1):37-44.
NOTE: This article may be obtained online without charge.

Dalecki M, Bock O.
Changed joint position sense and muscle activity in simulated weightlessness by water immersion.
Aviat Space Environ Med. 2013 Feb;84(2):110-5.

Zhao XH, Fan XL.
[Relationship between simulated weightlessness-induced muscle spindle change and muscle atrophy]
Sheng Li Xue Bao. 2013 Feb 25;65(1):96-100. Chinese.
NOTE: This article may be obtained online without charge.

Hody S, Lacrosse Z, Leprince P, Collodoro M, Croisier JL, Rogister B.
Effects of eccentrically and concentrically biased training on mouse muscle phenotype.
Med Sci Sports Exerc. 2013 Feb 22. [Epub ahead of print]

Milanese C, Piscitelli F, Zenti MG, Moghetti P, Sandri M, Zancanaro C.
Ten-week whole-body vibration training improves body composition and muscle strength in obese women.
Int J Med Sci. 2013;10(3):307-11. Epub 2013 Feb 2.
NOTE: This article may be obtained online without charge.

Vikhlyantsev IM, Podlubnaya ZA.
New titin (connectin) isoforms and their functional role in striated muscles of mammals: Facts and suppositions.
Biochemistry (Mosc). 2012 Dec;77(13):1515-35.
NOTE: This article includes a review of microgravity and simulated microgravity research on this topic. The article is a translation in English of the Russian original published in Uspekhi Biologicheskoi Khimii 2012;52:239-80.

Turturici M, Roatta S.
Compression-induced hyperaemia in the rabbit masseter muscle: A model to investigate vascular mechano-sensitivity of skeletal muscle.
Physiol Meas. 2013 Mar;34(3):307-14. Epub 2013 Feb 12.

Lazareva MV, Trapeznikova KO, Vikhlyantsev IM, Bobylev AG, Klimov AA, Podlubnaya ZA.
Seasonal changes in the isoform composition of the myosin heavy chains in skeletal muscles of hibernating ground squirrels Spermophilus undulatus.
Biophysics. 2012 Nov;57(6):764-8.
NOTE: This paper is a translation in English of the Russian original published in Biofizika. 2012 Nov-Dec;57(6):982-7:

Frings-Meuthen P, Boehme G, Liphardt AM, Baecker N, Heer M, Rittweger J.
Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men.
J Musculoskelet Neuronal Interact. 2013 Mar;13(1):45-52.
NOTE: Bed rest studies. This article may be obtained online without charge.

Stolzenberg N, Belav DL, Beller G, Armbrecht G, Semler J, Felsenberg D.
Bone strength and density via pQCT in post-menopausal osteopenic women after 9 months resistive exercise with whole body vibration or proprioceptive exercise.
J Musculoskelet Neuronal Interact. 2013 Mar;13(1):66-76.
NOTE: This article may be obtained online without charge.

Marchand-Libouban H, Le Drevo MA, Chappard D.
Disuse induced by botulinum toxin affects the bone marrow expression profile of bone genes leading to a rapid bone loss.
J Musculoskelet Neuronal Interact. 2013 Mar;13(1):27-36.
NOTE: This article may be obtained online without charge.

Zhang P, Wu Y, Dai Q, Fang B, Jiang L.
p38-MAPK signaling pathway is not involved in osteogenic differentiation during early response of mesenchymal stem cells to continuous mechanical strain.
Mol Cell Biochem. 2013 Feb 23. [Epub ahead of print]

Vincent TL.
Targeting mechanotransduction pathways in osteoarthritis: A focus on the pericellular matrix.
Curr Opin Pharmacol. 2013 Feb 18. [Epub ahead of print]

Shimada M, Hirayama R, Komatsu K.
High LET radiation amplifies centrosome overduplication through a pathway of -tubulin monoubiquitination.
Int J Radiat Oncol Biol Phys. 2013 Feb 20. [Epub ahead of print]

Schmid TE, Zlobinskaya O, Multhoff G.
Differences in phosphorylated histone H2AX foci formation and removal of cells exposed to low and high linear energy transfer radiation.
Curr Genomics. 2012 Sep;13(6):418-25.
NOTE: This article may be obtained online without charge via PubMed Central.

Wada M, Suzuki M, Liu C, Kaneko Y, Fukuda S, Ando K, Matsufuji N.
Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation.
J Radiat Res. 2013 Feb 28. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Durante M.
Space radiobiology on the Moon.
Planet Space Sci. 2012 Dec;74(1):72-7.

Reitz G, Berger T, Matthiae D.
Radiation exposure in the moon environment.
Planet Space Sci. 2012 Dec;74(1):78-83.

De Vos WH, Meesen G, Szpirer C, Scohy S, Cherukuri C, Evrard O, Hutsebaut X, Beghuin D.
The AMERE project: Enabling real-time detection of radiation effects in individual cells in deep space.
Planet Space Sci. 2012 Dec;74(1):84-96.

Karim H, Fuhrman SI, Sparto P, Furman J, Huppert T.
Functional brain imaging of multi-sensory vestibular processing during computerized dynamic posturography using near-infrared spectroscopy.
Neuroimage. 2013 Feb 15. [Epub ahead of print]

Schneider S, Bubeev JA, Chouker A, Morukov B, Johannes B, Strueder HK.
Imaging of neuro-cognitive performance in extreme Environments--A (p)review.
Planet Space Sci. 2012 Dec;74(1):135-41.
NOTE: This article includes a review of space flight and analog environment research related to this topic.

Minetti AE, Pavei G, Biancardi CM.
The energetics and mechanics of level and gradient skipping: Preliminary results for a potential gait of choice in low gravity environments.
Planet Space Sci. 2012 Dec;74(1):142-5.

Newman MC, McCarthy GW, Glaser ST, Bonato F, Bubka A.
Motion sickness adaptation to Coriolis-inducing head movements in a sustained G flight simulator.
Aviat Space Environ Med. 2013 Feb;84(2):104-9.

Newlands SD, Wei M.
Tests of linearity in the responses of eye-movement-sensitive vestibular neurons to sinusoidal yaw rotation.
J Neurophysiol. 2013 Feb 27. [Epub ahead of print]

Hartmann M, Furrer S, Herzog MH, Merfeld DM, Mast FW.
Self-motion perception training: Thresholds improve in the light but not in the dark.
Exp Brain Res. 2013 Feb 8. [Epub ahead of print]

Thomas KE, Bent LR.
Subthreshold vestibular reflex effects in seated humans can contribute to soleus activation when combined with cutaneous inputs.
Motor Control. 2013 Jan;17(1):62-74.

Chen A, DeAngelis GC, Angelaki DE.
Functional specializations of the ventral intraparietal area for multisensory heading discrimination.
J Neurosci. 2013 Feb 20;33(8):3567-81.

Moeller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ.
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.
Proc Natl Acad Sci U S A. 2013 Feb 25. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH.
Circadian disruption leads to insulin resistance and obesity.
Curr Biol. 2013 Mar 4;23(5):372-81. Epub 2013 Feb 21.
NOTE: This article may be obtained online without charge.

Thompson T.
Joseph V. Brady: Synthesis reunites what analysis has divided.
Behav Anal. 2012 Fall;35(2):197-208.
NOTE: This article is a reflection on the career and impact of Joseph V. Brady, including his contributions to NASA and space-related research. This article may be obtained online without charge via PubMed Central.

Guidetti R, Rizzo AM, Altiero T, Rebecchi L.
What can we learn from the toughest animals of the Earth? Water bears (tardigrades) as multicellular model organisms in order to perform scientific preparations for lunar exploration.
Planet Space Sci. 2012 Dec;74(1):97-102.
NOTE: This article includes a review of previous space experiments with tardigrades conducted on Foton and the Shuttle.

Calich HJ, Wassersug RJ.
The architecture of the aquatic environment and its influence on the growth and development of tadpoles (Xenopus laevis).
Copeia 2012;(4):690-7.
NOTE: This article discusses the relevance of this research to raising aquatic vertebrates in artificial habitats with small volumes of water, and includes a review of aquatic vertebrate experiments in space.

Liu HB, Zhang J, Xin SY, Liu C, Wang CY, Zhao D, Zhang ZR.
Mechanosensitive properties in endothelium and their roles in regulation of endothelial function.
J Cardiovasc Pharmacol. 2013 Feb 20. [Epub ahead of print]

Spanjaard E, de Rooij J.
Mechanotransduction: Vinculin provides stability when tension rises.
Curr Biol. 2013 Feb 18;23(4):R159-61.

Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fuerst DO, Volkmer R, Hoffmann B, Kolanus W, Hoehfeld J.
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Curr Biol. 2013 Mar 4;23(5):430-5. Epub 2013 Feb 21.
NOTE: This research is featured on the cover of the journal:

Balasubramanian L, Lo CM, Sham JS, Yip KP.
Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction.
Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C382-91. Epub 2013 Jan 16.

Carpenter JD, Crawford IA, Cockell C, Koschny D, Jaumann R, Wieczorek M.
Scientific preparations for lunar exploration.
Planet Space Sci. 2012 Dec;74(1):1-2.

Crawford IA, Anand M, Cockell CS, Falcke H, Green DA, Jaumann R, Wieczorek MA.
Back to the Moon: The scientific rationale for resuming lunar surface exploration.
Planet Space Sci. 2012 Dec;74(1):3-14.

de Vera JP, Boettger U, de la Torre Noetzel R, Sanchez FJ, Grunow D, Schmitz N, Lange C, Huebers HW, Billi D, Baque M, Rettberg P, Rabbow E, Reitz G, Berger T, Moeller R, Bohmeier M, Horneck G, Westall F, Jaenchen J, Fritz J, Meyer C, Onofri S, Selbmann L, Zucconi L, Kozyrovska N, Leya T, Foing B, Demets R, Cockell CS, Bryce C, Wagner D, Serrano P, Edwards HG, Joshi J, Huwe B, Ehrenfreund P, Elsaesser A, Ott S, Meessen J, Feyh N, Szewzyk U, Jaumann R, Spohn T.
Supporting Mars exploration: BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology.
Planet Space Sci. 2012 Dec;74(1):103-10.
NOTE: This article describes a future experiment on ISS.

Carpenter JD, Fisackerly R, De Rosa D, Houdou B.
Scientific preparations for lunar exploration with the European Lunar Lander.
Planet Space Sci. 2012 Dec;74(1):208-23.

NOTE: The December 2012 issue of the Springer journal Human Physiology contains full translations of 26 articles that appeared, in Russian, in earlier issues of the journal Aviakosmicheskaia i ekologicheskaia meditsina. Some of the articles appeared in previous Current Awareness lists under the Aviakosmicheskaia journal. Duplicate articles are not entered in these lists; however, since this is an opportunity for those with free access to Springer journals to obtain translations of papers otherwise not available, they are mentioned here. Four of the articles report space flight results and they are listed below. The full table of contents can be viewed at:

Fomina GA, Kotovskaya AR, Temnova EV.
Dynamics of human cardiovascular responses in different periods of long-term exposure to weightlessness.
Hum Physiol. 2012 Dec;38(7):715-20.
NOTE: Mir results. This is a translation in English of the Russian original published in Aviakosmicheskaia i ekologicheskaia meditsina 2009 May-Jun;43(3):11-16.

Turchaninova VF, Alferova IV, Krivolapov VV.
Some aspects of the comparative analysis of hemodynamic responses to LBNP tests in cosmonauts of different age groups.
Hum Physiol. 2012 Dec;38(7):721-6.
NOTE: Mir, ISS results. This is a translation in English of the Russian original published in Aviakosmicheskaia i ekologicheskaia meditsina 2010 Jan-Feb;44(1):20-5.

Prostyakov IV, Morukov BV, Morukov IB.
Changes in bone mineral density and microarchitecture in cosmonauts after a six-month space flight,
Hum Physiol. 2012 Dec;38(7):727-31.
NOTE: ISS results. This is a translation in English of the Russian original published in Aviakosmicheskaia i ekologicheskaia meditsina 2010 May-Jun;44(3):24-8.

Oganov VS, Baranov VS, Kabitskaya OE, Novikov VE, Bakulin AV, Moskalenko MV, Aseev MV, Voitulevich LV.
Analysis of polymorphism of bone metabolism genes and evaluation of the risk of osteopenia in cosmonauts.
Hum Physiol. 2012 Dec;38(7):732-7.
NOTE: Mir, ISS results. This is a translation in English of the Russian original published in Aviakosmicheskaia i ekologicheskaia meditsina 2010 May-Jun;44(3):18-23.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.