NASA Spaceline Current Awareness 10 May 2013 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Saturday, May 11, 2013

image Next list: May 24, 2013
Papers deriving from NASA support:
Schlabs T, Rosales-Velderrain A, Ruckstuhl H, Stahn AC, Hargens AR.
Comparison of cardiovascular and biomechanical parameters of supine LBNP and upright LBPP to simulate activity in 1/6-G and 3/8-G.
J Appl Physiol. 2013 May 2. [Epub ahead of print]
(PI: A.R. Hargens)

Kothadia R, Kulecz WB, Kofman IS, Black AJ, Grier JW, Schlegel TT.
New system for digital to analog transformation and reconstruction of 12-lead ECGs.
PLoS One. 2013 Apr 11;8(4):e61076.
(PI: R. Kothadia, NSBRI summer student internship program)
NOTE: A patent application has been filed; see the "Competing Interests" section of the front matter of the article. This article may be obtained online without charge.

Parsons-Wingerter P, Reinecker HC.
For application to human spaceflight and ISS experiments: VESGEN mapping of microvascular network remodeling during intestinal inflammation.
Gravit Space Biol 2012 Oct;26(2):2-12.
NOTE: This article may be obtained online without charge.

Tedjasaputra V, Sa RC, Arai TJ, Holverda S, Theilmann RJ, Chen WT, Wagner PD, Davis CK, Prisk GK, Hopkins SR.
The heterogeneity of regional specific ventilation is unchanged following heavy exercise in athletes.
J Appl Physiol. 2013 May 2. [Epub ahead of print]
(PI: R.C. Sa, NSBRI Postdoctoral Fellowship Program)

Henderson AC, Sa RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR.
The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung.
J Appl Physiol. 2013 Apr 25. [Epub ahead of print]
(PIs: R.C. Sa, NSBRI Postdoctoral Fellowship Program; G.K. Prisk)

James JT, Lam CW, Santana PA, Scully RR.
Estimate of safe human exposure levels for lunar dust based on comparative benchmark dose modeling.
Inhal Toxicol. 2013 Apr;25(5):243-56.
(PIs: J.T. James, C.W. Lam)

Wong WC, Zalesak S, Yoets A, Capriotti J, Smith MJ, Castro VA, Pierson DL.
Engineering case report. Effectiveness of HEPA filter vacuum in removing transient microbial contaminants on cargo bags destined for the International Space Station.
J Occup Environ Hyg. 2013 Jun;10(6):D71-5.

Blaber EA, Dvorochkin N, Lee C, Alwood JS, Yousuf R, Pianetta P, Globus RK, Burns BP, Almeida EA.
Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21.
PLoS One. 2013 Apr 18;8(4):e61372.
(PI: E.A. Almeida)
NOTE: STS-131 results. This article may be obtained online without charge.

Zwart SR, Parsons H, Kimlin M, Innis SM, Locke JP, Smith SM.
A 250 g/week dose of vitamin D was as effective as a 50 g/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 g raised the risk of hypercalciuria.
Br J Nutr. 2013 Apr 18:1-7. [Epub ahead of print]
(PI: S.M. Smith, HRP Flight Analogs Project)

Bailey JF, Hargens AR, Cheng KK, Lotz JC.
Post-spaceflight recovery of biomechanical properties of murine intervertebral discs.
Gravit Space Biol 2012 Oct;26(2):38-47.
(PI: A.R. Hargens)
NOTE: STS-133 results. This article may be obtained online without charge.

Van Dyke JM, Bain JL, Riley DA.
Stretch activated signaling is modulated by stretch magnitude and contraction.
Muscle Nerve. 2013 Apr 26. [Epub ahead of print]
(J.M. Van Dyke, Wisconsin Space Grant Consortium graduate fellowship)

George K, Rhone J, Beitman A, Cucinotta FA.
Cytogenetic damage in the blood lymphocytes of astronauts: Effects of repeat long-duration space missions.
Mutat Res. 2013 Apr 29. [Epub ahead of print]
(PI: F.A. Cucinotta)
NOTE: ISS results. This article may be obtained online without charge.

Wang M, Saha J, Cucinotta FA.
Smad7 foci are present in micronuclei induced by heavy particle radiation.
Mutat Res. 2013 Apr 30. [Epub ahead of print]
(PIs: M. Wang; F.A. Cucinotta)

Kronenberg A, Gauny S, Kwoh E, Grossi G, Dan C, Grygoryev D, Lasarev M, Turker MS.
Comparative analysis of cell killing and autosomal mutation in mouse kidney epithelium exposed to 1 GeV protons in vitro or in vivo.
Radiat Res. 2013 May;179(5):511-20. Epub 2013 Apr 5.
(PIs: A. Kronenberg, M.S. Turker)

Turker MS, Grygoryev D, Dan C, Eckelmann B, Lasarev M, Gauny S, Kwoh E, Kronenberg A.
Autosomal mutations in mouse kidney epithelial cells exposed to high-energy protons in vivo or in culture.
Radiat Res. 2013 May;179(5):521-9. Epub 2013 Apr 5.
(PIs: M.S. Turker, A. Kronenberg)
NOTE: This article is featured on the cover of the journal:

Haley GE, Yeiser L, Olsen RH, Davis MJ, Johnson LA, Raber J.
Early effects of whole-body (56)Fe irradiation on hippocampal function in C57BL/6J mice.
Radiat Res. 2013 May;179(5):590-6. Epub 2013 Mar 19.
(PIs: G.E. Haley, NSBRI Postdoctoral Fellowship Program; J. Raber; G.A. Nelson/J. Raber/NSCOR)

Le PN, Maranon DG, Altina NH, Battaglia CL, Bailey SM.
TERRA, hnRNP A1, and DNA-PKcs interactions at human telomeres.
Front Oncol. 2013 Apr 17;3:91.
(PI: S.M. Bailey)
NOTE: This article may be obtained online without charge.

Aravindan S, Natarajan M, Herman TS, Aravindan N.
Radiation-induced TNF cross signaling-dependent nuclear import of NFB favors metastasis in neuroblastoma.
Clin Exp Metastasis. 2013 Apr 14. [Epub ahead of print]
(PI: M. Natarajan)

Mohawk JA, Pezuk P, Menaker M.
Methamphetamine and dopamine receptor D1 regulate entrainment of murine circadian oscillators.
PLoS One. 2013 Apr 23;8(4):e62463.
(PI: M. Menaker)
NOTE: This article may be obtained online without charge.

Bjorum SM, Simonette RA, Alanis R Jr, Wang JE, Lewis BM, Trejo MH, Hanson KA, Beckingham KM.
The Drosophila BTB domain protein jim lovell has roles in multiple larval and adult behaviors.
PLoS One. 2013 Apr 19;8(4):e61270.
(PI: K.M. Beckingham)
NOTE: This article may be obtained online without charge.

Chan KL, Inan OT, Bhattacharya S, Marcu O.
Estimating the speed of Drosophila locomotion using an automated behavior detection and analysis system.
Fly (Austin). 2012 Jul-Sep;6(3):205-10.
(PI: S. Bhattacharya)

Smith IM, Forsman AD.
Ovarian follicular and luteal development in the spaceflight mouse.
Gravit Space Biol 2012 Oct;26(2):30-7.
NOTE: STS-118 results. This article may be obtained online without charge.

Wan Salim WW, Zeitchek MA, Hermann AC, Ricco AJ, Tan M, Selch F, Fleming E, Bebout BM, Bader MM, ul Haque A, Porterfield DM.
Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research.
J Vis Exp. 2013 Apr 18;(74).

Schultz ER, Zupanska AK, Manning-Roach S, Camacho J, Levine H, Paul AL, Ferl RJ.
Testing the bio-compatibility of aluminum PDFU BRIC hardware.
Gravit Space Biol 2012 Oct;26(2):48-63.
NOTE: This article may be obtained online without charge.

Other papers of interest:

Xu D, Shoemaker JK, Blaber AP, Arbeille P, Fraser KS, Hughson RL.
Reduced heart rate variability during sleep in long-duration spaceflight.
Am J Physiol Regul Integr Comp Physiol. 2013 May 1. [Epub ahead of print]
NOTE: ISS results.

Zhang WC, Lu YM, Yang HZ, Xu PT, Chang H, Yu ZB.
[Four-week simulated weightlessness increases the expression of atrial natriuretic peptide in the myocardium]
Sheng Li Xue Bao. 2013 Apr 25;65(2):143-8. Chinese.
NOTE: Translated title of journal is Acta Physiologica Sinica. This article may be obtained online without charge.

Sun XQ.
[Microgravity-induced cardiovascular deconditioning: Mechanisms and countermeasures]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Nov;28(6):532-9.
NOTE: Translated title of journal is Chinese Journal of Applied Physiology.

Faes L, Mase M, Nollo G, Chon KH, Florian JP.
Measuring postural-related changes of spontaneous baroreflex sensitivity after repeated long-duration diving: Frequency domain approaches.
Auton Neurosci. 2013 Apr 13. [Epub ahead of print]

Kruel LF, Tartaruga LA, Coertjens M, Dias AB, da Silva RC, Rangel AC.
Using heart rate to prescribe physical exercise during head-out water immersion Exercise during head-out water immersion and heart rate.
J Strength Cond Res. 2013 Apr 15. [Epub ahead of print]

Xiao HJ, Liu XP, Zang B, Wang GY, Gu Z.
[The denitrogenation by breathing oxygen-rich gas to prevent altitude decompression sickness]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Nov;28(6):568-71.
NOTE: Translated title of journal is Chinese Journal of Applied Physiology.

Wang Q, Belhomme M, Guerrero F, Mazur A, Lambrechts K, Theron M.
Diving under a microscope -- A new simple and versatile in vitro diving device for fluorescence and confocal microscopy allowing the controls of hydrostatic pressure, gas pressures, and kinetics of gas saturation.
Microsc Microanal. 2013 Apr 17:1-9. [Epub ahead of print]

Trinel D, Picquet F, Bastide B, Canu MH.
Dendritic spine remodeling induced by hindlimb unloading in adult rat sensorimotor cortex.
Behav Brain Res. 2013 Apr 19. [Epub ahead of print]

Yoshioka M, Yamaguchi T, Ohta H, Gyotoku J, Miyamoto M, Ochiai T.
Effects of parabolic flight on serotonin-related gene expression in the mouse brain.
Gravit Space Biol 2012 Oct;26(2):22-9.
NOTE: Parabolic flight results. This article may be obtained online without charge.

van Hees VT, Gorzelniak L, Dean Leon EC, Eder M, Pias M, Taherian S, Ekelund U, Renstroem F, Franks PW, Horsch A, Brage S.
Separating movement and gravity components in an acceleration signal and implications for the assessment of human daily physical activity.
PLoS One. 2013 Apr 23;8(4):e61691.
NOTE: This article may be obtained online without charge.

Roda A, Mirasoli M, Guardigli M, Simoni P, Festi D, Afonin B, Vasilyeva G.
Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project.
World J Gastroenterol. 2013 Apr 14;19(14):2208-16.
NOTE: This article may be obtained online without charge.

Ichijo T, Hieda H, Ishihara R, Yamaguchi N, Nasu M.
Bacterial monitoring with adhesive sheet in the International Space Station-"Kibo", the Japanese Experiment Module.
Microbes Environ. 2013 Apr 20. [Epub ahead of print]
NOTE: ISS results. This article may be obtained online without charge.

Rouble AN, Hefler J, Mamady H, Storey KB, Tessier SN.
Anti-apoptotic signaling as a cytoprotective mechanism in mammalian hibernation.
PeerJ. 2013 Feb 12;1:e29.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher's site:

Senf SM, Howard TM, Ahn B, Ferreira LF, Judge AR.
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.
PLoS One. 2013 Apr 23;8(4):e62687.
NOTE: This article may be obtained online without charge.

Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM.
Two weeks of reduced activity decreases leg lean mass and induces 'anabolic resistance' of myofibrillar protein synthesis in healthy elderly.
J Clin Endocrinol Metab. 2013 Apr 15. [Epub ahead of print]

Hazell TJ, Olver TD, Hamilton CD, Lemon PW.
Addition of synchronous whole-body vibration to body mass resistive exercise causes little or no effects on muscle damage and/or inflammation.
J Strength Cond Res. 2013 Apr 23. [Epub ahead of print]

Mikus CR, Boyle LJ, Borengasser SJ, Oberlin DJ, Naples SP, Fletcher J, Meers GM, Ruebel M, Laughlin MH, Dellsperger KC, Fadel PJ, Thyfault JP.
Simvastatin impairs exercise training adaptations.
J Am Coll Cardiol. 2013 Apr 10. [Epub ahead of print]

Kavanagh JJ, Cresswell AG, Sabapathy S, Carroll TJ.
Bilateral tremor responses to unilateral loading and fatiguing muscle contractions.
J Neurophysiol. 2013 May 1. [Epub ahead of print]

Schulte FA, Ruffoni D, Lambers FM, Christen D, Webster DJ, Kuhn G, Mueller R.
Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level.
PLoS One. 2013 Apr 24;8(4):e62172.
NOTE: This article may be obtained online without charge.

Shiffman CA.
Circuit modeling of the electrical impedance: Part III. Disuse following bone fracture.
Physiol Meas. 2013 May;34(5):487-502. Epub 2013 Apr 15.
NOTE: From abstract: "Fundamental considerations aside, the sensitivity, reproducibility and technical simplicity of the technique recommend its use for in-flight assessments of muscles during orbital or interplanetary missions."

Wang H, Ji B, Liu XS, van Oers RF, Guo XE, Huang Y, Hwang KC.
Osteocyte-viability-based simulations of trabecular bone loss and recovery in disuse and reloading.
Biomech Model Mechanobiol. 2013 Apr 13. [Epub ahead of print]
NOTE: A modeling/simulation approach.

Dallas SL, Prideaux M, Bonewald LF.
The osteocyte: An endocrine cell and more.
Endocr Rev. 2013 Apr 26. [Epub ahead of print]

Starnes JW, Neidre DB, Nyman JS, Roy A, Nelson MJ, Gutierrez G, Wang X.
Synergistic effect of exercise and statins on femoral strength in rats.
Exp Gerontol. 2013 Apr 26. [Epub ahead of print]

Davis ME, Gumucio JP, Sugg KB, Bedi A, Mendias CL.
MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix.
J Appl Physiol. 2013 May 2. [Epub ahead of print]

Morgan WF, Bair WJ.
Issues in low dose radiation biology: The controversy continues. A perspective.
Radiat Res. 2013 May;179(5):501-10. Epub 2013 Apr 5.

Taleei R, Nikjoo H.
The non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks: I. A mathematical model.
Radiat Res. 2013 May;179(5):530-9. Epub 2013 Apr 5.

Taleei R, Girard PM, Sankaranarayanan K, Nikjoo H.
The non-homologous end-joining (NHEJ) mathematical model for the repair of double-strand breaks: II. Application to damage induced by ultrasoft X rays and low-energy electrons.
Radiat Res. 2013 May;179(5):540-8. Epub 2013 Apr 5.

Mueller I, Merk B, Voss KO, Averbeck N, Jakob B, Durante M, Taucher-Scholz G.
Species conserved DNA damage response at the inactive human X chromosome.
Mutat Res. 2013 Apr 27. [Epub ahead of print]

Narici L, Paci M, Brunetti V, Rinaldi A, Sannita WG, Carozzo S, DeMartino A.
Bovine rod rhodopsin:2. Bleaching in vitro upon (12)C ions irradiation as source of effects as light flash for patients and for humans in the space.
Int J Radiat Biol. 2013 May 2. [Epub ahead of print]

Mairani A, Boehlen TT, Dokic I, Cabal G, Brons S, Haberer T.
Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation.
Int J Radiat Biol. 2013 Apr 29. [Epub ahead of print]

Nieri D, Berardinelli F, Sgura A, Cherubini R, De Nadal V, Gerardi S, Tanzarella C, Antoccia A.
Cyogenetics effects in AG01522 human primary fibroblasts exposed to low-doses of radiations with different quality.
Int J Radiat Biol. 2013 Apr 22. [Epub ahead of print]

Shirai H, Fujimori H, Gunji A, Maeda D, Hirai T, Poetsch AR, Harada H, Yoshida T, Sasai K, Okayasu R, Masutani M.
Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation.
Biochem Biophys Res Commun. 2013 Apr 23. [Epub ahead of print]

Schmael F.
Neuronal mechanisms and the treatment of motion sickness.
Pharmacology. 2013 May;91(3-4):229-41.
NOTE: The article includes the author's categorization and discussion of various types of sensory conflicts that can provoke motion sickness. The article may be obtained online without charge.

Wang ZB, Han P, Tu Y, Liu WY, Tao BL, Zhang LC, Li L.
Oxidative stress is not involved in motion sickness in mice.
CNS Neurosci Ther. 2013 Apr 24. [Epub ahead of print]

Saradjian AH, Tremblay L, Perrier J, Blouin J, Mouchnino L.
Cortical facilitation of proprioceptive inputs related to gravitational balance constraints during step preparation.
J Neurophysiol. 2013 Apr 10. [Epub ahead of print]
NOTE: Parabolic flight results.

Barresi M, Grasso C, Li Volsi G, Manzoni D.
Effects of body to head rotation on the labyrinthine responses of rat vestibular neurons.
Neuroscience. 2013 Apr 13. [Epub ahead of print]

Belmonti V, Cioni G, Berthoz A.
Development of anticipatory orienting strategies and trajectory formation in goal-oriented locomotion.
Exp Brain Res. 2013 May;227(1):131-47. Epub 2013 Apr 16.

Pfeiffer C, Lopez C, Schmutz V, Duenas JA, Martuzzi R, Blanke O.
Multisensory origin of the subjective first-person perspective: Visual, tactile, and vestibular mechanisms.
PLoS One. 2013 Apr 22;8(4):e61751.
NOTE: This article may be obtained online without charge.

Dimiccoli M, Girard B, Berthoz A, Bennequin D.
Striola magica. A functional explanation of otolith geometry.
J Comput Neurosci. 2013 Apr 16. [Epub ahead of print]

Ferre ER, Vagnoni E, Haggard P.
Vestibular contributions to bodily awareness.
Neuropsychologia. 2013 Apr 25. [Epub ahead of print]

Fisher SP, Foster RG, Peirson SN.
The circadian control of sleep.
Handb Exp Pharmacol. 2013;217:157-83.
NOTE: This volume is on the topic "Circadian Clocks":

Tobaldini E, Cogliati C, Fiorelli EM, Nunziata V, Wu MA, Prado M, Bevilacqua M, Trabattoni D, Porta A, Montano N.
One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians.
Eur J Intern Med. 2013 Apr 16. [Epub ahead of print]

Gomoiu I, Chatzitheodoridis E, Vadrucci S, Walther I.
The effect of spaceflight on growth of Ulocladium chartarum colonies on the International Space Station.
PLoS One. 2013 Apr 24;8(4):e62130.
NOTE: ISS results. This article may be obtained online without charge.

Yang W, Han L, Mandlaa M, Chen H, Jiang M, Zhang Z, Xu H.
Spaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis.
Lett Appl Microbiol. 2013 May 9. [Epub ahead of print]
NOTE: Results from strains flown on Shenzhou 7.

Timofeev VI, Kuznetsov SA, Akparov VKh, Chestukhina GG, Kuranova IP.
Three-dimensional structure of carboxypeptidase T from Thermoactinomyces vulgaris in complex with N-BOC-L-leucine.
Biochemistry (Mosc). 2013 Mar;78(3):252-9.
NOTE: Crystals grown on ISS. This is a translation in English of the Russian original published in Biokhimiya 2013;78(3):338-47. The article may be obtained online without charge.

Herbst-Kralovetz MM, Radtke AL, Lay MK, Hjelm BE, Bolick AN, Sarker SS, Atmar RL, Kingsley DH, Arntzen CJ, Estes MK, Nickerson CA.
Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells.
Emerg Infect Dis. 2013 Mar;19(3):431-8.
NOTE: Used rotating wall vessel bioreactor. This article may be obtained online without charge. This is another journal with covers featuring art:

Seong J, Wang N, Wang Y.
Mechanotransduction at focal adhesions: From physiology to cancer development.
J Cell Mol Med. 2013 Apr 18. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Buer CS, Kordbacheh F, Truong TT, Hocart CH, Djordjevic MA.
Alteration of flavonoid accumulation patterns in transparent testa mutants disturbs auxin transport, gravity responses, and imparts long-term effects on root and shoot architecture.
Planta. 2013 Apr 27. [Epub ahead of print]

Azuma T, Inoue Y, Hamada Y, Okishio T, Sasayama D, Itoh K.
Anoxia promotes gravitropic curvature in rice pulvini but inhibits it in wheat and oat pulvini.
J Plant Physiol. 2013 Apr 13. [Epub ahead of print]

Rosquete MR, von Wangenheim D, Marhav P, Barbez E, Stelzer EH, Benkova E, Maizel A, Kleine-Vehn J.
An auxin transport mechanism restricts positive orthogravitropism in lateral roots.
Curr Biol. 2013 May 6;23(9):817-22.
NOTE: This article may be obtained online without charge.

Nardone E, Kevan PG, Stasiak M, Dixon M.
Atmospheric pressure requirements of bumblebees (Bombus impatiens) as pollinators of lunar or Martian greenhouse grown food.
Gravit Space Biol 2012 Oct;26(2):13-21.
NOTE: This article may be obtained online without charge.

Taylor E, Krikorian AD.
Somatic embryos at low gravity in space - Cosmos 782.
Google YouTube video, published April 24, 2013.
NOTE: Note that accompanies video: "Abraham D. Krikorian reminisces about US/USSR plant biosatellite program with embryogenic cells of wild carrot (Daucus carota L.) flown for 19.5 days at low gravity in Nov-Dec 1975." This and other Cosmos 782 US experiments were the first in a series of US/USSR collaborations on Cosmos/Bion flights. A disturbingly young R. Dutcher appears at the 2:17:30 mark.

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