NASA Spaceline Current Awareness 20 September 2013 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 20, 2013

Papers deriving from NASA support:



Mao XW, Pecaut MJ, Stodieck LS, Ferguson VL, Bateman TA, Bouxsein M, Jones TA, Moldovan M, Cunningham CE, Chieu J, Gridley DS.

Spaceflight environment induces mitochondrial oxidative damage in ocular issue.

Radiat Res. 2013 Sep 13. [Epub ahead of print]

NOTE: STS-135 results. The Radiation Research journal site now has access to in press articles, for those who may have institutional or personal access. The BioOne Radiation Research site still does not have access to in press articles. Radiation Research journal site:



Nusbaum DM, Clark JB, Brady KM, Kibler KK, Sutton JP, Easley RB.

Intracranial pressure and optic nerve sheath diameter as cephalic venous pressure increases in swine.

Aviat Space Environ Med. 2013 Sep;84(9):946-51.



Liu JH, Lynch JE, Rosales-Velderrain A, Chang DG, Weinreb RN, Hargens AR.

Anterior-posterior transcranial ultrasound to measure cranial oscillations.

Aviat Space Environ Med. 2013 Sep;84(9):995-1000.

(PI: A.R. Hargens)



Garvin NM, Levine BD, Raven PB, Pawelczyk JA.

Pneumatic anti-shock garment inflation activates the human sympathetic nervous system by abdominal compression.

Exp Physiol. 2013 Sep 6. [Epub ahead of print]

(PIs: C.G. Blomqvist/B.D. Levine/P.B. Raven/J.A. Pawelczyk/NSCORT)



Ray CA, Sauder CL, Chin-Sang SA, Cook JS.

Is there diurnal variation of the vestibulosympathetic reflex: Implications for orthostatic tolerance.

Am J Physiol Heart Circ Physiol. 2013 Sep 6. [Epub ahead of print]



Pattarini JM, Blue RS, Aikins LT, Law J, Walshe AD, Garbino A, Turney MW, Clark JB.

Flat spin and negative Gz in high-altitude free fall: Pathophysiology, prevention, and treatment.

Aviat Space Environ Med. 2013 Sep;84(9):961-70.

NOTE: Research in support of the Red Bull Stratos/F. Baumgartner parachute drop.



Lane HW, Bourland C, Barrett A, Heer M, Smith SM.

The role of nutritional research in the success of human space flight.

Adv Nutr. 2013 Sep 1;4(5):521-3.

(PIs: A. Barrett, S.M. Smith)



Sun GS, Tou JC, Yu D, Girten BE, Cohen J.

The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments.



Sanzari JK, Wan SX, Diffenderfer ES, Cengel KA, Kennedy AR.

Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model.

J Radiat Res. 2013 Sep 11. [Epub ahead of print]

(PIs: A.R. Kennedy/K.A. Cengel/Center of Acute Radiation Research)

NOTE: This article may be obtained online without charge.



Plante I, Ponomarev AL, Cucinotta FA.

Calculation of the energy deposition in nanovolumes by protons and HZE particles: Geometric patterns of initial distributions of DNA repair foci.

Phys Med Biol. 2013 Sep 21;58(18):6393-405. Epub 2013 Sep 2.

(PI: F.A. Cucinotta)



Petrik D, Yun S, Latchney SE, Kamrudin S, LeBlanc JA, Bibb JA, Eisch AJ.

Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires Cdk5.

PLoS One. 2013 Aug 26;8(8):e72819.

(PI: A.J. Eisch)

NOTE: This article may be obtained online without charge.



Toyota M, Ikeda N, Sawai-Toyota S, Kato T, Gilroy S, Tasaka M, Morita MT.

Amyloplast displacement is necessary for gravisensing in Arabidopsis shoots as revealed by a centrifuge microscope.

Plant J. 2013 Sep 5. [Epub ahead of print]

(PI: S. Gilroy)

NOTE: Additional evidence that amyloplasts are directly involved in plant shoot gravisensing.



Kim SJ, Bassham DC.

Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana.

BMC Biochem. 2013 Sep 11;14:22. [Epub ahead of print]

(PI: D.C. Bassham)

NOTE: This article may be obtained online without charge.



Other papers of interest:



Carter JR, West JB.

Space physiology within an exercise physiology curriculum.

Adv Physiol Educ. 2013 Sep 1;37(3):220-6.

NOTE: This article may be obtained online without charge.



Kölegård R, Mekjavic IB, Eiken O.

Effects of physical fitness on relaxed G-tolerance and the exercise pressor response.

Eur J Appl Physiol. 2013 Aug 29. [Epub ahead of print]



Pereira BC, Pauli JR, de Souza CT, Ropelle ER, Cintra DE, Freitas EC, Silva AS.

Eccentric exercise leads to performance decrease and insulin signaling impairment.

Med Sci Sports Exerc. 2013 Aug 30. [Epub ahead of print]



Helmi M, Lima A, Gommers D, Bakker J, van Bommel J.

Inflatable external upper and lower leg compression improves stroke volume and peripheral perfusion during central hypovolemia in healthy volunteers.

Future Cardiol. 2013 Sep;9(5):649-55.



Schoenenberger AW, Schoenenberger-Berzins R, Suter PM, Erne P.

Effects of weight on blood pressure at rest and during exercise.

Hypertens Res. 2013 Aug 22. [Epub ahead of print]

NOTE: Adding artificial weight raised blood pressure, which has implications for obesity-related hypertension and weight-bearing physiology. There is a comment on this article entitled “Is gravitation your friend or foe?” Discussing these results and various space-related effects, the comment authors conclude: “Therefore, too much and too little gravitational challenges to the cardiovascular system can have adverse cardiovascular health effects.” Comment:



Ax M, Karlsson LL, Sanchez-Crespo A, Lindahl SG, Linnarsson D, Mure M, Petersson J.

Regional lung ventilation in humans during hypergravity studied with quantitative SPECT.

Respir Physiol Neurobiol. 2013 Sep 1. [Epub ahead of print]



Gattinoni L, Pesenti A, Carlesso E.

Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure: Impact and clinical fallout through the following 20 years.

Intensive Care Med. 2013 Sep 12. [Epub ahead of print]



Nikolaev VP.

Simulation of gas bubble growth and dissolution in human tissues during dives and recompression.

Aviat Space Environ Med. 2013 Sep;84(9):938-45.



Dachner AM, Saxton BM, Noe RA, Keeton KE.

To infinity and beyond: Using a narrative approach to identify training needs for unknown and dynamic situations.

Hum Resource Dev Q. 2013 Sum;24(2):239-67. Epub 2013 Jun 13.

NOTE: From abstract: “Second, the utility of a narrative approach is examined using SME [subject matter experts] interviews from National Aeronautics and Space Administration (NASA) to identify crew training needs for a future long duration mission.”



Demin AV, Dyachenko AI, Ivanov AI, Orlov OI, Suvorov AV.

Instrumental monitoring of the autonomous nervous system in the Mars-520 experiment.

Biomed Eng. 2013 Jul;47(2):86-90.

NOTE: This is a translation in English of the Russian original published in Meditsinskaya Tekhnika 2013 Mar-Apr;47(2):27-31:



Grimpo K, Kutschke M, Kastl A, Meyer CW, Heldmaier G, Exner C, Jastroch M.

Metabolic depression during warm torpor in the Golden spiny mouse (Acomys russatus) does not affect mitochondrial respiration and hydrogen peroxide release.

Comp Biochem Physiol A Mol Integr Physiol. 2013 Sep 7. [Epub ahead of print]



Camerino GM, Pierno S, Liantonio A, De Bellis M, Cannone M, Sblendorio V, Conte E, Mele A, Tricarico D, Tavella S, Ruggiu A, Cancedda R, Ohira Y, Danieli-Betto D, Ciciliot S, Germinario E, Sandonà D, Betto R, Camerino DC, Desaphy JF.

Effects of pleiotrophin overexpression on mouse skeletal muscles in normal loading and in actual and simulated microgravity.

PLoS One. 2013 Aug 28;8(8):e72028.

NOTE: Ground research is compared to results of the 91-day Mice Drawer System experiment conducted on ISS. This article may be obtained online without charge.



Li R, Narici MV, Erskine RM, Seynnes OR, Rittweger J, Pišot R, Šimunič B, Flück M.

Costamere remodeling with muscle loading and unloading in healthy young men.

J Anat. 2013 Sep 8. [Epub ahead of print]

NOTE: Bed rest study. This article may be obtained online without charge.



Magne H, Savary-Auzeloux I, Migné C, Peyron MA, Combaret L, Rémond D, Dardevet D.

Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet.

PLoS One. 2013 Aug 27;8(8):e70130.

NOTE: This article may be obtained online without charge.



Kostovski E, Boon H, Hjeltnes N, Lundell LS, Ahlsén M, Chibalin AV, Krook A, Iversen PO, Widegren U.

Altered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects.

Am J Physiol Endocrinol Metab. 2013 Sep 10. [Epub ahead of print]



Lee D, Goldberg AL.

SIRT1 by blocking the activities of FoxO1 and 3 inhibits muscle atrophy and promotes muscle growth.

J Biol Chem. 2013 Sep 3. [Epub ahead of print]

NOTE: This article may temporarily be obtained online without charge.



Osawa Y, Oguma Y, Ishii N.

The effects of whole-body vibration on muscle strength and power: A meta-analysis.

J Musculoskelet Neuronal Interact. 2013 Sep;13(3):342-52.

NOTE: This article may be obtained online without charge.



Cianferotti L, Brandi ML.

Muscle-bone interactions: Basic and clinical aspects.



Wallace IJ, Kwaczala AT, Judex S, Demes B, Carlson KJ.

Physical activity engendering loads from diverse directions augments the growing skeleton.

J Musculoskelet Neuronal Interact. 2013 Sep;13(3):245-50.

NOTE: This article may be obtained online without charge.



Tamaki H, Yotani K, Ogita F, Takahashi H, Kirimto H, Onishi H, Yamamoto N.

Changes over time in structural plasticity of trabecular bone in rat tibiae immobilized by reversible sciatic denervation.

J Musculoskelet Neuronal Interact. 2013 Sep;13(3):251-8.

NOTE: This article may be obtained online without charge.



Mullen CA, Haugh MG, Schaffler MB, Majeska RJ, McNamara LM.

Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation.

J Mech Behav Biomed Mater. 2013 Jul 18;28C:183-94. [Epub ahead of print]



Ponnaiya B, Amundson SA, Ghandhi SA, Smilenov LB, Geard CR, Buonanno M, Brenner DJ.

Single-cell responses to ionizing radiation.

Radiat Environ Biophys. 2013 Aug 31. [Epub ahead of print]

NOTE: This article may be obtained online without charge.



Davis AJ, Chen DJ.

DNA double strand break repair via non-homologous end-joining.

Transl Cancer Res. 2013 Jun;2(3):130-43.

NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:



Heuskin AC, Michiels C, Lucas S.

Toward computer simulation of high-LET in vitro survival curves.

Phys Med Biol. 2013 Sep 21;58(18):6495-510. Epub 2013 Sep 3.



Zhou X, Zhang X, Xie Y, Tanaka K, Wang B, Zhang H.

DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption.

PLoS One. 2013 Aug 27;8(8):e72641.

NOTE: This article may be obtained online without charge.



Kazama Y, Hirano T, Nishihara K, Ohbu S, Shirakawa Y, Abe T.

Effect of high-LET Fe-ion beam irradiation on mutation induction in Arabidopsis thaliana.

Genes Genet Syst. 2013;88(3):189-97.

NOTE: This article may be obtained online without charge.



de Winkel KN, Soyka F, Barnett-Cowan M, Bülthoff HH, Groen EL, Werkhoven PJ.

Integration of visual and inertial cues in the perception of angular self-motion.

Exp Brain Res. 2013 Sep 8. [Epub ahead of print]



Seno T, Palmisano S, Ito H, Sunaga S.

Perceived gravitoinertial force during vection.

Aviat Space Environ Med. 2013 Sep;84(9):971-4.



Nadler JW, Barbash D, Kim HR, Shimpi S, Angelaki DE, DeAngelis GC.

Joint representation of depth from motion parallax and binocular disparity cues in macaque area MT.

J Neurosci. 2013 Aug 28;33(35):14061-74.



Ruzic L, Prpic T, Madarevic T, Radman I, Tudor A, Rakovac I, Sestan B.

Physiological load and posture control thresholds.

Gait Posture. 2013 Aug 18. [Epub ahead of print]



Chandler JF, Arnold RD, Phillips JB, Turnmire AE.

Predicting individual differences in response to sleep loss: Application of current techniques.

Aviat Space Environ Med. 2013 Sep;84(9):927-37.



Mastroleo F, Van Houdt R, Atkinson S, Mergeay M, Hendrickx L, Wattiez R, Leys N.

Modeled microgravity cultivation modulates N-acylhomoserine lactone production in Rhodospirillum rubrum S1H independently of cell density.



Song Y, Wei Z, Song C, Xie S, Feng J, Fan J, Zhang Z, Shi Y.

Simulated microgravity combined with polyglycolic acid scaffold culture conditions improves the function of pancreatic islets.

Biomed Res Int. 2013;2013:150739. Epub 2013 Aug 6.

NOTE: This article may be obtained online without charge.



Rungarunlert S, Klincumhom N, Tharasanit T, Techakumphu M, Pirity MK, Dinnyes A.

Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells.

Cell Reprogram. 2013 Sep 10. [Epub ahead of print]



Feric M, Brangwynne CP.

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells.

Nat Cell Biol. 2013 Sep 1. [Epub ahead of print]



Bainer R, Weaver V.

Cell biology. Strength under tension.

NOTE: This is a comment on the following article:



Huang H, Bae C, Sachs F, Suchyna TM.

Caveolae regulation of mechanosensitive channel function in myotubes.

PLoS One. 2013 Aug 30;8(8):e72894.

NOTE: This article may be obtained online without charge.



Zhu C.

Mechanochemistry: A molecular biomechanics view of mechanosensing.

Ann Biomed Eng. 2013 Sep 5. [Epub ahead of print]



De Micco V, De Pascale S, Paradiso R, Aronne G.

Microgravity effects on different stages of higher plant life cycle and completion of the seed-to-seed cycle.

Plant Biol (Stuttg). 2013 Sep 9. [Epub ahead of print]



Tatsumi H, Furuichi T, Nakano M, Toyota M, Hayakawa K, Sokabe M, Iida H.

Mechanosensitive channels are activated by stress in the actin stress fibres, and could be involved in gravity sensing in plants.

Plant Biol (Stuttg). 2013 Sep 9. [Epub ahead of print]



Manzano AI, Larkin OJ, Dijkstra CE, Anthony P, Davey MR, Eaves L, Hill RJ, Herranz R, Medina FJ.

Meristematic cell proliferation and ribosome biogenesis are decoupled in diamagnetically levitated Arabidopsis seedlings.

BMC Plant Biol. 2013 Sep 5;13:124.

NOTE: This article may be obtained online without charge.



Srivastava VK, Tuteja R, Tuteja N.

Calcium-energized motor protein forisome controls damage in phloem: Potential applications as biomimetic "smart" material.

Crit Rev Biotechnol. 2013 Sep 11. [Epub ahead of print]



Li HF, Zhu FH, Li HY, Zhu W, Chen XP, Hong YB, Liu HY, Wu H, Liang XQ.

Proteomic identification of gravitropic response genes in peanut gynophores.

J Proteomics. 2013 Aug 28. [Epub ahead of print]


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