NASA Spaceline Current Awareness 4 October 2013 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 4, 2013

Papers deriving from NASA support:



Kassemi M, Iskovitz I, Thomas JD.

Impact of weightlessness on cardiac shape and left ventricular stress/strain distributions.

J Biomech Eng. 2013 Sep 1. [Epub ahead of print]

(PI: J.D. Thomas)

NOTE: Predictions for cardiac parameters under different gravitational loads, derived from a finite element model of the heart, are compared to parabolic flight experiment results.



Stabley JN, Prisby RD, Behnke BJ, Delp MD.

Chronic skeletal unloading of the rat femur: Mechanisms and functional consequences of vascular remodeling.

(PI: M.D. Delp)



Reed EB, Hanson AM, Cavanagh PR.

Optimising muscle parameters in musculoskeletal models using Monte Carlo simulation.

Comput Methods Biomech Biomed Engin. 2013 Sep 19. [Epub ahead of print]

(PIs: A.M. Hanson, NSBRI Postdoctoral Fellowship Program; P.R. Cavanagh)



Uddin SM, Qin YX.

Enhancement of osteogenic differentiation and proliferation in human mesenchymal stem cells by a modified low intensity ultrasound stimulation under simulated microgravity.

PLoS One. 2013 Sep 12;8(9):e73914.

(PI: Y.X. Qin)

NOTE: This article may be obtained online without charge.



Iwaniec UT, Turner RT, Smith BJ, Stoecker BJ, Rust A, Zhang B, Vasu VT, Gohil K, Cross CE, Traber MG.

Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents.

Free Radic Biol Med. 2013 Sep 16. [Epub ahead of print]

(PIs: R.T. Turner, B.J. Stoecker)



Gridley DS, Mao XW, Stodieck LS, Ferguson VL, Bateman TA, Moldovan M, Cunningham CE, Jones TA, Slater JM, Pecaut MJ.

Changes in mouse thymus and spleen after return from the STS-135 mission in space.

PLoS One. 2013 Sep 19;8(9):e75097.

NOTE: STS-135 results. This article may be obtained online without charge.



Dwivedi P, Gazda DB, Keelor JD, Limero TF, Wallace WT, Macatangay AV, Fernandez FM.

Electro-thermal vaporization direct analysis in real time-mass spectrometry (DART-ETV-MS) for rapid water contaminant analysis during space missions.

Anal Chem. 2013 Sep 20. [Epub ahead of print]



Yin Y, Withers TR, Wang X, Yu HD.

Evidence for sigma factor competition in the regulation of alginate production by Pseudomonas aeruginosa.

PLoS One. 2013 Aug 22;8(8):e72329.

NOTE: This article may be obtained online without charge.



Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR.

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.

Radiat Res. 2013 Aug;180(2):156-65. Epub 2013 Jul 2.

(PI: D.R. Spitz)



Sanzari JK, Wan XS, Krigsfeld GS, King GL, Miller A, Mick R, Gridley DS, Wroe AJ, Rightnar S, Dolney D, Kennedy AR.

Effects of solar particle event proton radiation on parameters related to ferret emesis.

Radiat Res. 2013 Aug;180(2):166-76. Epub 2013 Jul 24.

(PIs: A.R. Kennedy/X.S. Wan/Center of Acute Radiation Research)



Romero-Weaver AL, Wan XS, Diffenderfer ES, Lin L, Kennedy AR.

Kinetics of neutrophils in mice exposed to radiation and/or granulocyte colony-stimulating factor treatment.

Radiat Res. 2013 Aug;180(2):177-88. Epub 2013 Jul 5.

(PIs: A.R. Kennedy/X.S. Wan/Center of Acute Radiation Research)



Krigsfeld GS, Kennedy AR.

Is disseminated intravascular coagulation the major cause of mortality from radiation at relatively low whole body doses?

Radiat Res. 2013 Sep;180(3):231-4. Epub 2013 Aug 14.

(PI: A.R. Kennedy)



Grygoryev D, Moskalenko O, Hinton TG, Zimbrick JD.

DNA damage caused by chronic transgenerational exposure to low dose gamma radiation in medaka fish ( Oryzias latipes ).

Radiat Res. 2013 Sep;180(3):235-46. Epub 2013 Aug 6.

(PI: J.D. Zimbrick)



Kim SB, Ly P, Kaisani A, Zhang L, Wright WE, Shay JW.

Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells.

Radiat Res. 2013 Sep;180(3):259-67. Epub 2013 Aug 6.

(PIs: J.W. Shay; J. Minna/J.W. Shay/W.E. Wright/NSCOR; A.J. Fornace Jr/J.W. Shay/W.E. Wright/NSCOR)



Grabham P, Sharma P, Bigelow A, Geard C.

Two distinct types of the inhibition of vasculogenesis by different species of charged particles.

Vasc Cell. 2013 Sep 17;5:16. [Epub ahead of print]

(PIs: P. Grabham, C. Geard)

NOTE: This article may be obtained online without charge.



Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruiz H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH.

Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.

Stem Cells. 2013 Aug 23. [Epub ahead of print]

(PIs: M.H. Barcellos-Hoff/J.H. Ma/S.V. Costes/NSCOR)



Phillips AJ, Fulcher BD, Robinson PA, Klerman EB.

Mammalian rest/activity patterns explained by physiologically based modeling.

PLoS Comput Biol. 2013 Sep;9(9):e1003213. Epub 2013 Sep 5.

(PIs: A.J. Phillips, NSBRI Postdoctoral Fellowship Program; E.B. Klerman)

NOTE: This article may be obtained online without charge.



Hainley CJ Jr, Duda KR, Oman CM, Natapoff A.

Pilot performance, workload, and situation awareness during lunar landing mode transitions.

J Spacecr Rockets. 2013 Jul;50(4):793-801.

(PI: K.R. Duda)



Seref O, Brooks JP, Fong SS.

Decomposition of flux distributions into metabolic pathways.

IEEE/ACM Trans Comput Biol Bioinform. 2013 Sep 18. [Epub ahead of print]

NOTE: From abstract: “The proposed method is applied to compare predicted flux distributions for Salmonella typhimurium to study changes in metabolism that cause enhanced virulence during a space flight.”



Abboud T, Berinstain A, Bamsey M, Ferl R, Paul A-L, Graham T, Dixon M, Leonardos D, Stasiak M, Noumeir R.

Multispectral Plant Health Imaging System for space biology and hypobaric plant growth studies.

Insciences J. 2013 Jun 3;3(2):24-44.

(PIs: A-L Paul, R. Ferl)

NOTE: This article may be obtained online without charge.



Other papers of interest:



Stepanova SI, Katuntsev VP, Osipov IuIu, Galichiĭ VA.

[Heart rate and energy expenditure during extravehicular activity in different time of day]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):9-13. Russian.

NOTE: Analysis of Mir results.



Gratas-Delamarche A, Derbré F, Vincent S, Cillard J.

Physical inactivity, insulin resistance and the oxidative-inflammatory loop.

Free Radic Res. 2013 Sep 24. [Epub ahead of print]



Tesini S, Frotzler A, Bersch I, Tobón A.

Prevention of orthostatic hypotension with electric stimulation in persons with acute spinal cord injury.

Biomed Tech (Berl). 2013 Sep 7. [Epub ahead of print]

NOTE: This article may be obtained online without charge.



Duschek S, Werner NS, Reyes del Paso GA.

The behavioral impact of baroreflex function: A review.



Wang YC, Lu DY, Shi F, Zhang S, Yang CB, Wang B, Cao XS, Du TY, Gao Y, Zhao JD, Sun XQ.

Clinorotation enhances autophagy in vascular endothelial cells.

Biochem Cell Biol. 2013 Oct;91(5):309-14. Epub 2013 May 16.



Qvarlander S, Sundström N, Malm J, Eklund A.

Postural effects on intracranial pressure: Modeling and clinical evaluation.

J Appl Physiol (1985). 2013 Sep 19. [Epub ahead of print]



Donina ZhA, Lavrova IN, Baranov VM.

Intersystem relationships of respiration and hemodynamics in the initial period of postural effects.

Bull Exp Biol Med. 2013 Jul;155(3):298-301.

NOTE: This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny. 2013 Mar;155(3):271-4.



Bryndina IG, Vasilieva NN, Krivonogova YuA, Baranov VM.

Effect of long-term simulated weightlessness on surfactant and water balance in mouse lungs.

Bull Exp Biol Med. 2013 Jul;155(3):306-8.

NOTE: This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny. 2013 Mar;155(3):279-81.



Johnson MA, Mills DE, Brown PI, Sharpe GR.

Prior upper body exercise reduces cycling work capacity but not critical power.

Med Sci Sports Exerc. 2013 Sep 12. [Epub ahead of print]



Rovniak LS, Denlinger L, Duveneck E, Sciamanna CN, Kong L, Freivalds A, Ray CA.

Feasibility of using a compact elliptical device to increase energy expenditure during sedentary activities.

J Sci Med Sport. 2013 Aug 8. [Epub ahead of print]



Ushakov IB, Orlov OI, Baevskiĭ RM, Bersenev EIu, Chernikova AG.

[New technologies for evaluation of health status of apparently healthy people]

Ross Fiziol Zh Im I M Sechenova. 2013 Mar;99(3):313-9. Russian.

NOTE: Technology described in the article has been used in the Mars-500 project.



Li Z, Ding L, Yue G.

[Study of mechanical effects of the EVA glove on finger base with finite element modeling]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Aug;30(4):767-71. Chinese.



Zavalishin DA, Belyaev MYu, Sazonov VV.

Study of vibration microaccelerations onboard the International Space Station.

Cosmic Res. 2013 Jul;51(4):261-9.

NOTE: ISS results. This paper is a translation in English of the Russian original published in Kosmicheskie Issledovaniya 2013;51(4):294-302.



Belyaev MYu, Volkov ON, Ryabukha SB.

Microdisturbances on the International Space Station during dynamic operations.

Cosmic Res. 2013 Jul;51(4):270-4.

NOTE: ISS results. This paper is a translation in English of the Russian original published in Kosmicheskie Issledovaniya 2013;51(4):303-7.



Panchenkov DN, Baranov MV, Astakhov DA, Nechunaev AA, Leonov SD, Behteva ME.

[Biochemical aspects of the influence of antiorthostatic hypokinesia on the experimental peritonitis]

Patol Fiziol Eksp Ter. 2013 Jan-Mar;(1):56-60. Russian.



Morukov BV, Popov IN, Levin G, Markin AA, Zhuravleva OA, Kuzichkin DS.

[Status of the water-soluble component of the antioxidant defense system in the conditions of 520-day isolation]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):48-50. Russian.



Shumilina GA, Shumilina IV, Solov'eva SO.

[Means and methods of personal hygiene in the experiment with 520-day isolation]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):33-6. Russian.



Nikolaev VP.

[Analysis of evolution of the size of decompression gas bubbles in diver tissues during schedules of medical recompression]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):41-6. Russian.



Il'in VK, Suvorov AN, Kiriukhina NV, Usanova NA, Starkova LV, Boiarintsev VV, Karaseva AB.

[Autochthonous probiotics in prevention of infectious and inflammatory diseases of a human in the altered habitats]

Vestn Ross Akad Med Nauk. 2013;(2):56-62. Russian.

NOTE: Microflora were studied in isolation experiments.



Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ.

Microfluidic opportunities in the field of nutrition.

Lab Chip. 2013 Sep 17;13(20):3993-4003.



Granovetter M, Boyce N.

Kevin Fong: Medicine at the final frontier.

NOTE: This article describes the career of, and a recent book by, a physician and science communicator who has been involved in space medicine. This article may be obtained online without charge at the Lancet site:



Murdoch N, Rozitis B, Green SF, Michel P, de Lophem TL, Losert W.

Simulating regoliths in microgravity.

Monthly Notices Royal Astronom Soc. 2013 Jul 21;433(1):506-14.



Stenvinkel P, Fröbert O, Anderstam B, Palm F, Eriksson M, Bragfors-Helin AC, Qureshi AR, Larsson T, Friebe A, Zedrosser A, Josefsson J, Svensson M, Sahdo B, Bankir L, Johnson RJ.

Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos).

PLoS One. 2013 Sep 9;8(9):e72934.

NOTE: This article may be obtained online without charge.



Kanazawa Y, Maekawa K, Okumura Y, Fujita N, Fujino H.

Preventive effect of nucleoprotein on hindlimb unloading-induced capillary regression in rat soleus muscle.

Biotech Histochem. 2013 Sep 24. [Epub ahead of print]



Piccirillo R, Demontis F, Perrimon N, Goldberg AL.

Mechanisms of muscle growth and atrophy in mammals and Drosophila.

Dev Dyn. 2013 Aug 29. [Epub ahead of print]



Afanas'ev MA, Kuznetsov SL.

[Effects of a real and modeled microgravity influencing on some structural and metabolic parameters of skeletal muscles]

Vestn Ross Akad Med Nauk. 2013;(1):47-51. Russian.



Schaffler MB, Cheung WY, Majeska R, Kennedy O.

Osteocytes: Master orchestrators of bone.

Calcif Tissue Int. 2013 Sep 17. [Epub ahead of print]



Iolascon G, Resmini G, Tarantino U.

Mechanobiology of bone.

Aging Clin Exp Res. 2013 Sep 18. [Epub ahead of print]



Worton LE, Ausk BJ, Downey LM, Bain SD, Gardiner EM, Srinivasan S, Gross TS, Kwon RY.

Systems-based identification of temporal processing pathways during bone cell mechanotransduction.

PLoS One. 2013 Sep 11;8(9):e74205.

NOTE: This article may be obtained online without charge.



Islamov RR, Tiapkina OV, Nikol'skiĭ EE, Kozlovskaia IB, Grigor'ev AI.

[The role of spinal motoneurons in the mechanisms of hypogravitational motor syndrome development]

Ross Fiziol Zh Im I M Sechenova. 2013 Mar;99(3):281-93. Russian.



Morgan WF, Sowa MB.

Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects.

Cancer Lett. 2013 Sep 14. [Epub ahead of print]



Grigor'ev AI, Krasavin EA, Ostrovskiĭ MA.

[Galactic heavy charged particles damaging effect on biological structures]

Ross Fiziol Zh Im I M Sechenova. 2013 Mar;99(3):273-80. Russian.



Liu J, Kim J, Oberdoerffer P.

Metabolic modulation of chromatin: Implications for DNA repair and genomic integrity.

Front Genet. 2013 Sep 17;4:182.

NOTE: This article may be obtained online without charge:



Moscariello M, Iliakis G.

Effects of chromatin decondensation on alternative NHEJ.

DNA Repair (Amst). 2013 Sep 17. [Epub ahead of print]



Abolfath RM, Carlson DJ, Chen ZJ, Nath R.

A molecular dynamics simulation of DNA damage induction by ionizing radiation.

Phys Med Biol. 2013 Oct 21;58(20):7143-57. Epub 2013 Sep 19.



Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A.

The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

DNA Repair (Amst). 2013 Sep 13. [Epub ahead of print]



Ballarini F, Altieri S, Bortolussi S, Giroletti E, Protti N.

A model of radiation-induced cell killing: Insights into mechanisms and applications for hadron therapy.

Radiat Res. 2013 Sep;180(3):307-15. Epub 2013 Aug 14.



Bronstein AM, Golding JF, Gresty MA.

Vertigo and dizziness from environmental motion: Visual vertigo, motion sickness, and drivers' disorientation.

Semin Neurol. 2013 Jul;33(3):219-30. Epub 2013 Sep 21.



Dokka K, MacNeilage PR, DeAngelis GC, Angelaki DE.

Multisensory self-motion compensation during object trajectory judgments.

Cereb Cortex. 2013 Sep 22. [Epub ahead of print]



Myznikov IL, Miloshevskiĭ AV, Askerko NV, Ustimenko LI, Pleskach VV, Burtsev NN, Tur IuS.

[Health, morbidity and injury rate among the north fleet seafaring personnel]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):13-20. Russian.



Solov'eva KB, Dolbin IV, Koroleva EB.

[Hemodynamics variation in hypertensive pilots of polar transport aviation on different flight phases]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):21-5. Russian.



Es'kov KN.

[Effectiveness of interrelative operators' work as a criterion for classification of isolated small groups]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):25-9. Russian.



Markov AL, Zenchenko TA, Solonin IuG, Boĭko ER.

[Vulnerability to atmospheric and geomagnetic factors of the body functions in healthy male dwellers of the Russian North]

Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):29-33. Russian.



Li X, Yang Y, Li Q, Dai Y, Wang C, Chen J.

Morphological characteristics and proliferation of rabbit corneal stromal cells onto complexes of collagen-chitosan-sodium hyaluronate under simulated microgravity.

Invest Ophthalmol Vis Sci. 2013 Sep 26. [Epub ahead of print]



Pani G, Samari N, Quintens R, de Saint-Georges L, Meloni M, Baatout S, Van Oostveldt P, Benotmane MA.

Morphological and physiological changes in mature in vitro neuronal networks towards exposure to short-, middle- or long-term simulated microgravity.

PLoS One. 2013 Sep 16;8(9):e73857.

NOTE: This article may be obtained online without charge.



Cairns LS, Marlow VL, Bissett E, Ostrowski A, Stanley-Wall NR.

A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis.

Mol Microbiol. 2013 Oct;90(1):6-21. Epub 2013 Aug 14.

NOTE: This article presents evidence that inhibition of flagellar rotation is a trigger for bacteria to switch to biofilm formation. A comment on this article, “When the swimming gets tough, the tough form a biofilm” is at:

The article and the comment may be obtained online without charge.



Tipping MJ, Delalez NJ, Lim R, Berry RM, Armitage JP.

Load-dependent assembly of the bacterial flagellar motor.

NOTE: This article may be obtained online without charge.



Nampe D, Tsutsui H.

Engineered micromechanical cues affecting human pluripotent stem cell regulations and fate.

J Lab Autom. 2013 Sep 23. [Epub ahead of print]



Budnar S, Yap AS.

A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton.

F1000Prime Rep. 2013 Sep 2;5:35.

NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:



Clemons MJ, Vandermeer LA, Gunstone I, Jacobs C, Kaizer L, Paterson AH.

Lost in transition? Thoughts on retirement--"Will You Still Need Me, Will You Still Feed Me, When I'm Sixty-Four?"

NOTE: Thoughts on retirement from the physician/oncologist perspective.



Jin K, Shen J, Ashton RW, Dodd IC, Parry MA, Whalley WR.

How do roots elongate in a structured soil?

J Exp Bot. 2013 Sep 16. [Epub ahead of print]



Cui D, Zhao J, Jing Y, Fan M, Liu J, Wang Z, Xin W, Hu Y.

The Arabidopsis IDD14, IDD15, and IDD16 cooperatively regulate lateral organ morphogenesis and gravitropism by promoting auxin biosynthesis and transport.

PLoS Genet. 2013 Sep;9(9):e1003759. Epub 2013 Sep 5.

NOTE: This article may be obtained online without charge.



Hu L, Mei Z, Zang A, Chen H, Dou X, Jin J, Cai W.

Microarray analyses and comparisons of upper or lower flanks of rice shoot base preceding gravitropic bending.

PLoS One. 2013 Sep 5;8(9):e74646.

NOTE: This article may be obtained online without charge.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.