NASA Spaceline Current Awareness 25 October 2013 (Recent Space Life Science Research Results)

Status Report From: Spaceline
Posted: Saturday, October 26, 2013

Next list:  November 15, 2013


Papers deriving from NASA support:



Marshburn TH, Hadfield CA, Sargsyan AE, Garcia K, Ebert D, Dulchavsky SA.

New heights in ultrasound: First report of spinal ultrasound from the International Space Station.

J Emerg Med. 2013 Oct 15. [Epub ahead of print]

(PI: S.A. Dulchavsky)

NOTE: ISS results. The figures below the publisher’s site abstract are informative.



Stankovski T, Cooke WH, Rudas L, Stefanovska A, Eckberg DL.

Time-frequency methods and voluntary ramped-frequency breathing: A powerful combination for exploration of human neurophysiological mechanisms.

J Appl Physiol (1985). 2013 Oct 10. [Epub ahead of print]

(PI: D.L. Eckberg)



Cortez D, Sharma N, Devers C, Devers E, Schlegel TT.

Visual transform applications for estimating the spatial QRS-T angle from the conventional 12-lead ECG: Kors is still most Frank.

J Electrocardiol. 2013 Oct 4. [Epub ahead of print]



Lam CW, Scully RR, Zhang Y, Renne RA, Hunter RL, McCluskey RA, Chen BT, Castranova V, Driscoll KE, Gardner DE, McClellan RO, Cooper BL, McKay DS, Marshall L, James JT.

Toxicity of lunar dust assessed in inhalation-exposed rats.

Inhal Toxicol. 2013 Oct;25(12):661-78.

(PIs: C-W. Lam, D.S. McKay, J.T. James)



Lloyd SA, Lang CH, Zhang Y, Paul EM, Laufenberg LJ, Lewis GS, Donahue HJ.

Interdependence of muscle atrophy and bone loss induced by mechanical unloading.

J Bone Miner Res. 2013 Oct 11. [Epub ahead of print]

(PI: H.J. Donahue)



Baldwin KM, Haddad F, Pandorf CE, Roy RR, Edgerton VR.

Alterations in muscle mass and contractile phenotype in response to unloading models: Role of transcriptional/pretranslational mechanisms.

Front Physiol. 2013 Oct 11;4:284.

(PI: K.M. Baldwin)

NOTE: This article may be obtained online without charge.



Karim L, Judex S.

Low level irradiation in mice can lead to enhanced trabecular bone morphology.

J Bone Miner Metab. 2013 Oct 11. [Epub ahead of print]

(PI: S. Judex)



Li M, Gonon G, Buonanno M, Autsavapromporn N, de Toledo SM, Pain D, Azzam EI.

Health risks of space exploration: Targeted and non-targeted oxidative injury by high charge and high energy particles.

Antioxid Redox Signal. 2013 Oct 10. [Epub ahead of print]

(PI: E.I. Azzam)

NOTE: This review article includes a section on gravitational changes in space and oxidative stress.



Bahadori AA, Sato T, Slaba TC, Shavers MR, Semones EJ, Van Baalen M, Bolch WE.

A comparative study of space radiation organ doses and associated cancer risks using PHITS and HZETRN.

Phys Med Biol. 2013 Oct 21;58(20):7183-207. Epub 2013 Sep 23.

(PI: A.A. Bahadori, NASA Graduate Student Researcher Program)

NOTE: This article may be obtained online without charge.



Beheshti A, Pinzer BR, McDonald JT, Stampanoni M, Hlatky L.

Early tumor development captured through nondestructive, high resolution differential phase contrast X-ray imaging.

Radiat Res. 2013 Oct 14. [Epub ahead of print]

(PI: L. Hlatky/NSCOR)



Shay JW.

Are short telomeres predictive of advanced cancer?

Cancer Discov. 2013 Oct;3(10):1096-8.

(PIs: J.W. Shay; J.D. Minna/J.W. Shay/NSCOR; A.J. Fornace/J.W. Shay/NSCOR)

NOTE: This is a comment on this article:



Li L, Chakraborty S, Yang CR, Hatanpaa KJ, Cipher DJ, Puliyappadamba VT, Rehman A, Jiwani AJ, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle SC, Kesari S, Boothman DA, Habib AA.

An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.

(PI: S. Burma)



Cohen HS, Mulavara AP, Peters BT, Sangi-Haghpeykar H, Kung DH, Mosier DR, Bloomberg JJ.

Sharpening the tandem walking test for screening peripheral neuropathy.

South Med J. 2013 Oct;106(10):565-9.

(PIs: A.P. Mulavara, J.J. Bloomberg)



Hammond TG, Stodieck L, Birdsall HH, Becker J, Koenig P, Hammond J, Gunter M, Allen PL.

Effects of microgravity on the virulence of Salmonella toward Caenorhabditis elegans.

New Space. 2013 Sep;1(3):123-31.

NOTE: ISS and Shuttle results.



Other papers of interest:



Fu Q, Levine BD.

Exercise and the autonomic nervous system.

Handb Clin Neurol. 2013;117:147-60.

NOTE: This article and the following article are chapters in a volume entitled: “Autonomic Nervous System.”



He JY, Zheng XF, Jiang LS.

Autonomic control of bone formation: Its clinical relevance.

Handb Clin Neurol. 2013;117:161-71.



Wieser M, Gisler S, Sarabadani A, Ruest RM, Buetler L, Vallery H, Klamroth-Marganska V, Hund-Georgiadis M, Felder M, Schoenberger JL, Gutknecht C, Riener R.

Cardiovascular control and stabilization via inclination and mobilization during bed rest.

Med Biol Eng Comput. 2013 Oct 7. [Epub ahead of print]

NOTE: Bed rest study.



Mischel NA, Llewellyn-Smith IJ, Mueller PJ.

Physical (in)activity dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla.

J Comp Neurol. 2013 Oct 1. [Epub ahead of print]



Wade CE, Baer LA, Wu X, Silliman DT, Walters TJ, Wolf SE.

Severe burn and disuse in the rat independently adversely impact body composition and adipokines.

Crit Care. 2013 Oct 7;17:R225. [Epub ahead of print]

NOTE: This article may be obtained online without charge.



Xu X, Tan C, Li P, Zhang S, Pang X, Liu H, Li L, Sun X, Zhang Y, Wu H, Chen X, Ge Q.

Changes of cytokines during a spaceflight analog - a 45-day head-down bed rest.

PLoS One. 2013 Oct 15;8(10):e77401.

NOTE: Bed rest study. This article may be obtained online without charge.



Vallée N, Gaillard S, Peinnequin A, Risso JJ, Blatteau JE.

Evidence of cell damages caused by circulating bubbles: High level of free mitochondrial DNA in plasma of rats.

J Appl Physiol (1985). 2013 Sep 26. [Epub ahead of print]



Arbeille P, Fornage B, Boucher A, Ruiz J, Georgescu M, Blouin J, Cristea J, Carles G, Farin F, Vincent N.

Telesonography: Virtual 3D image processing of remotely acquired abdominal, vascular, and fetal sonograms.

J Clin Ultrasound. 2013 Sep 30. [Epub ahead of print]



Weber T, Ducos M, Mulder E, Beijer A, Herrera F, Zange J, Degens H, Bloch W, Rittweger J.

The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading.

Clin Physiol Funct Imaging. 2013 Oct 7. [Epub ahead of print]



Vitadello M, Gherardini J, Gorza L.

The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal nNOS.

Antioxid Redox Signal. 2013 Oct 5. [Epub ahead of print]



Baptista IL, Silva WJ, Artioli GG, Guilherme JP, Leal ML, Aoki MS, Miyabara EH, Moriscot AS.

Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.

PLoS One. 2013 Oct 4;8(10):e76752.

NOTE: This article may be obtained online without charge.



Furlow JD, Watson ML, Waddell DS, Neff ES, Baehr LM, Ross AP, Bodine SC.

Altered gene expression patterns in muscle ring finger 1 null mice during denervation and dexamethasone induced muscle atrophy.

Physiol Genomics. 2013 Oct 15. [Epub ahead of print]



Boesen AP, Dideriksen K, Couppé C, Magnusson P, Schjerling P, Boesen M, Kjaer M, Langberg H.

Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: Effect of growth hormone administration.

J Physiol. 2013 Sep 30. [Epub ahead of print]



Marsh M, Souza RB, Wyman BT, Hellio Le Graverand MP, Karuppasamy S, Link TM, Majumdar S.

Differences between X-ray and MRI-determined knee cartilage thickness in weight-bearing and non-weight-bearing conditions.

Osteoarthritis Cartilage. 2013 Sep 30. [Epub ahead of print]



Wall BT, Snijders T, Senden JM, Ottenbros CL, Gijsen AP, Verdijk LB, van Loon LJ.

Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men.

J Clin Endocrinol Metab. 2013 Oct 9. [Epub ahead of print]



Mortensen B, Friedrichsen M, Andersen NR, Alibegovic AC, Højbjerre L, Sonne MP, Stallknecht B, Dela F, Wojtaszewski JF, Vaag A.

Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner.

J Diabetes Complications. 2013 Oct 10. [Epub ahead of print]

NOTE: Bed rest study.



Buehring B, Binkley N.

Myostatin - The holy grail for muscle, bone, and fat?

Curr Osteoporos Rep. 2013 Sep 27. [Epub ahead of print]



Demontis F, Piccirillo R, Goldberg AL, Perrimon N.

Mechanisms of skeletal muscle aging: Insights from Drosophila and mammalian models.

Dis Model Mech. 2013 Oct 2. [Epub ahead of print]

NOTE: This article may be obtained online without charge.



Fernandez-Gonzalo R, Lundberg TR, Tesch PA.

Acute molecular responses in untrained and trained muscle subjected to aerobic and resistance exercise training versus resistance training alone.

Acta Physiol (Oxf). 2013 Oct 1. [Epub ahead of print]



Sun L, Pan J, Peng Y, Wu Y, Li J, Liu X, Qin Y, Bauman WA, Cardozo C, Zaidi M, Qin W.

Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling.

J Spinal Cord Med. 2013 Feb 20. [Epub ahead of print]



Wang B, Lai X, Price C, Thompson WR, Li W, Quabili TR, Tseng WJ, Liu XS, Zhang H, Pan J, Kirn-Safran CB, Farach-Carson MC, Wang L.

Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system.

J Bone Miner Res. 2013 Sep 24. [Epub ahead of print]



Lee KL, Sobieraj M, Baldassarri M, Gupta N, Pinisetty D, Janal MN, Tovar N, Coelho PG.

The effects of loading conditions and specimen environment on the nanomechanical response of canine cortical bone.

Mater Sci Eng C Mater Biol Appl. 2013 Dec 1;33(8):4582-6. Epub 2013 Jul 19.



Witt F, Duda G, Bergmann C, Petersen A.

Cyclic mechanical loading enables solute transport and oxygen supply in bone healing - an in vitro investigation.

Tissue Eng Part A. 2013 Oct 15. [Epub ahead of print]



Li HY, Zhang H, Miao GY, Xie Y, Sun C, Di CX, Liu Y, Liu YY, Zhang X, Ma XF, Xu S, Gan L, Zhou X.

Simulated microgravity conditions and carbon ion irradiation induce spermatogenic cell apoptosis and sperm DNA damage.

Biomed Environ Sci. 2013 Sep;26(9):726-34.

NOTE: Tail suspension was used to simulate microgravity. This article may be obtained online without charge (large file).



Moeller R, Raguse M, Reitz G, Okayasu R, Li Z, Klein S, Setlow P, Nicholson WL.

Resistance of Bacillus subtilis spore DNA to lethal ionizing radiation damage relies primarily on spore core components and DNA repair, with minor effects of oxygen radical detoxification.

Appl Environ Microbiol. 2013 Oct 11. [Epub ahead of print]



Dieser M, Battista JR, Christner BC.

Double-strand DNA break repair at -15{degrees}C.

Appl Environ Microbiol. 2013 Sep 27. [Epub ahead of print]



Al Anid H, Lewis BJ, Bennett LG, Takada M, Duldig M.

Aircrew radiation dose estimates during recent solar particle events and the effect of particle anisotropy.

Radiat Prot Dosimetry. 2013 Sep 30. [Epub ahead of print]



Sarabon N, Rosker J.

Effect of 14 days of bed rest in older adults on parameters of the body sway and on the local ankle function.

J Electromyogr Kinesiol. 2013 Sep 20. [Epub ahead of print]

NOTE: Bed rest study.



Sylos-Labini F, Ivanenko YP, Cappellini G, Portone A, MacLellan MJ, Lacquaniti F.

Changes of gait kinematics in different simulators of reduced gravity.

J Mot Behav. 2013 Nov-Dec;45(6):495-505. Epub 2013 Sep 30.

NOTE: From article: “To simulate reduced gravity, we used two different apparatuses: a vertical body weight unloading system and a tilting body weight unloading system.” They were used in various configurations.



Chaudhuri SE, Karmali F, Merfeld DM.

Whole-body motion-detection tasks can yield much lower thresholds than direction-recognition tasks: Implications for the role of vibration.

J Neurophysiol. 2013 Sep 25. [Epub ahead of print]



McAuliffe J, Johnson MJ, Weaver B, Deller-Quinn M, Hansen S.

Body position differentially influences responses to exogenous and endogenous cues.

Atten Percept Psychophys. 2013 Oct;75(7):1342-6.



Medrea I, Cullen KE.

Multisensory integration in early vestibular processing in mice: The encoding of passive versus active motion.

J Neurophysiol. 2013 Oct 2. [Epub ahead of print]



Shapiro M.

Spatial navigation: Head direction cells are anchored by gravity.

Curr Biol. 2013 Sep 23;23(18):R841-3.

NOTE: This is a comment about this article:

Both articles may be obtained online without charge.



Laurens J, Meng H, Angelaki DE.

Computation of linear acceleration through an internal model in the macaque cerebellum.

Nat Neurosci. 2013 Sep 29. [Epub ahead of print]



Kheradmand A, Lasker A, Zee DS.

Transcranial magnetic stimulation (TMS) of the supramarginal gyrus: A window to perception of upright.

Cereb Cortex. 2013 Oct 1. [Epub ahead of print]



Bardi L, Regolin L, Simion F.

The first time ever I saw your feet: Inversion effect in newborns' sensitivity to biological motion.

Dev Psychol. 2013 Oct 7. [Epub ahead of print]

NOTE: From abstract: “These results suggest that humans possess an inborn predisposition about the direction of the gravity force that imprints biological motion and supports the hypothesis that a mechanism for the detection of biological motion is already at work before visual experience.”



Trentzsch H, Urban B, Sandmeyer B, Hammer T, Strohm PC, Lazarovici M.

[Does simulator-based team training improve patient safety?]



Horn ER, Gabriel M.

Gender-related sensitivity of development and growth to real microgravity in Xenopus laevis.

J Exp Zool A Ecol Genet Physiol. 2013 Sep 30. [Epub ahead of print]

NOTE: ISS results.



Wang J, Liu C, Liu J, Fang X, Xu C, Guo Y, Chang D, Su L.

Space mutagenesis of genetically engineered bacteria expressing recombinant human interferon α1b and screening of higher yielding strains.

World J Microbiol Biotechnol. 2013 Oct 5. [Epub ahead of print]

NOTE: Shenzhou 8 results.



Wei L, Diao Y, Qi J, Khokhlov A, Feng H, Yan X, Li Y.

Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor.

PLoS One. 2013 Oct 7;8(10):e76710.

NOTE: This article may be obtained online without charge.



Takahashi S, Ohta K, Furubayashi N, Yan B, Koga M, Wada Y, Yamada M, Inaka K, Tanaka H, Miyoshi H, Kobayashi T, Kamigaichi S.

JAXA protein crystallization in space: Ongoing improvements for growing high-quality crystals.

J Synchrotron Radiat. 2013 Nov;20(Pt 6):968-73. Epub 2013 Sep 26.

NOTE: This article, a review of the JAXA protein crystallization program and experiments performed on ISS, may be obtained online without charge.



Tanaka H, Sasaki S, Takahashi S, Inaka K, Wada Y, Yamada M, Ohta K, Miyoshi H, Kobayashi T, Kamigaichi S.

Numerical model of protein crystal growth in a diffusive field such as the microgravity environment.

J Synchrotron Radiat. 2013 Nov;20(Pt 6):1003-9. Epub 2013 Oct 1.

NOTE: This article may be obtained online without charge.



Mammoto T, Mammoto A, Ingber DE.

Mechanobiology and developmental control.

Annu Rev Cell Dev Biol. 2013 Oct 6;29:27-61.



Delmas P, Coste B.

Mechano-gated ion channels in sensory systems.

NOTE: This article may be obtained online without charge.



Chen W, Zhu C.

Mechanical regulation of T-cell functions.

Immunol Rev. 2013 Nov;256(1):160-76.



Hoson T, Soga K, Wakabayashi K, Hashimoto T, Karahara I, Yano S, Tanigaki F, Shimazu T, Kasahara H, Masuda D, Kamisaka S.

Growth stimulation in inflorescences of an Arabidopsis tubulin mutant under microgravity conditions in space.

Plant Biol (Stuttg). 2013 Oct 22. [Epub ahead of print]

NOTE: ISS results.



Herranz R, Medina FJ.

Cell proliferation and plant development under novel altered gravity environments.

Plant Biol (Stuttg). 2013 Sep 24. [Epub ahead of print]



Ueda J, Miyamoto K, Uheda E, Oka M, Yano S, Higashibata A, Ishioka N.

Close relationships between polar auxin transport and graviresponse in plants.

Plant Biol (Stuttg). 2013 Oct 15. [Epub ahead of print]



Dong Z, Jiang C, Chen X, Zhang T, Ding L, Song W, Luo H, Lai J, Liu R, Chen H, Zhang X, Jin W.

Maize LAZY1 mediates shoot gravitropism and inflorescence development through regulating auxin transport, auxin signaling and light response.

Plant Physiol. 2013 Oct 2. [Epub ahead of print]



Baluška F, Mancuso S.

Root apex transition zone as oscillatory zone.

Front Plant Sci. 2013 Oct 2;4:354.

NOTE: This article may be obtained online without charge.


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