NASA Spaceline Current Awareness List #601 6 June 2014

Status Report From: Spaceline
Posted: Friday, June 6, 2014

Papers deriving from NASA support:


Smith SM, Castaneda-Sceppa C, O'Brien KO, Abrams SA, Gillman P, Brooks NE, Cloutier GJ, Heer M, Zwart SR, Wastney ME.

Calcium kinetics during bed rest with artificial gravity and exercise countermeasures.

Osteoporos Int. 2014 May 27. [Epub ahead of print]

(PI: NASA Flight Analysis Project; C. Castaneda-Sceppa)

NOTE: Bed rest study.


Darquenne C.

Aerosol deposition in the human lung in reduced gravity.

J Aerosol Med Pulm Drug Deliv. 2014 Jun;27(3):170-7.

(PI: G.K. Prisk/C. Darquenne)

NOTE: Parabolic flight results.


Stowe RP, Ruiz RJ, Fagundes CP, Stowe RH, Chen M, Glaser R.

An ELISA method to compute endpoint titers to Epstein-Barr virus and cytomegalovirus: Application to population-based studies.

J Immunol Methods. 2014 May 22. [Epub ahead of print]

(PI: R.P. Stowe)


Krainski F, Hastings JL, Heinicke K, Romain N, Pacini EL, Snell PG, Wyrick P, Palmer MD, Haller RG, Levine BD.

The effect of rowing ergometry and resistive exercise on skeletal muscle structure and function during bed rest.

J Appl Physiol (1985). 2014 May 1. [Epub ahead of print]

(PI: B.D. Levine)

NOTE: Bed rest study.


Ozcivici E, Judex S.

Trabecular bone recovers from mechanical unloading primarily by restoring its mechanical function rather than its morphology.

(PI: S. Judex)

NOTE: Hindlimb unloading study.


Poliachik SL, Khokhlova TD, Wang YN, Simon JC, Bailey MR.

Pulsed focused ultrasound treatment of muscle mitigates paralysis-induced bone loss in the adjacent bone: A study in a mouse model.

Ultrasound Med Biol. 2014 May 21. [Epub ahead of print]

(PIs: J.C. Simon/M.R. Bailey/L. Crum)


Lima F, Ding D, Goetz W, Yang AJ, Baulch JE.

High LET (56)Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouse.

Environ Mol Mutagen. 2014 Apr;55(3):266-77. Epub 2013 Nov 30.

(PI: J.E. Baulch)

NOTE: This article may be obtained online without charge.


Thomas SN, Liao Z, Clark D, Chen Y, Samadani R, Mao L, Ann DK, Baulch JE, Shapiro P, Yang AJ.

Exosomal proteome profiling: A potential multi-marker cellular phenotyping tool to characterize hypoxia-induced radiation resistance in breast cancer.

(PI: J.E. Baulch)

NOTE: This article may be obtained online without charge.


Li L, Wang W, Welford S, Zhang T, Wang X, Zhu X.

Ionizing radiation causes increased tau phosphorylation in primary neurons.

J Neurochem. 2014 May 26. [Epub ahead of print]

(PI: X. Zhu/X. Wang)


Roux SJ.

A start point for extracellular nucleotide signaling.

Mol Plant. 2014 Jun;7(6):937-8. Epub 2014 Mar 11.

(PI: S.J. Roux)


Dyachok J, Sparks JA, Liao F, Wang YS, Blancaflor EB.

Fluorescent protein-based reporters of the actin cytoskeleton in living plant cells: Fluorophore variant, actin binding domain, and promoter considerations.

Cytoskeleton (Hoboken). 2014 May;71(5):311-27. Epub 2014 Apr 18.

(PI: E.B. Blancaflor)


Jayaraman D, Gilroy S, Ane JM.

Staying in touch: Mechanical signals in plant-microbe interactions.

Curr Opin Plant Biol. 2014 May 26;20C:104-9. [Epub ahead of print] Review.

(PI: S. Gilroy)

Other papers of interest:


van Oosterhout WP, Terwindt GM, Vein AA, Ferrari MD.

Space headache on Earth: Head-down-tilted bed rest studies simulating outer-space microgravity.

NOTE: Bed rest study.


Garg A, Xu D, Laurin A, Blaber AP.

Physiological interdependence of the cardiovascular and postural control systems under orthostatic stress.

Am J Physiol Heart Circ Physiol. 2014 May 23. [Epub ahead of print]


Albi E, Curcio F, Lazzarini A, Floridi A, Cataldi S, Lazzarini R, Loreti E, Ferri I, Ambesi-Impiombato FS.

A firmer understanding of the effect of hypergravity on thyroid tissue: Cholesterol and thyrotropin receptor.

PLoS One. 2014 May 27;9(5):e98250.

NOTE: This article may be obtained online without charge.


Wei Y, Ying M, Xu S, Wang F, Zou A, Cao S, Jiang X, Wang Y.

Microdialysis pharmacokinetic study of scopolamine in plasma, olfactory bulb and vestibule after intranasal administration.

Drug Deliv. 2014 May 28:1-6. [Epub ahead of print]


Lang-Ouellette D, Morin PJ.

Differential expression of miRNAs with metabolic implications in hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.

Mol Cell Biochem. 2014 May 30. [Epub ahead of print]


Smith JR, Ade CJ, Broxterman RM, Skutnik BC, Barstow TJ, Wong BJ, Harms CA.

Influence of exercise intensity on respiratory muscle fatigue and brachial artery blood flow during cycling exercise.

Eur J Appl Physiol. 2014 May 21. [Epub ahead of print]


Belavy DL.

Comment on Matsumura et al.: Changes in water content of intervertebral discs and paravertebral muscles before and after bed rest.

J Orthop Sci. 2014 May 27. [Epub ahead of print]

NOTE: This article is a Comment on The original article appeared in the SPACELINE Current Awareness List published on 2/20/09 and is a bed rest study.


Sambandam Y, Townsend MT, Pierce JJ, Lipman CM, Haque A, Bateman TA, Reddy SV.

Microgravity control of autophagy modulates osteoclastogenesis.

NOTE: Microgravity simulated via rotary cell culture system.


Pan G, Cao J, Yang N, Ding K, Fan C, Xiong WC, Hamrick M, Isales CM, Shi XM.

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition.

J Biol Chem. 2014 May 23. [Epub ahead of print]

NOTE: This article may temporarily be obtained online without charge.


Beck M, Moreels M, Quintens R, Abou-El-Ardat K, El-Saghire H, Tabury K, Michaux A, Janssen A, Neefs M, Van Oostveldt P, De Vos WH, Baatout S.

Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts.

Int J Mol Med. 2014 May 22. [Epub ahead of print]

NOTE: Simulated space conditions were ionizing radiation and microgravity simulated with random positioning machine.


Zhao Y, de Toledo SM, Hu G, Hei TK, Azzam EI.

Connexins and cyclooxygenase-2 crosstalk in the expression of radiation-induced bystander effects.

Br J Cancer. 2014 May 27. [Epub ahead of print]


Leijon S, Magnusson AK.

Physiological characterization of vestibular efferent brainstem neurons using a transgenic mouse model.

PLoS One. 2014 May 27;9(5):e98277.

NOTE: This article may be obtained online without charge.


Hubner PP, Khan SI, Migliaccio AA.

Velocity-selective adaptation of the horizontal and cross-axis vestibulo-ocular reflex in the mouse.

Exp Brain Res. 2014 May 28. [Epub ahead of print]


Gillis G, Ekstrom L, Azizi E.

Biomechanics and control of landing in toads.

Integr Comp Biol. 2014 May 29. [Epub ahead of print]


Zakharova K, Marzban G, de Vera JP, Lorek A, Sterflinger K.

Protein patterns of black fungi under simulated Mars-like conditions.

Sci Rep. 2014 May 29;4:5114.

NOTE: This article may be obtained online without charge.


Benavides Damm T, Walther I, Wuest SL, Sekler J, Egli M.

Cell cultivation under different gravitational loads using a novel random positioning incubator.

Biotechnol Bioeng. 2014 Jun;111(6):1180-90. Epub 2014 Jan 22.

NOTE: From the Introduction: “In this paper, we present a newly designed and built RPM equipped with an integrated incubator, thus called random positioning incubator (RPI) that in addition to generating simulated microgravity, offers new features such as partial gravity simulation during an extended period of time.” This article may be obtained online without charge.


Lai YS, Stefano G, Brandizzi F.

ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase.

J Cell Sci. 2014 May 29. [Epub ahead of print]


Walton TA, Idigo CA, Herrera N, Rees DC.

MscL: Channeling membrane tension.

Pflugers Arch. 2014 May 27. [Epub ahead of print]

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