(PIs: R.J. Simpson; R.P. Stowe; C. Sams; B. Crucian, NASA Flight Analogs Project)
Note: From the abstract: “Terrestrial space analogs generally replicate some of the physiological or psychological stress responses associated with spaceflight. These include the use of human test subjects in a laboratory setting (i.e. exercise, bed rest, confinement, circadian misalignment) and human remote deployment analogs (Antarctica winterover, undersea, etc.) that incorporate confinement, isolation, extreme environment, physiological mission stress and disrupted circadian rhythms…This article will characterize the array of terrestrial analogs for spaceflight immune dysregulation, the current evidence base for each, and interpret the analog catalog in the context of acute and chronic stress.”
Journal Impact Factor: 6.128
Funding: “Part of this work was supported by National Institutes of Health, National Center for Advancing Translational Sciences, grant 1UL1RR029876-01 and the NASA Flight Analogs Project (B. Crucian); by NASA grant NNX12AB48G to RJ Simpson and by NASA grant NNJ04HD75G to RP Stowe. A. Chouker was supported by the European Space Agency (ESA) ELIPS 3 and 4 programs and the German National Space Program (DLR, #50WB0719 and #WB0919).”
Dunmire B, Lee FC, Hsi RS, Cunitz BW, Paun M, Bailey MR, Sorensen MD, Harper JD.
Tools to improve the accuracy of kidney stone sizing with ultrasound.
Funding: “Funding was provided through the NIH DK43881 and DK092197, and NSBRI through NASA NCC 9-58. This material is the result of work supported by the resources from the VA Puget Sound Health Care System, Seattle, Washington. Funds and resources have also been provided by the University of Washington C4C, Institute of Translational Health Sciences, Coulter Institute, Washington Biotechnology & Biomedical Association (WBBA), and Washington Research Foundation.”
(PIs: S.A. Bloomfield; R.D. Boudreaux and J.M. Swift, NSBRI Bioastronautics Graduate Education Program Summer Institute)
Journal Impact Factor: 4.459
Funding: “This study was funded by the Sydney and JL Huffines Institute for Sports Medicine and Human Performance (HGG), through the NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (SAB), and by the National Institutes of Health (grant no. AG01025; JDF). RDB and JMS were supported by a National Space Biomedical Research Institute Graduate Fellowship (grant no. NSBRI-RFP-05-02).”
Morgan JL, Heer M, Hargens AR, Macias BR, Hudson EK, Shackelford LC, Zwart SR, Smith SM.
Sex-specific responses of bone metabolism and renal stone risk during bed rest.
Physiol Rep. 2014 Aug 7;2(8). pii: e12119. Print 2014 Aug 1.
Note: Bed rest study. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal.
Funding: “This project was funded by the National Aeronautics and Space Administration’s Human Research Program, and by a grant from the German Federal Ministry for Economics and Technology/DLR Forschung unter Weltraumbedingungen (50WB0931) to the University of Bonn (M.H.). It was also funded by National Aeronautics and Space Administration grants NAG 9-1425, 199-80-025-05, and NCC-2-1133 to A.R.H.”
Suman S, Moon BH, Thakor H, Fornace AJ Jr, Datta K.
Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality.
Funding: “This study is supported in part by NASA grants NNX13AD58G and NNX09AU95G. We acknowledge the Histopathology and Tissue Shared Resources supported by Award Number P30CA051008 from the National Cancer Institute.”
Weil MM, Ray FA, Genik PC, Yu Y, McCarthy M, Fallgren CM, Ullrich RL.
Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma.
Funding: “This project was partially supported by grants from National Science Foundation (IIS-1064965, IIS-1065013, CNS-1059281, CNS-1059218, IIS-0964597, IIS-0964385), National Space Biomedical Research Institute through NASA NCC 9-58, the Center for Identification Technology Research, a National Science Foundation (NSF) Industry/University Cooperative Research Center, and funds provided by the University of North Carolina at Charlotte.”
Mitchell LA, Tovar TM, LeVan MD.
High pressure excess isotherms for adsorption of oxygen and argon in a carbon molecular sieve.
Note: From the abstract: “The present work reports the first successful attempt of the experimental determination of the effective dose equivalent in space, both for extra-vehicular activity (EVA) and intravehicular activity (IVA).” This article may be obtained online without charge.
Chung EJ, Hudak K, Horton JA, White A, Scroggins BT, Vaswani S, Citrin D.
Transforming growth factor alpha is a critical mediator of radiation lung injury.
The most recent issue of Progress in Molecular Biology and Translational Science is focused on mechanotransduction. From the Preface: “The chapters in this edition of the Progress in Molecular Biology and Translational Science series highlight a range of topics leading from the development and use of tools in molecular biology to commonly studied cellular structures, including focal adhesions and the nucleus…[and] various aspects of mechanotransduction in these uncommitted cells: in cardiac cells during their maturation, in the malignant behavior of tumor-initiating cells, and in stem cells...our final chapters focus on mechanotransduction in tissues.”
The detection and role of molecular tension in focal adhesion dynamics.