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NASA Spaceline Current Awareness List #627 - 12 December 2014

Status Report From: Spaceline
Posted: Friday, December 12, 2014

Papers deriving from NASA support:

1

Pattarini JM, Blue RS, Castleberry TL, Vanderploeg JM.

Preflight screening techniques for centrifuge-simulated suborbital spaceflight.

Aviat Space Environ Med. 2014 Dec;85(12):1217-21.

http://www.ncbi.nlm.nih.gov/pubmed/25479265

(PI: J.M. Vanderploeg)

Journal Impact Factor:0.782

Funding:"The authors acknowledge additional support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58."

2

Sasi SP, Rahimi L, Yan X, Silver M, Qin G, Losordo DW, Kishore R, Goukassian DA.

Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia model.

FASEB J. 2014 Dec 2. pii: fj.14-249813. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25466901

(PI: D.A. Goukassian)

Journal Impact Factor:5.48

Funding:"Supported by U.S. National Institutes of Health Grant R21-AG02677, AHA Grants 0630113N and 14GRNT18860032, and NASA Grant NNJ10-ZSA001N to D.A.G.; and by grants from National Heart, Lung, and Blood Institute HL106098 to X.Y. and HL091983 to R.K."

3

Paixao AR, Chakravorty R, Khera A, Leonard D, DeFina LF, Barlow CE, Radford NB, Levine BD.

Disagreement between different definitions ofcoronary artery calcium progression.

JACC Cardiovasc Imaging. 2014 Nov 12. pii: S1936-878X(14)00773-6. [Epub ahead of print] Letter.

http://www.ncbi.nlm.nih.gov/pubmed/25457766

(PI: B.D. Levine)

Journal Impact Factor:6.986

Funding:"This work was supported by grant #NSBRI CA02201 from the National Space Biomedical Research Institute."

4

Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW.

Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans.

Brain Behav Immun. 2014 Nov 13. pii: S0889-1591(14)00518-2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25452149

(PIs: S.W. Lockley, S.A. Shea)

Journal Impact Factor:6.128

Funding:"This work was supported by the National Space Biomedical Research Institute: HPF01301; National Heart, Lung, and Blood Institute: 1RC2HL101340-01; National Institute for Neurological Disorders and Stroke: U54NS060659; Atlanta Clinical and Translational Science Institute Pilot grant supported in part by PHS Grants: UL1 RR025008, KL2 RR025009 or TL1 RR025010 from the Clinical and Translational Science Award program. SAR, SWL and CAC were supported in part by the National Space Biomedical Research Institute through NASA NCC 9-58. SAS is supported by NASA Grant NASANNX1 OAR 1 OG and NHLBI Grant K24-HL076446. FAS was supported by NHLBI Grant R01 HL094806. The project described was supported by Brigham and Women's Hospital General Clinical Research Center Grant M01 RR02635. The project described was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women's Hospital from the National Center for Research Resources."

5

Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A.

Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress.

Cell Rep. 2014 Nov 20;9(4):1387-401. Epub 2014 Nov 6.

http://www.ncbi.nlm.nih.gov/pubmed/25456133

(PIs: A. Asaithamby; J.D. Minna/A. Asaithamby/D.J. Chen/NSCOR)

Note:This article may be obtained online without charge.

Journal Impact Factor:7.207

Funding:"This work was supported by NIH Grant CA134991 (to D.J.C.) and the National Aeronautics and Space Association grants NNX13AD57G (to A.A.) and NNX11AC54G (to D.J.C. and A.A.)."

6

Wallace IJ, Judex S, Demes B.

Effects of load-bearing exercise on skeletal structure and mechanics differ between outbred populations of mice.

http://www.ncbi.nlm.nih.gov/pubmed/25460574

(PI: S. Judex)

Journal Impact Factor:4.461

Funding:"This research was supported primarily by a grant from the L.S.B. Leakey Foundation (49357), as well as grants from the National Science Foundation (BCS 0935321), the National Aeronautics and Space Administration (NNX12AL25G and NNX08BA35G), and Sigma Xi (G20120315159591)."

7

Sanzari JK, Billings PC, Wilson JM, Diffenderfer ES, Arce-Esquivel AA, Thorne PK, Laughlin M, Kennedy AR.

Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.

Life Sci Space Res. 2014 Dec 5. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S2214552414000649

(PI: A.R. Kennedy)

Journal Impact Factor:1.183

Funding:"This study was funded by the National Space Biomedical Research Institute (NSBRI) Center of Acute Radiation Research Grant. The NSBRI is funded through NASA NCC 9-58."

8

Datta K, Suman S, Fornace AJ Jr.

Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine.

Int J Biochem Cell Biol. 2014 Oct 23;57C:167-176. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25449263

(PI: K. Datta; A.J. Fornace, Jr./K. Datta/NSCOR)

Journal Impact Factor:4.24

Funding:"This study is supported in part by NASA Grant# NNX13AD58G and NNX09AU95G. We acknowledge the Histopathology and Tissue Shared Resources supported by Award Number P30CA051008 from the National Cancer Institute."

9

Poulose SM, Bielinski DF, Carrihill-Knoll KL, Rabin BM, Shukitt-Hale B.

Protective effects of blueberry- and strawberry diets on neuronal stress following exposure to (56)Fe particles.

Brain Res. 2014 Dec 17;1593:9-18. Epub 2014 Oct 22.

http://www.ncbi.nlm.nih.gov/pubmed/25451098

(PI: B.M. Rabin)

Journal Impact Factor:2.828

Funding:"This research was supported in part by USDA Intramural and N.A.S.A. Grants NX08AM66G and NNX13AB73G."

10

Abercromby AFJ, Conkin J, Gernhardt ML.

Modeling a fifteen-minute extravehicular activity prebreathe protocol using NASA's exploration atmosphere (56.5 kPa/34% O2).

Acta Astronaut. 2014 Dec 8. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0094576514004937

Journal Impact Factor:0.816

Funding:"This report was made possible, in part, through a National Aeronautics and Space Administration Cooperative Agreement (NNJ11HE31A) with the Universities Space Research Association." M.L. Gernhardt is at NASA Johnson Space Center.

11

Barr YR.

Lumbar puncture during spaceflight: Operational considerations, constraints, concerns, and limitations.

Aviat Space Environ Med. 2014 Dec;85(12):1209-13. Review.

http://www.ncbi.nlm.nih.gov/pubmed/25479263

Journal Impact Factor:0.782

Funding:"This study was sponsored by NASA."

12

Blaber E, Sato K, Almeida EA.

Stem cell health and tissue regeneration in microgravity.

Stem Cells Dev. 2014 Dec;23 Suppl 1:73-8.

http://www.ncbi.nlm.nih.gov/pubmed/25457968

(PIs: E.A. Almeida; E. Blaber, NASA Postdoctoral Fellowship Program)

Note:This article describes the Bioculture System, used for cell science experiments on ISS. This article may be obtained online without charge.

Journal Impact Factor:4.202

Funding:"This work was supported by the NASA Space Biology Program, NASA Fundamental Space Biology Grants NNH08ZTT003N and NNH07ZTT001N to E. Almeida, and NASA Postdoctoral Program Fellowship to E. Blaber."

13

Paulus DC, Settlage DM.

Automated testing of the controlled resistance exercise device (C-red) for spaceflight.

Biomed Sci Instrum. 2014;50:164-70.

http://www.ncbi.nlm.nih.gov/pubmed/25405419

Journal Impact Factor:Not available for this journal.

Funding:"This work was supported by NASA Phase III SBIR "Compact Crew Exercise Device" with Streamline Automation, LLC."

14

Campbell MR.

Body mass changes during long-duration spaceflight: Letter.

Aviat Space Environ Med. 2014 Dec;85(12):1229. Letter.

http://www.ncbi.nlm.nih.gov/pubmed/25479267

Response by:

Zwart SR, Launius RD, Coen GK, Morgan JL, Charles JB, Smith SM.

Body mass changes during long-duration spaceflight: Response.

Aviat Space Environ Med. 2014 Dec;85(12):1229-30. Letter.

http://www.ncbi.nlm.nih.gov/pubmed/25479268

Note:These letters are in response to the article: Zwart SR, Launius RD, Coen GK, Morgan JL, Charles JB, Smith SM . Body mass changes during long-duration spaceflight. Aviat Space Environ Med 2014;85:897-904. This article was cited in SPACELINE Current Awareness List #614, 5 September 2014.http://www.ncbi.nlm.nih.gov/pubmed/25197887

______________________________________________________________

Other papers of interest:

1

Naumenko VS, Kulikov AV, Kondaurova EM, Tsybko AS, Kulikova EA, Krasnov IB, Shenkman BS, Sychev VN, Bazhenova EY, Sinyakova NA, Popova NK.

Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-X(L) genes expression in mouse brain regions.

http://www.ncbi.nlm.nih.gov/pubmed/25451288

Note:Bion-M1 results.

2

Novoselova EG, Lunin SM, Khrenov MO, Parfenyuk SB, Novoselova TV, Shenkman BS, Fesenko EE.

Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space.

http://www.ncbi.nlm.nih.gov/pubmed/25468559

Note:Bion-M1 results.

3

Rudwill F, Bergouignan A, Gastebois C, Gauquelin-Koch G, Lefai E, Blanc S, Simon C.

Effect of enforced physical inactivity induced by 60-d of bed rest on hepatic markers of NAFLD in healthy normal-weight women.

Liver Int. 2014 Nov 21. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25413107

Note:Bed rest study.

4

Zhang X, Li L, Bai Y, Shi R, Wei H, Zhang S.

Mouse undifferentiated spermatogonial stem cells cultured as aggregates under simulated microgravity.

http://www.ncbi.nlm.nih.gov/pubmed/25436272

Note:A Rotating Cell Culture System was used.

5

Federenko YF, Merkov PL, Yaroshenko YN, Denogratov SK, Charapakhin KP, Neofitov NH.

Potential benefits of potassium deposition with periodic fluid redistribution using periodic head down tilt during diminished muscular activity.

Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):30-8.

http://www.ncbi.nlm.nih.gov/pubmed/25464674

Note:Subjects were placed in -8 to -12 head-down tilt for 8-10 hours per day.

6

Tang C, Niu Z, Zheng Y, Chen Y, Bao B, Meng Q.

[Effects of hypergravity exposure after 30-days simulated weightlessness on chemokine CCL20 and its receptor CCR6 in lingual mucosa of rhesus macaque].

Zhonghua Yi Xue Za Zhi. 2014 Aug 26;94(32):2525-30. Chinese.

http://www.ncbi.nlm.nih.gov/pubmed/25410926

Note:Information about what methods were used for hypergravity and weightlessness simulation is unavailable in English.

7

Buzzacott P, Lambrechts K, Mazur A, Wang Q, Papadopoulou V, Theron M, Balestra C, Guerrero F.

A ternary model of decompression sickness in rats.

Comput Biol Med. 2014 Dec;55:74-8. Epub 2014 Oct 22.

http://www.ncbi.nlm.nih.gov/pubmed/25450221

8

Hughson RL, Shoemaker JK.

Autonomic responses to exercise: Deconditioning/inactivity.

Auton Neurosci. 2014 Oct 22. pii: S1566-0702(14)00167-2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25458429

9

Xu H, Wu F, Cao H, Kan G, Zhang H, Yeung EW, Shang P, Dai Z, Li Y.

Effects of simulated microgravity on microRNA and mRNA expression profile of rat soleus.

Acta Astronaut. 2015 Feb-Mar;107:40-9.

http://www.sciencedirect.com/science/article/pii/S009457651400455X

Note:Hindlimb unloading study.

10

Wall BT, Dirks ML, Snijders T, Stephens FB, Senden JM, Verscheijden ML, van Loon LJ.

Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males.

Exp Gerontol. 2014 Nov 29;61C:76-83. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25457674

Note:A full leg cast was the means of immobilization.

11

Hindle AG, Otis JP, Epperson LE, Hornberger TA, Goodman CA, Carey HV, Martin SL.

Prioritization of skeletal muscle growth for emergence from hibernation.

J Exp Biol. 2014 Dec 1. pii: jeb.109512. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25452506

12

Lei J, Pertovaara A, You HJ.

Effects of simulated weightlessness on intramuscular hypertonic saline induced muscle nociception and spinal Fos expression in rats.

Brain Res. 2015 Jan 12;1594:204-14. Epub 2014 Nov 15.

http://www.ncbi.nlm.nih.gov/pubmed/25446440

Note:Hindlimb unloading study.

13

Norman SC, Wagner DW, Beaupre GS, Castillo AB.

Comparison of three methods of calculating strain in the mouse ulna in exogenous loading studies.

J Biomech. 2014 Nov 15. pii: S0021-9290(14)00571-5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25443882

Note:From the abstract: "The purpose of this study was to compare the relationship between load-induced one formation rates and periosteal strain at ulnar midshaft using three different methods to estimate strain: (A) Nominal strain values based solely on load-strain calibration; (B) Strains calculated from load-strain calibration, but scaled for differences in mid-shaft cross-sectional geometry among animals; and (C) An alternative image-based computational method for calculating strains based on beam theory and animal-specific bone geometry."

14

Gerbaix M, Vico L, Ferrari SL, Bonnet N.

Periostin expression contributes to cortical bone loss during unloading.

http://www.ncbi.nlm.nih.gov/pubmed/25445447

Note:Hindlimb unloading study.

15

Haugh MG, Vaughan TJ, McNamara LM.

The role of integrin (V)(3) in osteocyte mechanotransduction.

J Mech Behav Biomed Mater. 2014 Nov 10;42C:67-75. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25460927

16

Shimizu N, Wood S, Kushiro K, Yanai S, Perachio A, Makishima T.

Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice.

http://www.ncbi.nlm.nih.gov/pubmed/25446357

17

Yang YC, Wang XD, Huang K, Wang L, Jiang ZL, Qi YX.

Temporal phosphoproteomics to investigate the mechanotransduction of vascular smooth muscle cells in response to cyclic stretch.

J Biomech. 2014 Oct 16;47(15):3622-3629. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25458152

18

Klotzsch E, Stiegler J, Ben-Ishay E, Gaus K.

Do mechanical forces contribute to nanoscale membrane organisation in T cells?

Biochim Biophys Acta. 2014 Nov 1. pii: S0167-4889(14)00384-X. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/25447546

19

Sazonova OV, Isenberg BC, Herrmann J, Lee KL, Purwada A, Valentine AD, Buczek-Thomas JA, Wong JY, Nugent MA.

Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction.

Matrix Biol. 2014 Nov 15. pii: S0945-053X(14)00201-7. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25448408

Note:This article may be obtained online without charge.

20

Kakinoki S, Seo JH, Inoue Y, Ishihara K, Yui N, Yamaoka T.

Mobility of the Arg-Gly-Asp (RGD) ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions.

Acta Biomater. 2014 Nov 25. pii: S1742-7061(14)00514-5. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25463493

Some recent articles from Aviakosmicheskaia i ekologicheskaia meditsina:

21

Mednikova EI, Gur'eva TS, Dadasheva OA, Sychev VN, Morozova IuA.

[Ion-exchange substrate as a source of nitrogen mobile forms in the conveyor method of vegetables cultivation on artificial soil].

Aviakosm Ekolog Med. 2014;48(4):57-62. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365879

22

Mednikova EI, Gur'eva TS, Dadasheva OA, Sychev VN, Morozova IuA.

[Development of paste-type food for experiments with mice onboard unmanned spacecrafts].

Aviakosm Ekolog Med. 2014;48(4):53-6. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365878

23

Voekova TA, Tiaglov BV, Novikova LM, Krest'ianova IN, Emel'ianova LK, Korshunov DV, Morozova IuA, Il'in VK.

[Bion-M1. Biological activities of microorganisms under the conditions of a 30-day space flight].

Aviakosm Ekolog Med. 2014;48(4):46-52. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365877

Note:Bion-M1 results.

24

Ogneva IV, Biriukov NS, Lensoo TA, Larina IM.

[Structure of the cortical cytoskeleton of the left cardiac ventricle hystiocytes and of soleus muscle fibers in rats following short-time suspension].

Aviakosm Ekolog Med. 2014;48(4):37-45. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365876

Note:Hindlimb unloading study.

25

Stepanova GP, Bulov SP, Eshchenko AI, Skedina MA, Voronkov IuI.

[Effects of the 520-day isolation on the functional state of the cardiovascular system].

Aviakosm Ekolog Med. 2014;48(4):23-7. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365873

26

Afonin BV, Sedova EA, Tikhonova GA, Solov'eva AA, Valuev VA.

[Evaluation of the liver functional changes due to modeling the hemodynamic effects of microgravity in bed rest studies].

Aviakosm Ekolog Med. 2014;48(4):17-22. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365872

Note:Bed rest study.

27

Zhdan'ko IM, Zinkin VN, Soldatov SK, Bogomolov AV, Sheshegov PM.

[Fundamental and applied aspects of preventing the adverse effects of aviation noise].

Aviakosm Ekolog Med. 2014;48(4):5-16. Russian.

http://www.ncbi.nlm.nih.gov/pubmed/25365871

// end //

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