NASA Spaceline Current Awareness List #641 - 27 March 2015

Status Report From: Spaceline
Posted: Friday, March 27, 2015

Papers deriving from NASA support:



Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER.

Masticatory muscles of mouse do not undergo atrophy in space.

FASEB J. 2015 Mar 20. [Epub ahead of print]

PI: E.R. Barton

Note: STS-135 results.

Journal Impact Factor: 5.480

Funding: “The study was supported, in part, by NASA Space Biology Grant NNX09AH44G (to E.R.B.), U.S. National Institutes of Health Grant R052646 (to E.R.B.), the Canadian Institutes for Health Research (to D.E.R.), and the Natural Science and Engineering Research Council of Canada (to D.E.R.).”



Lin L, Lin W, Qin YX.

Enhanced correlation between quantitative ultrasound and structural and mechanical properties of bone using combined transmission-reflection measurement.

J Acoust Soc Am. 2015 Mar;137(3):1144.

PI: Y.X. Qin

Journal Impact Factor: 1.555

Funding: “This work is kindly supported by NSBRI through National Aeronautics and Space Administration (NASA) Cooperative Agreement NCC 9-58, NASA, National Institutes of Health (AR52379 and AR61821), and New York State Office of Science, Technology and Academic Research (NYSTAR).”



Sanzari JK, Krigsfeld GS, Shuman AL, Diener AK, Lin L, Mai W, Kennedy AR.

Effects of a granulocyte colony stimulating factor, Neulasta, in mini pigs exposed to total body proton irradiation.

Life Sci Space Res. 2015 Mar 25. [Article in Press]

PI: A.R. Kennedy/Center of Acute Radiation Research

Journal Impact Factor: 1.183

Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) Center of Acute Radiation Research (CARR) grant. The NSBRI is funded through the National Aeronautics and Space Administration (NASA) Class Code (NCC) 9-58. The research was also supported by the NIH Radiation Biology Training Grant 2T32CA009677.”



Other papers of interest:



Ciuha U, Eiken O, Mekjavic IB.

Effects of normobaric hypoxic bed rest on the thermal comfort zone.

J Therm Biol. 2015 Apr-May;49-50:39-46. Epub 2015 Feb 3.

Note: Bed rest study.



Matzuka B, Mehlsen J, Tran H, Olufsen M.

Using Kalman filtering to predict time-varying parameters in a model predicting baroreflex regulation during head-up tilt.

IEEE Trans Biomed Eng. 2015 Mar 5. [Epub ahead of print]



Bao XC, Chen H, Fang YQ, Yuan HR, You P, Ma J, Wang FF.

Clopidogrel reduces the inflammatory response of lung in a rat model of decompression sickness.

Respir Physiol Neurobiol. 2015 Mar 14. [Epub ahead of print]



Belova SP, Lomonosova YN, Shenkman BS, Nemirovskaya TL.

The blockade of dihydropyridine channels prevents an increase in µ-calpain level under m. soleus unloading.

Dokl Biochem Biophys. 2015 Jan;460(1):1-3. Epub 2015 Mar 16.

Note: Hindlimb unloading study.



Genchi GG, Cialdai F, Monici M, Mazzolai B, Mattoli V, Ciofani G.

Hypergravity stimulation enhances PC12 neuron-like cell differentiation.

Biomed Res Int. 2015;2015:748121. Epub 2015 Feb 16.

Note: Centrifugation was used. This article may be obtained online without charge.



Ohira T, Wang XD, Ito T, Kawano F, Goto K, Izawa T, Ohno H, Kizaki T, Ohira Y.

Macrophage deficiency in osteopetrotic (op/op) mice inhibits activation of satellite cells and prevents muscle hypertrophy in single soleus fibers.

Am J Physiol Cell Physiol. 2015 Mar 18:ajpcell.00348.2014. [Epub ahead of print]

Note: Hindlimb unloading study.



Tajino J, Ito A, Nagai M, Zhang X, Yamaguchi S, Iijima H, Aoyama T, Kuroki H.

Discordance in recovery between altered locomotion and muscle atrophy induced by simulated microgravity in rats.

J Mot Behav. 2015 Mar 19:1-10. [Epub ahead of print]

Note: Hindlimb unloading study.



Matsumoto T, Sato S.

Stimulating angiogenesis mitigates the unloading-induced reduction in osteogenesis in early-stage bone repair in rats.

Physiol Rep. 2015 Mar;3(3).

Note: Hindlimb unloading study. This article may be obtained online without charge.



Guastello SJ, Reiter K, Malon M, Timm P, Shircel A, Shaline J.

Catastrophe models for cognitive workload and fatigue in N-back tasks.

Nonlinear Dynamics Psychol Life Sci. 2015 Apr;19(2):173-200.



Wiest G.

The origins of vestibular science.

Ann N Y Acad Sci. 2015 Mar 12. [Epub ahead of print] Review.



Cartwright IM, Bell JJ, Maeda J, Genet MD, Romero A, Fujii Y, Fujimori A, Kitamuta H, Kamada T, Chen DJ, Kato TA.

Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity.

Oncol Lett. 2015 Apr;9(4):1621-7. Epub 2015 Feb 17.

Note: This article may be obtained online without charge.



Crowley KD, Cullings HM, Landes RD, Shore RE, Ullrich RL.

Comments on estimating risks of low radiation doses—A critical review of the BEIR VII Report and its use of the linear no-threshold (LNT) hypothesis by Edward J. Calabrese and Michael K. O'Connor.

Radiat Res. 2015 Mar 25. [Epub ahead of print]


O'Connor MK, Calabrese EJ.

Response to Comments on “Estimating risks of low radiation doses—A critical review of the BEIR VII Report and its use of the linear no-threshold (LNT) hypothesis”.

Radiat Res. 2015 Mar 25. [Epub ahead of print]

Note: These letters refer to the article: Calabrese EJ, O'Connor MK. Estimating risk of low radiation doses – A critical review of the BEIR VII report and its use of the linear no-threshold (LNT) hypothesis. Radiat Res. 2014 Nov;182(5):463-74. Epub 2014 Oct 20. (, which appeared in Current Awareness List 622, October 31, 2014.



Cucinotta FA.

A new approach to reduce uncertainties in space radiation cancer risk predictions.

PLoS One. 2015 Mar 19;10(3):e0120717.

Note: This article may be obtained online without charge.



Nakano T, Mitsusada Y, Salem AM, Shoulkamy MI, Sugimoto T, Hirayama R, Uzawa A, Furusawa Y, Ide H.

Induction of DNA-protein cross-links by ionizing radiation and their elimination from the genome.

Mutat Res. 2015 Jan;771:45-50. Epub 2014 Dec 24.



Wang T, Sun Q, Xu W, Li F, Li H, Lu J, Wu L, Wu Y, Liu M, Bian P.

Modulation of modeled microgravity on radiation-induced bystander effects in Arabidopsis thaliana.

Mutat Res. 2015 Mar;773:27-36. Epub 2015 Jan 24.

Note: A 2-D rotation clinostat was used.



Uzer G, Thompson WR, Sen B, Xie Z, Yen SS, Miller S, Bas G, Styner M, Rubin CT, Judex S, Burridge K, Rubin J.

Cell mechanosensitivity to extremely low magnitude signals is enabled by a LINCed nucleus.

Stem Cells. 2015 Mar 18. [Epub ahead of print]



Laing EE, Johnston JD, Moller-Levet CS, Bucca G, Smith CP, Dijk DJ, Archer SN.

Exploiting human and mouse transcriptomic data: Identification of circadian genes and pathways influencing health.

Note: This article may be obtained online without charge.

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.