NASA Spaceline Current Awareness List #652 - 12 June 2015

Status Report From: Spaceline
Posted: Friday, June 12, 2015


Papers deriving from NASA support:



Madansingh S, Bloomberg JJ.

Understanding the effects of spaceflight on head–trunk coordination during walking and obstacle avoidance.

Acta Astronaut. 2015 Oct-Nov;115:165-72.

Note: ISS and bed rest study results.

Journal Impact Factor: 0.816

Funding: No funding cited. J.J. Bloomberg is at NASA Johnson Space Center.



Ross CL, Siriwardane M, Almeida-Porada G, Porada CD, Brink P, Christ GJ, Harrison BS.

The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation.

Stem Cell Res. 2015 May 12;15(1):96-108. [Epub ahead of print]

PI: C.D. Porada

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.912

Funding: "The authors wish to acknowledge the Guth Family Fund 120-330-740196, NIH grant numbers R01-HL097623 and R21-HL117704, Grant NNX13AB67G from National Aeronautics and Space Administration (NASA), P20-DK097806, DOD W81XWH-14-2-0004, TATRC W81XWHH-12-1-0422, and R01-GM88180."



Clément G, Bukley A, Paloski W.

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions.

Front Syst Neurosci. 2015;9. Epub 2014 May 30

Note: Artificial gravity measures discussed include rotating spacecraft, short-radius centrifugation, and partial gravity simulators such as inclination and suspension. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: No funding cited. W.H. Paloski is at NASA Johnson Space Center.



Paulus DC, DeWitt J.

Human subject evaluation of the Controlled Resistance Exercise Device (C-Red) for spaceflight.

Biomed Sci Instrum. 2015 Apr 10;51:46-53.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by NASA Phase III SBIR “Compact Crew Exercise Device” with Streamline Automation, LLC."



Moore ST, Dilda V, Morris T, Yungher D, MacDougall H.

Pre-adaptation to noisy galvanic vestibular stimulation is associated with enhanced sensorimotor performance in novel vestibular environments.

Front Syst Neurosci. 2015 Jun 8;9.

PI: S.T. Moore

Note: A full-motion flight simulator was used. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This study was funded by grants from the National Space Biomedical Research Institute (SA01603) and the National Aeronautics and Space Administration (NNX12AM25G)."



Goyden J, Tawara K, Hedeen D, Willey JS, Thom Oxford J, Jorcyk CL.

The effect of OSM on MC3T3-E1 osteoblastic cells in simulated microgravity with radiation.

PLoS One. 2015 Jun 1;10(6):e0127230.

PI: J.S. Willey, NSBRI Career Advancement Award

Note: A Rotary Cell Culture System was used. This article may be obtained online without charge.

Journal Impact Factor: 3.534

Funding: "This work was supported in part by the National Institutes of Health (R15CA137510, P20GM109095, and P20GM103408), the National Space Biomedical Research Institute (#EO00008 through NASA NCC 9–58), and the National Aeronautics and Space Administration (NNX10AN29A and NNX13AB10A)."



Mellor L, Mohiti-Asli M, Williams J, Kannan A, Dent MR, Guilak F, Loboa E.

Extracellular calcium modulates chondrogenic and osteogenic differentiation of human derived adipose stem cells: A novel approach for osteochondral tissue engineering using a single stem cell source.

Tissue Eng Part A. 2015 Jun 2. [Epub ahead of print]

PI: L. Mellor

Journal Impact Factor: 4.254

Funding: "This work was supported in part by the National Space Biomedical Research Institute though NASA NCC9-58, NIH/NIBIB 1R03EB008790 (EGL), NSF/CBET 1133427 (EGL), NIH R48182 (FG) and NIH AR48852 (FG)."



Wickens CD, Gutzwiller RS, Santamaria A.

Discrete task switching in overload: A meta-analyses and a model.

Int J Hum Comput Stud. 2015 Jul;79:79-84.

PI: A. Sebok

Journal Impact Factor: 1.165

Funding: "This material is based upon work supported by NASA under Grant NNX12AE69G, technical monitor Dr. Mary Kaiser."



Other papers of interest:



Noskov VB, Nichiporuk IA, Vasilieva GY, Smirnov YI.

[Human body composition during extended stay in microgravity].

Aviakosm Ekolog Med. 2015;49(1):19-25. Russian.

Note: ISS results.



Dorozhkina OV, Ivanov AA.

[Cytogenetic investigations of bone marrow cells from mice exposed onboard biosatellite "Bion-M1"].

Aviakosm Ekolog Med. 2015;49(1):37-42. Russian.

Note: Bion-M1 results.



Drobyshev SG, Benghin VV.

[Analysis of the importance of cosmonaut's location and orientation onboard the International Space Station to levels of visceral irradiation during traverse of the region of the South Atlantic Anomaly].

Aviakosm Ekolog Med. 2015;49(1):57-63. Russian.

Note: ISS results.



Polyakov AV, Bogomolov VV.

[The perspective of building-up the emergency medical aid resources on the Russian segment of the International space station].

Aviakosm Ekolog Med. 2015;49(1):70-3. Russian.

Note: Discusses ISS medical resources.



Voiculescu SE, Rosca AE, Zeca V, Zagrean L, Zagrean AM.

Impact of maternal melatonin suppression on forced swim and tail suspension behavioral despair tests in adult offspring.

J Med Life. 2015 Apr-Jun;8(2):202-6.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Pinto-Teixeira F, Viader-Llargués O, Torres-Mejía E, Turan M, González-Gualda E, Pola-Morell L, López-Schier H.

Inexhaustible hair-cell regeneration in young and aged zebrafish.

Biol Open. 2015 May 22. [Epub ahead of print]

Note: This article may be obtained online without charge.



Nordine M, Maggioni MA, Stahn A, Mendt S, Brauns K, Gunga H-C, Habazettl H, Nitsche A, Opatz O.

Form influences function: Anthropometry and orthostatic stability during sustained acceleration in a short arm human centrifuge.

Acta Astronaut. 2015 Oct;115:138-46.

Note: A short-arm centrifuge was used.



Liao Y, Lei M, Huang H, Wang C, Duan J, Li H, Liu X.

The time course of altered brain activity during 7-day simulated microgravity.

Front Behav Neurosci. 2015 May 12;9:124.

Note: Bed rest study. This article may be obtained online without charge.



Michelini LC, O'Leary DS, Raven PB, Nóbrega AC.

Neural control of circulation and exercise: Translational approach disclosing interactions between central command, arterial baroreflex and muscle metaboreflex.

Am J Physiol Heart Circ Physiol. 2015 May 29:ajpheart.00077.2015. [Epub ahead of print] Review.



Pastuchkova L, Fomina EV, Lysova NY, Kononikhin AS, Tiys ES, Larina IM.

[Urine protein profile in healthy people following locomotor loading with changing intensity].

Aviakosm Ekolog Med. 2015;49(1):26-31. Russian.



Bock O, Schott N, Papaxanthis C.

Motor imagery: Lessons learned in movement science might be applicable for spaceflight.

Front Syst Neurosci. 2015 May 18;9:75.

Note: From the abstract: ". . . we propose a quick, simple and inexpensive approach that could be used to prepare astronauts both for the absence and for the renewed presence of gravity. This approach is based on motor imagery (MI), a process in which actions are produced in working memory without any overt output." This article may be obtained online without charge.



Han C, Jiang C, Yu C, Shen H.

Differentiation of transforming growth factor beta1-induced mesenchymal stem cells into nucleus pulposus-like cells under simulated microgravity conditions.

Cell Mol Biol (Noisy-le-grand). 2015 May 16;61(2):50-5.

Note: A Rotary Cell Culture System was used.



Persat A, Inclan YF, Engel JN, Stone HA, Gitai Z.

Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa.

Proc Natl Acad Sci U S A. 2015 Jun 3. [Epub ahead of print]



Huangfu J, Zhang G, Li J, Li C.

Advances in engineered microorganisms for improving metabolic conversion via microgravity effects.

Note: From the abstract: "In this commentary, we discuss the microgravity effects in engineered microorganisms for improving metabolic conversion, including cell growth kinetics, antimicrobial susceptibility, resistance to stresses, secondary metabolites production, recombinant protein production and enzyme activity, as well as gene expression changes."



Klingberg D, Hammam E, Macefield VG.

Motion sickness is associated with an increase in vestibular modulation of skin but not muscle sympathetic nerve activity.

Exp Brain Res. 2015 May 30. [Epub ahead of print]



Yasnetsov VV, Karsanova SK, Yasnetsov VV.

[A new approach to the search for vestibuloprotectors].

Aviakosm Ekolog Med. 2015;49(1):5-12. Russian.



Sun J, Li X, Yang C, Wang Y, Shi F, Gao Y, Luan Q, Zhu Y, Sun X.

Transcutaneous electrical acupuncture stimulation as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans.

Acupunct Med. 2015 May 29. [Epub ahead of print]

Note: Bed rest study. This article may be obtained online without charge.



Kotovskaya AR, Fomina GA, Salnikov AV.

[Normal values of the major parameters of lower limb veins in Russian cosmonauts prior to flight and in healthy untrained subjects].

Aviakosm Ekolog Med. 2015;49(1):13-8. Russian.



Lomonosova Y, Turtikova OV, Shenkman BS.

[Translocation of MuRF isoforms to nuclei in postural muscle during gravitational unloading].

Ross Fiziol Zh Im I M Sechenova. 2015 Jan;101(1):64-73. Russian.

Note: Hindlimb unloading study.



Leung KS, Li YH, Liu Y, Wang H, Tam KF, Chow DH, Wan Y, Ling S, Dai Z, Qin L, Cheung WH.

Effect of daily short-duration weight-bearing on disuse-induced deterioration of musculoskeletal system.

J Musculoskelet Neuronal Interact. 2015 Jun;15(2):207-14.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Eremeev AA, Chebotarev MA, Kuznetsov MV, Baltin ME, Shenkman BS.

[Neuromotor apparatus in the condition of gravitational unloading: Central and peripheral effects].

Aviakosm Ekolog Med. 2015;49(1):32-6. Russian.

Note: Hindlimb unloading study.



Ribeiro FO, Gómez-Benito MJ, Folgado J, Fernandes PR, García-Aznar JM.

In silico mechano-chemical model of bone healing for the regeneration of critical defects: The effect of BMP-2.

PLoS One. 2015 Jun 4;10(6):e0127722.

Note: This article may be obtained online without charge.



Sandal GM, Bye HH.

Value diversity and crew relationships during a simulated space flight to Mars.

Acta Astronaut. 2015 Sep;114:164-73.

Note: Results are from the Mars520 isolation study.



Acharya MM, Patel NH, Craver BM, Tran KK, Giedzinski E, Tseng BP, Parihar VK, Limoli CL.

Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment.

PLoS One. 2015 Jun 4;10(6):e0128316.

Note: This article may be obtained online without charge.



Vasilieva IN, Bespalov VG, Zinkin VN, Podgornaya OI.

[Sequencing of low-molecular-weight DNA in blood plasma of irradiated rats].

Aviakosm Ekolog Med. 2015;49(1):43-9. Russian.



Vorozhtsova SV, Bulynina TM, Molokanov AG, Ivanov AA.

[Cytogenetic damage to the corneal epithelium of mice due to the in vivo exposure to ionizing radiation with different levels of linear energy transfer].

Aviakosm Ekolog Med. 2015;49(1):50-6. Russian.



Sletten TL, Segal AY, Flynn-Evans EE, Lockley SW, Rajaratnam SM.

Inter-individual differences in neurobehavioural impairment following sleep restriction are associated with circadian rhythm phase.

PLoS One. 2015 Jun 4;10(6):e0128273.

Note: This article may be obtained online without charge.



Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S.

Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1Per2, and Bmal1 in the amygdala and hippocampus of mice.

Neurosci Res. 2015 May 27. [Epub ahead of print]



Haga K, Sakai T.

PINOID functions in root phototropism as a negative regulator.

Plant Signal Behav. 2015 May 4;10(5):e998545.



Voytsekovskaya SA, Astafurova TP, Verkhoturova GS, Postovalova VM.

[Effect of hypobaric hypoxia on the dehydrogenase activities of respiration and photosynthetic metabolism in barley seedlings].

Aviakosm Ekolog Med. 2015;49(1):64-9. Russian.



Retraction: Mechanosensitive channel candidate MCA2 is involved in touch-induced root responses in Arabidopsis.

Front Plant Sci. 2015 Mar 5;6:153.

Note: The retracted article appeared in SPACELINE Current Awareness List #615 on September 12, 2014. From the abstract: "The authors and the journal wish to retract the 21 Aug 2014 article . . . in light of new experimental evidence. Following the publication of the study, we performed a DNA microarray analysis to detect genes with expression levels that were specifically lower in the mca2-null mutant than in the Col-0 wild type, and found that the expression level of the AXR4 gene (At1G54990), which encodes a protein required for the subcellular localization of the auxin influx carrier AUX1 (Dharmasirietal., 2006), was significantly lower in the mca2-null mutant." This article may be obtained online without charge.



Xiao Z, Quarles LD.

Physiological mechanisms and therapeutic potential of bone mechanosensing.

Rev Endocr Metab Disord. 2015 Jun 3. [Epub ahead of print]



Notbohm J, Lesman A, Rosakis P, Tirrell DA, Ravichandran G.

Microbuckling of fibrin provides a mechanism for cell mechanosensing.

J R Soc Interface. 2015 Jul 6;12(108).



Butler PJ, Dey KK, Sen A.

Impulsive enzymes: A new force in mechanobiology.

Cell Mol Bioeng. 2015 Mar 1;8(1):106-18.

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