SpaceRef

SpaceRef


NASA Spaceline Current Awareness List #668 9 October 2015

Status Report From: Spaceline
Posted: Friday, October 9, 2015

Papers deriving from NASA support:

1

Blaber EA, Finkelstein H, Dvorochkin N, Sato KY, Yousuf R, Burns BP, Globus RK, Almeida E.

Microgravity reduces the differentiation and regenerative potential of embryonic stem cells.

Stem Cells Dev. 2015 Sep 28. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26414276

PIs: E. Almeida; E.A. Blaber, NASA Postdoctoral Program Fellowship

Note: STS-131 results.

Journal Impact Factor: 3.727

Funding: "This work was supported by NASA Space Life and Physical Sciences Grant NNH08ZTT003N to Eduardo Almeida. Elizabeth Blaber's work was supported by an Australian Postgraduate Award at University of New South Wales and a NASA Postdoctoral Program Fellowship at NASA Ames Research Center."

2

Zwart SR, Gibson CR, Smith SM.

Space flight ophthalmic changes, diet, and vitamin metabolism.

In: Handbook of Nutrition, Diet and the Eye. San Diego: Academic Press, 2014. p. 393-9.

http://www.sciencedirect.com/science/article/pii/B978012401717700040X

PI: S.M. Smith

Journal Impact Factor: Not applicable

Funding: No funding cited. PI reports funding under Directed Research.

3

Broxterman RM, Craig JC, Smith JR, Wilcox SL, Jia C, Warren S, Barstow TJ.

Influence of blood flow occlusion on the development of peripheral and central fatigue during small muscle mass handgrip exercise.

J Physiol. 2015 Sep 1;593(17):4043-54. Epub 2015 Aug 2.

www.ncbi.nlm.nih.gov/pubmed/26104881

PI: T.J. Barstow

Journal Impact Factor: 5.037

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA) under Grant NNX10AK60G awarded to T.J.B. and by NASA Experimental Program to Stimulate Competitive Research (EPSCoR) under Grant NNX11AM05A supporting R.M.B."

4

Petrik D, Latchney SE, Masiulis I, Yun S, Zhang Z, Wu JI, Eisch AJ.

Chromatin remodeling factor Brg1 supports the early maintenance and late responsiveness of nestin-lineage adult neural stem and progenitor cells.

Stem Cells. 2015 Sep 29. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26418130

PI: A.J. Eisch

Journal Impact Factor: 6.523

Funding: "This work was supported to by grants to AJE from the NH (DA02355, DA016765, MH107945), NASA (NNX12AB55G, NNX15AE09G), and a NARSAD Independent Investigator Grant from the Brain and Behavior Foundation, and by grants to JW from the Whitehall Foundation, Welch Foundation, and NIH (MH102820). IM and SEL were supported by T32DA007290, PI AJE. SY was supported by T32MH076690, PI Carol A. Tamminga."

5

Fleenor CJ, Higa K, Weil MM, DeGregori J.

Evolved cellular mechanisms to respond to genotoxic insults: Implications for radiation-induced hematologic malignancies.

Radiat Res. 2015 Sep 28. [Epub ahead of print] Review.

www.ncbi.nlm.nih.gov/pubmed/26414506

PIs: M.M. Weil; R. Ullrich/M.M. Weil/NSCOR

Journal Impact Factor: 2.911

Funding: "These studies were supported by the National Institutes of Health (NIH), grant nos. R01CA180175 (JD), R21CA179501 (JD), 5F31CA165688-03 (CJF) and the National Aeronautics and Space Administration (NASA), grant nos. NNX12AB54G and NNX09AM08G (MMW)."

6

Belov OV, Boyda DL, Plante I, Shirmovsky SE.

Simulation of the charge migration in DNA under irradiation with heavy ions.

Biomed Mater Eng. 2015 Aug 17;26 Suppl 1:S1937-44.

www.ncbi.nlm.nih.gov/pubmed/26405967

PI: S. Blattnig

Journal Impact Factor: 1.091

Funding: "This research was supported by the SC IACP DVO RAS and the JINR Grant # 14091-01. This project is also supported by the Far Eastern Federal University, Grant 13-09-617-m_a and by the NASA Space Radiation Program (NAS9-02078)." I. Plante is funded through the NASA Space Radiation Risk Assessment Project.

7

Coleman MA, S PS, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev Y, Yan X, Goukassian DA.

Low dose radiation affects cardiac physiology: Gene networks and molecular signaling in cardiomyocytes.

Am J Physiol Heart Circ Physiol. 2015 Sep 25:ajpheart.00050.2015. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26408534

PIs: D.A. Goukassian, M. Natarajan

Journal Impact Factor: 3.838

Funding: "This work was supported by the National Aeronautic and Space Administration (NASA) under Grant No. NNX11AD22G and American Heart Association (AHA) Grant No. 14GRNT18860032 to D.A.G. This work was also supported in part by the U.S. Department of Energy under contract number DE-AC52-07NA27344 with funding from the US DOE Low Dose Radiation Research Program Grant KP110202 to M.A.C and by grants from AHA 10GRNT4710003 and NHLBI HL106098 to X.Y. This work was also supported by the National Space Biomedical Research Institute (NSBRI) grant CA02802 through NASA NCC 9-58-298 to M.N."

8

Morris CJ, Garcia JI, Myers S, Yang JN, Trienekens N, Scheer FA.

The human circadian system has a dominating role in causing the morning/evening difference in diet-induced thermogenesis.

Obesity (Silver Spring). 2015 Oct;23(10):2053-8.

www.ncbi.nlm.nih.gov/pubmed/26414564

PI: C.J. Morris, NSBRI Postdoctoral Fellowship Program

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.724

Funding: "This study was supported by National Heart, Lung, and Blood Institute Grant R01 HL094806 to F.A.J.L.S. C.J.M. was partly supported by the National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant NCC 9-58 and by National Heart, Lung, and Blood Institute Grant R01 HL094806, National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK099512, and National Heart, Lung, and Blood Institute Grant R01 HL118601. F.A.J.L.S. was supported in part by National Heart, Lung, and Blood Institute Grant R01 HL094806, National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK099512, and National Heart, Lung, and Blood Institute Grant R01 HL118601. The project described was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women's Hospital from the National Center for Research Resources."

9

Laws CJ, Berg-Johansen B, Hargens AR, Lotz JC.

The effect of simulated microgravity on lumbar spine biomechanics: An in vitro study.

European Spine Journal. 2015 Sep 24. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26403291

PI: A.R. Hargens

Note: From the Abstract: [Human lumbar] "disks were free-swelled in saline to varying supraphysiologic heights consistent with prolonged weightlessness."

Journal Impact Factor: 2.066

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA), Grants NNX10AM18G and NNX13AM89G."

10

Yang X, Wang B, Farris B, Clark G, Roux SJ.

Modulation of root skewing in Arabidopsis by apyrases and extracellular ATP.

Plant Cell Physiol. 2015 Sep 27. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26412783

PI: S.J. Roux

Journal Impact Factor: 4.931

Funding: "This work was supported by the National Science Foundation grant [IOS-1027514 to S.J.R. and G.C.]; the National Aeronautics and Space Administration grant [NNX13AM54G to S.J.R. and G.C.]; the National Natural Science Foundation of China [Project No. 11172337 to X.Y. and B.W.]; and the Chinese Scholarship Council [CSC 2013 to X.Y.]"

11

Gerttula S, Zinkgraf M, Muday G, Lewis D, Ibatullin FM, Brumer H, Hart F, Mansfield SD, Filkov V, Groover A.

Transcriptional and hormonal regulation of gravitropism of woody stems in Populus.

Plant Cell. 2015 Sep 26. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26410302

PI: G. Muday

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.338

Funding: "This work was supported by Grants 2011-67013-30062 and 2015-67013-22891 from USDA AFRI to A.G. and V.F. M.Z. is supported by NSF Postdoctoral Research Fellowship in Biology Grant IOS-1402064. This work used the Vincent J. Coates Genomics Sequencing Laboratory at UC Berkeley, supported by NIH S10 Instrumentation Grants S10RR029668 and S10RR027303." PI reports funding under NNX09AK82G.

______________________________________________________

Other papers of interest:

1

Murata Y, Yasuda T, Watanabe-Asaka T, Oda S, Mantoku A, Takeyama K, Chatani M, Kudo A, Uchida S, Suzuki H, Tanigaki F, Shirakawa M, Fujisawa K, Hamamoto Y, Terai S, Mitani H.

Histological and transcriptomic analysis of adult Japanese medaka sampled onboard the International Space Station.

PLoS One. 2015 Oct 1;10(10):e0138799.

www.ncbi.nlm.nih.gov/pubmed/26427061

Note: ISS results. This article may be obtained online without charge.

2

Liu J, Li Y, Verheyden B, Chen Z, Wang J, Li Y, Aubert AE, Yuan M.

Orthostatic intolerance is independent of the degree of autonomic cardiovascular adaptation after 60 days of head-down bed rest.

Biomed Res Int. 2015;2015:896372. Epub 2015 Sep 3.

www.ncbi.nlm.nih.gov/pubmed/26425559

Note: Bed rest study. This article may be obtained online without charge.

3

Kawano F, Nimura K, Ishino S, Nakai N, Nakata K, Ohira Y.

Differences in histone modifications between slow- and fast-twitch muscle of adult rats and following overload, denervation or valproic acid administration.

J Appl Physiol (1985). 2015 Sep 24:jap.00289.2015. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26404615

4

Tekari A, Luginbuehl R, Hofstetter W, Egli R.

Bovine osteochondral tissues: A questionable model to evaluate mechanical loading.

IEEE Trans Nanobioscience. 2015 Sep 25. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26415204

5

Komori T.

[Bone cell biology assessed by microscopic approach. Response to mechanical stress by osteocyte network].

Clin Calcium. 2015;25(10):1467-74. Japanese.

www.ncbi.nlm.nih.gov/pubmed/26412725

6

Peres SC, Kortum PT, Akladios M, Muddimer A.

Developing and validating a self-report assessment tool for software biomechanics.

Work. 2015 Aug 7. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26409385

7

Shimizu N, Ooka M, Takagi T, Takeda S, Hirota K.

Distinct DNA damage spectra induced by ionizing radiation in normoxic and hypoxic cells.

Radiat Res. 2015 Oct 2. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26430822

8

Murigi FN, Mohindra P, Hung C, Salimi S, Goetz W, Pavlovic R, Jackson IL, Vujaskovic Z.

Dose optimization study of AEOL 10150 as a mitigator of radiation-induced lung injury in CBA/J mice.

Radiat Res. 2015 Sep 28. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26414508

9

Paul S, Smilenov LB, Elliston CD, Amundson SA.

Radiation dose-rate effects on gene expression in a mouse biodosimetry model.

Radiat Res. 2015 Jul;184(1):24-32. Epub 2015 Jun 26.

www.ncbi.nlm.nih.gov/pubmed/26114327

10

Xiao X, Wanyan X, Zhuang D.

Mental workload prediction based on attentional resource allocation and information processing.

Biomed Mater Eng. 2015 Aug 17;26 Suppl 1:S871-9.

www.ncbi.nlm.nih.gov/pubmed/26406085

11

Hbner PP, Khan SI, Migliaccio AA.

The mammalian efferent vestibular system plays a crucial role in the high-frequency response and short-term adaptation of the vestibulo-ocular reflex.

J Neurophysiol. 2015 Sep 30:jn.00307.2015. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26424577

12

Bigelow RT, Agrawal Y.

Vestibular involvement in cognition: Visuospatial ability, attention, executive function, and memory.

J Vestib Res. 2015 Jun 2;25(2):73-89. Review.

www.ncbi.nlm.nih.gov/pubmed/26410672

Note: Includes a discussion of microgravity and cognitive function.

13

Gerth WA.

On diver thermal status and susceptibility to decompression sickness.

Diving Hyperb Med. 2015 Sep;45(3):208.

www.ncbi.nlm.nih.gov/pubmed/26415073

14

Tan TH, Silverberg JL, Floss DS, Harrison MJ, Henley CL, Cohen I.

How grow-and-switch gravitropism generates root coiling and root waving growth responses in Medicago truncatula.

Proc Natl Acad Sci U S A. 2015 Oct 2. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26432881

15

Muratov A, Baulin VA.

Mechanism of dynamic reorientation of cortical microtubules due to mechanical stress.

Biophys Chem. 2015 Sep 25;207:82-9. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/26422460

16

Fernandez-Sanchez ME, Brunet T, Rper JC, Farge E.

Mechanotransduction's impact in animal development, evolution, and tumorigenesis.

Annu Rev Cell Dev Biol. 2015 Sep 24. [Epub ahead of print] Review.

www.ncbi.nlm.nih.gov/pubmed/26407212

17

LaCroix AS, Rothenberg KE, Hoffman BD.

Molecular-scale tools for studying mechanotransduction.

Annu Rev Biomed Eng. 2015 Sep 29. [Epub ahead of print] Review.

www.ncbi.nlm.nih.gov/pubmed/26421895

18

Seedhouse E.

Microgravity and vision impairments in astronauts.

Cham, Switzerland: Springer International; 2015. 96 p.

http://link.springer.com/book/10.1007/978-3-319-17870-7

Note: Chapters include Long Duration Flight, Earthbound and Microgravity Pathophysiology of Increased Intracranial Pressure, Papilledema and Microgravity-Induced Fluid Shift, the Role of Carbon Dioxide and Exercise, and Diet and Personalized Medicine.

19

Stratmann HG.

Using medicine in science fiction: The SF writer's guide to human biology.

New York: Springer International; 2015. 564 p.

http://link.springer.com/book/10.1007/978-3-319-16015-3

Note: Three chapters are devoted to space life sciences: Chapter 3 - Space Is a Dangerous Place (atmosphere and pressure; temperature, toxins, and trauma; psychological stress; circadian rhythm and sleep; risks of space debris; acceleration and deceleration); Chapter 4 - Microgravity and the Human Body (space adaptation syndrome; effects on cardiovascular, hematological, musculoskeletal, vision, gastrointestinal, genitourinary and endocrine, and pulmonary systems; dealing with microgravity); and Chapter 5 - Space Medicine: Paging Dr. McCoy (medical care, preventive care, exercise and nutrition, infectious diseases, and first aid and surgery).

// end //

More status reports and news releases or top stories.

Please follow SpaceRef on Twitter and Like us on Facebook.

SpaceRef Newsletter