NASA Spaceline Current Awareness List #686 19 February 2016

Status Report From: Spaceline
Posted: Friday, February 19, 2016

Papers deriving from NASA support:


Lee AG, Tarver WJ, Mader TH, Gibson CR, Hart SF, Otto CA.

Neuro-ophthalmology of space flight.

J Neuroophthalmol. 2016 Mar;36(1):85-91. Review.

Note: ISS results. This paper was presented in part at the 41st Annual North American Neuro-Ophthalmology Society (NANOS) Meeting, February 2126, 2015, at the Hotel del Coronado in San Diego, CA.

Journal Impact Factor: 1.950

Funding: No funding cited. W.J. Tarver is at NASA Johnson Space Center.


Simpson RJ, Bigley AB, Spielmann G, LaVoy EC, Kunz H, Bollard CM.

Human cytomegalovirus infection and the immune response to exercise.

Exerc Immunol Rev. 2016;22:8-27.

PI: R.J. Simpson

Journal Impact Factor: 4.176

Funding: "This work was supported by NASA grants NNJ10ZSA003N and NNJ14ZSA001N-FLAGSHIP to R.J. Simpson and NIH grant P01 CA148600-01A1 to C.M. Bollard." The grant numbers are NNX12AB48G and NNX16AB29G, respectively.


Bhagwandin VJ, Bishop JM, Wright WE, Shay JW.

The metastatic potential and chemoresistance of human pancreatic cancer stem cells.

PLoS One. 2016 Feb 9;11(2):e0148807.

PIs: J.D.Minna/J.W.Shay/W.E. Wright/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.234

Funding: "This work was supported by: 1. National Aeronautics and Space AdministrationSpecialized Center of Research: NNJ05HD36G (VJB, WEW, JWS), and 2. National Institute of Health, Ruth L. Kirschstein National Research Service Award, Institutional Training Grant (T32) for The G.W. Hooper Research Foundation: CA09043 (VJB, JMB)."


Bhattacharya S, Asaithamby A.

Ionizing radiation and heart risks.

Semin Cell Dev Biol. 2016 Feb 2. [Epub ahead of print] Review.

PIs: A. Asaithamby, H. Sadek

Journal Impact Factor: 6.265

Funding: "This work was supported by the National Aeronautics and Space Association grants NNX13AD57G and NNX15AE06G (to A.A.)." The PI for grant NNX15AE06G is H. Sadek.


Schreurs AS, Shirazi-Fard Y, Shahnazari M, Alwood JS, Truong TA, Tahimic CG, Limoli CL, Turner ND, Halloran B, Globus RK.

Dried plum diet protects from bone loss caused by ionizing radiation.

Sci Rep. 2016 Feb 11;6:21343.

PIs: R.K. Globus; J.S. Alwood and A.-S. Schreurs, NASA Post-Doctoral Program

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.578

Funding: "Research was supported by National Space Biomedical Research Institute grant #MA02501 (RKG, CL, JSA) under NASA cooperative agreement NCC 958, a DOE-NASA Interagency Award #DE-SC0001507, supported by the Office of Science (BER), U.S. Department of Energy (RKG), and a NASA Postdoctoral Program fellowship (AS, JSA)."


Morris CJ, Purvis TE, Hu K, Scheer FA.

Circadian misalignment increases cardiovascular disease risk factors in humans.

Proc Natl Acad Sci U S A. 2016 Feb 8. [Epub ahead of print]

PI: C.J. Morris, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 9.674

Funding: "This study was supported by National Heart, Lung, and Blood Institute (NHLBI) Grant R01 HL094806 (to F.A.J.L.S.). C.J.M. was supported by the National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant NCC 9-58, NHLBI Grant R01 HL094806, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant R01 DK099512, and NHLBI Grant R01 HL118601. F.A.J.L.S. was supported by NHLBI Grant R01 HL094806, NIDDK Grant R01 DK099512, and NHLBI Grant R01 HL118601. K.H. was supported by NHLBI Grant R00 HL102241 and National Institute on Aging Grant P01AG009975. The project described was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women's Hospital from the National Center for Research Resources."


Larkin RM, Stefano G, Ruckle ME, Stavoe AK, Sinkler CA, Brandizzi F, Malmstrom CM, Osteryoung KW.

REDUCED CHLOROPLAST COVERAGE genes from Arabidopsis thaliana help to establish the size of the chloroplast compartment.

Proc Natl Acad Sci U S A. 2016 Feb 9. [Epub ahead of print]

PI: F. Brandizzi

Note: This article may be obtained online without charge.

Journal Impact Factor: 9.674

Funding: "This work was supported by National Science Foundation (NSF) Grants IOB 0517841 and IOS 1021755 (to R.M.L.); NSF Grant MCB-1121943 (to K.W.O.); NSF Grant MCB1243792 and NASA Grant NNX12AN71G (to F.B.); AgBioResearch (F.B.); and US Department of Energy, Office of Science, Basic Energy Sciences Grant DE-FG02-91ER20021 (to R.M.L. and F.B.) and Grant DE-FG02-06ER15808 (to K.W.O.)."


Other papers of interest:


Verhaar A, Peppelenbosch M.

Correspondence on: "Microgravity reduces the differentiation and regenerative potential of embryonic stem cells".

Stem Cells Dev. 2016 Feb 5. [Epub ahead of print]

Note: This is a comment on the paper: Blaber EA, Finkelstein H, Dvorochkin N, Sato KY, Yousuf R, Burns BP, Globus RK, Almeida E. Microgravity reduces the differentiation and regenerative potential of embryonic stem cells. Stem Cells Dev. 2015 Nov 15;24(22):2605-21. Epub 2015 Oct 22. ( The original article appeared in Current Awareness List #668, 9 October 2015. The paper reports results from STS-131.


de Maistre S, Valle N, Gempp E, Lambrechts K, Louge P, Duchamp C, Blatteau JE.

Colonic fermentation promotes decompression sickness in rats.

Sci Rep. 2016 Feb 8;6:20379.

Note: This article may be obtained online without charge.


Kalpana D, Im C, Lee YS.

Comparative growth, cross stress resistance, transcriptomics of Streptococcus pyogenes cultured under low shear modeled microgravity and normal gravity.

Saudi J Biol Sci. 2016 Jan;23(1):24-33. Epub 2015 Feb 7.

Note: A high aspect ratio vessel (HARV) was used. This article may be obtained online without charge.


Ogawa Y, Yanagida R, Ueda K, Aoki K, Iwasaki KI.

The relationship between widespread changes in gravity and cerebral blood flow.

Environ Health Prev Med. 2016 Feb 9. [Epub ahead of print]

Note: A short-arm centrifuge was used.


Kawahara K, Suzuki T, Yasaka T, Nagata H, Okamoto Y, Kita K, Morisaki H.

Evaluation of the site specificity of acute disuse muscle atrophy developed during a relatively short period in critically ill patients according to the activities of daily living level: A prospective observational study.

Aust Crit Care. 2016 Feb 6. [Epub ahead of print]

Note: Bed rest study. Participants were intensive care unit patients.


Meigal A, Fomina E.

Electromyographic evaluation of countermeasures during the terrestrial simulation of interplanetary spaceflight in Mars500 project.

Pathophysiology. 2015 Oct 24. [Epub ahead of print]

Note: Data are from the Mars500 Project.


Morales MG, Abrigo J, Acua MJ, Santos RA, Bader M, Brandan E, Simon F, Olguin H, Cabrera D, Cabello-Verrugio C.

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy via the Mas receptor.

Dis Model Mech. 2016 Feb 5. [Epub ahead of print]

Note: Hindlimb immobilization (casting) was used. This article may be obtained online without charge.


Tsukamoto M, Menuki K, Murai T, Hatakeyama A, Takada S, Furukawa K, Sakai A.

Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells.

Bone. 2016 Feb 3;85:70-80. [Epub ahead of print]

Note: Hindlimb unloading study.


Brown GN, Sattler RL, Guo XE.

Experimental studies of bone mechanoadaptation: Bridging in vitro and in vivo studies with multiscale systems.

Interface Focus. 2016 Feb 6;6(1):20150071. Review.


Mueller AS, Gonzlez EG, McNorgan C, Steinbach MJ, Timney B.

Effects of vertical direction and aperture size on the perception of visual acceleration.

Perception. 2016 Feb 6. [Epub ahead of print]


McGuire S, Mller U, Elmenhorst EM, Basner M.

Inter-individual differences in the effects of aircraft noise on sleep fragmentation.

Sleep. 2016 Feb 1. [Epub ahead of print]


Huppert D, Oldelehr H, Krammling B, Benson J, Brandt T.

What the ancient Greeks and Romans knew (and did not know) about seasickness.

Neurology. 2016 Feb 9;86(6):560-5.

Note: A literature search yielded 20 ancient texts that describe the symptoms, treatment, and prevention of seasickness.


Pagel JI, Choukr A.

Effects of isolation and confinement on humans - Implications for manned space explorations.

J Appl Physiol (1985). 2016 Feb 4:jap.00928.2015. [Epub ahead of print] Review.

Note: Isolation space analogs reviewed include the Mars500 Project, Antarctic winter-over missions, and the NEEMO underwater habitat.


Botella C, Baos RM, Etchemendy E, Garca-Palacios A, Alcaiz M.

Psychological countermeasures in manned space missions: "EARTH" system for the Mars-500 project.

Comput Hum Behav. 2016 Feb;55, Part B:898-908.

Note: Data are from the Mars500 Project.


Meshkov NA, Valtseva EA, Kharlamova EN, Kulikova AZ.

[Real and unreal backlashes of aerospace activity for the health of population residing near areas of fall of being separated parts of carrier rockets].

Gig Sanit. 2015;94(7):117-22. Russian.

Note: Researchers assessed the presence of rocket propellants in water, soil, and food as well as health risk in areas where fragments of rocket carriers may fall after liftoff in Russia.


Pedersen FT, Jackson JS.

Redefining the (emergency) physician-astronaut.

EM Resident. 2016 Jan 30.

Note: This article offers a good review of emergency medical services in space travel. This article may be obtained online without charge.

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