NASA Spaceline Current Awareness List #692 1 April 2016

Status Report From: Spaceline
Posted: Friday, April 1, 2016

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here:

Papers deriving from NASA support:



Britten RA, Jewell JS, Miller VD, Davis LK, Hadley MM, Wyrobek AJ.

Impaired spatial memory performance in adult Wistar rats exposed to low (5-20 cGy) doses of 1 GeV/n Fe particles.

Radiat Res. 2016 Mar 185(3):332-7.

PIs: R.A. Britten, A.J. Wyrobek

Journal Impact Factor: 2.911

Funding: "This work was funded by the National Aeronautics and Space Administration (NASA grant nos. NNJ06HD89D, NNX11AC56G and NNX14AE73G). . . .The contribution of AJW to this work was supported by NASA grant no. NNJ14HP06I."



Chmielewski NN, Caressi C, Giedzinski E, Parihar VK, Limoli CL.

Contrasting the effects of proton irradiation on dendritic complexity of subiculum neurons in wild type and MCAT mice.

Environ Mol Mutagen. 2016 Mar 20. [Epub ahead of print]

PIs: C.L. Limoli; G.A. Nelson/C.L. Limoli/NSCOR; C.L. Limoli/V.K. Parihar/NSCOR

Journal Impact Factor: 2.630

Funding: "Grant sponsor: NASA; Grant numbers: NNX13AD59G, NNX10AD59G, and NNX15AI22G."



Loucas BD, Shuryak I, Cornforth MN.

Three-color chromosome painting as seen through the eyes of mFISH: Another look at radiation-induced exchanges and their conversion to whole-genome equivalency.

Front Oncol. 2016 Mar 15;6:52.

PIs: M.N. Cornforth, B.D. Loucas

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by the following grants from NASA: NNX15AG74G (MC) and NNX14AC76G (BL)."



Nelson GA.

Space radiation and human exposures, a primer.

Radiat Res. 2016 Mar 28. [Epub ahead of print]

PIs: G.A. Nelson/NSCOR; M. Boerma/G.A. Nelson/Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 2.911

Funding: "This work was supported by NASA (grant no. NNX10AD59G) and NSBRI (grant no. RE03701) through NASA cooperative agreement NCC 9-58."



Dick SJ. (Editor)

Historical studies in the societal impact of spaceflight.

Washington, DC: National Aeronautics and Space Administration, 2015. 678 p. NASA SP-2015-4803.

Note: From the Introduction: "Following the publication in 2007 of the Societal Impact of Spaceflight volume in the NASA History series, the NASA History Division commissioned a series of more in-depth studies on specific subjects. This volume presents those studies to scholars and the public, and represents what is hoped will be a continuing series in the effort to understand the mutual interaction of space exploration and society—part of a larger need to understand the relationship between science, technology, and society." This book may be obtained online without charge.

Funding: No funding cited; sponsored by NASA HQ.



Other papers of interest:



Liu B, Ma H, Zhu Y, Ziao Y, Wang J.

[Analysis of astronaut’s tolerance to landing impact after long-term inhabitation in space station]

Space Med Med Eng (Beijing). 2016;2016(1):67-72. Chinese.

Note: The specific spaceflight missions are not identified in the English abstract..



Zhang H, Ren N, Li J, Zhang R, Zhang Y, Wang Z, Mao K, Huan P, Cui G.

[Comparative study on microstructural changes of dorsal root ganglia in female and male simulated weightlessness rats]

Space Med Med Eng (Beijing). 2016;2016(1):9-13. Chinese.

Note: Hindlimb unloading study.



Chen R, Wang Y, Sun X.

[Review of autophagy effects in weightlessness induced cardiovascular deconditioning]

Space Med Med Eng (Beijing). 2016;2016(1):62-6. Chinese.

Note: Methods of weightlessness simulation used are not specified in the English abstract.



Cho SH, Kim JH, Song W.

In vivo rodent models of skeletal muscle adaptation to decreased use.

Endocrinol Metab (Seoul). 2016 Mar 3;31(1):31-7. Review.

Note: Models discussed are immobilization, spinal cord transection, hindlimb unloading, and aging. This article may be obtained online without charge.



Fu JP, Mo WC, Liu Y, He RQ.

Decline of cell viability and mitochondrial activity in mouse skeletal muscle cell in a hypomagnetic field.

Bioelectromagnetics. 2016 Mar 22. [Epub ahead of print]



Mirzoev TM, Tyganov SA, Lomonosova YN, Musienko PE, Shenkman BS.

[Signaling pathways regulating protein synthesis in rat soleus muscle during early stages of hindlimb unloading].

Ross Fiziol Zh Im I M Sechenova. 2015 Nov;101(11):1299-308. Russian.

Note: Hindlimb unloading study.



Yamashita A, Hatazawa Y, Hirose Y, Ono Y, Kamei Y.

FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation.

Biosci Biotechnol Biochem. 2016 Mar 24:1-5. [Epub ahead of print]



Cazzaniga A, Maier JA, Castiglioni S.

Impact of simulated microgravity on human bone stem cells: New hints for space medicine.

Biochem Biophys Res Commun. 2016 Mar 19. [Epub ahead of print]

Note: A Random Positioning Machine was used.



Grimm D, Grosse J, Wehland M, Mann V, Reseland JE, Sundaresan A, Corydon TJ.

The impact of microgravity on bone in humans.

Bone. 2016 Mar 24. [Epub ahead of print]

Note: From the Introduction: "In this review, we present the current knowledge on sodium and calcium metabolism of humans in space. Moreover, we will focus on bone metabolism, the mechanisms of bone loss in space, the combined effects of radiation and microgravity on bone and available countermeasures to protect crewmembers against bone loss." Data are taken from a number of missions dating back to Skylab.



Jing D, Tong S, Cai J, Zhai M, Shen G, Wang X, Luo E, Luo Z.

Mechanical vibration mitigates the decrease of bone quantity and bone quality of leptin receptor-deficient db/db mice by promoting bone formation and inhibiting bone resorption.

J Bone Miner Res. 2016 Mar 17. [Epub ahead of print]

Note: Whole body vibration was used.



Li D, Chen Z, Liu Z, Lin Y, Ding C, Zhao F, Arfat Y, Hu L, Li Y, Shang P, Qian A.

[Qiang Gu Kang Wei prescription increases bone mineral density of load-bearing bone in tail suspended rats]

Space Med Med Eng (Beijing). 2016;2016(1):1-8. Chinese.

Note: Hindlimb unloading study.



Cacao E, Cucinotta FA.

Modeling impaired hippocampal neurogenesis after radiation exposure.

Radiat Res. 2016 Mar 185(3):319-31.



El-Jaby S.

Corrigendum to “Monte Carlo simulations of the secondary neutron ambient and effective dose equivalent rates from surface to suborbital altitudes and low Earth orbit”.

Life Sci Space Res. 2016 Mar 26. [Article in Press]

Note: This Corrigendum corrects earlier estimates of the secondary neutron ambient and effective dose equivalent rates, in air, from surface altitudes up to suborbital altitudes and low Earth orbit. The original article was published in Life Sciences in Space Research 2015;6:1-9 and was cited in Current Awareness List #648, 15 May 2015.



Hauptmann M, Haghdoost S, Gomolka M, Sarioglu H, Ueffing M, Dietz A, Kulka U, Unger K, Babini G, Harms-Ringdahl M, Ottolenghi A, Hornhardt S.

Differential response and priming dose effect on the proteome of human fibroblast and stem cells induced by exposure to low doses of ionizing radiation.

Radiat Res. 2016 Mar 185(3):299-312.



Singh VK, Kulkarni S, Fatanmi OO, Wise SY, Newman VL, Romaine PL, Hendrickson H, Gulani J, Ghosh SP, Kumar KS, Hauer-Jensen M.

Radioprotective efficacy of gamma-tocotrienol in nonhuman primates.

Radiat Res. 2016 Mar;185(3):285-98.



Townsend LW, Porter JA, deWet WC, Smith WJ, McGirl NA, Heilbronn LH, Moussa HM.

Extreme solar event of AD775: Potential radiation exposure to crews in deep space.

Acta Astronaut. 2016 Jun-Jul;123:116-20.



Liu X, Liu Y, Zhu X.

[Review of spatial disorientation in manned spaceflight and preflight adaptation training based on virtual reality]

Space Med Med Eng (Beijing). 2016;2016(1):73-8. Chinese.



Maffei V, Mazzarella E, Piras F, Spalletta G, Caltagirone C, Lacquaniti F, Daprati E.

Processing of visual gravitational motion in the peri-sylvian cortex: Evidence from brain-damaged patients.

Cortex. 2016 Feb 21;78:55-69. [Epub ahead of print]



Deng K, Yu L, Zheng X, Zhang K, Wang W, Dong P, Zhang J, Ren M.

Target of rapamycin is a key player for auxin signaling transduction in Arabidopsis.

Front Plant Sci. 2016 Mar 11;7:291.

Note: This article may be obtained online without charge.



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