NASA SPACELINE Current Awareness List #696 29 April 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, April 29, 2016


Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here:


Papers deriving from NASA support:



Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ.

Spaceflight activates lipotoxic pathways in mouse liver.

PLoS One. 2016 Apr 20;11(4):e0152877.

PI: M.L. Bouxsein

Note: STS-135 results. From the Data Availability Statement: "Metabolomics data are contained within the Supporting Information files associated with the paper. Transcriptomics data are available from NASA's open access GeneLab repository" This article may be obtained online without charge.

Journal Impact Factor: 3.234

Funding: "This work was partially funded by the National Aeronautics and Space Administration grant NNX10AJ31G (D.S.G. and M.J.P.; and NNX10AE39G (M.L.B.). Additional support was provided by Department of Anesthesiology at the University of Colorado Anschutz Medical Campus (K. R.J.) and the LLUMC Department of Radiation Medicine (D.S.G., M.J.P.)."



Bernier MC, Alberici RM, Keelor JD, Dwivedi P, Zambrzycki SC, Wallace WT, Gazda DB, Limero TF, Symonds JM, Orlando TM, Macatangay A, Fernández FM.

Microplasma ionization of volatile organics for improving air/water monitoring systems on-board the International Space Station.

J Am Soc Mass Spectrom. 2016 Apr 14. [Epub ahead of print]

Note: ISS results

Journal Impact Factor: 2.945

Funding: "M.C.B, P.D., J.M.S., and F.M.F. acknowledge support through NASA award number NNX13AF51G. J.D.K., T.M.O., and F.M.F. acknowledge additional support through the Center for Chemical Evolution, jointly sponsored by NSF and the NASA Astrobiology Program (NSF CHE-1004570). W.T.W and T.F.L. acknowledge funding under NASA contract no. NAS 9-02078." A. Macatangay is at NASA Johnson Space Center.



Feola AJ, Myers JG, Raykin J, Mulugeta L, Nelson ES, Samuels BC, Ethier CR.

Finite element modeling of factors influencing optic nerve head deformation due to intracranial pressure.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1901-11.

PI: C.R. Ethier

Note: Finite element modeling was used. This article may be obtained online without charge.

Journal Impact Factor: 3.404

Funding: "Supported by NASA grant NNX13AP91G and the Georgia Research Alliance."



Chowdhury P, Akel N, Jamshidi-Parsian A, Gaddy D, Griffin RJ, Yadlapalli JS, Dobretsov M.

Degenerative tissue responses to space-like radiation doses in a rodent model of simulated microgravity.

Ann Clin Lab Sci. 2016 Mar;46(2):190-7.

Note: Hindlimb unloading study.

Journal Impact Factor: 0.910

Funding: "This work was supported by Arkansas Space Grant Consortium/NASA award NNX13AB29A and Winthrop P. Rockefeller Cancer Institute."



Chang AM, Bjones AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Reen EV, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R.

Circadian gene variants influence sleep and the sleep electroencephalogram in humans.

Chronobiol Int. 2016 Apr 18:1-13. [Epub ahead of print]

PI: C.A. Czeisler

Journal Impact Factor: 3.343

Funding: "This study was funded by National Institute of Health (NIH) grant R21-DK089378, a pilot grant from Harvard Catalyst, Harvard Clinical and Translational Science Center (UL1 RR025758) and financial contributions from Harvard University. Additional funding was provided by NIH grants HL080978, MH045130 and HL077453; National Space Biomedical Research Institute (NSBRI) grant HFP01601; the BWH General Clinical Research Center (NIH M01-02635); and a BWH Faculty Career Development Award to AMC. AMC was supported in part by NIH grant K01-HL115458. DA was supported in part by the German Aerospace Center. SAS was supported in part by NIH grant K24-HL076446. FAJLS and RS were supported by a Harvard Catalyst Pilot Grant, R21-DK089378, R01-DK102696 and R21-HL121728."



Other papers of interest:



Bourrelly A, McIntyre J, Morio C, Despretz P, Luyat M.

Perception of affordance during short-term exposure to weightlessness in parabolic flight.

PLoS One. 2016 Apr 20;11(4):e0153598.

Note: Parabolic flight results. This article may be obtained online without charge.



Brioche T, Pagano AF, Py G, Chopard A.

Muscle wasting and aging: experimental models, fatty infiltrations, and prevention.

Mol Aspects Med. 2016 Apr 19. [Epub ahead of print] Review.

Note: This review contains a brief discussion of results from Spacelab, Spacehab, BION, and ISS.



Chen B, Wang Y.

Proteomic and physiological studies provide insight into photosynthetic response of rice (Oryza sativa L.) seedlings to microgravity.

Photochem Photobiol. 2016 Apr 20. [Epub ahead of print]

Note: Shenzhou 8 results.



Macaluso T, Bourdin C, Buloup F, Mille ML, Sainton P, Sarlegna FR, Taillebot V, Vercher JL, Weiss P, Bringoux L.

Kinematic features of whole-body reaching movements underwater: Neutral buoyancy effects.

Neuroscience. 2016 Apr 16. [Epub ahead of print]

Note: Water immersion was used. The study examines the effects of neutral buoyancy applied to body segments versus center of mass during astronaut training to achieve movement kinematics close to those reported in weightlessness. This article may be obtained online without charge.



Wu CW, Biggar KK, Luu BE, Szereszewski KE, Storey KB.

Analysis of microRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel.

Physiol Genomics. 2016 Apr 15:physiolgenomics.00005.2016. [Epub ahead of print]



Eiken O, Mekjavic IB, Kounalakis SN, Kölegård R.

Pressure distension in leg vessels as influenced by prolonged bedrest and a pressure habituation regimen.

J Appl Physiol (1985). 2016 Apr 14:jap.00922.2015. [Epub ahead of print]

Note: Bed rest study.



Keramidas ME, Mekjavic IB, Kölegård R, Choukèr A, Strewe C, Eiken O.

PlanHab: Hypoxia counteracts the erythropoietin suppression, but seems to exaggerate the plasma volume reduction induced by 3 weeks of bed rest.

Physiol Rep. 2016 Apr;4(7). Epub 2016 Apr 13.

Note: Bed rest study. PlanHab is the Planetary Habitat simulation project supported by the European Union and ESA. This article may be obtained online without charge.



Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K.

Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading.

Acta Physiol (Oxf). 2016 Apr 16. [Epub ahead of print]

Note: Hindlimb unloading was used.



Wojda SJ, Gridley RA, McGee-Lawrence ME, Drummer TD, Hess A, Kohl F, Barnes BM, Donahue SW.

Arctic ground squirrels limit bone loss during the prolonged physical inactivity associated with hibernation.

Physiol Biochem Zool. 2016 Jan-Feb;89(1):72-80. Epub 2015 Dec 14.



Lister LJ, Suheimat M, Verkicharla PK, Mallen EA, Atchison DA.

Influence of gravity on ocular lens position.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1885-91.

Note: Upright and prone positions were used. This article may be obtained online without charge.



Sunkara A, DeAngelis GC, Angelaki DE.

Joint representation of translational and rotational components of optic flow in parietal cortex.

Proc Natl Acad Sci U S A. 2016 Apr 19. [Epub ahead of print]



Tang H, Chen L, Liu J, Shi J, Li Q, Wang T, Wu L, Zhan F, Bian P.

Radioadaptive response for reproductive cell death demonstrated in in vivo tissue model of Caenorhabditis elegans.

Radiat Res. 2016 Apr;185(4):402-10. Epub 2016 Mar 29.



Asadi H, Mohamed S, Lim CP, Nahavandi S.

A review on otolith models in human perception.

Behav Brain Res. 2016 Apr 14. [Epub ahead of print] Review.



Feng L, Yue XF, Chen YX, Liu XM, Wang LS, Cao FR, Wang Q, Liao YH, Pan RL, Chang Q.

LC/MS-based metabolomics strategy to assess the amelioration effects of ginseng total saponins on memory deficiency induced by simulated microgravity.

J Pharm Biomed Anal. 2016 Apr 1;125:329-38. [Epub ahead of print]

Note: Hindlimb unloading study.



Qiong W, Yong-Liang Z, Ying-Hui L, Shan-Guang C, Jiang-Hui G, Yi-Xi C, Ning J, Xin-Min L.

The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats.

J Ethnopharmacol. 2016 Apr 18. [Epub ahead of print]

Note: Hindlimb unloading study.



Sabine A, Saygili Demir C, Petrova TV.

Endothelial cell responses to biomechanical forces in lymphatic vessels.

Antioxid Redox Signal. 2016 Apr 20. [Epub ahead of print] Review.


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