NASA Spaceline Current Awareness List #702 10 June 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, June 10, 2016


Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here:


Papers deriving from NASA support:



Mayer T, Blachowicz A, Probst AJ, Vaishampayan P, Checinska A, Swarmer T, de Leon P, Venkateswaran K.

Microbial succession in an inflated lunar/Mars analog habitat during a 30-day human occupation.

Microbiome. 2016 Jun 2;4(1):22.

PI: K. Venkateswaran

Note: Students at the University of North Dakota designed and developed an advanced inflatable habitat that can be adapted for use on surfaces of the Moon and Mars. Students occupied the analog habitat for two different periods of time (10 and 30 days) and cataloged microbial succession during a 30-day human occupation. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This research was funded by a 2012 Space Biology NNH12ZTT001N Grant No. 19-12829-26 under Task Order NNN13D111T award to KV."



Yang J, Barrila J, Roland KL, Ott CM, Nickerson CA.

Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurim D23580.

npj Microgravity. 2016 Jun 9;2:16021.

PI: C.A. Nickerson

Note: A Rotating Wall Vessel (RWV) bioreactor was used. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This study was funded by the National Aeronautics and Space Administration (NASA) NNH12ZTT001N (C.N.) and an award from the ASU School of Life Sciences, Opportunities for Graduate Students to use Core Facilities (J.Y.)."



Raykin J, Forte TE, Wang R, Feola A, Samuels BC, Myers JG, Mulugeta L, Nelson ES, Gleason RL, Ethier CR.

Characterization of the mechanical behavior of the optic nerve sheath and its role in spaceflight-induced ophthalmic changes.

Biomech Model Mechanobiol. 2016 May 28. [Epub ahead of print]

PIs: C.R. Ethier; J.A. Pennline; J. Raykin, NSBRI First Award Fellowship Program

Note: From the Abstract: "In this study, we developed a custom mechanical testing system that allowed for unconfined lengthening, twisting, and circumferential distension of the porcine optic nerve sheath during inflation and axial loading."

Journal Impact Factor: 3.145

Funding: "This work was supported by the National Space Biomedical Research Institute through NCC 9-58, by NASA’s Human Research Program through the Digital Astronaut Project (DAP) and NASA Grant Number NNX13AP91G, and by the Georgia Research Alliance."



Bellone JA, Gifford PS, Nishiyama NC, Hartman RE, Mao XW.

Long-term effects of simulated microgravity and/or chronic exposure to low-dose gamma radiation on behavior and blood–brain barrier integrity.

npj Microgravity. 2016 Jun 9;2:16019.

PI: X.W. Mao

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This work was supported by NASA NRA NNX13AL97G (XWM) and Loma Linda University Department of Basic Sciences."



Mishra B, Ortiz L, Luderer U.

Charged iron particles, components of space radiation, destroy ovarian follicles.

Hum Reprod. 2016 May 31. [Epub ahead of print]

PIs: U. Luderer; B. Mishra, NSBRI First Award Fellowship

Journal Impact Factor: 4.569

Funding: This study was supported by a National Aeronautics and Space Administration grant NNX14AC50G to U.L.; National Institutes of Health grant P30CA062203 for the University of California Irvine (UC Irvine) Chao Family Comprehensive Cancer Center; the Center for Occupational and Environmental Health, UC Irvine; the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core funded by the Eunice Kennedy Shriver NICHD/NIH (NCTRI) grant P50-HD28934. B.M. was partially supported by a First award fellowship from the National Space Biomedical Research Institute grant PF04302."



Wyrobek AJ, Britten RA.

Individual variations in dose response for spatial memory learning among outbred Wistar rats exposed from 5 to 20 cGy of Fe particles.

Environ Mol Mutagen. 2016 May 30. [Epub ahead of print] 

PIs: A.J. Wyrobek, R.A. Britten

Journal Impact Factor: 2.630

Funding: "This animal portion of this project was supported by the National Aeronautics and Space Administration (NASA grant nos. NNJ06HD89D, NNX11AC56G, and NNX14AE73G). AJW’s contribution to this manuscript was supported by NASA grant NNJ14HP06I and NNJ14AC86G."



Wang X, Ma X, Wang H, Li B, Clark G, Guo Y, Roux S, Sun D, Tang W.

Proteomic study of microsomal proteins reveals a key role for Arabidopsis annexin 1 in mediating heat stress-induced increase in intracellular calcium levels.

Mol Cell Proteomics. 2015 Mar;14(3):686-94.

PI: S. Roux

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.564

Funding: "This work was supported by the Ministry of Agriculture of China (2013ZX08009–003-002); “one hundred talents project” of Hebei province (E2012100004 to W.T.); the National Natural Science Foundation of China (31270357 to Y.G.); and by grants from the National Science Foundation (IOS 0718890 to S.J.R. and G.C.) and the National Aeronautics and Space Administration (NNX13AM54G to S.J.R. and G.C.)."



Committee on Spacecraft Exposure Guidelines; Board on Environmental Studies; Toxicology Division on Earth and Life Studies; National Academies of Sciences, Engineering, and Medicine.

Refinements to the methods for developing spacecraft exposure guidelines.

Washington (DC): National Academies Press (US); 2016. 64 p.

Note: This article may be obtained online without charge.

Funding: "This activity was supported by Grant No. NNX15AB47A from the National Aeronautics and Space Administration."



Other papers of interest:



O'Sullivan J.

In the footsteps of Columbus: European missions to the International Space Station.

Chaum, Switzerland: Springer-Praxis Books; 2016. 391 p.

Note: ISS results. From the Abstract: "The European Space Agency has a long history of human spaceflight, flying in space with both NASA and the Soviet/Russian space agencies over the years. This book tells the story of the ESA astronauts who have visited the International Space Station over its first decade and how they have lived on board, helped construct the space laboratory and performed valuable scientific experiments." Chapters devoted to specific missions include STS-100, Andromède, Marco Polo, STS-111, Odissea, Cervantes, DELTA, Encide, Astrolab, Celsius, Experia, Columbus Phase I and II, Oasiss, Aliseé, Magisstra, DAMA, and Promisse.



Koslucher F, Munafo J, Stoffregen TA.

Postural sway in men and women during nauseogenic motion of the illuminated environment.

Exp Brain Res. 2016 May 28. [Epub ahead of print]



Wang H, Zhu H, Liu Z, Zhao H.

Computer simulation of effects of altered gravity on cardiovascular system in astronauts.

Space Med Med Eng. 2016;2016(2):101-8. Chinese.

Note: The type of altered gravity used in the simulation was not identified in the English language abstract.



Jang TY, Jung AY, Kim YH.

Hormetic effect of chronic hypergravity in a mouse model of allergic asthma and rhinitis.

Sci Rep. 2016 Jun 2;6:27260.

Note: Rotation was used. This article may be obtained online without charge.



Li H, Bai H, Diao Y, Zhang H, Zhao H, Wang Z.

Protective effect of pine polyphenols and its transformation by Aspergillus carbonarius on γ-radiation induced immune injuries in mice.

Space Med Med Eng. 2016;2016(2):84-9. Chinese.



Li Z, Gao Y, Zhao J, Sun J, Yang C, Shi F, Wang Y, Sun X.

Effects of artificial gravity combined with moderate exercise on aerobic and anaerobic powers after 4 d head-down bed rest.

Space Med Med Eng. 2016;2016(2):95-100.

Note: Bed rest study. Acceleration was used.



Dideriksen K, Boesen AP, Kristiansen JF, Magnusson SP, Schjerling P, Holm L, Kjaer M.

Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication.

Exp Gerontol. 2016 May 25. [Epub ahead of print]

Note: Immobilization was accomplished by leg casts.



Segizbaeva MO, Aleksandrova NP, Donina ZA, Baranova EV, Katuntsev VP, Tarasenkov GG, Baranov VM.

Effect of simulated microgravity and lunar gravity on human inspiratory muscle function: 'SELENA-T' 2015 study.

Adv Exp Med Biol. 2016 May 31. [Epub ahead of print]

Note: Bed rest study.



Plotkin LI, Bellido T.

Osteocytic signalling pathways as therapeutic targets for bone fragility.

Nat Rev Endocrinol. 2016 May 27. [Epub ahead of print] Review.



Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP.

Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice.

J Nutr Biochem. 2016 Aug;34:73-82. Epub 2016 May 10.



Dachev TP, Bankov NG, Horneck G, Häder DP.

Letter to the Editor: EXPOSE-R2 cosmic radiation time profile (Preliminary results).

Radiat Prot Dosimetry. 2016 May 31. [Epub ahead of print]



Zhang H, Ren NT, Zhou FQ, Li J, Lei W, Liu N, Bi L, Wu ZX, Zhang R, Zhang YG, Cui G.

Effects of hindlimb unweighting on MBP and GDNF expression and morphology in rat dorsal root ganglia neurons.

Neurochem Res. 2016 May 26. [Epub ahead of print]

Note: Hindlimb unloading study.



Causse M, Peysakhovich V, Fabre EF.

High working memory load impairs language processing during a simulated piloting task: An ERP and pupillometry study.

Front Hum Neurosci. 2016 May 25;10:240.

Note: This article may be obtained online without charge.



Flynn-Evans EE, Lockley SW.

A pre-screening questionnaire to predict non-24 hour sleep wake rhythm disorder (N24HSWD) among the blind.

J Clin Sleep Med. 2016 May 15;12(5):703-10.



MacDougall HG, McGarvie LA, Halmagyi GM, Rogers SJ, Manzari L, Burgess AM, Curthoys IS, Weber KP.

A new saccadic indicator of peripheral vestibular function based on the video head impulse test.

Neurology. 2016 Jun 1. [Epub ahead of print]



Armengot L, Marquès-Bueno MM, Jaillais Y.

Regulation of polar auxin transport by protein and lipid kinases.

J Exp Bot. 2016 May 30. [Epub ahead of print]



Harmoko R, Yoo JY, Ko KS, Ramasamy NK, Hwang BY, Lee EJ, Kim HS, Lee KJ, Oh DB, Kim DY, Lee S, Li Y, Lee SY, Lee KO.

N-glycan containing a core alpha1,3-fucose residue is required for basipetal auxin transport and gravitropic response in rice (Oryza sativa).

New Phytol. 2016 May 31. [Epub ahead of print]



Chistiakov DA, Orekhov AN, Bobryshev YV.

Effects of shear stress on endothelial cells: Go with the flow.

Acta Physiol (Oxf). 2016 Jun 1. [Epub ahead of print] Review.



Zhang Q, Matsui H, Horiuchi H, Liang X, Sasaki K.

A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.

Biochem Biophys Res Commun. 2016 May 27. [Epub ahead of print]


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