NASA Spaceline Current Awareness List #706 8 July 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, July 8, 2016


Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here:


Papers deriving from NASA support:



Radford NB, DeFina LF, Barlow CE, Lakoski SG, Leonard D, Paixao AR, Khera A, Levine BD.

Progression of CAC score and risk of incident CVD.

JACC Cardiovasc Imaging. 2016 Jun 23. [Epub ahead of print]

PI: B.D. Levine

Journal Impact Factor: 7.815

Funding: "This study was supported by the National Space Biomedical Research Institute through NASA NCC 9-58."



Shah PK.

Temporal change in CACS and prognosis: Follow-up score is simpler and as good as a change in score.

JACC Cardiovasc Imaging. 2016 Jun 23. [Epub ahead of print]

Note: This article is an editorial about the above article by Radford NB, DeFina LF, Barlow CE, Lakoski SG, Leonard D, Paixao AR, Khera A, Levine BD. Progression of CAC score and risk of incident CVD. JACC Cardiovasc Imaging. 2016 Jun 23.



Stepanov VG, Tirumalai MR, Montazari S, Checinska A, Venkateswaran K, Fox GE.

Bacillus pumilus SAFR-032 genome revisited: Sequence update and re-annotation.

PLoS One. 2016 Jun 28;11(6):e0157331.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.057

Funding: No funding cited. K. Venkateswaran is affiliated with NASA Jet Propulsion Laboratory.



Iwaniec UT, Turner RT.

Influence of body weight on bone mass, architecture, and turnover.

J Endocrinol. 2016 Jun 27. [Epub ahead of print] Review.

PI: R.T. Turner

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.498

Funding: "This work was supported by NIH (AR 060913) and NASA (NNX12AL24G)."



Britten RA, Miller VD, Hadley MM, Jewell JS, Macadat E.

Performance in hippocampus- and PFC- dependent cognitive domains are not concomitantly impaired in rats exposed to 20 cGy of 1 GeV/n 56Fe particles.

Life Sci Space Res. 2016 Jun 27. [Article in Press]

PI: R.A. Britten

Journal Impact Factor: 1.183

Funding: "This work was funded by NASA grant support NNX11AC56G and NNX14AE73G."



Kolev OI, Reschke MF.

Acquisition of predictable vertical visual targets: Eye-head coordination and the triggering effect.

J Mot Behav. 2016 Jun 30:1-10. [Epub ahead of print]

Journal Impact Factor: 1.573

Funding: No funding cited. M.F. Reschke is affiliated with NASA Johnson Space Center.



Other papers of interest:



Zabel P, Bamsey M, Schubert D, Tajmar M.

Review and analysis of over 40 years of space plant growth systems.

Life Sci Space Res. 2016 Jul 1. [Article in Press] Review.

Note: The plant growth systems discussed were flown on Salyut space stations, Mir, Space Shuttles, and the International Space Station. From the abstract: "The paper reviews the different designs and technological solutions implemented in higher plant flight experiments. Using these analyses a comprehensive comparison is compiled to illustrate the development trends of controlled environment agriculture technologies in bio-regenerative life support systems, enabling future human long-duration missions into the solar system."



Moissl-Eichinger C, Cockell C, Rettberg P.

Venturing into new realms? Microorganisms in space.

FEMS Microbiol Rev. 2016 Jun 26. [Epub ahead of print] Review. 

Note: ISS results.



Voorhies AA, Lorenzi HA.

The challenge of maintaining a healthy microbiome during long-duration space missions.

Front Astron Space Sci. 2016;3:23. Review. Epub 2016 Jul 8.

Note: This article may be obtained online without charge.



Zhang Y, Storey KB.

Regulation of gene expression by NFAT transcription factors in hibernating ground squirrels is dependent on the cellular environment.

Cell Stress Chaperones. 2016 Jun 25. [Epub ahead of print]



Zhao HW, Zhao J, Hu LN, Liang JN, Shi YY, Nie C, Qiu CY, Nan XS, Li YX, Gao FL, Liu Y, Dong Y, Luo L.

Effect of long-term weightlessness on retina and optic nerve in tail-suspension rats.

Int J Ophthalmol. 2016 Jun;9(6):825-30.

Note: Hindlimb unloading was used. This article may be obtained online without charge.



Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJ.

One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation.

Diabetes. 2016 Jun 29. [Epub ahead of print]

Note: Bed rest study.



Devlin MJ, Brooks DJ, Conlon C, Vliet M, Louis L, Rosen CJ, Bouxsein ML.

Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice.

J Endocrinol. 2016 Jun;229(3):295-306.



Lerebours C, Buenzli PR.

Towards a cell-based mechanostat theory of bone: The need to account for osteocyte desensitisation and osteocyte replacement.

J Biomech. 2016 May 26. [Epub ahead of print]



Tshen Chuang AT.

Interplanetary regenerative medicine for mission Mars of SpaceX and NASA.

Regen Med. 2016 Jun 27. [Epub ahead of print]



Note: A new issue of the Russian language Aviakosmicheskaia i ekologicheskaia meditsina (Aerospace and environmental medicine) is available. Articles of interest to the space life sciences are listed below.



Stepanova SI, Karpova OI, Galichiy VA, Nesterov VF, Saraev IF.

[Work-rest cycle of cosmonauts in missions 22/23-39/40 of the International Space Station].

Aviakosm Ekolog Med. 2016;50(1):7-12. Russian.             

Note: ISS results.



Kotovskaya AR, Koloteva MI.

[Development of human cardiovascular deconditioning on the stage of returning to Earth after stay in microgravity].

Aviakosm Ekolog Med. 2016;50(1):13-6. Russian.

Note: The authors present results from earlier published papers and reports. The English abstract does not identify individual spaceflights.



Naumov IA, Kornilova LN, Glukhikh DO, Pavlova AS, Khabarova EV, Ekimovsky GA, Vasin AV.

[Effect of repeated space flights on ocular tracking].

Aviakosm Ekolog Med. 2016;50(1):17-27. Russian.

Note: ISS results.



Vil'chinskaya NA, Mirzoev TM, Lomonosova YN, Kozlovskaya IB, Shenkman BS.

[Effect of short-term dry immersion on proteolytic signaling in human soleus muscle].

Aviakosm Ekolog Med. 2016;50(1):28-34. Russian.

Note: Dry immersion was used.



Novikov VE, Oganov VS, Kabitskaya OE, Murashko LM, Naidina VP, Chernikhova EA.

[Mineral bone density and body composition in participants in experiment Mars-500].

Aviakosm Ekolog Med. 2016;50(1):35-8. Russian.

Note: Data are from the Mars500 Project.



Ushakov IB, Grigoriev YG, Shafirkin AV, Shurshakov VA.

[Substantiation of dose limits for a new normative document on radiation safety of long-duration space missions at orbit altitudes of up to 500 km].

Aviakosm Ekolog Med. 2016;50(1):39-54. Russian.



Vorozhtsova SV, Bulynina TM, Ivanov AA.

[Cytogenetic effects in mice bone marrow after irradiation by fast neutrons].

Aviakosm Ekolog Med. 2016;50(1):55-60. Russian.



Popova, II, Orlov OI, Matsnev EI, Revyakin YG.

[Modern instruments for ear, nose and throat rendering and evaluation in researches on russian segment of the International Space Station].

Aviakosm Ekolog Med. 2016;50(1):73-5. Russian.

Note: ISS results.



Orlov OI, Belakovsky MS, Kolar J, Kussmaul AR, Komissarova DV.

[20th Human-in-Space Symposium of the International Academy of Astronautics].

Aviakosm Ekolog Med. 2016;50(1):76-83. Russian.

Note: The Conference was held June 29 - July 03, 2015 in Prague, Czech Republic.



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