NASA Spaceline Current Awareness List #708 22 July 2016

Status Report From: Spaceline
Posted: Friday, July 22, 2016


Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here:


Please note: The next issue of SPACELINE Current Awareness (List #709) will be sent on August 5, 2016.


Papers deriving from NASA support:



Safikhani Z, El-Hachem N, Quevedo R, Smirnov P, Goldenberg A, Juul Birkbak N, Mason C, Hatzis C, Shi L, Aerts HJ, Quackenbush J, Haibe-Kains B.

Assessment of pharmacogenomic agreement.

F1000Res. 2016 May 9;5:825.

PI: C. Mason

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Z Safikhani was supported by the Cancer Research Society (Canada; grant #19271) and the Ontario Institute for Cancer Research through funding provided by the Government of Ontario. P Smirnov was supported by the Canadian Cancer Society Research Institute. C Hatzis was supported by Yale University. N Juul Birkbak was funded by The Villum Kann Rasmussen Foundation. C Mason was supported by the Starr Cancer Consortium grants (I7-A765, I9-A9-071), Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, WorldQuant Foundation (CEM), Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G), and the National Institutes of Health (R25EB020393, R01NS076465). L Shi was supported by the National High Technology Research and Development Program of China (2015AA020104), the National Natural Science Foundation of China (31471239), the 111 Project (B13016), and the National Supercomputer Center in Guangzhou, China. J Quackenbush was supported by grants from the NCI GAME-ON Cancer Post-GWAS initiative (5U19 CA148065) and the NHLBI (5R01HL111759). B Haibe-Kains was supported by the Gattuso Slaight Personalized Cancer Medicine Fund at Princess Margaret Cancer Centre."



May PC, Haider Y, Dunmire B, Cunitz BW, Thiel J, Liu Z, Bruce M, Bailey MR, Sorensen MD, Harper JD.

Stone-mode ultrasound for determining renal stone size.

J Endourol. 2016 Jul 8. [Epub ahead of print]

PI: M.R. Bailey

Journal Impact Factor: 2.107

Funding: "Funding was provided by National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, and grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK043881 and DK092197)."



Liston DB, Wong LR, Stone LS.

Oculometric assessment of sensorimotor impairment associated with TBI.

Optom Vis Sci. 2016 Jul 6. [Epub ahead of print]

Journal Impact Factor: 1.442

Funding: "This work has been supported by the Office of Naval Research Force Health Protection program (N0001415IP00028/30)." L.S. Stone is affiliated with NASA Ames Research Center.



Ehresmann B, Hassler DM, Zeitlin C, Guo J, Köhler J, Wimmer-Schweingruber RF, Appel JK, Brinza DE, Rafkin SC, Böttcher SI, Burmeister S, Lohf H, Martin C, Böhm E, Matthiä D, Reitz G.

Charged particle spectra measured during the transit to Mars with the Mars Science Laboratory Radiation Assessment Detector (MSL/RAD).

Life Sci Space Res. 2016 Jul 16. [Article in Press]

Note: From the Conclusion: "Our findings, taken in complement with recent research about the neutral particle spectra and previous analyses of the radiation environment during the transit, give a detailed picture of the radiation environment a human crew might encounter on a trip into deep space, and give valuable input to radiation transport models used to estimate the radiation exposure under different times in the solar activity cycle."

Journal Impact Factor: 1.183

Funding: "The authors would like to thank the reviewers for their efforts in evaluating this work and their helpful comments. RAD is supported by NASA (HEOMD) under Jet Propulsion Laboratory (JPL) subcontract #1273039 to Southwest Research Institute and in Germany by the German Aerospace Center (DLR) and DLR’s Space Administration grant numbers 50QM0501 and 50QM1201 to the Christian-Albrechts-Universität zu Kiel."



Cassady K, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Castenada RR, Kofman I, Bloomberg J, Mulavara A, Seidler R.

Effects of a spaceflight analog environment on brain connectivity and behavior.

Neuroimage. 2016 Jul 13. [Epub ahead of print]

PIs: R.D. Seidler; V. Koppelmans, NSBRI First Award Fellowships

Note: Bed rest study.

Journal Impact Factor: 5.463

Funding: "This work was supported by grants from the National Space Biomedical Research Institute (NASA NCC 9-58, MA02701, and PF04101), from the National Aeronautics and Space Administration (NASA; NNX11AR02G) and NASA Flight Analogs Project, and the National Institutes of Health, and National Center for Advancing Translational Sciences, 1UL1RR029876-01."



Villasana LE, Weber S, Akinyeke T, Raber J.

Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species.

J Neurochem. 2016 Jul 14. [Epub ahead of print]

PIs: J. Raber; G. Nelson/J. Raber/NSCOR

Journal Impact Factor: 3.842

Funding: "This work was supported by NIA grant T32 NS007466-05, NIAAA T32 AA007290-33, NIEHS T32 ES007060, NIMH grant MH77647, NASA Grants NNJ05HE63G, NNJ12ZSA001N, and NNX10AD59G, Alzheimer’s Association Grant IIRG-05-14021 and an APA Dissertation Award."



Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R.

Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology.

Diabetes. 2016 Jun;65(6):1741-51. Epub 2016 Feb 11.

PIs: E.B. Klerman, C.A. Czeisler

Journal Impact Factor: 8.784

Funding: "This study was conducted with support from the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK089378 to R.S. and F.A.J.L.S.), support from Harvard Catalyst of the Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH Award 8UL1TR00017005 to F.A.J.L.S. and R.S.), support from the NHLBI (T32HL07901) and the National Institute on Aging (NIA) (F32 AG316902) to K.S., and financial contributions from Harvard University and its affiliated academic health care centers. J.M.L., S.R., and R.S. were further supported by the following grants: NHLBI R21 HL121728 (R.S.), NIDDK F32 DK102323 (J.M.L.), and NHLBI R01 HL113338 and NHLBI R01 HL098433 (S.R.). F.A.J.L.S. was further supported by the NHLBI (R01HL094806 and R01HL118601) and the NIDDK (R01DK099512). A.-M.C. was also supported by the NHLBI (K01 HL115458). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the NIH. The CARe study and SHHS are supported by the NHLBI cooperative agreements U01HL53941 (Boston University), U01HL53916 (University of California, Davis), U01HL53934 (University of Minnesota), U01HL53937 and U01HL63429 (Johns Hopkins University), and U01HL63463 (Case Western Reserve University). The following funding contributed to phenotype data collection in in-laboratory studies: NIA (R01AG06072, R01AG06072, and P01AG009975), NHLBI (R01HL077453, R01HL080978, R01HL093279, R01HL094654, and R01HL077399), Air Force Office of Scientific Research (FA9550), NIH (R21AT002571, R01NS054277, and R01MH45130), National Space Biomedical Research Institute (HFP01601), Brain & Behavior Research Foundation Young Investigator Award, and General Clinical Research Center (M01RR02635). J.F.D. was supported by the NIA (R01AG044416), the NHLBI (R01HL093279 and R01HL094654), and the Brigham and Women’s Hospital Brigham Research Institute Fund to Sustain Research Excellence. Investigators were also funded by financial contributions from Brigham and Women’s Hospital and from Harvard University and its affiliated academic health care centers. This study was also funded by the NHLBI (01EHLE114088, K24EHL105664, R01HL09327, R01HL09465, and RC2EHL101340), the National Space Biomedical Research Institute (HFP02802), and the NIH (M01RR02635 and R01EGME10501)."



Tripathy MK, Weeraratne G, Clark G, Roux S.

Apyrase inhibitors enhance the ability of diverse fungicides to inhibit the growth of different plant pathogenic fungi.

Mol Plant Pathol. 2016 Jul 9. [Epub ahead of print]

PI: S. Roux

Journal Impact Factor: 4.335

Funding: "This work was supported by the National Science Foundation grant [IOS-1027514 to S.J.R. and G.C.], the National Aeronautics and Space Administration grant [NAG10-295 to S.J.R. and G.C.], and CottonGen, LLC [UTA13-000682 to S.J.R. and G.C.]."



Other papers of interest:



Gunga H-C, Von Ahlefeld VW, Coriolano H-JA, Werner A, Hoffman U.

Cardiovascular system, red blood cells, and oxygen transport in microgravity.

Chaum, Switzerland: Springer International; 2016. 74 p.

Note: Results are from parabolic flight, Mir, STS, ISS, and a number of earlier missions not specified in the Introduction. The book begins with a general introduction and includes chapters on the cardiovascular system, red blood cells, respiration and respiratory control, and countermeasures.



Debevec T, Simpson EJ, Mekjavic IB, Eiken O, Macdonald IA.

Effects of prolonged hypoxia and bed rest on appetite and appetite-related hormones.

Appetite. 2016 Jul 6. [Epub ahead of print]

Note: Bed rest study.



Eklund A, Jóhannesson G, Johansson E, Holmlund P, Qvarlander S, Ambarki K, Wåhlin A, Koskinen LD, Malm J.

The pressure difference between eye and brain changes with posture.

Ann Neurol. 2016 Jun 28. [Epub ahead of print]

Note: Head-down tilt study. The study examines the relationship between intracranial hypertension and visual impairments in astronauts.



Joukar A, Niroomand-Oscuii H, Ghalichi F.

Numerical simulation of osteocyte cell in response to directional mechanical loadings and mechanotransduction analysis: Considering lacunar-canalicular interstitial fluid flow.

Comput Methods Programs Biomed. 2016 Sep;133:133-41. Epub 2016 Jul 1.



Maurel DB, Duan P, Farr J, Cheng AL, Johnson ML, Bonewald LF.

Beta-catenin haplo insufficient male mice do not lose bone in response to hindlimb unloading.

PLoS One. 2016 Jul 13;11(7):e0158381.

Note: Hindlimb unloading study. This article may be obtained online without charge.



York SL, Sethu P, Saunders MM.

In vitro osteocytic microdamage and viability quantification using a microloading platform.

Med Eng Phys. 2016 Jul 4. [Epub ahead of print]



Chen Z, Coy SL, Pannkuk EL, Laiakis EC, Hall AB, Fornace AJ Jr, Vouros P.

Rapid and high-throughput detection and quantitation of radiation biomarkers in human and nonhuman primates by differential mobility spectrometry-mass spectrometry.

J Am Soc Mass Spectrom. 2016 Jul 8. [Epub ahead of print]



Rinaldi A.

Research in space: In search of meaning: Life science research aboard the International Space Station has come under scrutiny for its costs and apparent lack of returns.

EMBO Rep. 2016 Jul 11. [Epub ahead of print]


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