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NASA Spaceline Current Awareness List #710 12 August 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, August 12, 2016

 

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

 

Papers deriving from NASA support:

 

1

Petersen N, Jaekel P, Rosenberger A, Weber T, Scott J, Castrucci F, Lambrecht G, Ploutz-Snyder L, Damann V, Kozlovskaya I, Mester J.

Exercise in space: the European Space Agency approach to in-flight exercise countermeasures for long-duration missions on ISS.

Extrem Physiol Med. 2016 Aug 2;5:9.

http://www.ncbi.nlm.nih.gov/pubmed/27489615

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal.

Funding: No funding cited. L. Ploutz-Snyder‘s contributions were made while she was affiliated with NASA Johnson Space Center as lead scientist on the exercise physiology and countermeasures portfolio.

 

2

Vijay P, McIntyre AB, Mason CE, Greenfield JP, Li S.

Clinical genomics: Challenges and opportunities.

Crit Rev Eukaryot Gene Expr. 2016;26(2):97-113.

http://www.ncbi.nlm.nih.gov/pubmed/27480773

PI: C.E. Mason

Journal Impact Factor: 1.668

Funding: "The authors would like to thank the following sources of financial support: Ty Louis Campbell Foundation, Elizabeth’s Hope and the Families of the Children’s Brain Tumor Project, WorldQuant Foundation, the Starr Cancer Consortium grants (I7-A765, I9-A9- 071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063 ), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964)."

 

3

Peterson LE, Kovyrshina T.

Adjustment of lifetime risks of space radiation-induced cancer by the healthy worker effect and cancer misclassification.

Heliyon. 2015 Dec;1(4):e00048. Epub 2016 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/27441231

PI: S. Blattnig

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This project was supported by NASA Contract NNX14AR32A." The contract is funded through NASA's  Space Radiation Risk Assessment Project.

 

4

Browning CL, Qin Q, Kelly DF, Prakash R, Vanoli F, Jasin M, Wise JP Sr.

Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells.

Toxicol Sci. 2016 Jul 22. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27449664

PI: J.P. Wise, Sr.

Journal Impact Factor: 3.880

Funding: "This work was supported by the National Institute of Environmental Health Sciences (ES016893 to J.P.W.); National Aeronautics and Space Administration (NASA) (ACD FSB-2009 to J.P.W.) and The Maine Center for Toxicology and Environmental Health."

 

5

Schneider SM, Lee SM, Feiveson AH, Watenpaugh DE, Macias BR, Hargens AR.

Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest.

Physiol Rep. 2016 Aug;4(15).

http://www.ncbi.nlm.nih.gov/pubmed/27495299

PI: A.R. Hargens

Note: Bed rest study. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "This study was supported by National Aeronautics and Space Administration Grants NAG9-1425, NNX10AM18G, NNX12AL66G and NIH grant M01 RR-00827 (to the UCSD GCRC)."

 

6

Hackney KJ, Downs ME, Ploutz-Snyder L.

Blood flow restricted exercise compared to high load resistance exercise during unloading.

Aerosp Med Hum Perform. 2016 Aug;87(8):688-96.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000008/art00004

PI: L. Ploutz-Snyder

Note: Unilateral lower limb suspension was used.

Journal Impact Factor: 0.755

Funding: "This study was partially supported by a National Aeronautic Space Administration (NASA) Graduate Student Research Program Training Grant (NNX08AW71H) and the NASA Human Research Program.

 

7

Schultz ER, Paul A-L, Ferl RJ.

Root growth patterns and morphometric change based on the growth media.

Microgravity Sci Technol. 2016 Aug 10:1-11. [Article in Press]

http://link.springer.com/article/10.1007/s12217-016-9514-9

PI: R.J. Ferl

Journal Impact Factor: 0.725

Funding: "The experimental work presented here is supported by the National Aeronautics and Space Administration grants NNX12AN69G and NNX07AH27G to A-L Paul and R.J. Ferl and the National Aeronautics and Space Administration Training Grant NNX15AI10H to Florida Space Grant Consortium to E.R. Schultz."

______________________________________________________

 

Other papers of interest:

 

1

Perez-Poch A, González DV, López D.

Hypogravity research and educational parabolic flight activities conducted in Barcelona: A new hub of innovation in Europe.

Microgravity Sci Technol. 2016 Aug 10:1-7. [Article in Press]

http://link.springer.com/article/10.1007%2Fs12217-016-9516-7

Note: Parabolic flight results.

 

2

Caiani E, Martin-Yebra A, Landreani F, Bolea J, Laguna P, Vaïda P.

Weightlessness and cardiac rhythm disorders: Current knowledge from space flight and bed-rest studies.

Front Astron Space Sci. 2016;3(27). Epub 2016 Aug 9. Review.

http://journal.frontiersin.org/article/10.3389/fspas.2016.00027

Note: Specific space flight missions were not identified; bed rest study. This article may be obtained online without charge.

 

3

Alexandrov S.

Algal research in space: History, current status, and future prospects.

Innovare J Life Sci. 2016 Aug-Sep;4(4):1-4.

http://innovareacademics.in/journals/index.php/ijls/article/view/13459

Note: Sputnik-2, Cosmos, Zond, Salyut, and FOTON-M results. This article may be obtained online without charge.

 

4

Genchi GG, Rocca A, Marino A, Grillone A, Mattoli V, Ciofani G.

Hypergravity as a tool for cell stimulation: Implications in biomedicine.

Front Astron Space Sci. 2016;3(26). Epub 2016 Aug 3. Review.

http://journal.frontiersin.org/article/10.3389/fspas.2016.00026

Note: Methods of achieving hypergravity included centrifugation and parabolic flight. This article may be obtained online without charge.

 

5

Gempp E, Louge P, de Maistre S, Morvan J-B, Vallée N, Blatteau J-E.

Initial severity scoring and residual deficit in scuba divers with inner ear decompression sickness.

Aerosp Med Hum Perform. 2016 Aug;87(8):735-9.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000008/art00010

 

6

Krnjajic D, Allen DR, Butts CL, Keller DM.

Carotid baroreflex control of heart rate is enhanced, while control of mean arterial pressure is preserved during whole-body heat stress in young healthy men.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 3:ajpregu.00152.2016. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27488886

 

7

Patel K, Rossler A, Lackner HK, Trozic I, Laing C, Lorr D, Green DA, Hinghofer-Szalkay H, Goswami N.

Effect of postural changes on cardiovascular parameters across gender.

Medicine (Baltimore). 2016 Jul;95(28):e4149.

http://www.ncbi.nlm.nih.gov/pubmed/27428203

Note: Head-down tilt study.

 

8

Smith JR, Broxterman RM, Hammer SM, Alexander AM, Didier KD, Kurti SP, Barstow TJ, Harms CA.

Sex differences in the cardiovascular consequences of the inspiratory muscle metaboreflex.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 3:ajpregu.00187.2016. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27488888

 

9

Nezami Asl A, Khoshvaghti A, Doaee M, Nikpajouh A, Nourmohammadi A.

The effect of erythropoietin on rat’s red blood cell indices in simulated microgravity (Experimental study).

Ann Mil Health Sci Res. 2015 Winter;14(1):22-6.

http://journals.ajaums.ac.ir/browse.php?a_id=1286&sid=1&slc_lang=en

Note: Hindlimb unloading study. This article may be obtained online without charge.

 

10

Montero D, Rauber S.

Brain perfusion and arterial blood flow velocity during prolonged body tilting.

Aerosp Med Hum Perform. 2016 Aug 87(8):682-7.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000008/art00003

Note: Both head-up and head-down tilt were used.

 

11

Kaji H.

Effects of myokines on bone.

Bonekey Rep. 2016 Jul 20;5:826. Review.

http://www.nature.com/bonekeyreports/2016/160720/bonekey201648/full/bonekey201648 

 

12

Rittweger J, Debevec T, Frings-Meuthen P, Lau P, Mittag U, Ganse B, Ferstl PG, Simpson EJ, Macdonald IA, Eiken O, Mekjavic IB.

On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study.

Bone. 2016 Jul 18;91:130-8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27443510

Note: Bed rest study. PlanHab is the Planetary Habitat simulation project supported by the European Union and ESA. This article may be obtained online without charge.

 

13

Kawamoto E, Koshinaka K, Yoshimura T, Masuda H, Kawanaka K.

Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation.

Physiol Rep. 2016 Aug;4(15).

http://www.ncbi.nlm.nih.gov/pubmed/27482072

Note: Hindlimbs were immobilized via casting. This article may be obtained online without charge.

 

14

Shibaguchi T, Yamaguchi Y, Miyaji N, Yoshihara T, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T.

Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats.

Physiol Rep. 2016 Aug;4(15).

http://www.ncbi.nlm.nih.gov/pubmed/27482075

Note: Hindlimbs were immobilized via casting. This article may be obtained online without charge.

 

15

Sprick JD, Soller BR, Rickards CA.

The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia.

Exp Biol Med (Maywood). 2016 Jul 19. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27439541

 

16

Segal AY, Sletten TL, Flynn-Evans EE, Lockley SW, Rajaratnam SM.

Daytime exposure to short- and medium-wavelength light did not improve alertness and neurobehavioral performance.

J Biol Rhythms. 2016 Jul 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27474192

 

17

Araniti F, Graña E, Krasuska U, Bogatek R, Reigosa MJ, Abenavoli MR, Sánchez-Moreiras AM.

Loss of gravitropism in farnesene-treated Arabidopsis is due to microtubule malformations related to hormonal and ROS unbalance.

PLoS One. 2016 Aug 4;11(8):e0160202.

http://www.ncbi.nlm.nih.gov/pubmed/27490179

Note: This article may be obtained online without charge.

 

18

Zou JJ, Zheng ZY, Xue S, Li HH, Wang YR, Le J.

The role of Arabidopsis Actin-Related Protein 3 in amyloplast sedimentation and polar auxin transport in root gravitropism.

J Exp Bot. 2016 Jul 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27473572

Note: This article may be obtained online without charge.

 

19

Lerner DJ, Parmet AJ, Don S, Shimony JS, Goyal MS.

Technique for performing lumbar puncture in microgravity using portable radiography.

Aerosp Med Hum Perform. 2016 Aug;87(8):745-7.

http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000008/art00012

Note: A proof of concept study.

 

20

Linnarsson D, Zuo L, Chuang CC, Li G, Gao F, Mekjavic PJ, Dua H, Amoaku W, Macdonald IA, Eiken O, Mekjavic IB.

Commentaries on viewpoint: Standardization of bed rest studies in the spaceflight context.

J Appl Physiol (1985). 2016 Jul 1;121(1):350-1.

http://www.ncbi.nlm.nih.gov/pubmed/27451275

Note: The Commentaries are four Letters to the Editor regarding the article: Sundblad P, Orlov O, Angerer O, Larina I, Cromwell R. Standardization of bed rest studies in the spaceflight context. J Appl Physiol (1985). 2016 Jul 1;121(1):348-9. Epub 2016 Feb 25. http://www.ncbi.nlm.nih.gov/pubmed/26917693, which appeared in Current Awareness List #688, 4 Mar 2016.

 

21

Coughlin TR, Schiavi J, Alyssa Varsanik M, Voisin M, Birmingham E, Haugh MG, McNamara LM, Niebur GL.

Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture.

Eur Cell Mater. 2016 Jul;32:111-22.

http://www.ncbi.nlm.nih.gov/pubmed/27434268

 

22

Shaw M, Elmi M, Pawar V, Srinivasan MA.

Investigation of mechanosensation in C. elegans using light field calcium imaging.

Biomed Opt Express. 2016 Jun 30;7(7):2877-87. Epub 2016 Jul 23.

http://www.ncbi.nlm.nih.gov/pubmed/27446713

Note: This article may be obtained online without charge.

 

 

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