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NASA Spaceline Current Awareness List #711 19 August 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, August 19, 2016

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999
that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag 

 

Papers deriving from NASA support

 

1

Vandenbrink JP, Herranz R, Medina FJ, Edelmann RE, Kiss JZ.

A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity.

Planta. 2016 Aug 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27507239

PI: J.Z. Kiss

Note: ISS results.

Journal Impact Factor: 3.239

Funding: "Funding for this study was provided by NASA Grant NNX12A065G."

 

2

McFadden CH, Hallacy TM, Flint DB, Granville DA, Asaithamby A, Sahoo N, Akselrod MS, Sawakuchi GO.

Time-lapse monitoring of DNA damage colocalized with particle tracks in single living cells.

Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):221-7.

http://www.ncbi.nlm.nih.gov/pubmed/27511858

PI: A. Asaithamby

Journal Impact Factor: 4.495

Funding: "This work was partially supported by the Sister Institution Network Fund, the Center for Radiation Oncology Research at the University of Texas MD Anderson Cancer Center, and Cancer Center Support (Core) Grant CA016672 to the MD Anderson Cancer Center." The PI reports funding through NASA grant NNX13AD57G.

 

3

Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba, II, Gazdar AF, Hayward NK, Minna JD.

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.

J Clin Invest. 2016 Aug 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27500490

PI: J.D. Minna/L. Girard/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 12.575

Funding: "This work was supported by the NCI Lung Cancer SPORE (P50CA70907), CTD2N CA176284, NASA NSCOR (NNJ05HD36G), and Cancer Prevention and Research Institute of Texas (CPRIT) (RP120732). JEL was supported by a National Health and Medical Research Council of Australia Overseas-Based Biomedical Training Fellowship (494511), Thoracic Society of Australia and New Zealand/Allen & Hanburys Respiratory Research Fellowship, and Cancer Australia/Cure Cancer Australia Priority Driven Collaborative Cancer Research Scheme (1070515)."

 

4

Kennedy AR, Maity A, Sanzari JK.

A review of radiation-induced coagulopathy and new findings to support potential prevention strategies and treatments.

Radiat Res. 2016 Aug;186(2):121-40.

http://www.ncbi.nlm.nih.gov/pubmed/27459701

PI: A.R. Kennedy/NSBRI Center of Acute Radiation Research

Journal Impact Factor: 3.022

Funding: "The experiments with ferrets and pigs described in this report were funded by the National Space Biomedical Research Institute (NSBRI), which is funded through NASA NCC 9-58."

 

5

Natarajan M, Aravindan N, Sprague EA, Mohan S.

Hemodynamic flow-induced mechanotransduction signaling influences the radiation response of the vascular endothelium.

Radiat Res. 2016 Aug;186(2):175-88.

http://www.ncbi.nlm.nih.gov/pubmed/27387860

PI: M. Natarajan

Journal Impact Factor: 3.022

Funding: "Support for this work was provide by the National Space Biomedical Research Institute (grant no. CA02802) through the National Aeronautics and Space Administration [grant no. NCC 9-58-298 (MN)] and the National Institute of Diabetes and Digestive and Kidney Diseases [grant no. 5 R01 DK-096119 (SM)]."

 

6

Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M.

Recombinant thrombomodulin (Solulin) ameliorates early intestinal radiation toxicity in a preclinical rat model.

Radiat Res. 2016 Aug;186(2):112-20.

http://www.ncbi.nlm.nih.gov/pubmed/27459702

PI: M. Boerma/M. Hauer-Jensen/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 3.022

Funding: "This study was supported by the National Institutes of Health (grant nos. P20 GM109005 and R37 CA71382), the U.S. Veterans Administration, Arkansas Space Grant Consortium through the National Aeronautics and Space Administration (grant no. NNX15AK32A) and the National Space Biomedical Research Institute (no. RE03701–NCC 9-58)."

 

7

Wang Y, Boerma M, Zhou D.

Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases.

Radiat Res. 2016 Aug;186(2):153-61.

http://www.ncbi.nlm.nih.gov/pubmed/27387862

PI: M. Boerma/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 3.022

Funding: "The studies on senescent cells conducted in Zhou’s laboratory were supported in part by the National Institutes of Health (grant nos. R01CA122023 and P20GM109005), a scholarship from the Arkansas Research Alliance and the Rockefeller Leukemia and Lymphoma Research Endowment; and those on radiation-induced cardiovascular tissue injury in Boerma’s laboratory were supported by the National Space Biomedical Research Institute through NCC 9-58."

 

8

Wilson ME, Mixdorf M, Berg RH, Haswell ES.

Plastid osmotic stress influences cell differentiation at the plant shoot apex.

Development. 2016 Aug 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27510974

PI: E.S. Haswell

Journal Impact Factor: 6.059

Funding: "This research was funded by NSF MCB-1253103 and NASA NNX13AM55G."

______________________________________________________

 

Other papers of interest:

 

1

Keramidas ME, Kölegård R, Mekjavic IB, Eiken O.

PlanHab: Hypoxia exaggerates the bed-rest-induced reduction in peak oxygen uptake during upright cycle ergometry.

Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H453-64.

http://www.ncbi.nlm.nih.gov/pubmed/27342877

Note: Bed rest study. PlanHab is the Planetary Habitat simulation project supported by the European Union and the European Space Agency (ESA).

 

2

Jha R, Wu Q, Singh M, Preininger MK, Han P, Ding G, Cho HC, Jo H, Maher KO, Wagner MB, Xu C.

Simulated microgravity and 3D culture enhance induction, viability, proliferation and differentiation of cardiac progenitors from human pluripotent stem cells.

Sci Rep. 2016 Aug 5;6:30956.

http://www.ncbi.nlm.nih.gov/pubmed/27492371

Note: A random positioning machine was used. The study was funded in part by the Center for the Advancement of Science in Space (CASIS). This article may be obtained online without charge.

 

3

Salerno-Goncalves R, Fasano A, Sztein MB.

Development of a multicellular three-dimensional organotypic model of the human intestinal mucosa grown under microgravity.

J Vis Exp. 2016 Jul 25(113).

http://www.ncbi.nlm.nih.gov/pubmed/27500889

Note: A rotating wall vessel was used.

 

4

Caswell JM, Singh M, Persinger MA.

Simulated sudden increase in geomagnetic activity and its effect on heart rate variability: Experimental verification of correlation studies.

Life Sci Space Res. 2016 Aug;10:47-52.

http://www.sciencedirect.com/science/article/pii/S2214552416300128

Note: From the paper: "Sudden increases in geomagnetic activity were simulated using two custom rectangular coils (about 1.15 m × 1.15 m) placed on either side of the participant seating area 1 m apart and 35 cm away from the body proper. The waveform used was designed to imitate sudden geomagnetic impulses with individual point durations of 69 ms each separated by 1 ms. The resultant magnetic field was produced using a DOS PC system with Complex2 software…" 

 

5

Eftestøl E, Egner IM, Lunde IG, Ellefsen S, Andersen T, Sjåland C, Gundersen K, Bruusgaard JC.

Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns.

Am J Physiol Cell Physiol. 2016 Aug 3. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27488660

 

6

Ogasawara R, Fujita S, Hornberger TA, Kitaoka Y, Makanae Y, Nakazato K, Naokata I.

The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise.

Sci Rep. 2016 Aug 9;6:31142.

http://www.ncbi.nlm.nih.gov/pubmed/27502839

Note: This article may be obtained online without charge

 

7

Chen AB, Minami K, Raposo JF, Matsuura N, Koizumi M, Yokota H, Ferreira HG.

Transient modulation of calcium and parathyroid hormone stimulates bone formation.

Endocrine. 2016 Aug 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27503319

 

8

Hughes JM, Popp KL, Yanovich R, Bouxsein ML, Matheny RW Jr.

The role of adaptive bone formation in the etiology of stress fracture.

Exp Biol Med (Maywood). 2016 Aug 5. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/27496801

 

9

Matic I, Matthews BG, Wang X, Dyment NA, Worthley DL, Rowe DW, Grcevic D, Kalajzic I.

Quiescent bone lining cells are a major source of osteoblasts during adulthood.

Stem Cells. 2016 Aug 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27507737

 

10

Flamant S, Tamarat R.

Extracellular vesicles and vascular injury: New insights for radiation exposure.

Radiat Res. 2016 Aug;186(2):203-18.

http://www.ncbi.nlm.nih.gov/pubmed/27459703

 

11

Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP.

A molecular profile of the endothelial cell response to ionizing radiation.

Radiat Res. 2016 Aug;186(2):141-52.

http://www.ncbi.nlm.nih.gov/pubmed/27387861

 

12

Rafii S, Ginsberg M, Scandura J, Butler JM, Ding BS.

Transplantation of endothelial cells to mitigate acute and chronic radiation injury to vital organs.

Radiat Res. 2016 Aug;186(2):196-202.

http://www.ncbi.nlm.nih.gov/pubmed/27459700

 

13

Arshad Q, Nigmatullina Y, Roberts RE, Goga U, Pikovsky M, Khan S, Lobo R, Flury AS, Pettorossi VE, Cohen-Kadosh R, Malhotra PA, Bronstein AM.

Perceived state of self during motion can differentially modulate numerical magnitude allocation.

Eur J Neurosci. 2016 Jul 16. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27422569

 

14

Botzer A, Meyer J, Parmet Y.

Effects of cues in a binary categorization task on dual-task performance, mental workload, and effort.

J Exp Psychol Appl. 2016 Aug 8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27505049

Note: The NASA Task Load Index was used.

 

15

Jipp M.

Reaction times to consecutive automation failures: A function of working memory and sustained attention.

Hum Factors. 2016 Aug 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27507167

 

16

Verrender A, Loughran SP, Dalecki A, McKenzie R, Croft RJ.

Pulse modulated radiofrequency exposure influences cognitive performance.

Int J Radiat Biol. 2016 Aug 8:1-8. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27501119

 

17

Bishehsari F, Levi F, Turek FW, Keshavarzian A.

Circadian rhythms in gastrointestinal health and diseases.

Gastroenterology. 2016 Jul 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27480174

 

18

Haji-Abolhassani I, Guitton D, Galiana HL.

Modeling eye-head gaze shifts in multiple contexts without motor planning.

J Neurophysiol. 2016 Jul 20:jn.00605.2015. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27440248

 

19

Muller M, Heeck K, Elemans CP.

Semicircular canals circumvent Brownian motion overload of mechanoreceptor hair cells.

PLoS One. 2016 Jul 22;11(7):e0159427.

http://www.ncbi.nlm.nih.gov/pubmed/27448330

Note: This article may be obtained online without charge.

 

20

Lee CP, Maksaev G, Jensen GS, Murcha MW, Wilson ME, Fricker M, Hell R, Haswell ES, Millar AH, Sweetlove L.

MSL1 is a mechanosensitive ion channel that dissipates mitochondrial membrane potential and maintains redox homeostasis in mitochondria during abiotic stress.

Plant J. 2016 Aug 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/27505616

 

21

Nascetti A, Caputo D, Scipinotti R, de Cesare G.

Technologies for autonomous integrated lab-on-chip systems for space missions.

Acta Astronaut. 2016 Nov-Dec;128:401-8. Epub 2016 Aug 11.

http://www.sciencedirect.com/science/article/pii/S0094576516307007

 

 

 

// end //

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