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NASA Spaceline Current Awareness List #716 23 September 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, September 23, 2016

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag 

Papers deriving from NASA support:

1
Higginson EE, Galen JE, Levine MM, Tennant SM.
Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria.
Pathog Dis. 2016 Sep 13. [Epub ahead of print] Review.
http://www.ncbi.nlm.nih.gov/pubmed/27630185 
Note: Spaceflight and rotating wall vessel studies are reviewed. Specific flights are not identified.
Journal Impact Factor: 2.483
Funding: "This work was supported the National Aeronautics and Space Administration (grant number NNX13AN80G to M.M.L.)."

2
Hateley S, Hosamani R, Bhardwaj SR, Pachter L, Bhattacharya S.
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity.
Genomics. 2016 Sep 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27621057 
PIs: S. Bhattacharya; R. Bodmer; R. Hosamani, NASA Post-Doctoral Program Fellowship
Note: Centrifugation was used. This article may be obtained online without charge.
Journal Impact Factor: 2.386
Funding: "This work was funded by NASA grants to SB (NNH09ZTT003N and NNX13AN38G). RH was supported by a NASA Post-Doctoral Program (NPP) Fellowship. SH was supported by the NSF Graduate Research Fellowship. This work used the Vincent J. Coates Genomics Sequencing Laboratory at UC Berkeley, supported by NIH S10 Instrumentation Grants S10RR029668 and S10RR027303."

3
Liu M, Wang H, Lee S, Liu B, Dong L, Wang Y.
DNA repair pathway choice at various conditions immediately post irradiation.
Int J Radiat Biol. 2016 Sep 13:1-11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27622834 
PIs: Y. Wang/H. Wang/NSCOR
Journal Impact Factor: 1.779
Funding: "This work is supported by grants from the National Aeronautics and Space Administration (NNX11AC30G to Y.W.) and the National Cancer Institute (CA186129, CA185882, to Y.W. and P30CA138292 to the Institute)."

4
Macias BR, Lima F, Swift JM, Shirazi-Fard Y, Greene ES, Allen MR, Fluckey J, Hogan HA, Braby L, Wang S, Bloomfield SA.
Simulating the lunar environment: Partial weightbearing and high-LET radiation-induce bone loss and increase sclerostin-positive osteocytes.
Radiat Res. 2016 Sep;186(3):254-63.
http://www.ncbi.nlm.nih.gov/pubmed/27538114 
PIs: S.A. Bloomfield; B.R. Macias and J.M. Swift, NSBRI Graduate Training Fellowship Program
Note: Hindlimb unloading study.
Journal Impact Factor: 3.022
Funding: "These studies were funded through the NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (SAB). Support was also provided by a National Space Biomedical Research Institute Graduate Training Fellowship (no. NSBRI-RFP-05-02; JMS and BRM) and the National Science Foundation Graduate Research Fellowship Program (BRM)."

5
Sandoval LR, Buckey JC, Ainslie R, Tombari M, Stone W, Hegel MT.
Randomized controlled trial of a computerized interactive media-based problem solving treatment for depression.
Behav Ther. 2016 May 3. [Article in Press]
http://www.sciencedirect.com/science/article/pii/S0005789416300090 
PI: J.C. Buckey
Journal Impact Factor: 3.276
Funding: "Drs. Hegel and Buckey receive support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC9–58. The imbPST program was also developed with support from the NSBRI through NASA NCC9–58."

6
Mulcahy RA, Blue RS, Vardiman JL, Castleberry TL, Vanderploeg JM.
Screening and mitigation of layperson anxiety in aerospace environments.
Aerosp Med Hum Perform. 2016 Oct;87(10):882-9.
http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000010/art00009 
PI: J.M. Vanderploeg
Journal Impact Factor: 0.755
Funding: "The authors acknowledge additional support from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58."

7
Williams MA, Malm J, Eklund A, Horton NJ, Voss SE.
Distortion product otoacoustic emissions and intracranial pressure during CSF infusion testing.
Aerosp Med Hum Perform. 2016 Oct;87(10):844-51.
http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000010/art00004 
PI: M.A. Williams
Journal Impact Factor: 0.755
Funding: "This work was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, NSBRI Project #SMST02802."

8
Klerman EB, Beckett SA, Landrigan CP.
Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules.
BMC Med Educ. 2016 Sep 13;16(1):239.
http://www.ncbi.nlm.nih.gov/pubmed/27623842 
PI: E.B. Klerman, D. Schreckenghost
Note: This article may be obtained online without charge.
Journal Impact Factor: 1.312
Funding: "This work was supported by the Agency for Healthcare Research and Quality through R03-HS017357 (Landrigan, Klerman). National Space Biomedical Research Institute through NASA NCC 9-58 HFP01603, HFP02802, HFP04201, and HFP0006 (Beckett, Klerman), NIH NIA P01-AG009975 (Beckett, Klerman), NIH K24-HL105664 (Klerman), NIH RC2- HL101340 (Beckett, Klerman), NIH R01-GM-105018 (Klerman), Boston Children’s Hospital Department of Medicine (Landrigan)."
______________________________________________________

Other papers of interest:

1
Hughson RL, Yee NJ, Greaves DK.
Elevated end-tidal Pco2 during long-duration spaceflight.
Aerosp Med Hum Perform. 2016 Oct;87(10):894-7.
http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000010/art00011 
Note: ISS results.

2
Logan SM, Storey KB.
Tissue-specific response of carbohydrate-responsive element binding protein (ChREBP) to mammalian hibernation in 13-lined ground squirrels.
Cryobiology. 2016 Sep 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27614289 

3
Sawtell NM, Thompson RL.
Herpes simplex virus and the lexicon of latency and reactivation: A call for defining terms and building an integrated collective framework.
F1000Res. 2016 Aug 19;5. Review.
http://www.ncbi.nlm.nih.gov/pubmed/27610228  
Note: This article may be obtained online without charge.

4
Nehra S, Bhardwaj V, Kar S, Saraswat D.
Chronic hypobaric hypoxia induces right ventricular hypertrophy and apoptosis in rats: Therapeutic potential of nanocurcumin in improving adaptation.
High Alt Med Biol. 2016 Sep 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27626325 

5
Paula JS, Asrani SG, Rocha EM.
Microgravity-induced ocular changes in astronauts: A sight odyssey.
Arq Bras Oftalmol. 2016 Jul-Aug;79(4):V-vi.
http://www.ncbi.nlm.nih.gov/pubmed/27626162
Note: This article may be obtained online without charge at http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000400000&lng=en&nrm=iso 

6
Kaur J, Alvarez A, Hanna HW, Krishnan AC, Senador D, Machado TM, Altamimi YH, Lovelace AT, Dombrowski MD, Spranger MD, O'Leary D.
Interaction between the muscle metaboreflex and the arterial baroreflex in control of arterial pressure and skeletal muscle blood flow.
Am J Physiol Heart Circ Physiol. 2016 Sep 9:ajpheart.00501.2016. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27614226 

7
Mukai R, Horikawa H, Lin PY, Tsukumo N, Nikawa T, Kawamura T, Nemoto H, Terao J.
8-prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice.
Am J Physiol Regul Integr Comp Physiol. 2016 Sep 14:ajpregu.00521.2015. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27629889 
Note: Hindlimb unloading via casting was used.

8
Rudrappa SS, Wilkinson DJ, Greenhaff PL, Smith K, Idris I, Atherton PJ.
Human skeletal muscle disuse atrophy: Effects on muscle protein synthesis, breakdown, and insulin resistance—A qualitative review.
Front Physiol. 2016 Aug 25;7:361.
http://www.ncbi.nlm.nih.gov/pubmed/27610086 
Note: This article may be obtained online without charge.

9
Than C, Tosovic D, Seidl L, Brown JM.
The effect of exercise hypertrophy and disuse atrophy on muscle contractile properties: A mechanomyographic analysis.
Eur J Appl Physiol. 2016 Sep 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27614880 

10
Wang J, Wang X, Feng W.
Reloading promotes recovery of disuse muscle loss by inhibiting TGFbeta pathway activation in rats after hind limb suspension.
Am J Phys Med Rehabil. 2016 Sep 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27610551 
Note: Hindlimb unloading study.

11
Doherty AH, Roteliuk DM, Gookin SE, McGrew AK, Broccardo CJ, Condon KW, Prenni JE, Wojda SJ, Florant GL, Donahue SW.
Exploring the bone proteome to help explain altered bone remodeling and preservation of bone architecture and strength in hibernating marmots.
Physiol Biochem Zool. 2016 Sep-Oct;89(5):364-76.
http://www.ncbi.nlm.nih.gov/pubmed/27617358 

12
Laurent MR, Jardí F, Dubois V, Schollaert D, Khalil R, Gielen E, Carmeliet G, Claessens F, Vanderschueren D.
Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.
Bone. 2016 Sep 10;93:33-42. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27622887 

13
Yavropoulou MP, Yovos JG.
The molecular basis of bone mechanotransduction.
J Musculoskelet Neuronal Interact. 2016 Sep 7;16(3):221-36.
http://www.ncbi.nlm.nih.gov/pubmed/27609037 
Note: This article may be obtained online without charge.

14
Sollazzo A, Shakeri-Manesh S, Fotouhi A, Czub J, Haghdoost S, Wojcik A.
Interaction of low and high LET radiation in TK6 cells-mechanistic aspects and significance for radiation protection.
J Radiol Prot. 2016 Sep 15;36(4):721-35. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27631423 
Note: This article may be obtained online without charge.

15
Andreassi MG, Borghini A, Pulignani S, Baffigi F, Fulgentini L, Koester P, Cresci M, Vecoli C, Lamia D, Russo G, Panetta D, Tripodi M, Gizzi LA, Labate L.
Radiobiological effectiveness of ultrashort laser-driven electron bunches: Micronucleus frequency, telomere shortening and cell viability.
Radiat Res. 2016 Sep;186(3):245-53.
http://www.ncbi.nlm.nih.gov/pubmed/27439449 

16
De Stefano I, Giardullo P, Tanno B, Leonardi S, Pasquali E, Babini G, Saran A, Mancuso M.
Nonlinear radiation-induced cataract using the radiosensitive Ptch1+/- mouse model.
Radiat Res. 2016 Sep;186(3):315-21.
http://www.ncbi.nlm.nih.gov/pubmed/27541824 

17
Goudarzi M, Mak TD, Jacobs JP, Moon BH, Strawn SJ, Braun J, Brenner DJ, Fornace AJ Jr, Li HH.
An integrated multi-omic approach to assess radiation injury on the host-microbiome axis.
Radiat Res. 2016 Sep;186(3):219-34.
http://www.ncbi.nlm.nih.gov/pubmed/27512828 

18
Otsuka K, Suzuki K.
Differences in radiation dose response between small and large intestinal crypts.
Radiat Res. 2016 Sep;186(3):302-14.
http://www.ncbi.nlm.nih.gov/pubmed/27556352 

19
Pejchal J, Sinkorova Z, Tichy A, Pruchova S, Kmochova A, Durisova K, Cechakova L, Lierova A, Ondrej M, Nemcova M, Kubelkova K, Fatorova I, Bures J, Tacheci I, Kuca K, Vavrova J.
Epidermal growth factor attenuates delayed ionizing radiation-induced tissue damage in bone marrow transplanted mice.
Radiat Res. 2016 Sep;186(3):264-74.
http://www.ncbi.nlm.nih.gov/pubmed/27538113 

20
Chen H, Lv K, Dai Z, Ji G, Wang T, Wang Y, Zhang Y, Kan G, Li Y, Qu L.
Intramuscular injection of mechano growth factor E domain peptide regulated expression of memory-related sod, miR-134 and miR-125b-3p in rat hippocampus under simulated weightlessness.
Biotechnol Lett. 2016 Sep 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27623796 
Note: Hindlimb unloading study.

21
Bock O, Bury N.
Flipping a switch "down" when not aligned with the gravitational vertical.
Aerosp Med Hum Perform. 2016 Oct;87(10):838-43.
http://www.ingentaconnect.com/content/asma/amhp/2016/00000087/00000010/art00003 

22
Jansen RJ, Sawyer BD, van Egmond R, de Ridder H, Hancock PA.
Hysteresis in mental workload and task performance: The influence of demand transitions and task prioritization.
Hum Factors. 2016 Sep 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27613827 
Note: The NASA Task Load Index was used.

23
De Sá Teixeira NA, Hecht H, Diaz Artiles A, Seyedmadani K, Sherwood DP, Young LR.
Vestibular stimulation interferes with the dynamics of an internal representation of gravity.
Q J Exp Psychol (Hove). 2016 Sep 5:1-43. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27595305 
Note: A short radius centrifuge was used.

24
Fendrych M, Leung J, Friml J.
TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls.
Elife. 2016 Sep 14;5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/27627746 
Note: This article may be obtained online without charge.

25
Jia W, Li B, Li S, Liang Y, Wu X, Ma M, Wang J, Gao J, Cai Y, Zhang Y, Wang Y, Li J, Wang Y.
Mitogen-activated protein kinase cascade MKK7-MPK6 plays important roles in plant development and regulates shoot branching by phosphorylating PIN1 in Arabidopsis.
PLoS Biol. 2016 Sep 12;14(9):e1002550.
http://www.ncbi.nlm.nih.gov/pubmed/27618482 
Note: This article may be obtained online without charge.

26
Zhang C, Qiu L, Gao L, Guan Y, Xu Q, Zhang X, Chen Q.
A novel dual-frequency loading system for studying mechanobiology of load-bearing tissue.
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:262-7. Epub 2016 Jun 27.
http://www.ncbi.nlm.nih.gov/pubmed/27612712 

// end //

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