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NASA Spaceline Current Awareness List #718 7 October 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 14, 2016

 

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here: http://www.spaceref.com/news/mission.html?mid=188&pag

 

In case you missed it: On September 29th, Kennedy Space Center’s Veggie facility was featured in a CNBC website article entitled "Strides in Space Farming May Boost Plan to Build Human Colony on Mars."  The article includes interviews with KSC Veggie Program Manager Trent Smith and KSC Principal Investigator Dr. Rob Ferl, University of Florida.  The article and a short video are available at: http://www.cnbc.com/2016/09/29/strides-in-space-farming-may-boost-plan-to-build-human-colony-on-mars.html

 

Papers deriving from NASA support:

 

1

Kintz NM, Chou C-P, Vessey WB, Leveton LB, Palinkas LA.

Impact of communication delays to and from the International Space Station on self-reported individual and team behavior and performance: A mixed-methods study.

Acta Astronaut. 2016 Dec;129:193-200. Epub 2016 Sep 16.

http://www.sciencedirect.com/science/article/pii/S009457651630697X

PI: L.A. Palinkas

Note: ISS results

Journal Impact Factor: 1.095

Funding: "This work was supported by NASA [NNX12AR21A]."

 

2

Domogauer JD, de Toledo SM, Azzam EI.

A mimic of the tumor microenvironment: A simple method for generating enriched cell populations and investigating intercellular communication.

J Vis Exp. 2016 Sep 20(115).

https://www.ncbi.nlm.nih.gov/pubmed/27684198

PI: E.I Azzam

Note: This article may be obtained online without charge. The video component can be found at http://www.jove.com/video/54429/

Journal Impact Factor: Not available for this journal

Funding: "This research was supported by grants from the New Jersey Commission on Cancer Research (Pre-Doctoral Fellowship DFHS13PPCO17), the National Institutes of Health (CA049062), and the National Aeronautics and Space Administration (NNX15AD62G)."

 

3

Bashir M, Ahmed M, Weinmaier T, Ciobanu D, Ivanova N, Pieber TR, Vaishampayan PA.

Functional metagenomics of spacecraft assembly cleanrooms: Presence of virulence factors associated with human pathogens.

Front Microbiol. 2016 Sep 9;7:1321.

https://www.ncbi.nlm.nih.gov/pubmed/27667984

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.165

Funding: "Part of the research described in this study was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. This research was funded by Planetary Protection Research program in NNH11ZDA001N, ROSES 2011 awarded to PV and NI." M. Ahmed, M. Bashir, and P.A. Vaishampayan are affiliated with the NASA Jet Propulsion Laboratory.

 

4

Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley MA, Carnell LS, Bowles DE.

Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.

Sci Rep. 2016 Sep 27;6:34091.

https://www.ncbi.nlm.nih.gov/pubmed/27670941

PI: D.E. Bowles

Note: A rotating wall vessel was used. This article may be obtained online without charge.

Journal Impact Factor: 5.228

Funding: "This work was supported by the National Aeronautics and Space Association grant NNX12AK76G to Dawn E. Bowles."

 

5

McConnell AM, Konda B, Kirsch DG, Stripp BR.

Distal airway epithelial progenitor cells are radiosensitive to high-LET radiation.

Sci Rep. 2016 Sep 23;6:33455.

https://www.ncbi.nlm.nih.gov/pubmed/27659946

PI: D.G. Kirsch/B.R. Stripp/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.228

Funding: "These studies were supported by NASA NSCOR NNX11AC60G (DGK and BRS), LRRC grant UO1HL111018, and CIRM grant LA1_C12-06915 (BRS)."

 

6

Meyen FE, Hecht MH, Hoffman JA.

Thermodynamic model of Mars Oxygen ISRU Experiment (MOXIE).

Acta Astronaut. 2016 Dec;129:82-7. Epub 2016 Aug 11.

http://www.sciencedirect.com/science/article/pii/S009457651630203X

Journal Impact Factor: 1.095

Funding: "This work was supported by the National Science Foundation Graduate Research Fellowship Program and NASA, including support from the Human Exploration and Operations Mission Directorate (HEOMD), Space Technology Mission Directorate (STMD), and the Science Mission Directorate (SMD)."

______________________________________________________

 

Other papers of interest:

 

1

Ritzmann R, Freyler K, Krause A, Gollhofer A.

Bouncing on Mars and the Moon - The role of gravity on neuromuscular control: Correlation of muscle activity and rate of force development.

J Appl Physiol (1985). 2016 Sep 22:jap.00692.2016. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27660301

Note: Parabolic flight results.

 

2

Gaber H, Abdellatif A.

Liver research in the International Space Station.

Arab J Gastroenterol. 2016 Sep 19. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27658327

Note: ISS results.

 

3

Espinosa-Jeffrey A, Nguyen K, Kumar S, Toshimasa O, Hirose R, Reue K, Vergnes L, Kinchen J, Vellis J.

Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism.

J Neurosci Res. 2016 Sep 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27680492

Note: Centrifugation was used.

 

4

Luu BE, Biggar KK, Wu CW, Storey KB.

Torpor-responsive expression of novel microRNAs regulating metabolism and other cellular pathways in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus.

FEBS Lett. 2016 Sep 27. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27670641

 

5

Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark NR, Jones MR, Kou Y, Goff T, Woodland H, Amaral FM, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bausela XB, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dishuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Dae Devlin T, Pérez-Garcia V, Ma'ayan A.

Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.

Nat Commun. 2016 Sep 26;7:12846.

https://www.ncbi.nlm.nih.gov/pubmed/27667448

Note: This article may be obtained online without charge.

 

6

Jacobson E, Perry JK, Long DS, Vickers MH, O'Sullivan JM.

A potential role for genome structure in the translation of mechanical force during immune cell development.

Nucleus. 2016 Sep 27:0. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27673560

 

7

Belavý DL, Gast U, Felsenberg D.

Exercise and transversus abdominis muscle atrophy after 60 d bed rest.

Med Sci Sports Exerc. 2016 Sep 28. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27685010

Note: Bed rest study.

 

8

Shimoide T, Kawao N, Tamura Y, Morita H, Kaji H.

Novel roles of FKBP5 in muscle alteration induced by gravity change in mice.

Biochem Biophys Res Commun. 2016 Sep 25. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27680313

Note: Centrifugation was used.

 

9

Barkaoui A, Ben Kahla R, Merzouki T, Hambli R.

Age and gender effects on bone mass density variation: Finite elements simulation.

Biomech Model Mechanobiol. 2016 Sep 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27659482

 

10

Xu Z, Sun W, Li Y, Ling S, Zhao C, Zhong G, Zhao D, Song J, Song H, Li J, You L, Nie G, Chang Y, Li Y.

The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Bone. 2016 Sep 26. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27686598

Note: Hindlimb unloading study.

 

11

Zhang X, Wang Q, Wan Z, Li J, Liu L, Zhang X.

CKIP-1 knockout offsets osteoporosis induced by simulated microgravity.

Prog Biophys Mol Biol. 2016 Sep 22. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27666961

Note: Hindlimb unloading study.

 

12

Yakushin SB, Martinelli GP, Raphan T, Cohen B.

The response of the vestibulosympathetic reflex to linear acceleration in the rat.

J Neurophysiol. 2016 Sep 28:jn.00217.2016. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/27683882

Note: Linear acceleration was used.

 

13

Dümmer M, Michalski C, Essen L-O, Rath M, Galland P, Forreiter C.

EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana.

J Plant Physiol. 2016 Sep 22. [Article in Press]

http://www.sciencedirect.com/science/article/pii/S0176161716302024

 

 

 

 

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