NASA Spaceline Current Awareness List #721 28 October 2016 (Space Life Science Research Results)

Status Report From: Spaceline
Posted: Friday, October 28, 2016

Editor's note: NASA's various life sciences programs have prepared the SPACELINE Current Awareness updates since 1999 covering all aspects of space life science, gravitational biology, space medicine, and human factors. NASA does not maintain a website - nor does it have an archive of this resource online. However, SpaceRef does have a complete archive of SPACELINE updates all the way back to 1999 that can be accessed here:


Papers deriving from NASA support:


McIntyre ABR, Rizzardi L, Yu AM, Alexander N, Rosen GL, Botkin DJ, Stahl SE, John KK, Castro-Wallace SL, McGrath K, Burton AS, Feinberg AP, Mason CE.

Nanopore sequencing in microgravity.

npj Microgravity. 2016 Oct 20;2:16035.

PIs: C.E. Mason; K.K. John, NASA Postdoctoral Program

Note: Parabolic flight results. This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: "Support was provided by the Tri-Institutional Training Program in Computational Biology and Medicine (via NIH training grant T32GM083937 in part), the International Space Station Program office, and the NASA Postdoctoral Program administered through a contract with Oak Ridge Associated Universities. For C.E.M we thank the Epigenomics Core Facility at Weill Cornell Medicine, as well as the Starr Cancer Consortium grants (I7-A765, I9-A9–071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L and N Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, 15-15Omni2-0063), the National Institutes of Health (R25EB020393, R01NS076465, R01AI125416, R01ES021006), the Bill and Melinda Gates Foundation (OPP1151054), the Alfred P. Sloan Foundation (G-2015–13964), and the collaborators of the NASA Twins Study."



Chang DG, Healey RM, Snyder AJ, Sayson JV, Macias BR, Coughlin DG, Bailey JF, Parazynski SE, Lotz JC, Hargens AR.

Lumbar spine paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the International Space Station.

Spine (Phila Pa 1976). 2016 Oct 25. [Epub ahead of print]

PIs: A.R. Hargens, B.R. Macias

Note: ISS results.

Journal Impact Factor: 2.439

Funding: "This research was supported by NASA grants NNX10AM18G and NNX13AM89G, a National Space Biomedical Research Institute grant NASA NCC 9-58 to BRM and Environmental and Exercise Section Gravitational Physiology Predoctoral Award to AJS, and American Physiological Society Excellence in Professional Student Research Travel Award to AJS."



Koturbash I, Merrifield M, Kovalchuk O.

Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner.

Int J Radiat Biol. 2016 Oct 19:1-8. [Epub ahead of print]

PIs: M. Boerma/I. Koturbash/NSBRI Center for Research on Cardiac, Vascular, and Acute Effects of Space Radiation

Journal Impact Factor: 1.779

Funding: "Igor Koturbash was supported by the National Institute of Health Center of Biological Research Excellence, grant # 1P20GM109005; NIH/UAMS Clinical and Translational Science Award UL1TR000039 and KL2TR000063, the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000, and the National Space Biomedical Research Institute through the National Aeronautics and Space Administration NCC 9-58, grant# RE03701. Olga Kovalchuk was supported by the Department of Energy Low Dose Radiation Research Program, grant #DE-SC0000984, the Canadian Institutes for Health Research and the National Science and Engineering Council of Canada, and the Alberta Cancer Foundation."



Parthasarathy S, Carskadon MA, Jean-Louis G, Owens J, Bramoweth A, Combs D, Hale L, Harrison E, Hart CN, Hasler BP, Honaker SM, Hertenstein E, Kuna S, Kushida C, Levenson JC, Murray C, Pack AI, Pillai V, Pruiksma K, Seixas A, Strollo P, Thosar SS, Williams N, Buysse D.

Implementation of sleep and circadian science: Recommendations from the Sleep Research Society and National Institutes of Health Workshop.

Sleep. 2016 Oct 10. [Epub ahead of print]

PI: S.S. Thosar

Journal Impact Factor: 4.793

Funding: "Dr. Thosar was supported by National Space Biomedical Research Institute through NCC 9-58, NIH/NHLBI R01 HL125893, NIH/NHLBI 1F32HL131308-01 during the writing of this manuscript."



Other papers of interest:



Sugimoto M, Oono Y, Kawahara Y, Gusev O, Maekawa M, Matsumoto T, Levinskikh M, Sychev V, Novikova N, Grigoriev A.

Gene expression of rice seeds surviving 13- and 20-month exposure to space environment.

Life Sci Space Res. 2016 Nov;11:10-7.

Note: ISS results. From the Introduction: "For this study, we exposed rice seeds outside of the ISS for 13 months and 20 months in a vented metal container without climate control."



Ritzmann R, Krause A, Freyler K, Gollhofer A.

Gravity and neuronal adaptation.

Microgravity Sci Technol. 2016 Oct 25:1-10. [Article in Press]

Note: Parabolic flight results.



Biolo G, Pišot R, Mazzucco S, Di Girolamo FG, Situlin R, Lazzer S, Grassi B, Reggiani C, Passaro A, Rittweger J, Gasparini M, Šimunič B, Narici M.

Anabolic resistance assessed by oral stable isotope ingestion following bed rest in young and older adult volunteers: Relationships with changes in muscle mass.

Clin Nutr. 2016 Sep 30. [Epub ahead of print]

Note: Bed rest study.



Jastroch M, Giroud S, Barrett P, Geiser F, Heldmaier G, Herwig A.

Seasonal control of mammalian energy balance: Recent advances in the understanding of daily torpor and hibernation.

J Neuroendocrinol. 2016 Oct 18. [Epub ahead of print]

Note: This article may be obtained online without charge.



Mao X, Chen Z, Luo Q, Zhang B, Song G.

Simulated microgravity inhibits the migration of mesenchymal stem cells by remodeling actin cytoskeleton and increasing cell stiffness.

Cytotechnology. 2016 Oct 15. [Epub ahead of print]

Note: A 2D-clinostat was used.



Chacon-Cabrera A, Gea J, Barreiro E.

Short- and long-term hindlimb immobilization and reloading: Profile of epigenetic events in gastrocnemius.

J Cell Physiol. 2016 Oct 7. [Epub ahead of print]

Note: Hindlimb immobilization study.



Fusi L, Percario V, Brunello E, Caremani M, Bianco P, Powers JD, Reconditi M, Lombardi V, Piazzesi G.

Minimum number of myosin motors accounting for shortening velocity under zero load in skeletal muscle.

J Physiol. 2016 Oct 20. [Epub ahead of print]



Jubeau M, Rupp T, Temesi J, Perrey S, Wuyam B, Millet GY, Verges S.

Neuromuscular fatigue during prolonged exercise in hypoxia.

Med Sci Sports Exerc. 2016 Oct 6. [Epub ahead of print]



Song J, Saeman MR, Baer LA, Cai AR, Wade CE, Wolf SE.

Exercise altered the skeletal muscle microRNAs and gene expression profiles in burn rats with hindlimb unloading.

J Burn Care Res. 2016 Sep 28. [Epub ahead of print]

Note: Hindlimb unloading study.



Wang W, Dounskaia N.

Neural control of arm movements reveals a tendency to use gravity to simplify joint coordination rather than to decrease muscle effort.

Neuroscience. 2016 Oct 14. [Epub ahead of print]



Okoukoni C, Randolph DM, McTyre ER, Kwok A, Weaver AA, Blackstock AW, Munley MT, Willey JS.

Early dose-dependent cortical thinning of the femoral neck in anal cancer patients treated with pelvic radiation therapy.

Bone. 2017 Jan;94:84-9. Epub 2016 Oct 22.



Kokhan VS, Matveeva MI, Mukhametov A, Shtemberg AS.

Risk of defeats in the central nervous system during deep space missions.

Neurosci Biobehav Rev. 2016 Oct 15. [Epub ahead of print] Review.

Note: The review examines such space flight factors as gravitational overloads, hypo-magnetic field and ionizing radiation, as well as acute and chronic central nervous system risks such as alterations in cognitive abilities, reduction of motor functions, and behavioral changes.



Li X, Anken R, Liu L, Wang G, Liu Y.

Effects of simulated microgravity on otolith growth of larval Zebrafish using a rotating-wall vessel: Appropriate rotation speed and fish developmental stage.

Microgravity Sci Technol. 2016 Oct 20:1-8. [Article in Press]

Note: A rotating wall vessel was used.



Toth AJ, Harris LR, Zettel J, Bent LR.

Vision can recalibrate the vestibular reafference signal used to re-establish postural equilibrium following a platform perturbation.

Exp Brain Res. 2016 Oct 17. [Epub ahead of print]



Chauvet H, Pouliquen O, Forterre Y, Legué V, Moulia B.

Inclination not force is sensed by plants during shoot gravitropism.

Sci Rep. 2016 Oct 14;6:35431.

Note: Centrifugation was used. This article may be obtained online without charge.



Ge L, Chen R.

Negative gravitropism in plant roots.

Nat Plants. 2016 Oct 17;2:16155.

Note: A clinostat was used.



Kościarz-Grzesiok A, Sieroń-Stołtny K, Polak M, Sieroń A, Karcz W.

Effect of low frequency pulsed magnetic field on gravitropic response and cell elongation in coleoptiles of maize seedlings.

Gen Physiol Biophys. 2016 Oct;35(4):417-24.



Mori A, Toyota M, Shimada M, Mekata M, Kurata T, Tasaka M, Morita MT.

Isolation of new gravitropic mutants under hypergravity conditions.

Front Plant Sci. 2016 Sep 29;7:1443.

Note: Centrifugation was used. This article may be obtained online without charge.



Bolodian I, Melikhov A, Tanklevskiy L.

Automatic fire-extinguishing system for inhabited pressurized compartments of manned spacecraft.

Acta Astronaut. 2016 Oct 15. [Article in Press]



Chung CS, Wang H, Hannan MJ, Ding D, Kelleher AR, Cooper RA.

Task-oriented performance evaluation for assistive robotic manipulators: A pilot study.

Am J Phys Med Rehabil. 2016 Oct 6. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Dye E, Wells N.

Subjective and objective measurement of neonatal nurse practitioner workload.

Adv Neonatal Care. 2016 Oct 13. [Epub ahead of print]

Note: The NASA Task Load Index was used.



Scerbo MW, Britt RC, Stefanidis D.

Differences in mental workload between traditional and single-incision laparoscopic procedures measured with a secondary task.

Am J Surg. 2016 Oct 8. [Epub ahead of print]

Note: The NASA Task Load Index was used.



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